Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells

Food and Chemical Toxicology

Volumn 46, Issue 1, 2008, Pages 168-174

  Whittaker, Paul ^a   Clarke, Jane J ^b   San, Richard H C ^b   Betz, Joseph M ^c   Seifried, Harold E ^d   de Jager, Lowri S ^a   Dunkel, Virginia C ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b BioReliance   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Kava; Kava pyrones; Kavalactones; Mouse lymphoma; Mutagenicity; Piper methysticum

Indexed keywords

DESMETHOXYYANGNIN; DEXTRO KAWAIN; DEXTROLEVO KAWAIN; DIHYDROKAWAIN; DIHYDROMETHYSTICIN; KAVA EXTRACT; METHYSTICIN; UNCLASSIFIED DRUG; YANGONIN;

ANALYSIS OF VARIANCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; GENE MUTATION; HUMAN; HUMAN TISSUE; LYMPHOMA CELL; MOUSE; MUTAGENICITY; MUTATIONAL ANALYSIS; NONHUMAN;

ANIMALS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOTOXINS; HUMANS; KAVA; LACTONES; LIVER; LYMPHOMA; MASS SPECTROMETRY; MICE; MUTAGENICITY TESTS; MUTAGENS; MUTATION; PLANT EXTRACTS; SUBCELLULAR FRACTIONS;

MAMMALIA; PIPER METHYSTICUM; PIPERACEAE;

EID: 36849036878     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.07.013     Document Type: Article

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