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Volumn 9, Issue SUPPL.2, 2009, Pages

Treatment of HER2-positive metastatic breast cancer following initial progression

Author keywords

Anthracycline; Antiangiogenesis; Lapatinib; Neratinib; Paclitaxel; Pertuzumab; Trastuzumab

Indexed keywords

4 [3 CHLORO 4 (2 PYRIDINYLMETHOXY)ANILINO] 3 CYANO 6 (4 DIMETHYLAMINOCROTONAMIDO) 7 ETHOXYQUINOLINE; ANASTROZOLE; BEVACIZUMAB; CANERTINIB; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FULVESTRANT; LAPATINIB; LETROZOLE; N [4 (3 BROMOANILINO) 6 QUINAZOLINYL] 2 BUTYNAMIDE; NAVELBINE; PACLITAXEL; PERTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P27; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN C RECEPTOR; TRASTUZUMAB; TRASTUZUMAB DM1; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; HER2 PROTEIN, HUMAN; MONOCLONAL ANTIBODY;

EID: 70249145859     PISSN: 15268209     EISSN: None     Source Type: Journal    
DOI: 10.3816/CBC.2009.s.005     Document Type: Article
Times cited : (21)

References (103)
  • 1
    • 0025162934 scopus 로고
    • Survival of premenopausal women with metastatic breast cancer: Long-term follow-up of Eastern Cooperative Group and Cancer and Leukemia Group B studies
    • Falkson G, Gelman RS, Leone L, et al. Survival of premenopausal women with metastatic breast cancer: long-term follow-up of Eastern Cooperative Group and Cancer and Leukemia Group B studies. Cancer 1990;66:1621-9.
    • (1990) Cancer , vol.66 , pp. 1621-1629
    • Falkson, G.1    Gelman, R.S.2    Leone, L.3
  • 2
    • 0029789811 scopus 로고    scopus 로고
    • Long-term follow-up of patients with complete remission following combination chemotherapy for metastatic breast cancer
    • Greenberg PA, Hortobagyi GN, Smith TL, et al. Long-term follow-up of patients with complete remission following combination chemotherapy for metastatic breast cancer. J Clin Oncol 1996;14:2197-205.
    • (1996) J Clin Oncol , vol.14 , pp. 2197-2205
    • Greenberg, P.A.1    Hortobagyi, G.N.2    Smith, T.L.3
  • 3
    • 0019198985 scopus 로고
    • The value of estrogen and progesterone receptors in the treatment of breast cancer
    • Osborne CK, Yochmowitz MG, Knight WA III, et al. The value of estrogen and progesterone receptors in the treatment of breast cancer. Cancer 1980;46(12 suppl) :2884-8.
    • (1980) Cancer , vol.46 , Issue.12 SUPPL. , pp. 2884-2888
    • Osborne, C.K.1    Yochmowitz, M.G.2    Knight III, W.A.3
  • 4
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-92.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 5
    • 0021688634 scopus 로고
    • The neu oncogene: An erb-B-related gene encoding a 185, 000-Mr tumour antigen
    • Schechter AL, Stern D F, Vaidyanathan L, et al. The neu oncogene: an erb-B-related gene encoding a 185, 000-Mr tumour antigen. Nature 1984;312:513-6.
    • (1984) Nature , vol.312 , pp. 513-516
    • Schechter, A.L.1    Stern, D.F.2    Vaidyanathan, L.3
  • 6
    • 0034600849 scopus 로고    scopus 로고
    • The ErbB signaling network: Receptor heterodimerization in development and cancer
    • Olayioye MA, Neve RM, Lane HA, et al. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J 2000;19:3159-67.
    • (2000) EMBO J , vol.19 , pp. 3159-3167
    • Olayioye, M.A.1    Neve, R.M.2    Lane, H.A.3
  • 7
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-82.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 8
    • 0035125614 scopus 로고    scopus 로고
    • ® (trastuzumab)
    • ® (trastuzumab). Eur J Cancer 2001;37(suppl 1):18-24.
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL. 1 , pp. 18-24
    • Baselga, J.1
  • 9
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel CL, Cobleigh MA, Tripathy D, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20:719-26.
    • (2002) J Clin Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 10
    • 0035873822 scopus 로고    scopus 로고
    • Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer
    • Burstein HJ, Kuter I, Campos SM, et al. Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer. J Clin Oncol 2001;19:2722-30.
    • (2001) J Clin Oncol , vol.19 , pp. 2722-2730
    • Burstein, H.J.1    Kuter, I.2    Campos, S.M.3
  • 11
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005;353:1673-84.
    • (2005) N Engl J Med , vol.353 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 12
    • 33845914783 scopus 로고    scopus 로고
    • 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: A randomised controlled trial
    • Smith I, Procter M, Gelber RD, et al. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 2007;369:29-36.
    • (2007) Lancet , vol.369 , pp. 29-36
    • Smith, I.1    Procter, M.2    Gelber, R.D.3
  • 13
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005;353:1659-72.
    • (2005) N Engl J Med , vol.353 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 14
    • 0035687013 scopus 로고    scopus 로고
    • Inhibitors of HER2/neu (erbB-2) signal transduction
    • Arteaga CL, Chinratanalab W, Carter MB. Inhibitors of HER2/neu (erbB-2) signal transduction. Semin Oncol 2001;28(6 suppl 18):30-5.
    • (2001) Semin Oncol , vol.28 , Issue.6 SUPPL. 18 , pp. 30-35
    • Arteaga, C.L.1    Chinratanalab, W.2    Carter, M.B.3
  • 15
    • 0034879275 scopus 로고    scopus 로고
    • Mechanism of action of anti-HER2 monoclonal antibodies
    • Baselga J, Albanell J. Mechanism of action of anti-HER2 monoclonal antibodies. Ann Oncol 2001;12(suppl 1):S35-41.
    • (2001) Ann Oncol , vol.12 , Issue.SUPPL. 1
    • Baselga, J.1    Albanell, J.2
  • 16
    • 0035169666 scopus 로고    scopus 로고
    • Mechanism of action of trastuzumab and scientific update
    • Baselga J, Albanell J, Molina MA, et al. Mechanism of action of trastuzumab and scientific update. Semin Oncol 2001;28(5 suppl 16):4-11.
    • (2001) Semin Oncol , vol.28 , Issue.5 SUPPL. 16 , pp. 4-11
    • Baselga, J.1    Albanell, J.2    Molina, M.A.3
  • 17
    • 0034873273 scopus 로고    scopus 로고
    • Modulation of p27/Cdk2 complex formation through 4D5-mediated inhibition of HER2 receptor signaling
    • Lane HA, Motoyama AB, Beuvink I, et al. Modulation of p27/Cdk2 complex formation through 4D5-mediated inhibition of HER2 receptor signaling. Ann Oncol 2001;12(suppl 1):S21-2.
    • (2001) Ann Oncol , vol.12 , Issue.SUPPL. 1
    • Lane, H.A.1    Motoyama, A.B.2    Beuvink, I.3
  • 18
    • 0032851961 scopus 로고    scopus 로고
    • Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin)
    • Sliwkowski MX, Lofgren JA, Lewis GD, et al. Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin). Semin Oncol 1999;26(4 suppl 12):60-70.
    • (1999) Semin Oncol , vol.26 , Issue.4 SUPPL. 12 , pp. 60-70
    • Sliwkowski, M.X.1    Lofgren, J.A.2    Lewis, G.D.3
  • 19
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
    • Petit AM, Rak J, Hung M-C, et al. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 1997;151:1523-30.
    • (1997) Am J Pathol , vol.151 , pp. 1523-1530
    • Petit, A.M.1    Rak, J.2    Hung, M.-C.3
  • 20
    • 0032532950 scopus 로고    scopus 로고
    • NH2-terminally truncated HER-2/neu protein: Relationship with shedding of the extracellular domain and with prognostic factors in breast cancer
    • Christianson TA, Doherty JK, Lin YJ, et al. NH2-terminally truncated HER-2/neu protein: relationship with shedding of the extracellular domain and with prognostic factors in breast cancer. Cancer Res 1998;58:5123-9.
    • (1998) Cancer Res , vol.58 , pp. 5123-5129
    • Christianson, T.A.1    Doherty, J.K.2    Lin, Y.J.3
  • 21
    • 0035874981 scopus 로고    scopus 로고
    • Trastuzumab (Herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells
    • Molina MA, Codony-Servat J, Albanell J, et al. Trastuzumab (Herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells. Cancer Res 2001;61:4744-9.
    • (2001) Cancer Res , vol.61 , pp. 4744-4749
    • Molina, M.A.1    Codony-Servat, J.2    Albanell, J.3
  • 22
    • 0033559210 scopus 로고    scopus 로고
    • Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells
    • Codony-Servat J, Albanell J, Lopez-Talavera JC, et al. Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells. Cancer Res 1999;59:1196-201.
    • (1999) Cancer Res , vol.59 , pp. 1196-1201
    • Codony-Servat, J.1    Albanell, J.2    Lopez-Talavera, J.C.3
  • 23
    • 0041885349 scopus 로고    scopus 로고
    • Trastuzumab and vinorelbine as firstline therapy for HER2-overexpressing metastatic breast cancer: Multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm
    • Burstein HJ, Harris LN, Marcom PK, et al. Trastuzumab and vinorelbine as firstline therapy for HER2-overexpressing metastatic breast cancer: multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm. J Clin Oncol 2003;21:2889-95.
    • (2003) J Clin Oncol , vol.21 , pp. 2889-2895
    • Burstein, H.J.1    Harris, L.N.2    Marcom, P.K.3
  • 24
    • 0035257923 scopus 로고    scopus 로고
    • Docetaxel (Taxotere) plus trastuzumab (Herceptin) in breast cancer
    • Burris HA III. Docetaxel (Taxotere) plus trastuzumab (Herceptin) in breast cancer. Semin Oncol 2001;28(1 suppl 3):38-44.
    • (2001) Semin Oncol , vol.28 , Issue.1 SUPPL. 3 , pp. 38-44
    • Burris III, H.A.1
  • 25
    • 0035015136 scopus 로고    scopus 로고
    • Weekly intravenous recombinant humanized anti-P185HER2 monoclonal antibody (Herceptin) plus docetaxel in patients with metastatic breast cancer: A pilot study
    • Meden H, Beneke A, Hesse T, et al. Weekly intravenous recombinant humanized anti-P185HER2 monoclonal antibody (Herceptin) plus docetaxel in patients with metastatic breast cancer: a pilot study. Anticancer Res 2001;21:1301-5.
    • (2001) Anticancer Res , vol.21 , pp. 1301-1305
    • Meden, H.1    Beneke, A.2    Hesse, T.3
  • 26
    • 0031903646 scopus 로고    scopus 로고
    • Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
    • Pegram MD, Lipton A, Hayes D F, et al. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol 1998;16:2659-71.
    • (1998) J Clin Oncol , vol.16 , pp. 2659-2671
    • Pegram, M.D.1    Lipton, A.2    Hayes, D.F.3
  • 27
    • 0035257198 scopus 로고    scopus 로고
    • Gemcitabine, paclitaxel, and trastuzumab in metastatic breast cancer
    • Miller KD, Sisk J, Ansari R, et al. Gemcitabine, paclitaxel, and trastuzumab in metastatic breast cancer. Oncology (Williston Park) 2001;15(2 suppl 3):38-40.
    • (2001) Oncology (Williston Park) , vol.15 , Issue.2 SUPPL. 3 , pp. 38-40
    • Miller, K.D.1    Sisk, J.2    Ansari, R.3
  • 28
    • 0035553174 scopus 로고    scopus 로고
    • The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
    • Rusnak DW, Lackey K, Affleck K, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther 2001;1:85-94.
    • (2001) Mol Cancer Ther , vol.1 , pp. 85-94
    • Rusnak, D.W.1    Lackey, K.2    Affleck, K.3
  • 29
    • 34247588567 scopus 로고    scopus 로고
    • Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
    • Scaltriti M, Rojo F, Ocaña A, et al. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst 2007;99:628-38.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 628-638
    • Scaltriti, M.1    Rojo, F.2    Ocaña, A.3
  • 30
    • 32944461545 scopus 로고    scopus 로고
    • Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumabtreated breast cancer cells
    • Konecny GE, Pegram MD, Venkatesan N, et al. Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumabtreated breast cancer cells. Cancer Res 2006;66:1630-9.
    • (2006) Cancer Res , vol.66 , pp. 1630-1639
    • Konecny, G.E.1    Pegram, M.D.2    Venkatesan, N.3
  • 31
    • 20244388653 scopus 로고    scopus 로고
    • Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies
    • Spector NL, Xia W, Burris H III, et al. Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. J Clin Oncol 2005;23:2502-12.
    • (2005) J Clin Oncol , vol.23 , pp. 2502-2512
    • Spector, N.L.1    Xia, W.2    Burris III, H.3
  • 32
    • 34548071359 scopus 로고    scopus 로고
    • Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network
    • Ritter CA, Perez-Torres M, Rinehart C, et al. Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network. Clin Cancer Res 2007;13:4909-19.
    • (2007) Clin Cancer Res , vol.13 , pp. 4909-4919
    • Ritter, C.A.1    Perez-Torres, M.2    Rinehart, C.3
  • 33
    • 46449113024 scopus 로고    scopus 로고
    • Efficacy and safety of lapatinib as firstline therapy for ErbB2-amplified locally advanced or metastatic breast cancer
    • Gomez HL, Doval DC, Chavez MA, et al. Efficacy and safety of lapatinib as firstline therapy for ErbB2-amplified locally advanced or metastatic breast cancer. J Clin Oncol 2008;26:2999-3005.
    • (2008) J Clin Oncol , vol.26 , pp. 2999-3005
    • Gomez, H.L.1    Doval, D.C.2    Chavez, M.A.3
  • 34
    • 84898694188 scopus 로고    scopus 로고
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer [published erratum in: N Engl J Med 2007;356:1487].
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer [published erratum in: N Engl J Med 2007;356:1487].
  • 35
    • 33845886440 scopus 로고    scopus 로고
    • N Engl J Med 2006;355:2733-43.
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
  • 36
    • 84898701058 scopus 로고    scopus 로고
    • Di Leo A, Gomez H, Aziz Z, et al. Lapatinib (L) with paclitaxel compared to paclitaxel as first-line treatment for patients with metastatic breast cancer: a phase III randomized, double-blind study of 580 patients. J Clin Oncol 2007;25(18 suppl) :34s (Abstract 1011).
    • Di Leo A, Gomez H, Aziz Z, et al. Lapatinib (L) with paclitaxel compared to paclitaxel as first-line treatment for patients with metastatic breast cancer: a phase III randomized, double-blind study of 580 patients. J Clin Oncol 2007;25(18 suppl) :34s (Abstract 1011).
  • 37
    • 84898696339 scopus 로고    scopus 로고
    • O'Shaughnessy J, Blackwell KL, Burstein H, et al. A randomized study of lapatinib alone or in combination with trastuzumab in heavily pretreated HER2+ breast cancer progressing on trastuzumab therapy. J Clin Oncol 2008;26(15 suppl) :44s (Abstract 1015).
    • O'Shaughnessy J, Blackwell KL, Burstein H, et al. A randomized study of lapatinib alone or in combination with trastuzumab in heavily pretreated HER2+ breast cancer progressing on trastuzumab therapy. J Clin Oncol 2008;26(15 suppl) :44s (Abstract 1015).
  • 38
    • 42949112556 scopus 로고    scopus 로고
    • Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer
    • Lin NU, Carey LA, Liu MC, et al. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 2008;26:1993-9.
    • (2008) J Clin Oncol , vol.26 , pp. 1993-1999
    • Lin, N.U.1    Carey, L.A.2    Liu, M.C.3
  • 39
    • 33644600485 scopus 로고    scopus 로고
    • Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab
    • Adams CW, Allison DE, Flagella K, et al. Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab. Cancer Immunol Immunother 2006;55:717-27.
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 717-727
    • Adams, C.W.1    Allison, D.E.2    Flagella, K.3
  • 40
    • 1842605531 scopus 로고    scopus 로고
    • Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
    • Franklin MC, Carey KD, Vajdos F F, et al. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell 2004;5:317-28.
    • (2004) Cancer Cell , vol.5 , pp. 317-328
    • Franklin, M.C.1    Carey, K.D.2    Vajdos, F.F.3
  • 41
    • 84898696418 scopus 로고    scopus 로고
    • Baselga J, Cameron D, Miles D, et al. Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with T. J Clin Oncol 2007;25(18 suppl) :33s (Abstract 1004).
    • Baselga J, Cameron D, Miles D, et al. Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with T. J Clin Oncol 2007;25(18 suppl) :33s (Abstract 1004).
  • 42
    • 33745847797 scopus 로고    scopus 로고
    • Semisynthetic maytansine analogues for the targeted treatment of cancer
    • Widdison WC, Wilhelm SD, Cavanagh EE, et al. Semisynthetic maytansine analogues for the targeted treatment of cancer. J Med Chem 2006;49:4392-408.
    • (2006) J Med Chem , vol.49 , pp. 4392-4408
    • Widdison, W.C.1    Wilhelm, S.D.2    Cavanagh, E.E.3
  • 43
    • 58149249694 scopus 로고    scopus 로고
    • A phase I study of trastuzumab-DM1, a firstin-class HER2 antibody-drug conjugate, in patients with advanced HER2+ breast cancer
    • Abstract 103
    • Krop IE, Beeram M, Modi S, et al. A phase I study of trastuzumab-DM1, a firstin-class HER2 antibody-drug conjugate, in patients with advanced HER2+ breast cancer. Breast Cancer Res Treat 2007;106(suppl 1):S33 (Abstract 103).
    • (2007) Breast Cancer Res Treat , vol.106 , Issue.SUPPL. 1
    • Krop, I.E.1    Beeram, M.2    Modi, S.3
  • 44
    • 84898692878 scopus 로고    scopus 로고
    • A phase II study of trastuzumab-DM1, a first-in-class HER2 antibody-drug conjugate, in patients with HER2+ metastatic breast cancer
    • 71s Abstract 33
    • Vukejla S, Rugo H, Vogel C, et al. A phase II study of trastuzumab-DM1, a first-in-class HER2 antibody-drug conjugate, in patients with HER2+ metastatic breast cancer. Cancer Res 2009;69(suppl) :71s (Abstract 33).
    • (2009) Cancer Res , vol.69 , Issue.SUPPL.
    • Vukejla, S.1    Rugo, H.2    Vogel, C.3
  • 45
    • 84898697237 scopus 로고    scopus 로고
    • Wong KK, Fracasso PM, Bukowski RM, et al. HKI-272, an irreversible pan erbB receptor tyrosine kinase inhibitor: preliminary phase I results in patients with solid tumors. J Clin Oncol 2006;24(18 suppl) :125s (Abstract 3018).
    • Wong KK, Fracasso PM, Bukowski RM, et al. HKI-272, an irreversible pan erbB receptor tyrosine kinase inhibitor: preliminary phase I results in patients with solid tumors. J Clin Oncol 2006;24(18 suppl) :125s (Abstract 3018).
  • 46
    • 67049161327 scopus 로고    scopus 로고
    • Neratinib (HKI-272), an irreversible pan erbB receptor tyrosine kinase inhibitor: Phase 2 results in patients with advanced HER2+ breast cancer
    • 73s Abstract 37
    • Burstein HJ, Sun Y, Tan AR, et al. Neratinib (HKI-272), an irreversible pan erbB receptor tyrosine kinase inhibitor: phase 2 results in patients with advanced HER2+ breast cancer. Cancer Res 2009;69(suppl) :73s (Abstract 37).
    • (2009) Cancer Res , vol.69 , Issue.SUPPL.
    • Burstein, H.J.1    Sun, Y.2    Tan, A.R.3
  • 47
    • 84898692743 scopus 로고    scopus 로고
    • Tanchiu E, Kaufman PA, Paik S, et al. registHER: a prospective, longitudinal cohort study of women with HER2 positive metastatic breast cancer. J Clin Oncol 2005;23(16 suppl) :46s (Abstract 670).
    • Tanchiu E, Kaufman PA, Paik S, et al. registHER: a prospective, longitudinal cohort study of women with HER2 positive metastatic breast cancer. J Clin Oncol 2005;23(16 suppl) :46s (Abstract 670).
  • 48
    • 1842614245 scopus 로고    scopus 로고
    • Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression
    • Tripathy D, Slamon DJ, Cobleigh M, et al. Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression. J Clin Oncol 2004;22:1063-70.
    • (2004) J Clin Oncol , vol.22 , pp. 1063-1070
    • Tripathy, D.1    Slamon, D.J.2    Cobleigh, M.3
  • 49
    • 0041696794 scopus 로고    scopus 로고
    • Continuation of trastuzumab beyond disease progression is feasible and safe in patients with metastatic breast cancer: A retrospective analysis of 80 cases by the Hellenic Cooperative Oncology Group
    • Fountzilas G, Razis E, Tsavdaridis D, et al. Continuation of trastuzumab beyond disease progression is feasible and safe in patients with metastatic breast cancer: a retrospective analysis of 80 cases by the Hellenic Cooperative Oncology Group. Clin Breast Cancer 2003;4:120-5.
    • (2003) Clin Breast Cancer , vol.4 , pp. 120-125
    • Fountzilas, G.1    Razis, E.2    Tsavdaridis, D.3
  • 50
    • 3042676349 scopus 로고    scopus 로고
    • Use of trastuzumab beyond disease progression: Observations from a retrospective review of case histories
    • Gelmon KA, Mackey J, Verma S, et al. Use of trastuzumab beyond disease progression: observations from a retrospective review of case histories. Clin Breast Cancer 2004;5:52-8.
    • (2004) Clin Breast Cancer , vol.5 , pp. 52-58
    • Gelmon, K.A.1    Mackey, J.2    Verma, S.3
  • 51
    • 84898698049 scopus 로고    scopus 로고
    • Von Minckwitz G, Zielinski C, Maarteense E, et al. Capecitabine versus capecitabine + trastuzumab in patients with HER2-positive metastatic breast cancer progressing during trastuzumab treatment: the TBP phase III study (GBG 26/BIG 3-05). J Clin Oncol 2008;26(15 suppl) :47s (Abstract 1025).
    • Von Minckwitz G, Zielinski C, Maarteense E, et al. Capecitabine versus capecitabine + trastuzumab in patients with HER2-positive metastatic breast cancer progressing during trastuzumab treatment: the TBP phase III study (GBG 26/BIG 3-05). J Clin Oncol 2008;26(15 suppl) :47s (Abstract 1025).
  • 52
    • 0032499440 scopus 로고    scopus 로고
    • Circulating concentrations of insulin-like growth factor-I and risk of breast cancer
    • Hankinson SE, Willett WC, Colditz GA, et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 1998;351:1393-6.
    • (1998) Lancet , vol.351 , pp. 1393-1396
    • Hankinson, S.E.1    Willett, W.C.2    Colditz, G.A.3
  • 53
    • 0032564190 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and risk of breast cancer
    • Holly J. Insulin-like growth factor-1 and risk of breast cancer. Lancet 1998;352:1388.
    • (1998) Lancet , vol.352 , pp. 1388
    • Holly, J.1
  • 54
    • 0030781526 scopus 로고    scopus 로고
    • Nickerson T, Huynh H, Pollak M. Insulin-like growth factor binding protein-3 induces apoptosis in MCF7 breast cancer cells [published erratum in: Biochem Biophys Res Commun 1997;240:246].
    • Nickerson T, Huynh H, Pollak M. Insulin-like growth factor binding protein-3 induces apoptosis in MCF7 breast cancer cells [published erratum in: Biochem Biophys Res Commun 1997;240:246].
  • 56
    • 0031767316 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-3 and breast cancer survival
    • Yu H, Levesque MA, Khosravi MJ, et al. Insulin-like growth factor-binding protein-3 and breast cancer survival. Int J Cancer 1998;79:624-8.
    • (1998) Int J Cancer , vol.79 , pp. 624-628
    • Yu, H.1    Levesque, M.A.2    Khosravi, M.J.3
  • 57
    • 0028957113 scopus 로고
    • Molecular and cellular aspects of the insulin-like growth factor I receptor
    • LeRoith D, Werner H, Beitner-Johnson D, et al. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 1995;16:143-63.
    • (1995) Endocr Rev , vol.16 , pp. 143-163
    • LeRoith, D.1    Werner, H.2    Beitner-Johnson, D.3
  • 58
    • 0033961671 scopus 로고    scopus 로고
    • Regulation of survival signals from the insulin-like growth factor-I receptor
    • O'Connor R, Fennelly C, Krause D. Regulation of survival signals from the insulin-like growth factor-I receptor. Biochem Soc Trans 2000;28:47-51.
    • (2000) Biochem Soc Trans , vol.28 , pp. 47-51
    • O'Connor, R.1    Fennelly, C.2    Krause, D.3
  • 59
    • 0346154748 scopus 로고    scopus 로고
    • Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells
    • Lu Y, Zi X, Pollak M. Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells. Int J Cancer 2004;108:334-41.
    • (2004) Int J Cancer , vol.108 , pp. 334-341
    • Lu, Y.1    Zi, X.2    Pollak, M.3
  • 60
    • 0035915421 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
    • Lu Y, Zi X, Zhao Y, et al. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 2001;93:1852-7.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1852-1857
    • Lu, Y.1    Zi, X.2    Zhao, Y.3
  • 61
    • 56249090038 scopus 로고    scopus 로고
    • Nahta R, Yuan LX, Du Y, et al. Lapatinib induces apoptosis in trastuzumabresistant breast cancer cells: effects on insulin-like growth factor I signaling [published erratum in: Mol Cancer Ther 2008;7:3654].
    • Nahta R, Yuan LX, Du Y, et al. Lapatinib induces apoptosis in trastuzumabresistant breast cancer cells: effects on insulin-like growth factor I signaling [published erratum in: Mol Cancer Ther 2008;7:3654].
  • 62
    • 33847369020 scopus 로고    scopus 로고
    • Mol Cancer Ther 2007;6:667-74.
    • (2007) Mol Cancer Ther , vol.6 , pp. 667-674
  • 63
    • 0033003079 scopus 로고    scopus 로고
    • Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma
    • Feilotter HE, Coulon V, McVeigh JL, et al. Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma. Br J Cancer 1999;79:718-23.
    • (1999) Br J Cancer , vol.79 , pp. 718-723
    • Feilotter, H.E.1    Coulon, V.2    McVeigh, J.L.3
  • 64
    • 0030801275 scopus 로고    scopus 로고
    • Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas
    • Rhei E, Kang L, Bogomolniy F, et al. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. Cancer Res 1997;57:3657-9.
    • (1997) Cancer Res , vol.57 , pp. 3657-3659
    • Rhei, E.1    Kang, L.2    Bogomolniy, F.3
  • 65
    • 0031916211 scopus 로고    scopus 로고
    • Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus
    • Singh B, Ittmann MM, Krolewski JJ. Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus. Genes Chromosomes Cancer 1998;21:166-71.
    • (1998) Genes Chromosomes Cancer , vol.21 , pp. 166-171
    • Singh, B.1    Ittmann, M.M.2    Krolewski, J.J.3
  • 66
    • 0035008874 scopus 로고    scopus 로고
    • Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
    • Hutchinson J, Jin J, Cardiff RD, et al. Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol 2001;21:2203-12.
    • (2001) Mol Cell Biol , vol.21 , pp. 2203-2212
    • Hutchinson, J.1    Jin, J.2    Cardiff, R.D.3
  • 67
    • 0035134656 scopus 로고    scopus 로고
    • Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice
    • Moorehead RA, Fata JE, Johnson MB, et al. Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice. Cell Death Differ 2001;8:16-29.
    • (2001) Cell Death Differ , vol.8 , pp. 16-29
    • Moorehead, R.A.1    Fata, J.E.2    Johnson, M.B.3
  • 68
    • 0029127042 scopus 로고
    • Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
    • Bellacosa A, de Feo D, Godwin AK, et al. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer 1995;64:280-5.
    • (1995) Int J Cancer , vol.64 , pp. 280-285
    • Bellacosa, A.1    de Feo, D.2    Godwin, A.K.3
  • 69
    • 0033618371 scopus 로고    scopus 로고
    • Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
    • Nakatani K, Thompson DA, Barthel A, et al. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem 1999;274:21528-32.
    • (1999) J Biol Chem , vol.274 , pp. 21528-21532
    • Nakatani, K.1    Thompson, D.A.2    Barthel, A.3
  • 70
    • 0037099532 scopus 로고    scopus 로고
    • Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
    • Yakes FM, Chinratanalab W, Ritter CA, et al. Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res 2002;62:4132-41.
    • (2002) Cancer Res , vol.62 , pp. 4132-4141
    • Yakes, F.M.1    Chinratanalab, W.2    Ritter, C.A.3
  • 71
    • 0036633164 scopus 로고    scopus 로고
    • Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells
    • Clark AS, West K, Streicher S, et al. Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. Mol Cancer Ther 2002;1:707-17.
    • (2002) Mol Cancer Ther , vol.1 , pp. 707-717
    • Clark, A.S.1    West, K.2    Streicher, S.3
  • 72
    • 18844365440 scopus 로고    scopus 로고
    • ®)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors
    • ®)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors. Breast Cancer Res Treat 2005;91:187-201.
    • (2005) Breast Cancer Res Treat , vol.91 , pp. 187-201
    • Chan, C.T.1    Metz, M.Z.2    Kane, S.E.3
  • 73
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Nagata Y, Lan K-H, Zhou X, et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004;6:117-27.
    • (2004) Cancer Cell , vol.6 , pp. 117-127
    • Nagata, Y.1    Lan, K.-H.2    Zhou, X.3
  • 74
    • 70149085341 scopus 로고    scopus 로고
    • PI3 kinase activation and response to trastuzumab or lapatinib in HER2-overexpressing locally advanced breast cancer (LABC)
    • 72s Abstract 34
    • Migliaccio I, Gutierrez M, Wu M-F, et al. PI3 kinase activation and response to trastuzumab or lapatinib in HER2-overexpressing locally advanced breast cancer (LABC). Cancer Res 2009;69(suppl) :72s (Abstract 34).
    • (2009) Cancer Res , vol.69 , Issue.SUPPL.
    • Migliaccio, I.1    Gutierrez, M.2    Wu, M.-F.3
  • 75
    • 0038607569 scopus 로고    scopus 로고
    • The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition
    • Le X-F, Claret F-X, Lammayot A, et al. The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition. J Biol Chem 2003;278:23441-50.
    • (2003) J Biol Chem , vol.278 , pp. 23441-23450
    • X-F, L.1    Claret, F.-X.2    Lammayot, A.3
  • 76
    • 57149103129 scopus 로고    scopus 로고
    • Nahta R, Takahashi T, Ueno NT, et al. P27kip1 down-regulation is associated with trastuzumab resistance in breast cancer cells [published erratum in: Cancer Res 2008;68:10005].
    • Nahta R, Takahashi T, Ueno NT, et al. P27kip1 down-regulation is associated with trastuzumab resistance in breast cancer cells [published erratum in: Cancer Res 2008;68:10005].
  • 77
    • 2542526069 scopus 로고    scopus 로고
    • Cancer Res 2004;64:3981-6.
    • (2004) Cancer Res , vol.64 , pp. 3981-3986
  • 78
    • 1042291150 scopus 로고    scopus 로고
    • Development of Herceptin resistance in breast cancer cells
    • Kute T, Lack CM, Willingham M, et al. Development of Herceptin resistance in breast cancer cells. Cytometry A 2004;57:86-93.
    • (2004) Cytometry A , vol.57 , pp. 86-93
    • Kute, T.1    Lack, C.M.2    Willingham, M.3
  • 79
    • 36148976786 scopus 로고    scopus 로고
    • Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells
    • Neckers L, Kern A, Tsutsumi S. Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells. Chem Biol 2007;14:1204-6.
    • (2007) Chem Biol , vol.14 , pp. 1204-1206
    • Neckers, L.1    Kern, A.2    Tsutsumi, S.3
  • 80
    • 0037075232 scopus 로고    scopus 로고
    • Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2
    • Basso A, Solit DB, Munster PN, et al. Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2. Oncogene 2002;21:1159-66.
    • (2002) Oncogene , vol.21 , pp. 1159-1166
    • Basso, A.1    Solit, D.B.2    Munster, P.N.3
  • 81
    • 0033902775 scopus 로고    scopus 로고
    • Effects of geldanamycin and other naturally occurring small molecule antagonists of heat shock protein 90 on HER2 protein expression
    • Neckers L. Effects of geldanamycin and other naturally occurring small molecule antagonists of heat shock protein 90 on HER2 protein expression. Breast Dis 2000;11:49-59.
    • (2000) Breast Dis , vol.11 , pp. 49-59
    • Neckers, L.1
  • 82
    • 34248166884 scopus 로고    scopus 로고
    • Phase I trial of KOS-953, a heat shock protein 90 inhibitor, and trastuzumab (T)
    • 18 suppl, 3s Abstract 501
    • Modi S, Stopeck A, Gordon MS, et al. Phase I trial of KOS-953, a heat shock protein 90 inhibitor, and trastuzumab (T). J Clin Oncol 2006;24(18 suppl) :3s (Abstract 501).
    • (2006) J Clin Oncol , pp. 24
    • Modi, S.1    Stopeck, A.2    Gordon, M.S.3
  • 83
    • 56949084272 scopus 로고    scopus 로고
    • Phase I trial of alvespimycin (KOS-1022;17-DMAG) and trastuzumab (T)
    • 18 suppl, 60s Abstract 1115
    • Miller K, Rosen LS, Modi S, et al. Phase I trial of alvespimycin (KOS-1022;17-DMAG) and trastuzumab (T). J Clin Oncol 2007;25(18 suppl) :60s (Abstract 1115).
    • (2007) J Clin Oncol , pp. 25
    • Miller, K.1    Rosen, L.S.2    Modi, S.3
  • 84
    • 0029143982 scopus 로고
    • Biological and clinical role of angiogenesis in breast cancer
    • Gasparini G. Biological and clinical role of angiogenesis in breast cancer. Breast Cancer Res Treat 1995;36:103-7.
    • (1995) Breast Cancer Res Treat , vol.36 , pp. 103-107
    • Gasparini, G.1
  • 85
    • 12144291334 scopus 로고    scopus 로고
    • Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients
    • Konecny GE, Meng YG, Untch M, et al. Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients. Clin Cancer Res 2004;10:1706-16.
    • (2004) Clin Cancer Res , vol.10 , pp. 1706-1716
    • Konecny, G.E.1    Meng, Y.G.2    Untch, M.3
  • 86
    • 0346366639 scopus 로고    scopus 로고
    • Overexpression of c-erbB-2 is related to a higher expression of vascular endothelial growth factor (VEGF) and constitutes an independent prognostic factor in primary node-positive breast cancer after adjuvant systemic treatment
    • Linderholm B, Andersson J, Lindh B, et al. Overexpression of c-erbB-2 is related to a higher expression of vascular endothelial growth factor (VEGF) and constitutes an independent prognostic factor in primary node-positive breast cancer after adjuvant systemic treatment. Eur J Cancer 2004;40:33-42.
    • (2004) Eur J Cancer , vol.40 , pp. 33-42
    • Linderholm, B.1    Andersson, J.2    Lindh, B.3
  • 87
    • 0036316476 scopus 로고    scopus 로고
    • Combined biological therapy of breast cancer using monoclonal antibodies directed against HER2/neu protein and vascular endothelial growth factor
    • Pegram MD, Reese DM. Combined biological therapy of breast cancer using monoclonal antibodies directed against HER2/neu protein and vascular endothelial growth factor. Semin Oncol 2002;29(3 suppl 11):29-37.
    • (2002) Semin Oncol , vol.29 , Issue.3 SUPPL. 11 , pp. 29-37
    • Pegram, M.D.1    Reese, D.M.2
  • 88
    • 0036604183 scopus 로고    scopus 로고
    • ErbB2 overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human breast carcinoma
    • Yang W, Klos K, Yang Y, et al. ErbB2 overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human breast carcinoma. Cancer 2002;94:2855-61.
    • (2002) Cancer , vol.94 , pp. 2855-2861
    • Yang, W.1    Klos, K.2    Yang, Y.3
  • 89
    • 1842543455 scopus 로고    scopus 로고
    • HER2-overexpressing human breast cancer xenografts exhibit increased angiogenic potential mediated by vascular endothelial growth factor (VEGF)
    • Abstract 570
    • Epstein M, Ayala R, Tchekmedyian N, et al. HER2-overexpressing human breast cancer xenografts exhibit increased angiogenic potential mediated by vascular endothelial growth factor (VEGF). Breast Cancer Res Treat 2002;76(suppl 1):S143 (Abstract 570).
    • (2002) Breast Cancer Res Treat , vol.76 , Issue.SUPPL. 1
    • Epstein, M.1    Ayala, R.2    Tchekmedyian, N.3
  • 90
    • 0036855224 scopus 로고    scopus 로고
    • Differential regulation of tumor angiogenesis by distinct ErbB homo-and heterodimers
    • Yen L, Benlimame N, Nie Z-R, et al. Differential regulation of tumor angiogenesis by distinct ErbB homo-and heterodimers. Mol Biol Cell 2002;13:4029-44.
    • (2002) Mol Biol Cell , vol.13 , pp. 4029-4044
    • Yen, L.1    Benlimame, N.2    Nie, Z.-R.3
  • 91
    • 21044443432 scopus 로고    scopus 로고
    • Phase I combined biological therapy of breast cancer using two humanized monoclonal antibodies directed against HER2 protooncogene and vascular endothelial growth factor (VEGF)
    • Abstract 3039
    • Pegram MD, Yeon C, Ku NC, et al. Phase I combined biological therapy of breast cancer using two humanized monoclonal antibodies directed against HER2 protooncogene and vascular endothelial growth factor (VEGF). Breast Cancer Res Treat 2004;88(suppl 1):S124 (Abstract 3039).
    • (2004) Breast Cancer Res Treat , vol.88 , Issue.SUPPL. 1
    • Pegram, M.D.1    Yeon, C.2    Ku, N.C.3
  • 92
    • 34247243265 scopus 로고    scopus 로고
    • Phase II combined biological therapy targeting the HER2 proto-oncogene and the vascular endothelial growth factor using trastuzumab (T) and bevacizumab (B) as first line treatment of HER2-amplified breast cancer
    • Abstract 301
    • Pegram M, Chan D, Dichmann RA, et al. Phase II combined biological therapy targeting the HER2 proto-oncogene and the vascular endothelial growth factor using trastuzumab (T) and bevacizumab (B) as first line treatment of HER2-amplified breast cancer. Breast Cancer Res Treat 2006;100(suppl 1):S28 (Abstract 301).
    • (2006) Breast Cancer Res Treat , vol.100 , Issue.SUPPL. 1
    • Pegram, M.1    Chan, D.2    Dichmann, R.A.3
  • 93
    • 0034987631 scopus 로고    scopus 로고
    • Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182, 780 (Faslodex)
    • McClelland RA, Barrow D, Madden T-A, et al. Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182, 780 (Faslodex). Endocrinology 2001;142:2776-88.
    • (2001) Endocrinology , vol.142 , pp. 2776-2788
    • McClelland, R.A.1    Barrow, D.2    Madden, T.-A.3
  • 94
    • 0042804495 scopus 로고    scopus 로고
    • Gefitinib (ZD1839) is active in acquired tamoxifen-resistant oestrogen receptor (ER)-positive and ER-negative breast cancer: Results from a phase II study
    • Abstract 23
    • Robertson J F, Gutteridge E, Cheung KL, et al. Gefitinib (ZD1839) is active in acquired tamoxifen-resistant oestrogen receptor (ER)-positive and ER-negative breast cancer: results from a phase II study. Proc Am Soc Clin Oncol 2003;22:7 (Abstract 23).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 7
    • Robertson, J.F.1    Gutteridge, E.2    Cheung, K.L.3
  • 95
    • 0034790009 scopus 로고    scopus 로고
    • Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer
    • Nicholson RI, Hutcheson IR, Harper ME, et al. Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer. Endocr Relat Cancer 2001;8:175-82.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 175-182
    • Nicholson, R.I.1    Hutcheson, I.R.2    Harper, M.E.3
  • 96
    • 0242710208 scopus 로고    scopus 로고
    • Adaptive hypersensitivity following longterm estrogen deprivation: Involvement of multiple signal pathways
    • Yue W, Wang J-P, Conaway MR, et al. Adaptive hypersensitivity following longterm estrogen deprivation: involvement of multiple signal pathways. J Steroid Biochem Mol Biol 2003;86:265-74.
    • (2003) J Steroid Biochem Mol Biol , vol.86 , pp. 265-274
    • Yue, W.1    Wang, J.-P.2    Conaway, M.R.3
  • 97
    • 22244446128 scopus 로고    scopus 로고
    • Serum HER-2/neu conversion to positive at the time of disease progression in patients with breast carcinoma on hormone therapy
    • Lipton A, Leitzel K, Ali SM, et al. Serum HER-2/neu conversion to positive at the time of disease progression in patients with breast carcinoma on hormone therapy. Cancer 2005;104:257-63.
    • (2005) Cancer , vol.104 , pp. 257-263
    • Lipton, A.1    Leitzel, K.2    Ali, S.M.3
  • 98
    • 84898693568 scopus 로고    scopus 로고
    • Rasmussen BB, Regan MM, Lykkesfeldt AE, et al. Central assessment of ER, PgR and HER2 in BIG 1-98 evaluating letrozole (L) compared to tamoxifen (T) as initial adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive breast cancer. J Clin Oncol 2007;25(18 suppl) :12s (Abstract 538)
    • Rasmussen BB, Regan MM, Lykkesfeldt AE, et al. Central assessment of ER, PgR and HER2 in BIG 1-98 evaluating letrozole (L) compared to tamoxifen (T) as initial adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive breast cancer. J Clin Oncol 2007;25(18 suppl) :12s (Abstract 538)
  • 99
    • 34250680938 scopus 로고    scopus 로고
    • Relationship between quantitative ER and PgR expression and HER2 status with recurrence in the ATAC trial
    • Abstract 48
    • Dowsett M, Allred DC. Relationship between quantitative ER and PgR expression and HER2 status with recurrence in the ATAC trial. Breast Cancer Res Treat 2006;100(suppl 1):S21 (Abstract 48).
    • (2006) Breast Cancer Res Treat , vol.100 , Issue.SUPPL. 1
    • Dowsett, M.1    Allred, D.C.2
  • 100
    • 33745988573 scopus 로고    scopus 로고
    • Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole
    • Ellis MJ, Tao Y, Young O, et al. Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole. J Clin Oncol 2006;24:3019-25.
    • (2006) J Clin Oncol , vol.24 , pp. 3019-3025
    • Ellis, M.J.1    Tao, Y.2    Young, O.3
  • 101
    • 35549002408 scopus 로고    scopus 로고
    • Trastuzumab plus anastrozole prolongs progression-free survival in postmenopausal women with HER2-positive, hormone-dependent metastatic breast cancer (MBC)
    • Paper presented at: September 29-October 3, Istanbul, Turkey. Abstract
    • Kaufman B, Mackey J, Clemens M, et al. Trastuzumab plus anastrozole prolongs progression-free survival in postmenopausal women with HER2-positive, hormone-dependent metastatic breast cancer (MBC). Paper presented at: 2006 European Society for Medical Oncology Congress; September 29-October 3, 2006; Istanbul, Turkey. Abstract LBA2.
    • (2006) 2006 European Society for Medical Oncology Congress
    • Kaufman, B.1    Mackey, J.2    Clemens, M.3
  • 102
    • 70349685919 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole vs. letrozole alone for front line postmenopausal hormone receptor positive (HR+) metastatic breast cancer (MBC) : First results from the EGF30008 trial
    • 74s Abstract 46
    • Johnston S, Pegram M, Press M, et al. Lapatinib combined with letrozole vs. letrozole alone for front line postmenopausal hormone receptor positive (HR+) metastatic breast cancer (MBC) : first results from the EGF30008 trial. Cancer Res 2009;69(suppl) :74s (Abstract 46).
    • (2009) Cancer Res , vol.69 , Issue.SUPPL.
    • Johnston, S.1    Pegram, M.2    Press, M.3
  • 103
    • 33846504444 scopus 로고    scopus 로고
    • Compressing drug development timelines in oncology using phase '0' trials
    • Kummar S, Kinders R, Rubinstein L, et al. Compressing drug development timelines in oncology using phase '0' trials. Nat Rev Cancer 2007;7:131-9.
    • (2007) Nat Rev Cancer , vol.7 , pp. 131-139
    • Kummar, S.1    Kinders, R.2    Rubinstein, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.