Transgenerational transmission of cortisol and PTSD risk

Progress in Brain Research

Volumn 167, Issue , 2007, Pages 121-135

  Yehuda, Rachel ^a   Bierer, Linda M ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

cortisol; epigenetics; glucocorticoid programming; intergenerational effects; posttraumatic stress disorder; risk factors

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; HYDROCORTISONE;

CRIME; EMOTIONAL ATTACHMENT; EPIGENETICS; HUMAN; HYDROCORTISONE BLOOD LEVEL; INJURY; MENTAL DISEASE; NEUROSECRETORY CELL; PARENTAL STRESS; POSTTRAUMATIC STRESS DISORDER; PREGNANT WOMAN; PRIORITY JOURNAL; PROGENY; REVIEW; RISK FACTOR; SALIVATION; SURVIVOR; URINARY EXCRETION;

ANIMALS; HUMANS; HYDROCORTISONE; PARENTS; RATS; RISK FACTORS; STRESS DISORDERS, POST-TRAUMATIC;

EID: 36249006451     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(07)67009-5     Document Type: Review

References (55)

1. Bachmann A.W., Sedgley T.L., Jackson R.V., Gibson J.N., Young R.M., and Torpy D.J. Glucocorticoid receptor polymorphisms and post-traumatic stress disorder. Psychoneuroendocrinology 30 3 (2005) 297-306
2. Beck A.T., Ward C.H., Mendelson M., Mock J., and Erbaugh J. An inventory for measuring depression. Arch. Gen. Psychiatry 4 (1961) 561-571
3. Bernstein D.P., Fink L., Handelsman L., Foote J., Lovejoy M., Wenzel K., Sapareto E., and Ruggiero J. Initial reliability and validity of a new retrospective measure of child abuse and neglect. Am. J. Psychiatry 151 8 (1994) 1132-1136
4. Blake D.D., Weathers F.W., Nagy L.M., Kaloupek D.G., Klauminzer G., Charney D.S., and Keane T.M. A clinician rating scale for assessing current and lifetime PTSD: the CAPS-1. Behav. Ther. 13 (1995) 187-188
5. Bremner J.D., Southwick S.M., Johnson D.R., Yehuda R., and Charney D.S. Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans. Am. J. Psychiatry 150 2 (1993) 235-239
6. Breslau N., Kessler R.C., Chilcoat H.D., Schultz L.R., Davis G.C., and Andreski P. Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma. Arch. Gen. Psychiatry 55 7 (1998) 626-632
7. Brewin C.R., Andrews B., and Valentine J.D. Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. J. Consult. Clin. Psychol. 68 5 (2000) 748-766
8. Clancy C.P., Graybeal A., Tompson W.P., Badgett K.S., Feldman M.E., Calhoun P.S., Erkanli A., Hertzberg M.A., and Beckham J.C. Lifetime trauma exposure in veterans with military-related posttraumatic stress disorder: association with current symptomatology. J. Clin. Psychiatry 67 9 (2006) 1346-1353
9. Clarke A.S., Kraemer G.W., and Kupfer D.J. Effects of rearing condition on HPA axis response to fluoxetine and desipramine treatment over repeated social separations in young rhesus monkeys. Psychiatry Res. 79 2 (1998) 91-104
10. Cohen M.E., White P.D., and Johnson R.E. Neurocirculatory asthenia, anxiety neurosis or the effort syndrome. Arch. Int. Med. 81 (1948) 260-281
11. Davidson J.R., Tupler L.A., Wilson W.H., and Connor K.M. A family study of chronic post-traumatic stress disorder following rape trauma. J. Psychiatr. Res. 32 5 (1998) 301-309
12. Delahanty D.L., Raimonde A.J., Spoonster E., and Cullado M. Injury severity, prior trauma history, urinary cortisol levels, and acute PTSD in motor vehicle accident victims. J. Anxiety Disord. 17 2 (2003) 149-164
13. Dettling A.C., Feldon J., and Pryce C.R. Early deprivation and behavioral and physiological responses to social separation/novelty in the marmoset. Pharmacol. Biochem. Behav. 73 1 (2002) 259-269
14. Drake A.J., and Walker B.R. The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk. J. Endocrinol. 180 1 (2004) 1-16
15. Francis D.D., Caldji C., Champagne F., Plotsky P.M., and Meaney M.J. The role of corticotropin-releasing factor-norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress. Biol. Psychiatry 46 9 (1999) 1153-1166
16. Gunnar M.R., and Vazquez D.M. Low cortisol and a flattening of expected daytime rhythm: potential indices of risk in human development. Dev. Psychopathol. 13 3 (2001) 515-538
17. Halligan S.L., Herbert J., Goodyer I.M., and Murray L. Exposure to postnatal depression predicts elevated cortisol in adolescent offspring. Biol. Psychiatry 55 4 (2004) 376-381
18. Keane T.M., Caddell J.M., and Taylor K.L. Mississippi Scale for Combat-Related Posttraumatic Stress Disorder: three studies in reliability and validity. J. Consult. Clin. Psychol. 56 1 (1988) 85-90
19. de Kloet E.R., Joels M., and Holsboer F. Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci. 6 6 (2005) 463-475 Review.
20. Koenen K.C., Harley R., Lyons M.J., Wolfe J., Simpson J.C., Goldberg J., Eisen S.A., and Tsuang M. A twin registry study of familial and individual risk factors for trauma exposure and posttraumatic stress disorder. J. Nerv. Ment. Dis. 190 4 (2002) 209-218
21. Koenen K.C., Moffitt T.E., Poulton R., Martin J., and Caspi A. Early childhood factors associated with the development of post-traumatic stress disorder: results from a longitudinal birth cohort. Psychol. Med. 37 2 (2007) 181-192
22. Macri S., and Wurbel H. Developmental plasticity of HPA and fear responses in rats: a critical review of the maternal mediation hypothesis. Horm. Behav. 50 5 (2006) 667-680
23. Mason J.W., Giller E.L., Kosten T.R., Ostroff R.B., and Podd L. Urinary free-cortisol levels in posttraumatic stress disorder patients. J. Nerv. Ment. Dis. 174 3 (1986) 145-149
24. Mathews S.G. Early programming of the hypothalamo-pituitary-adrenal axis. Trends Endocrinol. Metab. 13 9 (2002) 373-380
25. McCormick J.A., Lyons V., Jacobson M.D., Noble J., Diorio J., Nyirenda M., Weaver S., Ester W., Yau J.L., Meaney M.J., Seckl J.R., and Chapman K.E. 5′-Heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events. Mol. Endocrinol. 14 4 (2000) 506-517
26. McFarlane A.C. The aetiology of post-traumatic stress disorders following a natural disaster. Br. J. Psychiatry J. Ment. Sci. 152 (1988) 116-121
27. McFarlane A.C. The aetiology of post-traumatic morbidity: predisposing, precipitating and perpetuating factors. Br. J. Psychiatry J. Ment. Sci. 154 (1989) 221-228
28. Meaney M.J. Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu. Rev. Neurosci. 24 (2001) 1161-1192
29. Meaney M.J., Aitken D.H., Bhatnagar S., and Sapolsky R.M. Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats. Neurobiol. Aging 12 1 (1991) 31-38
30. Meaney M.J., Aitken D.H., Bodnoff S.R., Iny L.J., and Sapolsky R.M. The effects of postnatal handling on the development of the glucocorticoid receptor systems and stress recovery in the rat. Prog. Neuropsychopharmacol. Biol. Psychiatry 9 5-6 (1985) 731-734
31. Oppenheimer B.S., and Rothschild M.A. The psychoneurotic factor in the irritable heart of soldiers. JAMA 70 (1918) 1919-1922
32. O'Regan D., Welberg L.L., Holmes M.C., and Seckl J.R. Glucocorticoid programming of pituitary-adrenal function: mechanisms and physiological consequences. Semin. Neonatol. 6 4 (2001) 319-329
33. Parker G., Tupling H., and Brown L.B. A parental bonding instrument. Br. J. Med. Psychol. 52 (1979) 1-10
34. Reich J., Lyons M., and Cai B. Familial vulnerability factors to post-traumatic stress disorder in male military veterans. Acta Psychiatr. Scand. 93 2 (1996) 105-112
35. Resnick H.S., Yehuda R., Pitman R.K., and Foy D.W. Effect of previous trauma on acute plasma cortisol level following rape. Am. J. Psychiatry 152 11 (1995) 1675-1677
36. Seckl J.R. Prenatal glucocorticoids and long-term programming. Eur. J. Endocrinol. 151 Suppl 3 (2004) U49-U62
37. Segman R.H., and Shalev A.Y. Genetics of posttraumatic stress disorder. CNS Spectr. 8 9 (2003) 693-698
38. Solomon Z., Mikulincer M., and Avitzur E. Coping, locus of control, social support, and combat-related posttraumatic stress disorder: a prospective study. J. Pers. Soc. Psychol. 55 2 (1988) 279-285
39. Stein M.B., Jang K.L., Taylor S., Vernon P.A., and Livesley W.J. Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study. Am. J. Psychiatry 159 10 (2002) 1675-1681
40. Sutherland J.E., and Costa M. Epigenetics and the environment. Ann. N.Y. Acad. Sci. 983 (2003) 151-160
41. Swan J.M. An analysis of ninety cases of functional disease in soldiers. Arch. Intern. Med. 28 (1921) 586-602
42. True W.R., Rice J., Eisen S.A., Heath A.C., Goldberg J., Lyons M.J., and Nowak J. A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms. Arch. Gen. Psychiatry 50 4 (1993) 257-264
43. Weaver I.C., Szyf M., and Meaney M.J. From maternal care to gene expression: DNA methylation and the maternal programming of stress responses. Endocr. Res. 28 4 (2002) 699
44. Wolfsohn J.M. The predisposing factors of war psycho-neuroses. Lancet 1 (1918) 177-180
45. Yehuda R. Current status of cortisol findings in post-traumatic stress disorder. Psychiatr. Clin. North Am. 25 (2002) 341-368
46. Yehuda R., Bierer L.M., Schmeidler J., Aferiat D.H., Breslau I., and Dolan S. Low cortisol and risk for PTSD in adult offspring of holocaust survivors. Am. J. Psychiatry 157 8 (2000) 1252-1259
47. Yehuda R., Blair W., Labinsky E., and Bierer L.M. Effects of parental PTSD on the cortisol response to dexamethasone administration in their adult offspring. Am. J. Psychiatry 164 1 (2007) 163-166
48. Yehuda R., Engel S.M., Brand S.R., Seckl J., Marcus S.M., and Berkowitz G.S. Transgenerational effects of posttraumatic stress disorder in babies of mothers exposed to the World Trade Center attacks during pregnancy. J. Clin. Endocrinol. Metab. 90 7 (2005) 4115-4118
49. Yehuda R., Golier J.A., Yang R.K., and Tischler L. Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder. Biol. Psychiatry 55 11 (2004) 1110-1116
50. Yehuda R., Halligan S.L., and Bierer L.M. Relationship of parental trauma exposure and PTSD to PTSD, depressive and anxiety disorders in offspring. J. Psychiatr. Res. 35 5 (2001) 261-270
51. Yehuda R., Labinsky E., Tischler L., Brand S.R., Lavin Y., Blair W., Bierer L.M., Goodman R.Z., and Grossman R.A. Are adult offspring reliable informants about parental PTSD? A validation study. Ann. N.Y. Acad. Sci. 1071 (2006) 484-487
52. Yehuda R., and McFarlane A.C. Conflict between current knowledge about posttraumatic stress disorder and its original conceptual basis. Am. J. Psychiatry 152 12 (1995) 1705-1713
53. Yehuda R., Schmeidler J., Giller Jr. E.L., Siever L.J., and Binder-Brynes K. Relationship between posttraumatic stress disorder characteristics of Holocaust survivors and their adult offspring. Am. J. Psychiatry 155 6 (1998) 841-843
54. Yehuda R., Schmeidler J., Wainberg M., Binder-Brynes K., and Duvdevani T. Vulnerability to posttraumatic stress disorder in adult offspring of Holocaust survivors. Am. J. Psychiatry 155 9 (1998) 1163-1171
55. Yehuda R., Teicher M.H., Seckl J.R., Grossman R.A., Morris A., and Bierer L.M. Maternal but not paternal PTSD is a 'vulnerability' factor for low cortisol trait in offspring of Holocaust survivors. Arch. Gen. Psychiatry 64 9 (2007) 1040-1048