Insertion sequence ISEcp1-like element connected with a novel aph(2″) allele [aph(2″)-le] conferring high-level gentamicin resistance and a novel streptomycin adenylyltransferase gene in Enterococcus

Journal of Medical Microbiology

Volumn 55, Issue 11, 2006, Pages 1521-1525

  Chen, Ya Gang ^a   Qu, Ting Ting ^a   Yu, Yun Song ^a   Zhou, Jian Ying ^a   Li, Lan Juan ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; BACTERIAL ENZYME; GENTAMICIN; ISEPAMICIN; KANAMYCIN; NETILMICIN; PLASMID DNA; STREPTOMYCIN; STREPTOMYCIN ADENYLYLTRANSFERASE; TOBRAMYCIN; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; ENTEROCOCCUS; ESCHERICHIA COLI; GENE EXPRESSION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STR GENE;

ALLELES; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CLONING, MOLECULAR; CONJUGATION, GENETIC; CROSS INFECTION; DNA TRANSPOSABLE ELEMENTS; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS; GENTAMICINS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEOTIDYLTRANSFERASES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); POLYMERASE CHAIN REACTION; STREPTOCOCCAL INFECTIONS;

EID: 33750835406     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.46702-0     Document Type: Article

References (22)

1. Ahmed, A. M. & Shimamoto, T. A. (2004). Plasmid-encoded class I integren carrying sat, a putative phosphoserine phosphatase gene and aadA2 from enterotoxigenic Escherichia coli O159 isolated in Japan, FEMS Microbiol Lett 235, 243-248.
2. Cao, V., Lambert, T. & Courvalin, P. (2002). ColE1-like plasmid pIP843 of Klebsiella pneumoniae encoding extended-spectrum beta-lactamase CTX-M-17. Antimicrob Agents Chemother 46, 1212-1217.
3. Chow, J. W., Zervos, M. J., Lerner, S. A., Thal, L. A., Donabedian, S. M., Jaworski, D. D., Tsai, S., Shaw, K. J. & Clewell, D. B. (1997). A novel gentamicin resistance gene in Enterococcus. Antimicrob Agents Chemother 41, 511-514.
4. Clark, N. C., Olsvik, O., Swenson, J. M., Spiegel, C. A. & Tenover, F. C. (1999). Detection of a streptomycin/spectinomycin adenylyl-transferase gene (aadA) in Enterococcus faecalis. Antimicrob Agents Chemother 43, 157-160.
5. CLSI (2005). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically; Approved Standard. CLSI document M7-A6, 6th edn. Wayne, PA; Clinical and Laboratory Standards Institute.
6. Derbise, A., Aubert, S. & Solh, N. E. (1997). Mapping the regions carrying three contiguous antibiotic resistance genes aadE, sat4, and aphA-3 in the genomes of staphylococci. Antimicrob Agents Chemother 41, 1024-1032.
7. Donabedian, S. M., Thal, L. A., Hershberger, E. & 13 other authors (2003). Molecular characterization of gentamicin-resistant enterococci in the United States: Evidence of spread from animals to humans through food. J Clin Microbiol 41, 1109-1113.
8. Eliopoulos, G. M., Farber, B. F., Murray, B. E., Wennersten, C. & Moellering, R. C. (1984). Ribosomal resistance of clinical enterococcal isolates to streptomycin. Antimicrob Agents Chemother 25, 398-399.
9. Ferretti, J. J., Gilmore, K. S. & Courvalin, P. (1986). Nucleotide sequence analysis of the gene specifying the bifunctional 6′- aminoglycoside acetyltransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activities. J Bacteriol 167, 631-638.
10. Hallgren, A., Saeedi, B., Nilsson, M., Monstein, H. J., Isaksson, B., Hanberger, H. & Nilsson, L. E. (2003). Genetic relatedness among Enterococcus faecalis with transposon-mediated high-level gentamicin resistance in Swedish intensive care units. J Antimicrob Chemother 52, 162-167.
11. Ike, Y., Tanimoto, K., Tomita, H., Takeuchi, K. & Fujimoto, S. (1998). Efficient transfer of the pheromone-independent Enterococcus faecium plasmid pMG1 (Gmr) (65.1 kilobases) to Enterococcus strains during broth mating. J Bacteriol 180, 4886-4892.
12. Kao, S. J., You, I., Clewell, D. B., Donabedian, S. M., Zervos, M. J., Petrin, J., Shaw, K. J. & Chowl, J. W. (2000). Detection of the high-level aminoglycoside resistance gene aph(2″)-Ib in Enterococcus faecium. Antimicrob Agents Chemother 44, 2876-2879.
13. Murray, B. E. (1998). Diversity among multidrug-resistant enterococci. Emerg Infect Dis 4, 37-47.
14. Perreten, V., Schwarz, F. V., Teuber, M. & Levy, S. B. (2001). Mdt(A), a new efflux protein conferring multiple antibiotic resistance in Lactococcus lactis and Escherichia coli. Antimicrob Agents Chemother 45, 1109-1114.
15. CTX-M Escherichia coli. Antimicrob Agents Chemother 49, 447-450.
16. Projan, S. J., Moghazeh, S. & Novick, R. P. (1988). Nucleotide sequence of pS194, a streptomycin-resistance plasmid from Staphylococcus aureus. Nucleic Acids Res 16, 2179-2187.
17. Schaberg, D. R., Culver, D. H. & Gaynes, R. P. (1991). Major trends in the microbial etiology of nosocomial infection. Am J Med 91 (Suppl. 3B), 72S-75S.
18. Schwarz, F. V., Perreten, V. & Teuber, M. (2001). Sequence of the 50-kb conjugative multiresistance plasmid pRE25 from Enterococcus faecalis RE25. Plasmid 46, 170-187.
19. Simjee, S., Fraise, A. P. & Gill, M. J. (1999). Plasmid heterogeneity and identification of a Tn5281-like element in clinical isolates of high-level gentamicin-resistant Enterococcus faecium isolated in the UK. J Antimicrob Chemother 43, 625-635.
20. Tai, S. F., Zervos, M. J., Clewell, D. B., Donabedian, S. M., Sahm, D. F. & Chow, J. W. (1998). A new high-level gentamicin resistance gene, aph(2″)-Id, in Enterococcus spp. Antimicrob Agents Chemother 42, 1229-1232.
21. Wang, Q., Xu, Y. C., Wang, H., Chen, M. J., Zhang, X. Z., Xu, S. Z. & Wu, J. (1999). Antimicrobial resistant characteristics in enterococci and antibiotics for enterococcal infections. Chinese Journal of Laboratory Medicine 22, 154-156 (in Chinese).
22. Werner, G., Hildebrandt, B. & Witte, W. (2001). Aminoglycoside- streptothricin resistance gene cluster aadE-sat4-aphA-3 disseminated among multiresistant isolates of Enterococcus faecium. Antimicrob Agents Chemother 45, 3267-3269.