Upregulation of macrophage Migration Inhibitory Factor (MIF) and CD74, receptor for MIF, in rat bladder during persistent cyclophosphamide-induced inflammation

Experimental Biology and Medicine

Volumn 233, Issue 5, 2008, Pages 620-626

  Vera, Pedro L ^a   Wang, Xihai ^a,b   Meyer Siegler, Katherine L ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Bladder; Cox 2; Cytokines; Inflammation

Indexed keywords

CYCLOOXYGENASE 2; CYCLOPHOSPHAMIDE; CYTOKINE; CYTOKINE RECEPTOR; MACROPHAGE MIGRATION INHIBITION FACTOR; MACROPHAGE MIGRATION INHIBITION FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER; CONTROLLED STUDY; CYSTITIS; HISTOLOGY; IMMUNOREACTIVITY; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; RAT; RECEPTOR UPREGULATION; URINE; UROTHELIUM;

ANIMALS; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; BIOLOGICAL MARKERS; BODY WEIGHT; CYCLOPHOSPHAMIDE; CYSTITIS; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTOCOMPATIBILITY ANTIGENS CLASS II; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, IMMUNOLOGIC; SURVIVAL RATE; UP-REGULATION;

RATTUS;

EID: 43249129183     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0709-RM-240     Document Type: Article

References (35)

1. Bloom BR, Bennett B. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science 153:80-82, 1966.
2. David JR. Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc Natl Acad Sci U S A 56:72-77, 1966.
3. Donnelly SC, Bucala R. Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease. Mol Med Today 3:502-507, 1997.
4. Baugh JA, Donnelly SC. Macrophage migration inhibitory factor: a neuroendocrine modulator of chronic inflammation. J Endocrinol 179:15-23, 2003.
5. Mitchell RA. Mechanisms and effectors of MIF-dependent promotion of tumourigenesis. Cellular signalling 16:13-19, 2004.
6. Flaster H, Bernhagen J, Calandra T, Bucala R. The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity. Mol Endocrinol 21:1267-1280, 2007.
7. Cvetkovic I, Stosic-Grujicic S. Neutralization of macrophage migration inhibitory factor-novel approach for the treatment of immunoinflammatory disorders. Int Immunopharmacol 6:1527-1534, 2006.
8. Vera PL, Meyer-Siegler KL. Anatomical location of macrophage migration inhibitory factor in urogenital tissues, peripheral ganglia and lumbosacral spinal cord of the rat. BMC Neurosci 4:17, 2003.
9. Meyer-Siegler KL, Leifheit EC, Vera PL. Inhibition of macrophage migration inhibitory factor decreases proliferation and cytokine expression in bladder cancer cells. BMC Cancer 4:34, 2004.
10. Meyer-Siegler KL, Ordorica RC, Vera PL. Macrophage migration inhibitory factor is upregulated in an endotoxin-induced model of bladder inflammation in rats. J Interferon Cytokine Res 24:55-63, 2004.
11. Meyer-Siegler KL, Vera PL. Substance P induced release of macrophage migration inhibitory factor from rat bladder epithelium. J Urol 171:1698-1703, 2004.
12. Shi X, Leng L, Wang T, Wang W, Du X, Li J, McDonald C, Chen Z, Murphy JW, Lolis E, Noble P, Knudson W, Bucala R. CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity 25:595-606, 2006.
13. Leng L, Metz CN, Fang Y, Xu J, Donnelly S, Baugh J, Delohery T, Chen Y, Mitchell RA, Bucala R. MIF signal transduction initiated by binding to CD74. J Exp Med 197:1467-1476, 2003.
14. Meyer-Siegler KL, Vera PL. Substance P induced changes in CD74 and CD44 in the rat bladder. J Urol 173:615-620, 2005.
15. Meyer-Siegler KL, Vera PL. Intraluminal antibodies to macrophage migration inhibitory factor decrease substance P induced inflammatory changes in the rat bladder and prostate. J Urol 172:1504-1509, 2004.
16. Vera PL, Meyer-Siegler KL. Inflammation of the rat prostate evokes release of macrophage migration inhibitory factor in the bladder: evidence for a viscerovisceral reflex. J Urol 172:2440-2445, 2004.
17. Giuliano FA, Denys P, Chartier-Kastler E, Alexandre L, Bernabe J. L6-S1 spinal nerve stimulation reduces micturition frequency in anaesthetized rats with cyclophosphamide-induced cystitis. BJU Int 97:386-392, 2006.
18. Chopra B, Barrick SR, Meyers S, Beckel JM, Zeidel ML, Ford AP, de Groat WC, Birder LA. Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium. J Physiol 562:859-871, 2005.
19. Morais MM, Belarmino-Filho JN, Brito GA, Ribeiro RA. Pharmacological and histopathological study of cyclophosphamide-induced hemorrhagic cystitis - comparison of the effects of dexamethasone and Mesna. Brazilian J Med Biol Res 32:1211-1215, 1999.
20. Hu VY, Malley S, Dattilio A, Folsom JB, Zvara P, Vizzard MA. COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat. Am J Physiol Regul Integr Comp Physiol 284:R574-585, 2003.
21. Malley SE, Vizzard MA. Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis. Physiol Genomics 9:5-13, 2002.
22. Rodo J, Farre X, Martin E. Cyclophosphamide-induced hemorrhagic cystitis in rats that underwent colocystoplasty: experimental study. J Urol 165:660-666, 2001.
23. Chow YC, Yang S, Huang CJ, Tzen CY, Su YH, Wang PS. Prophylactic intravesical instillation of epinephrine prevents cyclophosphamide-induced hemorrhagic cystitis in rats. Exp Biol Med 232:565-570, 2007.
24. Zvarova K, Vizzard MA. Changes in galanin immunoreactivity in rat micturition reflex pathways after cyclophosphamide-induced cystitis. Cell Tissue Res 324:213-224, 2006.
25. Vera PL, Iczkowski KA, Leng L, Bucala R, Meyer-Siegler KL. Macrophage migration inhibitory factor is released as a complex with alpha1-inhibitor-3 in the intraluminal fluid during bladder inflammation in the rat. J Urol 174:338-343, 2005.
26. Vera PL, Meyer-Siegler KL. Substance P induces localization of MIF/alpha1-inhibitor-3 complexes to umbrella cells via paracellular transit through the urothelium in the rat bladder. BMC Urol 6:24, 2006.
27. Terado M, Nomura M, Mineta K, Nishii H, Fujimoto N, Sasaguri T, Sasaguri Y, Matsumoto T. Involvement of estrogen in the pathogenesis of cyclophosphamide-induced cystitis in rats. Endocrine 26:55-63, 2005.
28. Bon K, Lichtensteiger CA, Wilson SG, Mogil JS. Characterization of cyclophosphamide cystitis, a model of visceral and referred pain, in the mouse: species and strain differences. J Urol 170:1008-1012, 2003.
29. Fraiser L, Kehrer JP. Murine strain differences in metabolism and bladder toxicity of cyclophosphamide. Toxicology 75:257-272, 1992.
30. Vera PL, Ordorica RC, Meyer-Siegler KL. Hydrochloric acid induced changes in macrophage migration inhibitory factor in the bladder, peripheral and central nervous system of the rat. J Urol 170:623-627, 2003.
31. Saban MR, Nguyen NB, Hammond TG, Saban R. Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation. Am J Pathol 160:2095-2110, 2002.
32. Bouchelouche K, Alvarez S, Horn T, Nordling J, Bouchelouche P. Human detrusor smooth muscle cells release interleukin-6, interleukin-8, and RANTES in response to proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha. Urology 67:214-219, 2006.
33. Chen MC, Keshavan P, Gregory GD, Klumpp D. RANTES mediates TNF-dependent lamina propria mast cell accumulation and barrier dysfunction in neurogenic cystitis. Am J Physiol Renal Physiol 292:F1372-1379, 2007.
34. Jang J, Park EY, Seo SI, Hwang TK, Kim JC. Effects of intravesical instillation of cyclooxygenase-2 inhibitor on the expression of inducible nitric oxide synthase and nerve growth factor in cyclophosphamide-induced overactive bladder. BJU Int 98:435-439, 2006.
35. Meyer-Siegler KL, Iczkowski KA, Vera PL. Macrophage migration inhibitory factor is increased in the urine of patients with urinary tract infection: macrophage migration inhibitory factor-protein complexes in human urine. J Urol 175:1523-1528, 2006.