Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 19, 2009, Pages 5657-5660

  Martyn, Derek C ^a   Beletsky, Galina ^b   Cortese, Joseph F ^a   Tyndall, Erin ^a   Liu, Hanlan ^c   Fitzgerald, Maria M ^c   O'Shea, Thomas J ^c   Liang, Beirong ^c   Clardy, Jon ^a,d  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b 7 Cambridge Center   (United States)

^c GENZYME CORPORATION   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

1,2 Dioxolanes; Antiplasmodial; DMPK profiling; Malaria

Indexed keywords

1,2 DIOXOLANE DERIVATIVE; 1,3 DIOXOLANE DERIVATIVE; ANTIMALARIAL AGENT; CYTOCHROME P450; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CROSS COUPLING REACTION; DRUG INHIBITION; DRUG METABOLISM; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; MEMBRANE PERMEABILITY; MICROSOME; NONHUMAN; PLASMODIUM FALCIPARUM; RAT;

ANIMALS; ANTIMALARIALS; CYTOCHROME P-450 ENZYME SYSTEM; DIOXOLANES; HUMANS; MICROSOMES, LIVER; PLASMODIUM FALCIPARUM; PROTEIN ISOFORMS; RATS; SMALL MOLECULE LIBRARIES;

PLASMODIUM FALCIPARUM; RATTUS;

EID: 69949109904     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.024     Document Type: Article

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