Overexpressed focal adhesion kinase predicts a higher incidence of extrahepatic metastasis and worse survival in hepatocellular carcinoma

Human Pathology

Volumn 40, Issue 10, 2009, Pages 1384-1390

  Jan, Yee Jee ^a,b   Ko, Bor Sheng ^c,d   Hsu, Chiun ^c   Chang, Tzu Ching ^d   Chen, Shyh Chang ^a   Wang, John ^a,b   Liou, Jun Yang ^d  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b HUNGKUANG UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Focal adhesion kinase; Hepatocellular carcinoma; Metastasis

Indexed keywords

FOCAL ADHESION KINASE;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER TUMOR; MAJOR CLINICAL STUDY; MALE; METASTASIS; MORBIDITY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; FEMALE; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; TUMOR MARKERS, BIOLOGICAL;

EID: 70249142826     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.03.006     Document Type: Article

References (34)

1. El-Serag H.B., and Rudolph K.L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132 (2007) 2557-2576
2. El-Serag H.B., Marrero J.A., Rudolph L., and Reddy K.R. Diagnosis and treatment of hepatocellular carcinoma. Gastroenterology 134 (2008) 1752-1763
3. Natsuizaka M., Omura T., Akaike T., et al. Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol 20 (2005) 1781-1787
4. McLean G.W., Carragher N.O., Avizienyte E., et al. The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nat Rev Cancer 5 (2005) 505-515
5. Kornberg L., Earp H.S., Parsons J.T., et al. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J Biol Chem 267 (1992) 23439-23442
6. Clark E.A., and Brugge J.S. Integrins and signal transduction pathways: the road taken. Science 268 (1995) 233-239
7. Sieg D.J., Hauck C.R., Ilic D., et al. FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol 2 (2000) 249-256
8. Xu L.H., Owens L.V., Sturge G.C., et al. Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells. Cell Growth Differ 7 (1996) 413-418
9. van Nimwegen M.J., and van de Water B. Focal adhesion kinase: a potential target in cancer therapy. Biochem Pharmacol 73 (2007) 597-609
10. Abdel-Ghany M., Cheng H.C., Elble R.C., and Pauli B.U. Focal adhesion kinase activated by beta (4) integrin ligation to mCLCA1 mediates early metastatic growth. J Biol Chem 277 (2002) 34391-34400
11. Judson P.L., He X., Cance W.G., and Van Le L. Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer 86 (1999) 1551-1556
12. Miyazaki T., Kato H., Nakajima M., et al. FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma. Br J Cancer 89 (2003) 140-145
13. Cance W.G., Harris J.E., Iacocca M.V., et al. Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res 6 (2000) 2417-2423
14. Itoh S., Maeda T., Shimada M., et al. Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. Clin Cancer Res 10 (2004) 2812-2817
15. Sun C.K., Ng K.T., Sun B.S., et al. The significance of proline-rich tyrosine kinase 2 (Pyk2) on hepatocellular carcinoma progression and recurrence. Br J Cancer 97 (2007) 50-57
16. Yuan Z., Fan J., Wu Z.Q., et al. [Focal adhesion kinase mRNA overexpression in hepatocellular carcinoma HCC) and correlation thereof with prognosis of HCC]. Zhonghua Yi Xue Za Zhi 87 (2007) 1256-1259
17. Cai T., Lei Q.Y., Wang L.Y., and Zha X.L. TGF-beta 1 modulated the expression of alpha 5 beta 1 integrin and integrin-mediated signaling in human hepatocarcinoma cells. Biochem Biophys Res Commun 274 (2000) 519-525
18. Sutton A., Friand V., Papy-Garcia D., et al. Glycosaminoglycans and their synthetic mimetics inhibit RANTES-induced migration and invasion of human hepatoma cells. Mol Cancer Ther 6 (2007) 2948-2958
19. von Sengbusch A., Gassmann P., Fisch K.M., et al. Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids. Am J Pathol 166 (2005) 585-596
20. Su J.M., Wang L.Y., Liang Y.L., and Zha X.L. Role of cell adhesion signal molecules in hepatocellular carcinoma cell apoptosis. World J Gastroenterol 11 (2005) 4667-4673
21. Park S.S., Eom Y.W., Kim E.H., et al. Involvement of c-Src kinase in the regulation of TGF-beta1-induced apoptosis. Oncogene 23 (2004) 6272-6281
22. Zhang W., Wu N., Li Z., et al. PPAR gamma activator rosiglitazone inhibits cell migration via upregulation of PTEN in human hepatocarcinoma cell line BEL-7404. Cancer Biol Ther 5 (2006) 1008-1014
23. Fujii T., Koshikawa K., Nomoto S., et al. Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor. J Hepatol 41 (2004) 104-111
24. Llovet J.M., Bru C., and Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 19 (1999) 329-338
25. Barnes D.M., Harris W.H., Smith P., et al. Immunohistochemical determination of oestrogen receptor: comparison of different methods of assessment of staining and correlation with clinical outcome of breast cancer patients. Br J Cancer 74 (1996) 1445-1451
26. Chang G.C., Liu K.J., Hsieh C.L., et al. Identification of alpha-enolase as an autoantigen in lung cancer: its overexpression is associated with clinical outcomes. Clin Cancer Res 12 (2006) 5746-5754
27. Bruix J., Sherman M., Llovet J.M., et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 35 (2001) 421-430
28. Said A., and Lucey M.R. Liver transplantation: an update 2008. Curr Opin Gastroenterol 24 (2008) 339-345
29. Katyal S., Oliver III J.H., Peterson M.S., et al. Extrahepatic metastases of hepatocellular carcinoma. Radiology 216 (2000) 698-703
30. Shuto T., Hirohashi K., Kubo S., et al. Treatment of adrenal metastases after hepatic resection of a hepatocellular carcinoma. Dig Surg 18 (2001) 294-297
31. Ayaki M., Komatsu K., Mukai M., et al. Reduced expression of focal adhesion kinase in liver metastases compared with matched primary human colorectal adenocarcinomas. Clin Cancer Res 7 (2001) 3106-3112
32. Recher C., Ysebaert L., Beyne-Rauzy O., et al. Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis. Cancer Res 64 (2004) 3191-3197
33. Furuyama K., Doi R., Mori T., et al. Clinical significance of focal adhesion kinase in resectable pancreatic cancer. World J Surg 30 (2006) 219-226
34. Rocken C., and Carl-McGrath S. Pathology and pathogenesis of hepatocellular carcinoma. Dig Dis 19 (2001) 269-278