Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 7, 2009, Pages 2029-2032

  Bhowruth, Veemal ^a   Minnikin, David E ^a   Agger, Else Marie ^b   Andersen, Peter ^b   Bramwell, Vincent W ^c   Perrie, Yvonne ^c   Besra, Gurdyal S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b STATENS SERUM INSTITUT   (Denmark)

^c ASTON UNIVERSITY   (United Kingdom)

Author keywords

Adjuvant; Ag85B ESAT 6; Monomycolyl glycerol; Tuberculosis; Vaccine

Indexed keywords

BEHENIC ACID; DIMETHYLDIOCTADECYLAMMONIUM BROMIDE; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; GLYCEROL DERIVATIVE; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 6; MYCOLYLGLYCEROL; TREHALOSE; TREHALOSE 6,6' DIBEHENATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; IMMUNIZATION; IMMUNOSTIMULATION; MOUSE; NONHUMAN; SPLEEN CELL; TH1 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; GLYCEROL; INTERFERON-GAMMA; INTERLEUKIN-6; MICE; MICE, INBRED BALB C; QUATERNARY AMMONIUM COMPOUNDS; UP-REGULATION; VACCINATION;

MUS;

EID: 61849102445     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.027     Document Type: Article

References (15)

1. Hoft D.F. Lancet 372 (2008) 164
2. Lindblad E.B., Elhay M.J., Silva R., Appelberg R., and Andersen P. Infect. Immun. 65 (1997) 623
3. Freund J. Bibl. Tuberc. (1956) 130
4. Bast Jr. R.C., Zbar B., Borsos T., and Rapp H.J. N. Engl. J. Med. 290 (1974) 1458
5. Bast Jr. R.C., Zbar B., Borsos T., and Rapp H.J. N. Engl. J. Med. 290 (1974) 1413
6. Koike Y., Yoo Y.C., Mitobe M., Oka T., Okuma K., Tono-oka S., and Azuma I. Vaccine 16 (1998) 1982
7. Holten-Andersen L., Doherty T.M., Korsholm K.S., and Andersen P. Infect. Immun. 72 (2004) 1608
8. McBride B.W., Mogg A., Telfer J.L., Lever M.S., Miller J., Turnbull P.C., and Baillie L. Vaccine 16 (1998) 810
9. Rosenkrands I., Agger E.M., Olsen A.W., Korsholm K.S., Andersen C.S., Jensen K.T., and Andersen P. Infect. Immun. 73 (2005) 5817
10. Andersen C.S., Agger E.M., Rosenkrands I., Gomes J.M., Bhowruth V., Gibson K.J., Petersen R.V., Minnikin D.E., Besra G.S., and Andersen P. J. Immunol. 182 (2009) 424
11. Dobson, G.; Minnikin, D. E.; Minnikin, S. M.; Parlett, J. M.; Goodfellow, M.; Ridell, M.; Magnusson, M. In Chemical Methods in Bacterial Systematics; Goodfellow, M., Minnikin, D. E., Eds.; London: Academic Press, 1985; pp 237-265.
12. Datta A.K., Takayama K., Nashed M.A., and Anderson L. Carbohydr. Res. 218 (1991) 95
13. c. Subsequently, recombinant H1 was added to give the desired concentration of delivery system, adjuvant and protein for the purposes of administration outlined above.
14. Kirby D.J., Rosenkrands I., Agger E.M., Andersen P., Coombes A.G.A., and Perrie Y. J. Drug Target 16 (2008) 543
15. Perrie Y., Mohammed A.R., Kirby D.J., McNeil S.E., and Bramwell V.W. Int. J. Pharm. 364 (2008) 272