Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6509-6512

  Zheng, Guangrong ^a   Dwoskin, Linda P ^a   Deaciuc, Agripina G ^a   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

Author keywords

Lobelane; Structure activity relationship; Vesicular monoamine transporter

Indexed keywords

ALKALOID; LOBELANE; LOBELINE; LOBELINE DERIVATIVE; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER 2;

ARTICLE; BINDING AFFINITY; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEIN BINDING; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; KINETICS; LOBELINE; MODELS, CHEMICAL; OXYGEN; PIPERIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VESICULAR BIOGENIC AMINE TRANSPORT PROTEINS; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 56349168456     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.042     Document Type: Article

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13. 3) δ 0.96-1.82 (m, 11H), 2.34-2.76 (m, 6H)
14. 3H]DTBZ was measured using a Packard TopCount NXT scintillation counter and a Packard Windows NT-based operating system.