Oxidative breakdown of octanoic acid is maintained in patients with cirrhosis despite advanced disease

Neurogastroenterology and Motility

Volumn 15, Issue 2, 2003, Pages 113-120

  Van De Casteele, M ^a   Luypaerts, A ^b   Geypens, B ^b   Fevery, J ^a   Ghoos, Y ^b   Nevens, F ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Aminopyrine breath test; Cirrhosis; Octanoic acid breath test; Transjugular intrahepatic portosystemic shunt

Indexed keywords

CARBON DIOXIDE; OCTANOIC ACID;

ADULT; AGED; ARTICLE; BREATH ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FOOD; HALF LIFE TIME; HUMAN; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; OXIDATION; PORTOSYSTEMIC ANASTOMOSIS; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SOLID; STOMACH EMPTYING;

ADULT; BREATH TESTS; CARBON ISOTOPES; FEMALE; GASTRIC EMPTYING; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; OCTANOIC ACIDS; OXIDATION-REDUCTION; PORTASYSTEMIC SHUNT, TRANSJUGULAR INTRAHEPATIC; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY;

EID: 0038070515     PISSN: 13501925     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2982.2003.00397.x     Document Type: Article

References (26)

1. Ghoos YF, Maes BD, Geypens BJ et al. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 1993; 104: 1640-7.
2. Maes BD, Mys G, Geypens BJ, Evenepoel P, Ghoos YF, Rutgeerts PJ. Gastric emptying flow curves separated from carbon-labeled octanoic acid breath test results. Am J Physiol 1998; 275: G169-75.
3. Balan KK, Grime S, Sutton R, Critchley M, Jenkins SA. Abnormalities of gastric emptying in portal hypertension. Am J Gastroenterol 1996; 91: 530-4.
4. Madsen JL, Brinch K, Hansen EF, Fuglsang S. Gastrointestinal motor function in patients with portal hypertension. Scand J Gastroenterol 2000; 35: 490-3.
5. Morgan MY. Nutritional aspects of liver and biliary disease. In: Bircher J, Benhamou JP, McIntyre N, Rizzetto M, Rodés J, eds. Oxford Textbook of Clinical Hepatology, 2nd edn. Oxford: Oxford University Press, 1999: 1923-45.
6. Guillot E, Vaugelade P, Lemarchal P, Rerat A. Intestinal absorption and liver uptake of medium-chain fatty acids in non-anaesthetized pigs. Br J Nutr 1993; 69: 431-42.
7. Christensen E, Hagve TA, Gronn M, Christopherson BO. Beta-oxidation of median chain (C8-C14) fatty acids studied in isolated liver cells. Biochim Biophys Acta 1989; 1004: 187-95.
8. 13C: a comparison of oxidation after oral or parenteral administration in humans. J Nutr 1991; 121: 31-6.
9. DeLany JP, Windhauser MM, Champagne CM, Bray GA. Differential oxidation of individual dietary fatty acids in humans. Am J Clin Nutr 2001; 72: 905-11.
10. Guo W, Choi JK, Kirkland JL, Corkey BA, Hamilton JA. Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate. Biochem J 2000; 349: 463-71.
11. Yamamura N, Magata Y, Konishi J, Saji H. Evaluation of radioiodinated medium chain fatty acids as new diagnostic agents for the determinations of hepatic viability. Eur J Nucl Med 1999; 26: 1597-1605.
12. Reichen J. Assessment of hepatic function with xenobiotics. Sem Liver Dis 1995; 15: 189-201.
13. Maes BD, Ghoos YF, Geypens BJ, Hide MI, Rutgeerts PJ. Relation between gastric emptying rate and rate of intraluminal lipolysis. Gut 1996; 38: 23-7.
14. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transsection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60: 646-9.
15. Raat H, Stockx L, Ranschaert E, Nevens F, Wilms G, Baert AL. Percutaneous hydrodynamic thrombectomy of acute thrombosis in transjugular intrahepatic portosystemic shunt: a feasibility study in five patients. Cardiovasc Intervent Radiol 1997; 20: 180-3.
16. 13C-Octanoic acid breath test for gastric emptying rate of solids. Gastroenterology 1998; 114: 856-63.
17. 13C-mixed triacylglycerol breath test in children with cystic fibrosis. J Pediatr Gastroenterol 2000; 30: 368-72.
18. Renner EL. Liver function tests. Baillières Clin Gastroenterol 1995; 9: 661-77.
19. Fernandez-Esparrach G, Sanchez-Fueyo A, Ginès P et al. A prognostic model for predicting survival in cirrhosis with ascites. J Hepatol 2001; 34: 46-52.
20. Hepner GW, Vesell ES, Lipton A, Harvey HA, Wilkinson GR, Schenker S. Disposition of aminopyrine, antipyrine, diazepam, and indocyanine green in patients with liver disease or on anticonvulsant drug therapy: diazepam breath test and correlations in drug elimination. J Lab Clin Med 1977; 90: 440-55.
21. 13C-octanoic acid breath test for gastric emptying of solids. Am J Gastroenterol 1998; 93: 92-8.
22. Shangraw RE, Jahoor F. Lipolysis and lipid oxidation in cirrhosis and after liver transplantation. Am J Physiol 2000; 278: G967-73.
23. Tietge UJF, Boker KHW, Bahr MJ et al. Lipid parameters predicting liver function in patients with cirrhosis and after liver transplantation. Hepato-Gastroenterology 1998; 45: 2255-60.
24. Safka V. Pathophysiology of portal hypertension. In: Hulek P, Krajina A, eds. Current Practice of TIPS, 1st edn. Hradec Kralove: Olga Stambergova, 2001: 24-40.
25. Sanyal AJ, Freedman AM, Luketic VA et al. The natural history of portal hypertension after transjugular intrahepatic portosystemic shunts. Gastroenterology 1997; 112: 889-98.
26. Baron A, Gulberg V, Sauter G, Waggershauser T, Reiser M, Gerbes AL. Effects of transjugular intrahepatic portosystemic shunt on quantitative liver function tests. Hepato-Gastroenterology 1998; 45: 2315-21.