Effects of amlodipine, a calcium channel blocker, on rat renal arterioles

Current Therapeutic Research - Clinical and Experimental

Volumn 58, Issue 6, 1997, Pages 375-380

  Kimura, Kenjiro ^a   Suzuki, Naoe ^a   Ohba, Shigeyoshi ^a   Mise, Naobumi ^a   Miyashita, Kazuhisa ^a   Tojo, Akihiro ^a   Goto, Atsuo ^a   Omata, Masao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Arteriole; Calcium channel blockers; Glomerulus; Hydronephrosis; Kidney

Indexed keywords

AMLODIPINE; CALCIUM CHANNEL BLOCKING AGENT; DIHYDROPYRIDINE DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE THERAPY; ARTERIOLE; ARTERY BLOOD FLOW; ARTICLE; BLOOD PRESSURE REGULATION; DRUG EFFECT; GLOMERULUS; HYDRONEPHROSIS; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL ARTERY; RENOVASCULAR HYPERTENSION; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0030757176     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(97)80096-3     Document Type: Article

References (14)

1. Anderson S, Rennke HG, Brenner BM. Antihypertensive therapy must control glomerular hypertension to limit glomerular injury. J Hypertens Suppl. 1986;4:S242-S244.
2. Hostetter TH, Olson JL, Rennke HG, et al. Hyperfiltration in remnant nephrons: A potentially adverse response to renal ablation. Am J Physiol. 1981;241:F85-F93.
3. Anderson S, Meyer TW, Rennke HG, Brenner BM. Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass. J Clin Invest. 1985;76:612-619.
4. Arrowsmith JE, Campbell SF, Cross PE, et al. Long-acting dihydropyridine calcium antagonists. 1,2-Alkoxymethyl derivatives incorporating basic substituents. J Med Chem. 1986;29:1696-1702.
5. Beattie DT, Cunnane TC, Muir TC. Effects of calcium channel antagonists on action potential conduction and transmitter release in the guinea-pig vas deferens. Br J Pharmacol. 1986;89:235-244.
6. Faulkner JK, McGibney D, Chasseaud LF, et al. The pharmacokinetics of amlodipine in healthy volunteers after single intravenous and oral doses and after 14 repeated oral doses given once daily. Br J Clin Pharmacol. 1986;22:21-25.
7. Steinhausen M, Snoei H, Parekh N, et al. Hydronephrosis: A new method to visualize vas afferens, efferens, and glomerular network. Kidney Int. 1983;23:794-806.
8. Wayland H, Johnson PC. Erythrocyte velocity measurement in microvessels by a two-split photometric method. J Appl Physiol. 1967;22:333-337.
9. Fleming JT, Parekh N, Steinhausen M. Calcium antagonists preferentially dilate pre-glomerular vessels of hydronephrotic kidney. Am J Physiol. 1987;253:F1157-F1163.
10. Steinhausen M, Fleming JT, Holz FG, Parekh N. Nitrendipine and the pressure-dependent vasodilation of vessels in the hydronephrotic kidney. J Cardiovasc Pharmacol. 1987;9(Suppl 1):S39-S43.
11. Kimura K, Tojo A, Hirata Y, et al. Effects of a calcium antagonist and an angiotensin II receptor antagonist on rat renal arterioles. Blood Press Suppl. 1994;5:71-74.
12. Arima S, Ito S, Omata K, et al. Diverse effects of calcium antagonists on glomerular hemodynamics. Kidney Int. 1996;49(Suppl 55):S132-S134.
13. Kanno Y, Suzuki H, Okada H, Saruta T. Renal protective effects of amlodipine on partially nephrectomized spontaneously hypertensive rats fed a high-salt diet. J Cardiovasc Pharmacol. 1994;23:480-184.
14. Saruta T, Ishii M, Abe K, Iimura I. Efficacy and safety of amlodipine in hypertensive patients with renal dysfunction. Clin Cardiol. 1994;17:317-324.