Optimization of a GC-MS metabolic fingerprint method and its application in characterizing engineered bacterial metabolic shift

Journal of Separation Science

Volumn 32, Issue 13, 2009, Pages 2281-2288

  Tian, Jing ^a,b   Sang, Ping ^a,b   Gao, Peng ^b   Fu, Ruiyan ^c   Yang, Dawei ^a,b   Zhang, Lei ^b   Zhou, Jing ^b   Wu, Si ^a,b   Lu, Xin ^b   Li, Yin ^d   Xu, Guowang ^b  

^a DALIAN POLYTECHNIC UNIVERSITY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^c ANHUI AGRICULTURAL UNIVERSITY   (China)

^d INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

GC MS; Metabolic quenching; Metabolomics; Optimization; Sample pretreatment

Indexed keywords

CLUSTERING ANALYSIS; DERIVATIZATIONS; FULL FACTORIAL DESIGN; GC-MS; LIFE-SCIENCES; METABOLIC FINGERPRINTS; METABOLIC QUENCHING; METABOLIC SHIFT; METABOLOMIC ANALYSIS; METABOLOMICS; METHOD VALIDATIONS; SAMPLE DERIVATIZATION; SAMPLE PRETREATMENT; SYSTEMATIC OPTIMIZATION; TRIFLUOROACETAMIDES;

ACETONE; ACETONITRILE; ETHANOL; METHANOL; OPTIMIZATION; QUENCHING; STRAIN;

METABOLISM;

ACETONE; ALCOHOL; AMINOACETONITRILE; METHANOL; N,O BIS(TRIMETHYLSIYL)TRIFLUOROACETAMIDE; PYRIDINE; TRIFLUOROACETAMIDE DERIVATIVE; UNCLASSIFIED DRUG; ACETONITRILE; ACETONITRILE DERIVATIVE; SOLVENT;

ACCURACY; ANALYTIC METHOD; ARTICLE; BACTERIAL METABOLISM; BACTERIAL STRAIN; CLUSTER ANALYSIS; CONTROLLED STUDY; DERIVATIZATION; INTRACELLULAR BACTERIUM; MASS FRAGMENTOGRAPHY; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; TEMPERATURE; VALIDATION PROCESS; BACTERIUM; CHEMISTRY; EVALUATION; INSTRUMENTATION; LABORATORY DIAGNOSIS; METABOLISM; METHODOLOGY; REPRODUCIBILITY;

BACTERIA (MICROORGANISMS);

ACETONE; ACETONITRILES; BACTERIA; ETHANOL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; METABOLOMICS; METHANOL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLVENTS; SPECIMEN HANDLING;

EID: 70149114681     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200800727     Document Type: Article

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