Influence of clinical parameters on the results of 13C-octanoic acid breath tests: Examination of different mathematical models in a large patient cohort

Neurogastroenterology and Motility

Volumn 21, Issue 10, 2009, Pages

  Keller, J ^a   Andresen, V ^a   Wolter, J ^a   Layer, P ^a   Camilleri, M ^b  

^a UNIVERSITY OF HAMBURG   (Germany)

^b MAYO CLINIC   (United States)

Author keywords

13CO2 excretion; Absorption; Gastric emptying test; Gastroparesis; Motility; Scintigraphy

Indexed keywords

CARBON 13; OCTANOIC ACID;

ADULT; AGE; ARTICLE; BODY MASS; BREATH ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; DIGESTION; ENTERITIS; EXCRETION; FEMALE; GENDER; HALF LIFE TIME; HUMAN; LINEAR REGRESSION ANALYSIS; LIVER; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL MODEL; METABOLIC DISORDER; METABOLISM; PANCREAS; PRIORITY JOURNAL; REGRESSION ANALYSIS; STOMACH EMPTYING;

ADULT; AGING; ALGORITHMS; BODY MASS INDEX; BREATH TESTS; CARBON DIOXIDE; CARBON RADIOISOTOPES; COHORT STUDIES; DISEASE; FEMALE; GASTRIC EMPTYING; HALF-LIFE; HUMANS; MALE; MODELS, STATISTICAL; OCTANOIC ACIDS; REGRESSION ANALYSIS; SEX CHARACTERISTICS;

EID: 70049085357     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2009.01340.x     Document Type: Article

References (35)

1. Parkman HP, Hasler WL, Fisher RS. American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis. Gastroenterology 2004 127 : 1592 1622.
2. Schoeller DA, Schneider JF, Solomons NW, Watkins JB, Klein PD. Clinical diagnosis with the stable isotope 13C in CO2 breath tests: methodology and fundamental considerations. J Lab Clin Med 1977 90 : 412 421.
3. Maes BD, Ghoos YF, Geypens BJ, Hiele MI, Rutgeerts PJ. Relation between gastric emptying rate and energy intake in children compared with adults. Gut 1995 36 : 183 188.
4. Ramirez A, Wong WW, Shulman RJ. Factors regulating gastric emptying in preterm infants. J Pediatr 2006 149 : 475 479.
5. Leodolter A, von Arnim U, Gerards C, Glasbrenner B, Malfertheiner P. Is the accuracy of isotope-selective non-dispersive infrared spectrometry (NDIRS) sufficient for determination of gastric emptying using the 13C-octanoic acid breath test (13C-OABT): comparison with isotope-ratio mass spectrometry (IRMS). Gastroenterology 2000 118 : A850.
6. Savarino V, Mela GS, Zentilin P et al. Comparison of isotope ratio mass spectrometry and nondispersive isotope-selective infrared spectroscopy for 13C-urea breath test. Am J Gastroenterol 1999 94 : 1203 1208.
7. Mion F, Ecochard R, Guitton J, Ponchon T. (13)CO(2) breath tests: comparison of isotope ratio mass spectrometry and non-dispersive infrared spectrometry results. Gastroenterol Clin Biol 2001 25 : 375 379.
8. Camilleri M. Clinical practice. Diabetic gastroparesis. N Engl J Med 2007 356 : 820 829.
9. Ghoos YF, Maes BD, Geypens BJ et al. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 1993 104 : 1640 1647.
10. Delbende B, Perri F, Couturier O et al. 13C-octanoic acid breath test for gastric emptying measurement. Eur J Gastroenterol Hepatol 2000 12 : 85 91.
11. Lee JS, Camilleri M, Zinsmeister AR et al. Toward office-based measurement of gastric emptying in symptomatic diabetics using [13C]octanoic acid breath test. Am J Gastroenterol 2000 95 : 2751 2761.
12. Lee JS, Camilleri M, Zinsmeister AR, Burton DD, Kost LJ, Klein PD. A valid, accurate, office based non-radioactive test for gastric emptying of solids. Gut 2000 46 : 768 773.
13. Sanaka M, Yamamoto T, Ishii T, Kuyama Y. The Wagner-Nelson method can generate an accurate gastric emptying flow curve from CO2 data obtained by a 13C-labeled substrate breath test. Digestion 2004 69 : 71 8.
14. Bromer MQ, Kantor SB, Wagner DA, Knight LC, Maurer AH, Parkman HP. Simultaneous measurement of gastric emptying with a simple muffin meal using [13C]octanoate breath test and scintigraphy in normal subjects and patients with dyspeptic symptoms. Dig Dis Sci 2002 47 : 1657 1663.
15. Viramontes BE, Kim DY, Camilleri M et al. Validation of a stable isotope gastric emptying test for normal, accelerated or delayed gastric emptying. Neurogastroenterol Motil 2001 13 : 567 574.
16. Choi MG, Camilleri M, Burton DD, Zinsmeister AR, Forstrom LA, Nair KS. [13C]octanoic acid breath test for gastric emptying of solids: accuracy, reproducibility, and comparison with scintigraphy. Gastroenterology 1997 112 : 1155 1162.
17. Sanaka M, Nakada K, Nosaka C, Kuyama Y. The Wagner-Nelson method makes the [13C]-breath test comparable to radioscintigraphy in measuring gastric emptying of a solid/liquid mixed meal in humans. Clin Exp Pharmacol Physiol 2007 34 : 641 644.
18. Kim DY, Camilleri M, Schuster MM, Crowell MD, Koch KL. Stable Isotope Breath Test and Gastric Emptying. Schuster Atlas of Gastrointestinal Motility in Health and Disease. Volume 2. Hamilton, Londo : BC Decker Inc, 2002 : 203 218.
19. Odunsi ST, Camilleri M, Szarka LA, Zinsmeister AR. Optimizing analysis of stable isotope breath tests to estimate gastric emptying of solids. Neurogastroenterol Motil 2009 21 : 706 711.
20. Sanaka M, Yamamoto T, Kuyama Y. The "corrected" half emptying time is a valueless parameter in the 13C-octanoic acid breath test: misuse of the regression analysis. J Clin Gastroenterol 2003 36 : 284 285.
21. Maes BD, Ghoos YF, Geypens BJ, Hiele MI, Rutgeerts PJ. Relation between gastric emptying rate and rate of intraluminal lipolysis. Gut 1996 38 : 23 7.
22. DiMagno EP, Go VL, Summerskill WH. Relations between pancreatic enzyme ouputs and malabsorption in severe pancreatic insufficiency. N Engl J Med 1973 288 : 813 815.
23. Keller J, Layer P. Human pancreatic exocrine response to nutrients in health and disease. Gut 2005 54 (Suppl. 6 vi1 28.
24. van de CM, Luypaerts A, Geypens B, Fevery J, Ghoos Y, Nevens F. Oxidative breakdown of octanoic acid is maintained in patients with cirrhosis despite advanced disease. Neurogastroenterol Motil 2003 15 : 113 120.
25. Schneider AR, Kraut C, Lindenthal B, Braden B, Caspary WF, Stein J. Total body metabolism of 13C-octanoic acid is preserved in patients with non-alcoholic steatohepatitis, but differs between women and men. Eur J Gastroenterol Hepatol 2005 17 : 1181 1184.
26. Annese V, Bassotti G, Napolitano G et al. Gastric emptying of solids in patients with nonobstructive Crohn's disease is sometimes delayed. J Clin Gastroenterol 1995 21 : 279 282.
27. Grill BB, Lange R, Markowitz R, Hillemeier AC, McCallum RW, Gryboski JD. Delayed gastric emptying in children with Crohn's disease. J Clin Gastroenterol 1985 7 : 216 226.
28. Keller J, Szai S, Begliner C, Holst JJ, Fibbe C, Layer P. Disturbed gastric emptying in CrohnÔs disease: mediated by gastrointestinal hormones? Gastroenterology 2003 124 : A-676.
29. Keller J, Begliner C, Holst JJ et al. Gastric emptying of solids in ulcerative colitis and release of regulatory hormones. Regul Pept 2004 12 : 25.
30. Keller J, Fliegner-Baia M, Layer P. Physical activity alters normal values of the "European standard" 13C-octanoic acid breath test. Gut 2002 51 : A136.
31. Westerterp KR, Plasqui G. Physical activity and human energy expenditure. Curr Opin Clin Nutr Metab Care 2004 7 : 607 613.
32. Keim NL, Blanton CA, Kretsch MJ. America's obesity epidemic: measuring physical activity to promote an active lifestyle. J Am Diet Assoc 2004 104 : 1398 1409.
33. Peracchi M, Gebbia C, Ogliari C et al. Influence of caloric intake on gastric emptying of solids assessed by 13C-octanoic acid breath test. Scand J Gastroenterol 2000 35 : 814 818.
34. Tougas G, Eaker EY, Abell TL et al. Assessment of gastric emptying using a low fat meal: establishment of international control values. Am J Gastroenterol 2000 95 : 1456 1462.
35. Abell TL, Camilleri M, Donohoe K et al. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. J Nucl Med Technol 2008 36 : 44 54.