Synthesis, antibacterial activity, and toxicity of 7-(isoindolin-5-yl)-4-oxoquinoline-3-carboxylic acids: Discovery of the novel Des-F(6)-quinolone antibacterial agent garenoxacin (T-3811 or BMS-284756)

Arzneimittel-Forschung/Drug Research

Volumn 52, Issue 12, 2002, Pages 903-913

  Hayashi, Kazuya ^a   Takahata, Masahiro ^a   Kawamura, Yasuhito ^a   Todo, Yozo ^a  

^a TOYAMA CHEMICAL CO LTD   (Japan)

Author keywords

BMS 284756; CAS 194804 75 6; CAS 223652 90 2; Comparison, 6 fluoro and 6 desfluoro quinolones, 8 methoxy and 8 (difluoromethoxy) quinolones, antibacterial activity, toxicity

Indexed keywords

ANTIINFECTIVE AGENT; BORONIC ACID DERIVATIVE; CIPROFLOXACIN; DNA TOPOISOMERASE; GARENOXACIN; GARENOXIN; ISOINDOLE DERIVATIVE; LEVOFLOXACIN; PALLADIUM; QUINOLINE DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; MYCOPLASMA MYCOIDES; NONHUMAN; REACTION ANALYSIS; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STREPTOCOCCUS PNEUMONIAE;

EID: 0036909420     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1299988     Document Type: Article

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