Inhibition of MEK sensitizes paclitaxel-induced apoptosis of human colorectal cancer cells by downregulation of GRP78

Anti-Cancer Drugs

Volumn 20, Issue 7, 2009, Pages 601-606

  Mhaidat, Nizar M ^a   Alali, Feras Q ^a   Matalqah, Sina M ^b   Matalka, Ismail I ^a   Jaradat, Saied A ^a   Al Sawalha, Nour A ^a   Thorne, Rick F ^c  

^a JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Jordan)

^b Ministry of Health Jordan   (Jordan)

^c UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

78 kDa glucose regulatory protein; Apoptosis; Colon cancer; Paclitaxel; Unfolded protein response

Indexed keywords

GLUCOSE REGULATORY PROTEIN 78; INITIATION FACTOR 1A; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; HEAT SHOCK PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MOLECULAR CHAPERONE GRP78;

APOPTOSIS; ARTICLE; CANCER CELL; COLORECTAL CANCER; CONTROLLED STUDY; DRUG EFFICACY; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; COLORECTAL TUMOR; DOWN REGULATION; DRUG EFFECT; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOPHYSIOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAT-SHOCK PROTEINS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PACLITAXEL; RNA, SMALL INTERFERING;

EID: 70149090804     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e32832e3120     Document Type: Article

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