Identification of epitopes and immunodominant regions on the MICA protein defined by alloantibodies from kidney transplant patients

Transplantation

Volumn 88, Issue SUPPL. 3, 2009, Pages

  Suárez Álvarez, Beatriz ^a   Alonso Arias, Rebeca ^a   Bravo Mendoza, Cristina ^a   López Vázquez, Antonio ^a   Ortega, Teresa ^a   Baltar, Jose Maria ^a   Coto, Eliecer ^a,b   Ortega, Francisco ^a,b   López Larrea, Carlos ^a,b  

^a HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^b Section of Nephrology   (Spain)

Author keywords

Acute and chronic rejection.; Epitope mapping; HLA; Kidney transplantation; MICA

Indexed keywords

ALLOANTIBODY; EPITOPE; GLYCOPROTEIN; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I RELATED CHAIN A; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I RELATED CHAIN A ANTIBODY; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; EPITOPE MAPPING; FEMALE; HLA SYSTEM; HUMAN; IMMUNOREACTIVITY; KIDNEY GRAFT REJECTION; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; PRIORITY JOURNAL; PROTEIN DOMAIN;

AGED; ANTIBODIES; ENDOTHELIAL CELLS; EPITOPES; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; IMMUNODOMINANT EPITOPES; INCIDENCE; ISOANTIBODIES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; REOPERATION; RETROSPECTIVE STUDIES; TREATMENT FAILURE;

EID: 70349097270     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181afeb7a     Document Type: Article

References (26)

1. Bahram S, Bresnahan M, Geraghty DE, et al. A second lineage of mammalian major histocompatibility complex class I genes. Proc Natl Acad Sci USA 1994; 91: 6259.
2. Groh V, Rhinehart R, Secrist H, et al. Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc Natl Acad Sci USA 1999; 96: 6879.
3. González S, López-Soto A, Suarez-Alvarez B, et al. NKG2D ligands: Key targets of the immune response. Trends Immunol 2008; 29: 397.
4. Wu J, Song Y, Bakker AB, et al. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 1999; 285: 730.
5. Bauer S, Groh V, Wu J, et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999; 285: 727.
6. Suárez-Alvarez B, López-Vázquez A, Baltar JM, et al. Potential role of NKG2D and its ligands in organ transplantation: New target for immu-nointervention. Am J Transplant 2009; 9: 251.
7. Zwirner NW, Marcos CY, Mirbaha F, et al. Identification of MICA as a new polymorphic alloantigen recognized by antibodies in sera of organ transplant recipients. Hum Immunol 2000; 61: 917.
8. Zou Y, Mirbaha F, Lazaro A, et al. MICA is a target for complement-dependent cytotoxicity with mouse monoclonal antibodies and human alloantibodies. Hum Immunol 2002; 63: 30.
9. Hankey KG, Drachenberg CB, Papadimitriou JC, et al. MIC expression in renal and pancreatic allografts. Transplantation 2002; 73: 304.
10. Mizutani K, Terasaki PI, Shih RN, et al. Frequency of MIC antibody in rejected renal transplant patients without HLA antibody. Hum Immunol 2006; 67: 223.
11. Zou Y, Heinemann FM, Grosse-Wilde H, et al. Detection of anti-MICA antibodies in patients awaiting kidney transplantation, during the post-transplant course, and in eluates from rejected kidney allografts by Luminex flow cytometry. Hum Immunol 2006; 67: 230.
12. Sumitran-Holgersson S, Wilczek HE, Holgersson J, et al. Identification of the nonclassical HLA molecules, mica, as targets for humoral immunity associated with irreversible rejection of kidney allografts. Transplantation 2002; 74: 268.
13. Terasaki PI, Ozawa M, Castro R. Four-year follow-up of a prospective trial of HLA and MICA antibodies on kidney graft survival. Am J Transplant 2007; 7: 408.
14. Mizutani K, Terasaki P, Rosen A, et al. Serial ten-year follow-up of HLA and MICA antibody production prior to kidney graft failure. Am J Transplant 2005; 5: 2265.
15. Zou Y, Stastny P, Susal C, et al. Antibodies against MICA antigens and kidney-transplant rejection. N Engl J Med 2007; 357: 1293.
16. Suarez-Alvarez B, Lopez-Vazquez A, Gonzalez MZ, et al. The relationship of anti-MICA antibodies and MICA expression with heart allo-graft rejection. Am J Transplant 2007; 7: 1842.
17. Zou Y, Qin Z, Silveus A, et al. Polymorphisms of MICA recognized by human alloantibodies. Immunogenetics 2009; 61: 91.
18. El-Awar N, Terasaki PI, Cai J, et al. Epitopes of the HLA-A, B, C, DR, DQ and MICA antigens [Review]. Clin Transpl 2007: 175.
19. Duquesnoy RJ, Mostecki J, Hariharan J, et al. Structurally based epitope analysis of major histocompatibility complex class I-related chain A (MICA) antibody specificity patterns. Hum Immunol 2008; 69: 826.
20. Tribbick G. Multipin peptide libraries for antibody and receptor epitope screening and characterization. J Immunol Methods 2002; 267: 27.
21. Porollo A, Meller J. Versatile annotation and publication quality visualization of protein complexes using POLYVIEW-3D. BMC Bioinformatics 2007; 8: 316.
22. Li P, Willie ST, Bauer S, et al. Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand. Immunity 1999; 10: 577.
23. Suárez-Alvarez B, López-Vázquez A, Díaz-Peña R, et al. Post-transplant soluble MICA and MICA antibodies predict subsequent heart graft outcome. Transpl Immunol 2006; 17: 43.
24. Panigrahi A, Gupta N, Siddiqui JA, et al. Post transplant development of MICA and anti-HLA antibodies is associated with acute rejection episodes and renal allograft loss. Hum Immunol 2007; 68: 362.
25. Morales-Buenrostro LE, Terasaki PI, Marino-Vázquez LA, et al. "Natural" human leukocyte antigen antibodies found in nonalloimmunized healthy males. Transplantation 2008; 86: 1111.
26. Cai J, Terasaki PI. Post-transplantation antibody monitoring and HLA antibody epitope identification. Curr Opin Immunol 2008; 20: 602.