Will the 13C-octanoic acid breath test ever replace scintigraphy as the gold standard to assess gastric emptying?

Neurogastroenterology and Motility

Volumn 21, Issue 10, 2009, Pages 1013-1016

  Verbeke, K ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

13C octanoic acid breath test; Gastric emptying; Scintigraphy

Indexed keywords

CARBON 13; OCTANOIC ACID; TECHNETIUM 99M; OCTANOIC ACID DERIVATIVE;

BREATH ANALYSIS; GAMMA SCINTIGRAPHY; GASTROINTESTINAL ABSORPTION; GOLD STANDARD; HUMAN; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; METABOLISM; POPULATION RESEARCH; PRIORITY JOURNAL; SHORT SURVEY; STOMACH EMPTYING; ARTICLE; METHODOLOGY; REPRODUCIBILITY; SCINTISCANNING; STANDARD; STATISTICAL MODEL; STOMACH;

BREATH TESTS; GASTRIC EMPTYING; HUMANS; LINEAR MODELS; OCTANOIC ACIDS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; STOMACH;

EID: 70049117062     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2009.01388.x     Document Type: Short Survey

References (21)

1. International Commission on Radiological Protection. Radiation Dose to Patients from Radiopharmaceuticals. London, UK : ICRP Publication 53, 226 (for 99mTc); 250 (for 111In), 1988.
2. Ghoos YF, Maes BD, Geypens BJ et al. Measurement of gastric-emptying rate of solids by means of a carbon-labeled octanoic-acid breath test. Gastroenterology 1993 104 : 1640 1647.
3. Perri F, Clemente R, Festa V, Andriulli A. C-13 octanoic acid breath test: valueless test for gastric emptying? Gastroenterology 1998 114 : 857 858.
4. Zahn A, Langhans CD, Hoffner S et al. Measurement of gastric emptying by C-13-octanoic acid breath test versus scintigraphy in diabetics. Z Gastroenterol 2003 41 : 383 390.
5. Ziegler D, Schadewaldt P, Mirza AP et al. [C-13]Octanoic acid breath test for non-invasive assessment of gastric emptying in diabetic patients: validation and relationship to gastric symptoms and cardiovascular autonomic function. Diabetologia 1996 39 : 823 830.
6. Bromer MQ, Kantor SB, Wagner DA, Knight LC, Maurer AH, Parkman HP. Simultaneous measurement of gastric emptying with a simple muffin meal using [C-13]octanoate breath test and scintigraphy in normal subjects and patients with dyspeptic symptoms. Dig Dis Sci 2002 47 : 1657 1663.
7. Maes BD, Mys G, Geypens BJ, Evenepoel P, Ghoos YF, Rutgeerts PJ. Gastric emptying flow curves separated from carbon-labeled octanoic acid breath test results. Am J Physiol 1998 275 : G169 75.
8. Maes B. Measurement of Gastric Emptying Using Dynamic Breath Testing. Leuven : Acco, 1994.
9. Maes BD, Ghoos YF, Geypens BJ, Hiele MI, Rutgeerts PJ. Influence of octreotide on the gastric-emptying of solids and liquids in normal healthy-subjects. Aliment Pharmacol Ther 1995 9 : 11 8.
10. Van de Casteele M, Luypaerts A, Geypens B, Fevery J, Ghoos Y, Nevens F. Oxidative breakdown of octanoic acid is maintained in patients with cirrhosis despite advanced disease. Neurogastroenterol Motil 2003 15 : 113 120.
11. Choi MG, Camilleri M, Burton DD, Zinsmeister AR, Forstrom LA, Nair KS. [C-13]octanoic acid breath test for gastric emptying of solids: accuracy, reproducibility, and comparison with scintigraphy. Gastroenterology 1997 112 : 1155 1162.
12. Lee JS, Camilleri M, Zinsmeister AR et al. Toward office-based measurement of gastric emptying in symptomatic diabetics using [C-13]octanoic acid breath test. Am J Gastroenterol 2000 95 : 2751 2761.
13. Viramontes BE, Kim DY, Camilleri M et al. Validation of a stable isotope gastric emptying test for normal, accelerated or delayed gastric emptying. Neurogastroenterol Motil 2001 13 : 567 574.
14. Odunsi ST, Camilleri M, Szarka LA, Zinsmeister AR. Optimizing analysis of stable isotope breath tests to estimate gastric emptying of solids. Neurogastroenterol Motil 2009 21 : 706 e38.
15. 13C-octanoic acid breath tests: examination of different mathematical models in a large patient cohort. Neurogastroenterol Motil 2009 21 : 1039 e83.
16. Sanaka M, Yamamoto T, Kuyama Y. Retention, fixation, and loss of the [C-13] label: a review for the understanding of gastric emptying breath tests. Dig Dis Sci 2008 53 : 1747 1756.
17. Sanaka M, Yamamoto T, Ishii T, Kuyama Y. The Wagner-Nelson method can generate an accurate gastric emptying flow curve from (CO2)-C-13 data obtained by a C-13-labeled substrate breath test. Digestion 2004 69 : 71 8.
18. Sanaka M, Nakada K, Nosaka C, Kuyama Y. The Wagner-Nelson method makes the [C-13]-breath test comparable to radioscintigraphy in measuring gastric emptying of a solid/liquid mixed meal in humans. Clin Exp Pharmacol Physiol 2007 34 : 641 644.
19. Sanaka M, Urita Y, Sugimoto M, Yamamoto T, Kuyama Y. Comparison between gastric scintigraphy and the [C-13]-acetate breath test with Wagner-Nelson analysis in humans. Clin Exp Pharmacol Physiol 2006 33 : 1239 1243. (Pubitemid 44923914)
20. Sanaka M, Yamamoto T, Osaki Y, Kuyama Y. Assessment of the gastric emptying velocity by the C-13-octanoate breath test: deconvolution versus a Wagner-Nelson analysis. J Gastroenterol 2006 41 : 638 646.
21. 13C-acetate processing on measurement of gastric emptying: a systematic investigation in health. Neurogastroenterol Motil 2009 21 : 1047 e85.