Evaluation of gremlin 1 (GREM1) as a candidate susceptibility gene for albuminuria-related traits in Mexican Americans with type 2 diabetes mellitus

Metabolism: Clinical and Experimental

Volumn 58, Issue 10, 2009, Pages 1496-1502

  Thameem, Farook ^a   Puppala, Sobha ^b   He, Xin ^a   Arar, Nedal H ^a,c   Stern, Michael P ^d   Blangero, John ^b   Duggirala, Ravindranath ^b   Abboud, Hanna E ^a,d  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^d Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT;

3' UNTRANSLATED REGION; ADULT; ALBUMINURIA; ANALYTIC METHOD; ARTICLE; ASSAY; BODY MASS; DISEASE DURATION; DNA POLYMORPHISM; ETHNICITY; EXON; FEMALE; GENE; GENE SEQUENCE; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; GENOTYPE; GLOMERULUS FILTRATION RATE; GREMLIN 1 GENE; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; VARIANCE;

ADULT; ALBUMINURIA; CHROMOSOMES, HUMAN, PAIR 15; CREATININE; DIABETES MELLITUS, TYPE 2; DNA; EXONS; FEMALE; GENOTYPE; HEMODYNAMICS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LINKAGE DISEQUILIBRIUM; MALE; MEXICAN AMERICANS; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 70149124506     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.04.039     Document Type: Article

References (22)

1. Weir M.R. Microalbuminuria and cardiovascular disease. Clin J Am Soc Nephrol 2 (2007) 581-590
2. Freedman B.I., Bostrom M., Daeihagh P., et al. Genetic factors in diabetic nephropathy. Clin J Am Soc Nephrol 2 (2007) 1306-1316
3. Bhandari K., Duggirala R., Kawalitt I., et al. Genome-wide search for albuminuria susceptibility gene in Mexican Americans. Diabetes 50 (2001) A240-A241
4. Lehman D.M., Leach R.J., Johnson-Pais T., et al. Evaluation of tight junction protein 1 encoding zona occludens 1 as a candidate gene for albuminuria in a Mexican American population. Exp Clin Endocrinol Diabetes 114 (2006) 432-437
5. Merino R., Rodriguez-Leon J., Macias D., et al. The BMP antagonist gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb. Development 126 (1999) 5515-5522
6. Michos O., Panman L., Vintersten K., et al. Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 131 (2004) 3401-3410
7. Maciel T.T., Melo R.S., Schor N., et al. Gremlin promotes vascular smooth muscle cell proliferation and migration. J Mol Cell Cardiol 44 (2008) 370-379
8. Walsh D.W., Roxburgh S.A., McGettigan P., et al. Co-regulation of gremlin and notch signalling in diabetic nephropathy. Biochim Biophys Acta 1782 (2008) 10-21
9. Puppala S., Dodd G.D., Fowler S., et al. A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans. Am J Hum Genet 78 (2006) 377-392
10. Duggirala R., Blangero J., Almasy L., et al. A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans. Am J Hum Genet 66 (2000) 1237-1245
11. Puppala S., Arya R., Thameem F., et al. Genotype by diabetes interaction effects on the detection of linkage of glomerular filtration rate to a region on chromosome 2q in Mexican Americans. Diabetes 56 (2007) 2818-2828
12. Boerwinkle E., Chakraborty R., and Sing C.F. The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods. Ann Hum Genet 50 (1986) 181-194
13. Almasy L., and Blangero J. Exploring positional candidate genes: linkage conditional on measured genotype. Behav Genet 34 (2004) 173-177
14. Abecasis G.R., Cookson W.O.C., and Cardon L.R. Pedigree tests of transmission disequilibrium. Eur J Hum Genet 8 (2000) 545-551
15. McMahon R., Murphy M., Clarkson M., et al. IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1. J Biol Chem 275 (2000) 9901-9904
16. Kane R., Stevenson L., Godson C., et al. Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose. Br J Ophthalmol 89 (2005) 1638-1642
17. Murphy M., McMahon R., Lappin D.W., et al. Gremlins: is this what renal fibrogenesis has come to?. Exp Nephrol 10 (2002) 241-244
18. Lappin D.W., McMahon R., Murphy M., et al. Gremlin: an example of the re-emergence of developmental programmes in diabetic nephropathy. Nephrol Dial Transplant 17 (2002) 65-67
19. Wingender E., Chen X., Hehl R., et al. TRANSFAC: an integrated system for gene expression regulation. Nucleic Acids Res 28 (2000) 316-319
20. Lamb E.J., Tomson C.R., and Roderick P.J. Clinical Sciences Reviews Committee of the Association for Clinical Biochemistry: estimating kidney function in adults using formulae. Ann Clin Biochem 42 (2005) 321-345
21. Schelling J.R., Abboud H.E., Nicholas S.B., et al. Family Investigation of Nephropathy and Diabetes Research Group: genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND). Diabetes 57 (2008) 235-243
22. Freedman B.I., Bowden D.W., Rich S.S., et al. Genome-wide linkage scans for renal function and albuminuria in type 2 diabetes mellitus: the Diabetes Heart Study. Diabet Med 25 (2008) 268-276