A Sulfilimine Bond Identified in Collagen IV

Science

Volumn 325, Issue 5945, 2009, Pages 1230-1234

  Vanacore, Roberto ^a   Ham, Amy Joan L ^a,d   Voehler, Markus ^a   Sanders, Charles R ^a   Conrads, Thomas P ^b,e   Veenstra, Timothy D ^b   Sharpless, Barry ^c   Dawson, Philip E ^c   Hudson, Billy G ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; COLLAGEN TYPE 4; HYDROXYLYSINE; METHIONINE; NITROGEN DERIVATIVE; SULFILIMINE; SULFOXIDE; SULFUR DERIVATIVE; UNCLASSIFIED DRUG;

ADAPTATION; CHEMICAL BONDING; COLLAGEN; FOURIER TRANSFORM; LIGAND; MEMBRANE; METAZOAN; PROTEIN; SPONGE;

ARTICLE; CHEMICAL STRUCTURE; COELENTERATE; COVALENT BOND; EXTRACELLULAR MATRIX; HYDROXYLATION; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; MACROMOLECULE; MECHANICAL STRESS; METAZOON; MOLECULAR BIOLOGY; MOLECULAR STABILITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CROSS LINKING;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; COLLAGEN TYPE IV; HUMANS; HYDROXYLYSINE; MASS SPECTROMETRY; METHIONINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NITROGEN; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHYSICOCHEMICAL PROCESSES; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; SEQUENCE ALIGNMENT; STRESS, MECHANICAL; SULFUR;

CNIDARIA; METAZOA;

EID: 69949177973     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1176811     Document Type: Article

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34. We thank D. Liebler for facilitating the initial contact with T. D. Veenstra from SAIC-Frederick, Incorporated, and C. Bolm (Aachen University, Germany) for helpful discussions. The technical assistance of P. Todd and M. Rati is greatly appreciated. We would also like to thank S. Hill and H. McDonald, from the Proteomics Laboratory at the Mass Spectrometry Research Center of Vanderbilt University, for their assistance with the Orbitrap-LTQ (Therme Electron, San Jose, CA) instrument. This work was supported in part by NIH grants DK065123 and DK18381 (to B.G.H.), DC007416 (C.R.S.), and GM059380 (P.E.D.); the W. M. Keck Foundation (K.B.S.); and the Skaggs Institute for Chemical Biology (K.B.S.). R.V. and B.G.H. have filed a provisional patent (1 June 2009) on the potential enzyme system that catalyses the sutfilimine bond formation and that may be involved in pathophysiological processes.