Prematurely condensed chromosome fragments in human lymphocytes induced by high doses of high-linear-energy-transfer irradiation

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 679, Issue 1-2, 2009, Pages 9-12

  Wang, Z Z ^a   Li, W J ^a   Zhi, D J ^b   Gao, Q X ^b   Qu, Y ^a   Wang, B Q ^a  

^a INSTITUTE OF MODERN PHYSICS   (China)

^b LANZHOU UNIVERSITY   (China)

Author keywords

Biodosimeter; Calyculin A; Carbon ions; G2 prematurely condensed chromosome fragments; High dose radiation

Indexed keywords

ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME CONDENSATION; CONTROLLED STUDY; GIEMSA STAIN; HEAVY ION RADIATION; HUMAN; HUMAN CELL; IN VITRO STUDY; ION THERAPY; IRRADIATION; LINEAR ENERGY TRANSFER; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RADIATION DOSE; SCORING SYSTEM;

CARBON; CELLS, CULTURED; CHROMOSOME BREAKAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; HEAVY IONS; HUMANS; LINEAR ENERGY TRANSFER; LYMPHOCYTES; RADIATION DOSAGE; RADIATION INJURIES; RADIOMETRY;

EID: 70249138657     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2009.08.001     Document Type: Article

References (15)

1. Lloyd D.C. An overview of radiation dosimetry by conventional cytogenetic methods. In: Eisert W.G., and Mendelsohn M.L. (Eds). Biological Dosimetry (1984), Springer, Berlin 3-14
2. Johnson R.T., and Rao P.N. Mammalian cell fusion: induction of premature chromosome condensation in interphase nuclei. Nature 226 (1970) 717-722
3. Hittelman W.N., and Rao P.N. Premature chromosome condensation. I. Visualization of X-ray-induced chromosome damage in interphase cells. Mutat. Res. 23 (1974) 251-258
4. Cornforth M.N., and Bedford J.S. X-ray-induced breakage and rejoining of human interphase chromosomes. Science 222 (1983) 1141-1143
5. Gotoh E., sakawa Y.A., and Kosaka H. Inhibition of protein serine/threonine phosphatases directly induces premature chromosome condensation in mammalian somatic cells. Biomed. Res. 16 (1995) 63-68
6. Gotoh E., and Asakawa Y. Detection and evaluation of chromosomal aberrations induced by high doses of gamma-irradiation using immunogold-silver painting of prematurely condensed chromosomes. Int. J. Radiat. Biol. 70 (1996) 517-520
7. Kanda R., Eguchi-Kosai K., and Hayata I. Phosphatase inhibitors and premature chromosome condensation in human peripheral lymphocytes at different cell cycle phase. Somat. Cell Mol. Genet. 25 (1999) 1-8
8. Kanda R., Hayata J., and Lloyd D.C. Easy biodosimetry for high-dose radiation exposures using drug-induced, prematurely condensed chromosomes. Int. J. Radiat. Biol. 75 (1999) 441-446
9. Lamadrid A.I., García O., Delbos M., Voisin P., and Roy L. PCC-ring induction in human lymphocytes exposed to gamma and neutron irradiation. J. Radiat. Res. 48 (2007) 1-6
10. Gotoh E., and Tanno Y. Simple biodosimetry method for cases of high-dose radiation exposure using the ratio of the longest/shortest length of Giemsa-stained drug-induced prematurely condensed chromosomes (PCC). Int. J. Radiat. Biol. 81 (2005) 379-385
11. Gotoh E., Tanno Y., and Takakura K. Simple biodosimetry method for use in cases of high-dose radiation exposure that scores the chromosome number of Giemsa-stained drug-induced prematurely condensed chromosomes (PCC). Int. J. Radiat. Biol. 81 (2005) 33-40
12. Hamada N. Recent insights into the biological action of heavy-ion radiation. J. Radiat. Res. 50 (2009) 1-9
13. Wang Z.Z., Li W.J., Zhi D.J., Jing X.G., Wei W., Gao Q.X., and Liu B. Biodosimetry estimate for high-LET irradiation. Radiat. Environ. Biophys. 46 (2007) 229-235
14. Manti L., Durante M., Grossi G., Pugliese M., Scampoli P., and Gialanella G. Chromosome aberrations in human lymphocytes from the plateau region of the Bragg curve for a carbon-ion beam. Nucl. Instrum. Methods Phys. Res. B 259 (2007) 884-888
15. Iliakis G.E., and Pantelias G.E. Production and repair of chromosome damage in an X-ray sensitive CHO mutant visualized and analyzed in interphase using the technique of premature chromosome condensation. Int. J. Radiat. Biol. 57 (1990) 1213-1223