Blockade of NMDA receptor channels by 9-aminoacridine and its derivatives

Neuroscience Letters

Volumn 451, Issue 1, 2009, Pages 29-33

  Barygin, Oleg I ^a   Gmiro, Valery E ^b   Kim, Kira Kh ^a   Magazanik, Lev G ^a   Tikhonov, Denis B ^a  

^a SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

Ion channel blockade; NMDA receptors; Structure function relationships

Indexed keywords

AMINOACRIDINE DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ISOLATION; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; HIPPOCAMPUS; KINETICS; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT;

AMINACRINE; ANIMALS; ANIMALS, NEWBORN; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HIPPOCAMPUS; ION CHANNEL GATING; KINETICS; MOLECULAR STRUCTURE; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES; PYRAMIDAL CELLS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTIC MEMBRANES; SYNAPTIC TRANSMISSION;

EID: 58249134996     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.12.036     Document Type: Article

References (19)

1. Benveniste M., and Mayer M.L. Trapping of glutamate and glycine during open channel block of rat hippocampal neuron NMDA receptors by 9-aminoacridine. J. Physiol. 483 (1995) 367-384
2. Blanpied T.A., Boeckman F.A., Aizenman E., and Johnson J.W. Trapping channel block of NMDA-activated responses by amantadine and memantine. J. Neurophysiol. 77 (1997) 309-323
3. Bolshakov K.V., Gmiro V.E., Tikhonov D.B., and Magazanik L.G. Determinants of trapping block of N-methyl-d-aspartate receptor channels. J. Neurochem. 87 (2003) 56-65
4. Chen H.S., and Lipton S.A. The chemical biology of clinically tolerated NMDA receptor antagonists. J. Neurochem. 97 (2006) 1611-1126
5. Johnson J.W., and Kotermanski S.E. Mechanism of action of memantine. Curr. Opin. Pharmacol. 6 (2006) 61-67
6. Kim K.H., Gmiro V.E., Tikhonov D.B., and Magazanik L.G. Mechanisms of blockade of glutamate receptor ionic channels: paradox of 9-aminoacridine. Membrane Cell Biol. 1 (2007) 88-95
7. Kroemer R.T., Koutsilieri E., Hecht P., Liedl K.R., Riederer P., and Kornhuber J. Quantitative analysis of the structural requirements for blockade of the N-methyl-d-aspartate receptor at the phencyclidine binding site. J. Med. Chem. 41 (1998) 393-400
8. MacDonald J.F., Bartlett M.C., Mody I., Pahapill P., Reynolds J.N., Salter M.W., Schneiderman J.H., and Pennefather P.S. Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampal neurons. J. Physiol. 432 (1991) 483-508
9. 2+ of NMDA responses in spinal cord neurons. Nature 309 (1984) 261-263
10. Nowak L., Bregestovski P., Ascher P., Herbet A., and Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurons. Nature 307 (1984) 462-465
11. Paoletti P., and Neyton J. NMDA receptor subunits: function and pharmacology. Curr. Opin. Pharmacol. 7 (2007) 39-47
12. Sobolevsky A.I., Koshelev S.G., and Khodorov B.I. Probing of NMDA channels with fast blockers. J. Neurosci. 19 (1999) 10611-10626
13. Sobolevsky A.I., and Yelshansky M.V. The trapping block of NMDA receptor channels in acutely isolated rat hippocampal neurons. J. Physiol. 526 (2000) 493-506
14. Sobolevsky A.I., Beck C., and Wollmuth L.P. Molecular rearrangements of the extracellular vestibule in NMDAR channels during gating. Neuron 33 (2002) 75-85
15. Vargas-Caballero M., and Robinson H.P. Fast and slow voltage-dependent dynamics of magnesium block in the NMDA receptor: the asymmetric trapping block model. J. Neurosci. 24 (2004) 6171-6180
16. Villmann C., and Becker C.M. On the hypes and falls in neuroprotection: targeting the NMDA receptor. Neuroscientist 13 (2007) 594-615
17. Vorobjev V.S., and Sharonova I.N. Tetrahydroaminoacridine blocks and prolongs NMDA receptor-mediated responses in a voltage-dependent manner. Eur. J. Pharmacol. 253 (1994) 1-8
18. Vorobjev V.S. Vibrodissociation of sliced mammalian nervous tissue. J. Neurosci. Meth. 38 (1991) 145-150
19. Woodhull A.M. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61 (1973) 687-708