Association between the PDE4D gene and ischaemic stroke in the Chinese Han population

Clinical Science

Volumn 117, Issue 7, 2009, Pages 265-272

  Sun, Yun ^a,b   Huang, Yanyan ^c   Chen, Xu ^d   Liu, Yun ^a,b   Lu, Xiaozhe ^c   Shi, Yongyong ^b   Tang, Wei ^b   Yang, Jiandong ^a,b   Chen, Wuyan ^b   Zhao, Xinzhi ^b   Gao, Linghan ^b   Li, Sheng ^a   Feng, Guoyin ^e   He, Lin ^a,b,f  

^a Chinese Academy of Sciences   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

^d Department of Urology   (China)

^e SHANGHAI MENTAL HEALTH CENTER   (China)

^f FUDAN UNIVERSITY   (China)

Author keywords

Haplotype; Ischaemic stroke; Phosphodiesterase 4D gene (PDE4D); Risk factor; Single nucleotide polymorphism (SNP)

Indexed keywords

PHOSPHODIESTERASE IV; MICROSATELLITE DNA;

AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; CHINESE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; POPULATION GENETICS; PRIORITY JOURNAL; PROTEIN FUNCTION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; BRAIN ISCHEMIA; CHINA; COHORT ANALYSIS; ETHNOLOGY; GENETICS; RISK FACTOR; STROKE;

AGED; BRAIN ISCHEMIA; CHINA; COHORT STUDIES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; FEMALE; GENETIC MARKERS; GENOTYPE; HUMANS; MALE; MICROSATELLITE REPEATS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; STROKE;

EID: 70249132958     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20080471     Document Type: Article

References (46)

1. Wu, Z., Yao, C., Zhao, D., Wu, G., Wang, W., Liu, J., Zeng, Z. and Wu, Y. (2001) Sino-MONICA Project: a collaborative study on trends and determinants in cardiovascular diseases in China, Part I: morbidity and mortality monitoring. Circulation 103, 462-468
2. Hassan, A. and Markus, H. S. (2000) Genetics and ischaemic stroke. Brain 123, 1784-1812
3. Dichgans, M. (2007) Genetics of ischaemic stroke. Lancet Neurol. 6, 149-161
4. Gretarsdottir, S., Sveinbjornsdottir, S., Jonsson, H. H., Jakobsson, F., Einarsdottir, E., Agnarsson, U., Shkolny, D., Einarsson, G., Gudjonsdottir, H. M., Valdimarsson, E. M. et al. (2002) The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Am. J. Hum. Genet. 70, 593-603
5. Gretarsdottir, S., Thorleifsson, G., Reynisdottir, S. T., Manolescu, A., Jonsdottir, S., Jonsdottir, T., Gudmundsdottir, T., Bjarnadottir, S. M., Einarsson, O. B., Gudjonsdottir, H. M. et al. (2003) Localization of a susceptibility gene for common forms of stroke to 5q12. Nat. Genet. 35, 131-138
6. a Gretarsdottir, S., Thorleifsson, G., Reynisdottir, S. T., Manolescu, A., Jonsdottir, S., Jonsdottir, T., Gudmundsdottir, T., Bjarnadottir, S. M., Einarsson, O. B., Gudjonsdottir, H. M. et al. (2005) Corrigendum: the gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nat. Genet. 37, 555
7. Nilsson-Ardnor, S., Wiklund, P. G., Lindgren, P., Nilsson, A. K., Janunger, T., Escher, S. A., Hallbeck, B., Stegmayr, B., Asplund, K. and Holmberg, D. (2005) Linkage of ischemic stroke to the PDE4D region on 5q in a Swedish population. Stroke 36, 1666-1671
8. Meschia, J. F., Brott, T. G., Brown, Jr, R. D., Crook, R., Worrall, B. B., Kissela, B., Brown, W. M., Rich, S. S., Case, L. D., Evans, E. W. et al. (2005) Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke. Ann. Neurol. 58, 351-361
9. Lohmussaar, E., Gschwendtner, A., Mueller, J. C., Org, T., Wichmann, E., Hamann, G., Meitinger, T. and Dichgans, M. (2005) ALOX5AP gene and the PDE4D gene in a Central European population of stroke patients. Stroke 36, 731-736
10. Kuhlenbaumer, G., Berger, K., Huge, A., Lange, E., Kessler, C., John, U., Funke, H., Nabavi, D. G., Stogbauer, F., Ringelstein, E. B. and Stoll, M. (2006) Evaluation of single nucleotide polymorphisms in the phosphodiesterase 4D gene (PDE4D) and their association with ischaemic stroke in a large German cohort. J. Neurol. Neurosurg. Psychiatry 77, 521-524
11. Bevan, S., Porteous, L., Sitzer, M. and Markus, H. S. (2005) Phosphodiesterase 4D gene, ischemic stroke, and asymptomatic carotid atherosclerosis. Stroke 36, 949-953
12. van Rijn, M. J., Slooter, A. J., Schut, A. F., Isaacs, A., Aulchenko, Y. S., Snijders, P. J., Kappelle, L. J., van Swieten, J. C., Oostra, B. A. and van Duijn, C. M. (2005) Familial aggregation, the PDE4D gene, and ischemic stroke in a genetically isolated population. Neurology 65, 1203-1209
13. Zee, R. Y. L., Cheng, S., Hegener, H. H., Erlich, H. A. and Ridker, P. M. (2006) Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: a nested case-control approach. Stroke 37, 2007-2011
14. Staton, J. M., Sayer, M. S., Hankey, G. J., Attia, J., Thakkinstian, A., Yi, Q., Cole, V. J., Baker, R. and Eikelboom, J.W. (2006) Association between phosphodiesterase 4D gene and ischaemic stroke. J. Neurol. Neurosurg. Psychiatry 77, 1067-1069
15. Saleheen, D., Bukhari, S., Haider, S. R., Nazir, A., Khanum, S., Shafqat, S., Anis, M. K. and Frossard, P. (2005) Association of phosphodiesterase 4D gene with ischemic stroke in a Pakistani population. Stroke 36, 2275-2277
16. Nakayama, T., Asai, S., Sato, N. and Soma, M. (2006) Genotype and haplotype association study of the STRK1 region on 5q12 among Japanese: a case-control study. Stroke 37, 69-76
17. Brophy, V. H., Ro, S. K., Rhees, B. K., Lui, L. Y., Lee, J. M., Umblas, N., Bentley, L. G., Li, J., Cheng, S. et al. (2006) Association of phosphodiesterase 4D polymorphisms with ischemic stroke in a US population stratified by hypertension status. Stroke 37, 1385-1390
18. Woo, D., Kaushal, R., Kissela, B., Sekar, P., Wolujewicz, M., Pal, P., Alwell, K., Haverbusch, M., Ewing, I., Miller, R. et al. (2006) Association of phosphodiesterase 4D with ischemic stroke: a population-based case-control study. Stroke 37, 371-376
19. Song, Q., Cole, J. W., O'Connell, J. R., Stine, O. C., Gallagher, M., Giles, W. H., Mitchell, B. D., Wozniak, M. A., Stern, B. J., Sorkin, J. D. et al. (2006) Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study. Hum. Mol. Genet. 15, 2468-2478
20. Xue, H., Wang, H., Song, X., Li, W., Sun, K., Zhang, W., Wang, X., Wang, Y. and Hui, R. (2009) Phosphodiesterase 4D gene polymorphism is associated with ischaemic and haemorrhagic stroke. Clin. Sci. 116, 335-340
21. WHO MONICA Project Principal Investigators (1998) The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration. J. Clin. Epidemiol. 41, 105-114
22. Adams, Jr, H. P., Bendixen, B. H., Kappelle, L. J., Biller, J., Love, B. B., Gordon, D. L. and Marsh, III, E. E. (1993) Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24, 35-41
23. Reference deleted
24. Sun, Y., Zhang, F., Gao, J., Gao, X., Guo, T., Zhang, K., Shi, Y., Zheng, Z., Tang, W., Zheng, Y. et al. (2006) Positive association between POU1F1 and mental retardation in young females in the Chinese Han population. Hum. Mol. Genet. 15, 1237-1243
25. Germer, S., Holland, M. J. and Higuchi, R. (2000) High-throughput SNP allele-frequency determination in pooled DNA samples by kinetic PCR. Genome Res. 10, 258-266
26. Shi, Y. Y. and He, L. (2005) SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 15, 97-98
27. Sham, P. C. and Curtis, D. (1995) Monte-Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann. Hum. Genet. 59, 97-105
28. Zapata, C., Carollo, C. and Rodriguez, S. (2001) Sampling variance and distribution of the D' measure of overall gametic disequilibrium between multiallelic loci. Ann. Hum. Genet. 65, 395-406
29. Dudbridge, F. (2003) Pedigree disequilibrium tests for multilocus haplotypes. Genet. Epidemiol. 25, 115-121
30. Storey, J. D. and Tibshirani, R. (2003) Statistical significance for genomewide studies. Proc. Natl. Acad. Sci. U.S.A. 100, 9440-9445
31. Erdfelder, E., Faul, F. and Buchner, A. (1996) G*Power: a general power analysis program. Behav. Res. Methods Instrum. Comput. 28, 1-11
32. Ardlie, K. G., Kruglyak, L. and Seielstad, M. (2002) Patterns of linkage disequilibrium in the human genome. Nat. Rev. Genet. 3, 299-309
33. Liu, H. and Maurice, D. H. (1999) Phosphorylation-mediated activation and translocation of the cyclic AMP-specific phosphodiesterase PDE4D3 by cyclic AMP-dependent protein kinase and mitogen-activated protein kinases. A potential mechanism allowing for the coordinated regulation of PDE4D activity and targeting. J. Biol. Chem. 274, 10557-10565
34. 1. Biochem. Biophys. Res. Commun. 274, 415-421
35. Shepherd, M. C., Baillie, G. S., Stirling, D. I. and Houslay, M. D. (2004) Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells. Br. J. Pharmacol. 142, 339-351
36. Ariga, M., Neitzert, B., Nakae, S., Mottin, G., Bertrand, C., Pruniaux, M. P., Jin, S. L. and Conti, M. (2004) Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation. J. Immunol. 173, 7531-7538
37. Houslay, M. D. and Adams, D. R. (2003) PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. Biochem. J. 370, 1-18
38. Lorenowicz, M. J., Fernandez-Borja, M. and Hordijk, P. L. (2007) cAMP signaling in leukocyte transendothelial migration. Arterioscler. Thromb. Vasc. Biol. 27, 1014-1022
39. Ichiki, T. (2006) Role of cAMP response element binding protein in cardiovascular remodeling: good, bad, or both? Arterioscler. Thromb. Vasc. Biol. 26, 449-455
40. Zhang, H. T., Huang, Y., Jin, S. L., Frith, S. A., Suvarna, N., Conti, M. and O'Donnell, J. M. (2002) Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme. Neuropsychopharmacology 27, 587-595
41. Kato, H., Araki, T., Itoyama, Y. and Kogure, K. (1995) Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil. Eur. J. Pharmacol. 272, 107-110
42. Block, F., Tondar, A., Schmidt, W. and Schwarz, M. (1997) Delayed treatment with rolipram protects against neuronal damage following global ischemia in rats. NeuroReport 8, 3829-3832
43. Bok, J., Zha, X. M., Cho, Y. S. and Green, S. H. (2003) An extranuclear locus of cAMP-dependent protein kinase action is necessary and sufficient for promotion of spiral ganglion neuronal survival by cAMP. J. Neurosci. 23, 777-787
44. Wang, X., Tang, X., Li, M., Marshall, J. and Mao, Z. (2005) Regulation of neuroprotective activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival. J. Biol. Chem. 280, 16705-16713
45. Nakagawa, S., Kim, J. E., Lee, R., Malberg, J. E., Chen, J., Steffen, C., Zhang, Y. J., Nestler, E. J. and Duman, R. S. (2002) Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J. Neurosci. 22, 3673-3682
46. Sasaki, T., Kitagawa, K., Omura-Matsuoka, E., Todo, K., Terasaki, Y., Sugiura, S., Hatazawa, J., Yagita, Y. and Hori, M. (2007) The phosphodiesterase inhibitor rolipram promotes survival of newborn hippocampal neurons after ischemia. Stroke 38, 1597-1605