9-Aminoacridine blocks NMDA and AMPA receptors by different mechanisms

Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology

Volumn 3, Issue 3, 2009, Pages 275-280

  Barygin, O I ^a   Luchkina, N V ^a   Gmiro, V E ^b   Tikhonov, Denis B ^a  

^a SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

^b RUSSIAN ACADEMY OF SCIENCES   (Russian Federation)

Author keywords

AMPA; Channel block; Ion channels; NMDA; Receptors; Synaptic transmission

Indexed keywords

AMANTADINE DERIVATIVE; AMINOACRIDINE; AMPA RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHENYLCYCLOHEXYL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CALCIUM TRANSPORT; CHANNEL GATING; CONCENTRATION PROCESS; CONTROLLED STUDY; ELECTRIC POTENTIAL; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NERVE CELL; NONHUMAN; PATCH CLAMP; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; WHOLE CELL;

RATTUS;

EID: 70349084126     PISSN: 19907478     EISSN: 19907494     Source Type: Journal    
DOI: 10.1134/S1990747809030052     Document Type: Article

References (21)

1. Dingledine, R., Borges, K., Bowie, D., and Traynelis, S.F., The Glutamate Receptor Ion Channels, Pharmacol. Rev., 1999, vol. 51, pp. 7-61.
2. Dingledine, R., N-Methyl Aspartate Activates Voltage-Dependent Calcium Conductance in Rat Hippocampal Pyramidal Cells, J. Physiol., 1983, vol. 343, pp. 385-405.
3. Nowak, L., Bregestovski, P., Ascher, P., Herbet, A., and Prochiantz, A., Magnesium Gates Glutamate-Activated Channels in Mouse Central Neurons, Nature, 1984, vol. 307, pp. 462-465.
4. 2+ of NMDA Responses in Spinal Cord Neurons, Nature, 1984, vol. 309, pp. 261-263.
5. Hume, R.I., Dingledine, R., and Heinemann, S.F., Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability, Science, 1991, vol. 253, pp. 1028-1031.
6. Villmann, C. and Becker, C.M., On the Hypes and Falls in Neuroprotection: Targeting the NMDA Receptor, Neuroscientist, 2007, vol. 13, pp. 594-615.
7. Vorobjev, V.S. and Sharonova, I.N., Tetrahydroaminoacridine Blocks and Prolongs NMDA Receptor-Mediated Responses in a Voltage-Dependent Manner, Eur. J. Pharmacol., 1994, vol. 253, pp. 1-8.
8. Benveniste, M. and Mayer, M.L., Trapping of Glutamate and Glycine during Open Channel Block of Rat Hippocampal Neuron NMDA Receptors by 9-Aminoacridine, J. Physiol., 1995, vol. 483, pp. 367-384.
9. Koshelev, S.G. and Khodorov, B.I., Tetrabutylammonium, Tacrine and 9-Aminoacridine Block Open NMDA Receptor Channels and Prevent Their Closure and Desensitization, Biologicheskie Membrany (Rus.), 1995, vol. 12, pp. 89-104.
10. Sobolevsky, A.I., Two-Component Blocking Kinetics of Open NMDA Channels by Organic Cations, Biochim. Biophys. Acta, 1999, vol. 12, pp. 69-91.
11. Chen, H.S. and Lipton, S.A., The Chemical Biology of Clinically Tolerated NMDA Receptor Antagonists, J. Neurochem., 2006, vol. 97, pp. 1611-1126.
12. Kim, K.Kh., Gmiro, V.E., Tikhonov, D.B., and Magazanik, L.G., Mechanisms of Glutamate Receptor Channel Block: Paradox of 9-Aminoacridine, Biologicheskie Membrany (Rus.), 2007, vol. 24, pp. 100-107.
13. Barygin, O.I., Gmiro, V.E., Kim, K.Kh., Magazanik, L.G., and Tikhonov, D.B., Blockade of NMDA Receptor Channels by 9-Aminoacridine and Its Derivatives, Neurosci. Lett., 2009, vol. 13, pp. 29-33.
14. Vorobjev, V.S., Vibrodissociation of Sliced Mammalian Nervous Tissue, J. Neurosci. Methods, 1991, vol. 68, pp. 303-307.
15. Magazanik, L.G., Buldakova, S.L., Samoilova, M.V., Gmiro, V.E., Mellor, I., and Usherwood, P.R.N., Block of Open Channels of Recombinant AMPA Receptors and Native AMPA/Kainate Receptors by Adamantane Derivatives, J. Physiol., 1997, vol. 505, pp. 655-663.
16. Vorobjev, V.S., Sharonova, I.N., and Haas, H.L., A Simple Perfusion System for Patch-Clamp Studies, J. Neurosci. Methods, 1996, vol. 68, pp. 303-307.
17. Woodhull, A.M., Ionic Blockage of Sodium Channels in Nerve, J. Gen. Physiol., 1973, vol. 61, pp. 687-708.
18. Bolshakov, K.V., Kim, K.H., Potapjeva, N.N., Gmiro, V.E., Tikhonov, D.B., Usherwood, P.N., Mellor, I.R., and Magazanik, L.G., Design of Antagonists for NMDA and AMPA Receptors, Neuropharmacology, 2005, vol. 49, pp. 144-155.
19. Bolshakov, K.V., Tikhonov, D.B., Gmiro, V.E., and Magazanik, L.G., Different Arrangement of Hydrophobic and Nucleophilic Components of Channel Binding Sites in N-Methyl-D-Aspartate and AMPA Receptors of Rat Brain Is Revealed by Channel Blockade, Neurosci. Lett., 2000, vol. 291, pp. 101-104.
20. Tikhonov, D.B., Samoilova, M.V., Buldakova, S.L., Gmiro, V.E., and Magazanik, L.G., Voltage-Dependent Block of Native AMPA Receptor Channels by Dicationic Compounds, Br. J. Pharmacol., 2000, vol. 129, pp. 265-274.
21. Tikhonov, D.B., Ion Channels of Glutamate Receptors: Structural Modeling, Mol. Membr. Biol., 2007, vol. 24, pp. 135-147.