Pedigree tests of transmission disequilibrium

European Journal of Human Genetics

Volumn 8, Issue 7, 2000, Pages 545-551

  Abecasis, Gonçalo R ^a   Cookson, William O C ^b   Cardon, Lon R ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NONE

Author keywords

ACE; Gene mapping; Large pedigrees; Linkage disequilibrium; Quantitative trait; SNP

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ARTICLE; CLONING; ERROR; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PEDIGREE ANALYSIS; POPULATION GENETICS; PRIORITY JOURNAL; QUANTITATIVE TRAIT;

ALLELES; CHROMOSOME MAPPING; COMPUTER SIMULATION; DNA MUTATIONAL ANALYSIS; GENETIC DISEASES, INBORN; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; PEDIGREE; PENETRANCE; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC; PREVALENCE;

EID: 0033923068     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5200494     Document Type: Article

References (39)

1. Collins FS: Positional cloning: let's not call it reverse anymore. Nat Genet 1992; 1:3-6.
2. Darvasi A, Soller M: A simple method to calculate the resolving power and confidence interval of QTL map location. Behav Genet 1997; 27: 125-132.
3. Roberts SB, MacLean CJ, Neale MC, Eaves LJ, Kendler KS: Replication of linkage studies in complex traits: an examination of variation in location estimates. Am J Hum Genet 1999; 65: 876-884.
4. Whittemore AS, Halpern J: A class of tests for linkage using affected pedigree members. Biometrics 1994; 50: 118-127.
5. Morton NE: Sequential tests for the detection of linkage. Am J Hum Genet 1955; 7: 277-318.
6. Elston RC, Stewart J: A general model for the genetic analysis of pedigree data. Hum Hered 1971; 21: 523-542.
7. Wijsman EM, Amos CI: Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: summary of GAW10 contributions. Genet Epidemiol 1997; 14: 719-735.
8. Badner JA, Gershon ES, Goldin LR: Optimal ascertainment strategies to detect linkage to common disease alleles. Am J Hum Genet 1998; 63: 880-888.
9. Collins FS, Guyer MS, Chakravarti A: Variations on a theme: cataloguing human DNA sequence variation. Science 1997; 278: 1580-1581.
10. Lander E: Array of hope. Nat Genet 1999; 21: 3-4.
11. Chakravarti A: It's raining SNPs, hallelujah? Nat Genet 1999; 19: 216-217.
12. Risch N, Merikangas K: The future of genetic studies of complex human diseases. Science 1996; 273: 1516-1517.
13. Abecasis GR, Cardon LR, Cookson WOC: A general test of association for quantitative traits in nuclear families. Am J Hum Genet 2000; 66: 279-292.
14. Allison DB: Transmission-disequilibrium tests for quantitative traits. Am J Hum Genet 1997; 60: 676-690.
15. Weinberg CR, Wilcox AJ, Lie RT: A log-linear approach to case-parent-triad data: assessing the effects of genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet 1998; 62: 969-978.
16. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993; 52: 506-516.
17. Rabinowitz D: A transmission disequilibrium test for quantitative trait loci. Hum Hered 1997; 47: 342-350.
18. Curtis D: Use of siblings as controls in case-control association studies. Ann Hum Genet 1997; 61: 319-333.
19. Fulker DW, Cherny SS, Sham PC, Hewitt JK: Combined linkage and association analysis for quantitative traits. Am J Hum Genet 1999; 64: 259-267.
20. Allison DB, Heo M, Kaplan N, Martin ER: Sibling-based tests of linkage and association for quantitative traits. Am J Hum Genet 1999; 64: 1754-1763.
21. Keavney B, McKenzie CA, Connell JM et al: Measured haplotype analysis of the angiotensin-I converting enzyme gene. Hum Mol Genet 1998; 7: 1745-1751.
22. Farrall M, Keavney B, McKenzie C, Delepine M, Matsuda F, Lathrop GM: Fine-mapping of an ancestral recombination break-point in DCP1. Nat Genet 1999; 23: 270-271.
23. Thomson G: HLA disease associations: models for insulin dependent diabetes mellitus and the study of complex human genetic disorders. Annu Rev Genet 1988; 22: 31-50.
24. Curtis D, Sham PC: A note on the application of the transmission disequilibrium test when a parent is missing. Am J Hum Genet 1995; 56: 811-812.
25. Martin ER, Kaplan NL, Weir BS: Tests for linkage and association in nuclear families. Am J Hum Genet 1997; 61: 439-448.
26. George VT, Elston RC: Testing of association between polymorphic markers and quantitative traits in pedigrees. Genet Epidemiol 1987; 4: 193-201.
27. Hopper JL, Mathews JD: Extensions of multivariate normal models for pedigree analysis. Ann Hum Genet 1982; 46: 373-383.
28. Falconer DS: Introduction to Quantitative Genetics. Longman Scientific and Technical: London, 1989.
29. Allison DB, Neale MC, Zannolli R, Schork NJ, Amos CI, Blangero J: Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure. Am J Hum Genet 1999; 65: 531-544.
30. Moffatt MF, Traherne JA, Abecasis GR, Cookson WOC: Single nucleotide polymorphisms and linkage disequilibrium with the TCR alpha/delta locus. Hum Mol Genet 2000; 9: 1011-1019.
31. Huttley GA, Smith MW, Carrington M, O'Brien SJ: A scan for linkage disequilibrium across the human genome. Genetics 1999; 152: 1711-1722.
32. Nickerson DA, Taylor SL, Weiss KM et al: DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene. Nat Genet 1998; 19:233-240.
33. Lewontin RC, Kojima K: The evolutionary dynamics of complex polymorphisms. Evolution 1960; 14: 450-472.
34. Sobel E, Lange K: Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am J Hum Genet 1996; 58: 1323-1337.
35. Horvath S, Laird NM: A discordant-sibship test for disequilibrium and linkage: no need for parental data. Am J Hum Genet 1998; 63: 1886-1897.
36. Cardon LR, Abecasis GR: Some properties of a variance components model for fine-mapping quantitative trait loci. Behav Genet 2000; (in press).
37. Suarez BK, Hampe CL, Eerdewegh PV: Problems of replicating linkage claims in psychiatry. In: Gershon ES, Cloninger CR (eds). Genetic Approaches to Mental Disorders. American Psychiatric Press: Washington, 1994, 23-46.
38. Rabinowitz D: Adjusting for population stratification and admixture when testing non-parametric hypotheses in statistical genetics. J Am Stat Assoc 2000; (submitted).
39. Rieder MJ, Taylor SL, Clark AG, Nickerson DA: Sequence variation in the human angiotensin converting enzyme. Nat Genet 1999; 22: 59-62.