Leishmanicidal activity of new megazol derivatives

Medicinal Chemistry

Volumn 5, Issue 4, 2009, Pages 392-397

  Riente, R R ^a   Souza, V P ^a   Carvalho, S A ^a,b   Kaiser, M ^c   Brun, R ^c   da Silva, E F ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

Cytotoxic; Heterocombretastatin; Leishmanicidal; Megazol derivatives; Molecular hybridization; Sulfones

Indexed keywords

2 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) 5 (3,4,5 TRIMETHOXY BENZYLSULFANYL) [1,3,4]THIADAZOLE; 2 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) 5 BENZYLSULFINYL [1,3,4]THIADAZOLE; 2 (2,3 DICHLORO BENZYLSULFANYL) 5 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) [1,3,4]THIADIAZOLE; 2 (2,3 DICHLORO BENZYLSULFINYL) 5 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) [1,3,4]THIADIAZOLE; 2 (3,4 DIMETHOXY BENZYLSULFANYL) 5 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) [1,3,4]THIADIAZOLE; 2 (4 CHLORO BENZYLSULFANYL) 5 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) [1,3,4]THIADIAZOLE; 2 (4 FLUORO BENZYLSULFANYL) 5 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) [1,3,4]THIADIAZOLE; 2 (4 FLUORO BENZYLSULFINYL) 5 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) [1,3,4]THIADIAZOLE; 2 (4 METHOXY BENZYLSULFANYL) 5 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) [1,3,4]THIADIAZOLE; 2 (4 METHOXY BENZYLSULFINYL) 5 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) [1,3,4]THIADIAZOLE; 2 (BENZO[1,3]DIOXO 5 YLMETHYLSULFANYL) 5 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) [1,3,4]THIADIAZOLE; 2 (BENZO[1,3]DIOXOL 5 YLMETHANESULFINYL) 5 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) [1,3,4]THIADAZOLE; 2 AMINO 5 (1 METHYL 5 NITRO 2 IMIDAZOLYL) 1,3,4 THIADIAZOLE; 2 AMINO 5 (1 METHYL 5 NITRO 2 IMIDAZOLYL) 1,3,4 THIADIAZOLE DERIVATIVE; 2 BENZYLSULFANYL 5 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) [1,3,4]THIADIAZOLE; COMBRETASTATIN; MILTEFOSINE; UNCLASSIFIED DRUG;

AMASTIGOTE; ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; LEISHMANIA DONOVANI; LEISHMANICIDAL ACTIVITY; MOLECULAR HYBRIDIZATION; PRIORITY JOURNAL;

EID: 70249112609     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340609788681467     Document Type: Article

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