Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo [4,5-b] pyridine, 5α-dihydrotestosterone, individually and in combination

International Journal of Oncology

Volumn 35, Issue 3, 2009, Pages 559-567

  Boyiri, Telih ^a   Somiari, Richard I ^b   Russell, Stephen ^b   Aliaga, Cesar ^a   El Bayoumy, Karam ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b Functional Genomics and Proteomics   (United States)

Author keywords

Androgen; Environmental carcinogens; Heterocyclic aromatic amines; Hormones; Prostate cancer; Protein expression; Proteomic analysis

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 2 N HYDROXYLAMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; ANDROSTANOLONE; BIOLOGICAL MARKER; NUCLEOSIDE DIPHOSPHATE KINASE; PHOSPHOLIPASE C; PHOSPHOLIPASE C ALPHA; PROTEIN S7; RAB7 PROTEIN; RIBOSOME PROTEIN; SAR1A PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEOMICS; RAT; TANDEM MASS SPECTROMETRY; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARCINOGENS; CHROMATOGRAPHY, LIQUID; DIHYDROTESTOSTERONE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION; IMAGE PROCESSING, COMPUTER-ASSISTED; IMIDAZOLES; MALE; PROSTATE; PROSTATIC NEOPLASMS; PROTEOMICS; RATS; RATS, INBRED F344; TANDEM MASS SPECTROMETRY;

EID: 70349125502     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000367     Document Type: Article

References (44)

1. American Cancer Society: Cancer facts and Figures. American Cancer Society, Atlanta, 2008.
2. Kolonel LN, Nomura AMY and Cooney RV: Dietary fat and prostate cancer: current status. J Natl Cancer Inst 91: 414-428, 1999.
3. WHO: The World Health Report. World Health Organization, Geneva, 1997.
4. Giovannucci E: Epidemiological characteristics of prostate cancer. Cancer 75: 1766-1777, 1995.
5. Wynder EL, Fujita Y, Harris RE, Hirayama T and Hiyama Y: Comparative epidemiology of cancer between the United States and Japan. A second look. Cancer 67: 746-763, 1999.
6. Shirai T, Sano M, Tamano S, Takahashi S, Hirose M, Futakuchi M, Hasegawa R, Imaida K, Matsumoto K, Wakabayashi K, Sugimura T and Ito N: The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods. Cancer Res 57: 195-198, 1997.
7. Takahashi S, Tamano S, Hirose M, Kimoto N, Ikeda Y, Sakakibara M, Tada M, Kadlubar FF, Ito N and Shirai T: Immunohistochemical demonstration of carcinogen-DNA adducts in tissues of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): detection in paraffin-embedded sections and tissue distribution. Cancer Res 58: 4307-4313, 1998.
8. Shirai T, Tamano S, Cui L, Takahashi S, Futakuchi M, Asamoto M, Kato K and Ito N: Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat prostate and induction of invasive carcinomas by subsequent treatment with testosterone propionate. Cancer Lett 143: 217-221, 1999.
9. Lipsett MB, Wilson H, Kirschner MA, Korenman SG, Fishman LM, Sarfaty GA and Bardin CW: Studies on Leydig cell physiology and pathology: secretion and metabolism of testosterone. Recent Prog Horm Res 22: 245-281, 1966.
10. Bosland MC and Prinsen MK: Induction of dorsolateral prostate adenocarcinomas and other accessory sex gland lesions in male Wistar rats by a single administration of N-methyl N-nitrosourea, 7,12-dimethylbenz(α)anthracene, and 3,2′dimethyl-4-aminobiphenyl after sequential treatment with cyproterone acetate and testosterone propionate. Cancer Res 50: 691-699, 1990.
11. Bosland MC, Prinsen MK, Dirksen TJM and Spit BJ: Characterization of adenocarcinomas of the dorsolateral prostate induced in Wistart rats by N-methyl N-nitrosourea, 7,12-dimethylbenz(α)anthracene, and 3,2′dimethyl-4-aminobiphenyl, following sequential treatment with cyproterone acetate and testosterone propionate. Cancer Res 50: 700-709, 1990.
12. Hsing AW, Reichardt JKV and Stanczyk FZ: Hormones and prostate cancer: current perspectives and future directions. Prostate 52: 213-235, 2002.
13. Aquilina JW, Lipsky JJ and Bostwick DG: Androgen deprivation as a strategy for prostate cancer chemoprevention. J Natl Cancer Inst 89: 689-696, 1997.
14. Makridakis MN and Reichardt JK: Molecular epidemiology of androgen-metabolic loci in prostate cancer: predisposition and progression. J Urol 171: S25-S29, 2004.
15. Ross RK, Bernstein L, Judd H, Hanisch R, Pike MK and Henderson BE: Serum testosterone levels in healthy young black and white men. J Natl Cancer Inst 76: 45-46, 1986.
16. Ross RK, Bernstein L, Lobo RA, Shimizu H, Stanczyk FZ, Pike MC and Henderson BE: 5-alpha reductase activity and risk of prostate cancer among Japanese and US white and black males. Lancet 339: 887-889, 1992.
17. Ellis L and Nyborg H: Racial/ethnic variations in male testosterone levels: a probable contributor to group differences in health. Steroids 57: 72-75, 1992.
18. Eng MH, Charles LG, Ross BD, Chrisp CE, Pienta KJ, Greenberg NM, Hsu CX and Sanda MG: Early castration reduces prostatic carcinogenesis in transgenic mice. Urology 54: 1112-1119, 1999.
19. Doll R: The lessons of life: keynote address to the nutrition and cancer conference. Cancer Res (Suppl) 52: S2024-S2029, 1992.
20. Doll R: Nature and nurture: possibilities for cancer control. Carcinogenesis 17: 177-184, 1996.
21. Department of Health Report on Health and Social insights: no. 48. HMSO, London, 1998.
22. Hill PB and Wynder EL: Effect of a vegetarian diet and dexamethasone on plasma prolactin, testosterone dehydroepiandrosterone in men and women. Cancer Lett 7: 273-282, 1979.
23. Somiari RI, Somiari S, Russell S and Shriver CD: Proteomics of breast carcinoma. J Chromatogr B815: 215-225, 2005.
24. Srinivas PR, Kramer BS and Srivastava S: Trends in biomarker research for cancer detection. Lancet Oncol 2: 698-704, 2001.
25. Liotta L and Petricoin EF: Beyond the genome to tissue proteomics. Breast Cancer Res 2: 13-14, 2000.
26. Srinivas PR, Srivastava S, Hanash S and Wright GL Jr: Proteomics in early detection of cancer. Clin Chem 47: 1901-1911, 2001.
27. Wilson KS, Roberts H, Leek R, Harris AL and Geradts J: Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cell lines and tissues. Am J Pathol 161: 1171-1185, 2002.
28. Pastwa E, Somiari SB, Czyz M and Somiari RI: Proteomics in human cancer research. J Proteomics Clin Appl 1: 4-17, 2007.
29. Anazawa Y, Nakagawa H, Furihara M, Ashida S, Tamura K, Yoshioka H, Shuin T, Fujioka T, Katagiri T and Nakamura Y: PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET. Cancer Res 65: 4578-4586, 2005.
30. Rantalainen M, Cloarec O, Beckonert O, Wilson ID, Jackson D, Tonge R, Rowlinson R, Rayner S, Nickson J, Wilkinson RW, Mills JD, Trygg J, Nicholson JK and Holmes E: Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice. J Proteome Res 5: 2642-2655, 2006.
31. Bindukumar B, Schwartz S, Aalinkeel R, Mahajan S, Lieberman A and Chadha K: Proteomic profiling of the effect of prostate-specific antigen on prostate cancer cells. Prostate 68: 1531-1545, 2008.
32. Somiari RI, Sullivan A, Russell S, Somiari S, Hu H, Jordan R, George A, Katenhusen R, Buchowiecka A, Arciero C, Brzeski H, Hooke J and Shriver C: High-throughput proteomic analysis of human infiltrating ductal carcinoma of the breast. Proteomics 3: 1863-1873, 2003.
33. Yates JR III, Eng JK, McCormack AL and Schieltz D: Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database. Anal Chem 67: 1426-1436, 1995.
34. Youn B, Kim HD and Kim J: Nm23-H1/nucleoside diphosphate kinase as a key molecule in breast tumor angiogenesis. Expert Opin Ther Targets 12: 1419-1430, 2008.
35. Tian R, Wei LM, Qin RY, Li Y, Du ZY, Xia W, Shi CJ and Jin H: Proteome analysis of human pancreatic ductal adenocarcinoma tissue using two-dimensional gel electrophoresis and tandem mass spectrometry for identification of disease-related proteins. Dig Dis Sci 53: 65-72, 2008.
36. Wan H, Wu M, Yu S, Qiang W and Liu T: Mutation and expression of nm23-H1 and CD44 gene in prostate cancers. Zhonghua Wai Ke Za Zhi 38: 382-384, 2000.
37. Lexander H, Franzén B, Hirschberg D, Becker S, Hellström M, Bergman T, Jörnvall H, Auer G and Egevad L: Differential protein expression in anatomical zones of the prostate. Proteomics 5: 2570-2576, 2005.
38. Kassahun WT, Günl B, Tannapfel A, Ungemach FR, Hauss J and Abraham G: Alpha1- and beta 2-adrenoceptors in the human liver with mass-forming intrahepatic cholangiocarcinoma: density and coupling to adenylate cyclase and phospholipase C. Naunyn-Schmiedeberg's Arch Pharmacol 327: 171-181, 2005.
39. Davidson B, Zhang Z, Kleinberg L, Li M, Fl¢renes VA, Wang T-L and Shih I-M: Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from diffuse malignant peritoneal mesothelioma. Clin Cancer Res 12: 5944-5950, 2006.
40. He H, Dai F, Yu L, She X, Zhao Y, Jiang J, Chen X and Zhao S: Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues. Gene Expr 10: 231-242, 2002.
41. Zamora DO, Riviere M, Choi D, Pan Y, Planck SR, Rosenbaum JT, David LL and Smith JR: Proteomic profiling of human retinal and choroidal endothelial cells reveals molecular heterogeneity related to tissue of origin. Mol Vis 13: 2058-2065, 2007.
42. Milon L, Meyer P, Chiadmi M, Munier A, Johansson M, Karlsson A, Lascu I, Capeau J, Janin J and Lacombe ML: The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase. J Biol Chem 275: 14264-14272, 2000.
43. Hsu NY, Chen CY, Hsu CP, Lin TY, Chou MC, Chiou SH and Chow KC: Prognostic significance of expression of nm23-H1 and focal adhesion kinase in non-small cell lung cancer. Oncol Rep 18: 81-85, 2007.
44. Huang HL, Cendan CM, Roza C, Okuse K, Cramer R, Timms JF and Wood JN: Proteomic profiling of neuromas reveals alterations in protein composition and local protein synthesis in hyperexcitable nerves. Mol Pain 4: 1-14, 2008.