Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness

Journal of Biological Chemistry

Volumn 284, Issue 36, 2009, Pages 24289-24296

  Ito, Takachika ^a   Suzuki, Shoichi ^a   Kanaji, Sachiko ^a   Shiraishi, Hiroshi ^a   Ohta, Shoichiro ^a   Arima, Kazuhiko ^a   Tanaka, Go ^a   Tamada, Taro ^b   Honjo, Eijiro ^b   Garcia, K Christopher ^c   Kuroki, Ryota ^b   Izuhara, Kenji ^a  

^a SAGA UNIVERSITY   (Japan)

^b Quantum Beam Science Directorate   (Japan)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINES; INTERACTING SITES; INTERLEUKIN-4; MUTATIONAL ANALYSIS; N-TERMINALS; PRINCIPAL FUNCTIONS; SPECIFIC BINDING; STRUCTURAL DATA; STRUCTURAL REQUIREMENTS; STRUCTURAL STABILITIES;

AMINATION; AMINES; AMINO ACIDS; BINDING ENERGY; CRYSTAL STRUCTURE; LIGANDS; ORGANIC ACIDS; STABILITY;

BINDING SITES;

ALANINE; AMINO ACID DERIVATIVE; CYTOKINE; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 13 RECEPTOR ALPHA1; INTERLEUKIN 4; ISOLEUCINE; LEUCINE; LYSINE; TRYPTOPHAN; VALINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; RECEPTOR BINDING;

CELL LINE; HUMANS; INTERLEUKIN-13; INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT; INTERLEUKIN-4; LIGANDS; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69949171889     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.007286     Document Type: Article

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