British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children

Journal of Infection

Volumn 59, Issue 3, 2009, Pages 167-187

  Thwaites, Guy ^a   Fisher, Martin ^b   Hemingway, Cheryl ^c   Scott, Geoff ^d   Solomon, Tom ^e   Innes, John ^f  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UK   (United Kingdom)

^c GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^e UNIVERSITY OF LIVERPOOL   (United Kingdom)

^f BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

Author keywords

Central nervous system; Clinical guidelines; Diagnosis; Meningitis; Spinal cord; Treatment; Tuberculoma; Tuberculosis

Indexed keywords

ACETAZOLAMIDE; ADENOSINE DEAMINASE; CORTICOSTEROID; DEXAMETHASONE; ETHAMBUTOL; ETHIONAMIDE; FUROSEMIDE; GAMMA INTERFERON; HYALURONIDASE; ISONIAZID; PREDNISOLONE; PYRAZINAMIDE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; THALIDOMIDE; TUBERCULOSTATIC AGENT;

ADJUVANT THERAPY; ADULT; ARTICLE; CENTRAL NERVOUS SYSTEM TUBERCULOSIS; CEREBROSPINAL FLUID ANALYSIS; CHILD; CHILD CARE; CLINICAL FEATURE; CLINICAL TRIAL; COMMUNICATING HYDROCEPHALUS; DRUG CEREBROSPINAL FLUID LEVEL; DRUG PENETRATION; DRUG WITHDRAWAL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRACRANIAL TUBERCULOMA; LUMBAR PUNCTURE; MYCOBACTERIUM TUBERCULOSIS; NAUSEA; NEUROIMAGING; NEUROSURGERY; NUCLEIC ACID AMPLIFICATION; OPTIC NERVE DISEASE; PRACTICE GUIDELINE; TUBERCULIN TEST; TUBERCULOUS MENINGITIS; TUBERCULOUS SPONDYLITIS; UNITED KINGDOM;

ADENOSINE DEAMINASE; ADULT; ANTIBIOTICS, ANTITUBERCULAR; ANTITUBERCULAR AGENTS; CEREBROSPINAL FLUID; CHILD; ETHAMBUTOL; HUMANS; ISONIAZID; MYCOBACTERIUM TUBERCULOSIS; PYRAZINAMIDE; RIFAMPIN; SPINAL PUNCTURE; TUBERCULIN TEST; TUBERCULOMA, INTRACRANIAL; TUBERCULOSIS, MENINGEAL; TUBERCULOSIS, SPINAL;

EID: 69949090358     PISSN: 01634453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinf.2009.06.011     Document Type: Article

References (194)

1. Rich A.R., and McCordock H.A. The pathogenesis of tuberculous meningitis. Bull John Hopkins Hosp 52 (1933) 5-37
2. Bidstrup C., Andersen P.H., Skinhoj P., and Andersen A.B. Tuberculous meningitis in a country with a low incidence of tuberculosis: still a serious disease and a diagnostic challenge. Scand J Infect Dis 34 11 (2002) 811-814
3. Bishburg E., Sunderam G., Reichman L.B., and Kapila R. Central nervous system tuberculosis with the acquired immunodeficiency syndrome and its related complex. Ann Intern Med 105 2 (1986) 210-213
4. Keane J. TNF-blocking agents and tuberculosis: new drugs illuminate an old topic. Rheumatology (Oxford) 44 6 (2005) 714-720
5. Atkins D., Best D., Briss P.A., Eccles M., Falck-Ytter Y., Flottorp S., et al. Grading quality of evidence and strength of recommendations. BMJ 328 7454 (2004) 1490
6. Girgis N.I., Sultan Y., Farid Z., Mansour M.M., Erian M.W., Hanna L.S., et al. Tuberculosis meningitis, Abbassia Fever Hospital-Naval Medical Research Unit No. 3-Cairo, Egypt, from 1976 to 1996. Am J Trop Med Hyg 58 1 (1998) 28-34
7. Hosoglu S., Geyik M.F., Balik I., Aygen B., Erol S., Aygencel T.G., et al. Predictors of outcome in patients with tuberculous meningitis. Int J Tuberc Lung Dis 6 1 (2002) 64-70
8. Farinha N.J., Razali K.A., Holzel H., Morgan G., and Novelli V.M. Tuberculosis of the central nervous system in children: a 20-year survey. J Infect 41 1 (2000) 61-68
9. Kent S.J., Crowe S.M., Yung A., Lucas C.R., and Mijch A.M. Tuberculous meningitis: a 30-year review. Clin Infect Dis 17 6 (1993) 987-994
10. Verdon R., Chevret S., Laissy J.P., and Wolff M. Tuberculous meningitis in adults: review of 48 cases. Clin Infect Dis 22 6 (1996) 982-988
11. Davis L.E., Rastogi K.R., Lambert L.C., and Skipper B.J. Tuberculous meningitis in the southwest United States: a community- based study. Neurology 43 9 (1993) 1775-1778
12. Thwaites G.E., and Tran T.H. Tuberculous meningitis: many questions, too few answers. Lancet Neurol 4 3 (2005) 160-170
13. Curless R.G., and Mitchell C.D. Central nervous system tuberculosis in children. Pediatr Neurol 7 4 (1991) 270-274
14. Yaramis A., Gurkan F., Elevli M., Soker M., Haspolat K., Kirbas G., et al. Central nervous system tuberculosis in children: a review of 214 cases. Pediatrics 102 5 (1998) E49
15. Torok M.E., Chau T.T., Mai P.P., Phong N.D., Dung N.T., Chuong L.V., et al. Clinical and microbiological features of HIV-associated tuberculous meningitis in Vietnamese adults. PLoS ONE 3 3 (2008) e1772
16. Kumar R., Singh S.N., and Kohli N. A diagnostic rule for tuberculous meningitis. Arch Dis Child 81 3 (1999) 221-224
17. Thwaites G.E., Chau T.T., Stepniewska K., Phu N.H., Chuong L.V., Sinh D.X., et al. Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. Lancet 360 9342 (2002) 1287-1292
18. Youssef F.G., Afifi S.A., Azab A.M., Wasfy M.M., Abdel-Aziz K.M., Parker T.M., et al. Differentiation of tuberculous meningitis from acute bacterial meningitis using simple clinical and laboratory parameters. Diagn Microbiol Infect Dis 55 4 (2006) 275-278
19. Torok M.E., Nghia H.D., Chau T.T., Mai N.T., Thwaites G.E., Stepniewska K., et al. Validation of a diagnostic algorithm for adult tuberculous meningitis. Am J Trop Med Hyg 77 3 (2007) 555-559
20. Sunbul M., Atilla A., Esen S., Eroglu C., and Leblebicioglu H. Thwaites' diagnostic scoring and the prediction of tuberculous meningitis. Med Princ Pract 14 3 (2005) 151-154
21. Checkley A.M., Njalale Y., and Scarborough M. Sensitivity and specificity of an index for the diagnosis of TB meningitis in patients in an urban teaching hospital in Malawi. Trop Med Int Health (2008)
22. Nicolls D.J., King M., Holland D., Bala J., and del Rio C. Intracranial tuberculomas developing while on therapy for pulmonary tuberculosis. Lancet Infect Dis 5 12 (2005) 795-801
23. Thwaites G.E., Macmullen-Price J., Tran T.H., Pham P.M., Nguyen T.D., Simmons C.P., et al. Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study. Lancet Neurol 6 3 (2007) 230-236
24. Bayindir C., Mete O., and Bilgic B. Retrospective study of 23 pathologically proven cases of central nervous system tuberculomas. Clin Neurol Neurosurg 108 4 (2006) 353-357
25. Rajeswari R., Sivasubramanian S., Balambal R., Parthasarathy R., Ranjani R., Santha T., et al. A controlled clinical trial of short-course chemotherapy for tuberculoma of the brain. Tuber Lung Dis 76 4 (1995) 311-317
26. Kalita J., Ranjan P., Misra U.K., and Das B.K. Hemichorea: a rare presentation of tuberculoma. J Neurol Sci 208 1-2 (2003) 109-111
27. Deogaonkar M., De R., Sil K., and Das S. Pituitary tuberculosis presenting as pituitary apoplexy. Int J Infect Dis 10 4 (2006) 338-339
28. Husain N., Husain M., and Rao P. Pituitary tuberculosis mimicking idiopathic granulomatous hypophysitis. Pituitary (2007)
29. Martinez-Vazquez C., Bordon J., Rodriguez-Gonzalez A., de la Fuente-Aguado J., Sopena B., Gallego-Rivera A., et al. Cerebral tuberculoma - a comparative study in patients with and without HIV infection. Infection 23 3 (1995) 149-153
30. du Plessis J., Andronikou S., Theron S., Wieselthaler N., and Hayes M. Unusual forms of spinal tuberculosis. Childs Nerv Syst 24 4 (2008) 453-457
31. Hristea A., Constantinescu R.V., Exergian F., Arama V., Besleaga M., and Tanasescu R. Paraplegia due to non-osseous spinal tuberculosis: report of three cases and review of the literature. Int J Infect Dis (2008)
32. Dastur H.M. Diagnosis and neurosurgical treatment of tuberculous disease of the CNS. Neurosurg Rev 6 3 (1983) 111-117
33. Moghtaderi A., and Alavi Naini R. Tuberculous radiculomyelitis: review and presentation of five patients. Int J Tuberc Lung Dis 7 12 (2003) 1186-1190
34. Chotmongkol V., Kitkuandee A., and Limpawattana P. Tuberculous radiculomyelitis (arachnoiditis) associated with tuberculous meningitis. Southeast Asian J Trop Med Public Health 36 3 (2005) 722-724
35. Katchanov J., Bohner G., Schultze J., Klingebiel R., and Endres M. Tuberculous meningitis presenting as mesencephalic infarction and syringomyelia. J Neurol Sci 260 1-2 (2007) 286-287
36. Stewart S.M. The bacteriological diagnosis of tuberculous meningitis. Journal of Clinical Pathology 6 (1953) 241-242
37. Kennedy D.H., and Fallon R.J. Tuberculous meningitis. JAMA 241 3 (1979) 264-268
38. Thwaites G.E., Chau T.T., and Farrar J.J. Improving the bacteriological diagnosis of tuberculous meningitis. J Clin Microbiol 42 1 (2004) 378-379
39. Yasuda T., Tomita T., McLone D.G., and Donovan M. Measurement of cerebrospinal fluid output through external ventricular drainage in one hundred infants and children: correlation with cerebrospinal fluid production. Pediatr Neurosurg 36 1 (2002) 22-28
40. Rubin R.C., Henderson E.S., Ommaya A.K., Walker M.D., and Rall D.P. The production of cerebrospinal fluid in man and its modification by acetazolamide. J Neurosurg 25 4 (1966) 430-436
41. Huang T.Y., Chung H.W., Chen M.Y., Giiang L.H., Chin S.C., Lee C.S., et al. Supratentorial cerebrospinal fluid production rate in healthy adults: quantification with two-dimensional cine phase-contrast MR imaging with high temporal and spatial resolution. Radiology 233 2 (2004) 603-608
42. Venkataswamy M.M., Rafi W., Nagarathna S., Ravi V., and Chandramuki A. Comparative evaluation of BACTEC 460TB system and Lowenstein-Jensen medium for the isolation of M. tuberculosis from cerebrospinal fluid samples of tuberculous meningitis patients. Indian J Med Microbiol 25 3 (2007) 236-240
43. Baker C.A., Cartwright C.P., Williams D.N., Nelson S.M., and Peterson P.K. Early detection of central nervous system tuberculosis with the gen-probe nucleic Acid amplification assay: utility in an inner city hospital. Clin Infect Dis 35 3 (2002) 339-342
44. Rajshekhar V., Abraham J., and Chandy M.J. Avoiding empiric therapy for brain masses in Indian patients using CT-guided stereotaxy. Br J Neurosurg 4 5 (1990) 391-396
45. Sumi M.G., Mathai A., Sheela R., Radhakrishnan N.S., Radhakrishnan V.V., Indhulekshmy R., et al. Diagnostic utility of polymerase chain reaction and immunohistochemical techniques for the laboratory diagnosis of intracranial tuberculoma. Clin Neuropathol 20 4 (2001) 176-180
46. Pai M., Flores L.L., Pai N., Hubbard A., Riley L.W., and Colford J.M. Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: a systematic review and meta-analysis. Lancet Infect Dis 3 10 (2003) 633-643
47. Dinnes J., Deeks J., Kunst H., Gibson A., Cummins E., Waugh N., et al. A systematic review of rapid diagnostic tests for the detection of tuberculosis infection. Health Technol Assess 11 3 (2007) 1-196
48. Thwaites G.E., Caws M., Chau T.T., Dung N.T., Campbell J.I., Phu N.H., et al. Comparison of conventional bacteriology with nucleic acid amplification (amplified mycobacterium direct test) for diagnosis of tuberculous meningitis before and after inception of antituberculosis chemotherapy. J Clin Microbiol 42 3 (2004) 996-1002
49. Bhigjee A.I., Padayachee R., Paruk H., Hallwirth-Pillay K.D., Marais S., and Connoly C. Diagnosis of tuberculous meningitis: clinical and laboratory parameters. Int J Infect Dis 11 4 (2007) 348-354
50. Donald P.R., Victor T.C., Jordaan A.M., Schoeman J.F., and van Helden P.D. Polymerase chain reaction in the diagnosis of tuberculous meningitis. Scand J Infect Dis 25 5 (1993) 613-617
51. Takahashi T., and Nakayama T. Novel technique of quantitative nested real-time PCR assay for Mycobacterium tuberculosis DNA. J Clin Microbiol 44 3 (2006) 1029-1039
52. Takahashi T., Tamura M., Asami Y., Kitamura E., Saito K., Suzuki T., et al. Novel "wide range" quantitative nested real-time PCR assay for Mycobacterium tuberculosis DNA -development and methodology. J Clin Microbiol (2008)
53. Joos T.J., Miller W.C., and Murdoch D.M. Tuberculin reactivity in bacille Calmette-Guerin vaccinated populations: a compilation of international data. Int J Tuberc Lung Dis 10 8 (2006) 883-891
54. Kilpatrick M.E., Girgis N.I., Tribble D., and Farid Z. The value of the tuberculin skin test in patients with tuberculous meningitis. J Egypt Public Health Assoc 71 1-2 (1996) 1-8
55. Mahadevan B., Mahadevan S., Serane V.T., and Narasimhan R. Tuberculin reactivity in tuberculous meningitis. Indian J Pediatr 72 3 (2005) 213-215
56. van den Bos F., Terken M., Ypma L., Kimpen J.L., Nel E.D., Schaaf H.S., et al. Tuberculous meningitis and miliary tuberculosis in young children. Trop Med Int Health 9 2 (2004) 309-313
57. Akhila K., Mahadevan S., and Adhisivam B. Qualitative evaluation of tuberculin test responses in childhood tuberculosis. Indian J Pediatr 74 7 (2007) 641-644
58. Donald P.R., Schoeman J.F., Van Zyl L.E., De Villiers J.N., Pretorius M., and Springer P. Intensive short course chemotherapy in the management of tuberculous meningitis. Int J Tuberc Lung Dis 2 9 (1998) 704-711
59. Mann M.D., Macfarlane C.M., Verburg C.J., and Wiggelinkhuizen J. The bromide partition test and CSF adenosine deaminase activity in the diagnosis of tuberculosis meningitis in children. S Afr Med J 62 13 (1982) 431-433
60. Coovadia Y.M., Dawood A., Ellis M.E., Coovadia H.M., and Daniel T.M. Evaluation of adenosine deaminase activity and antibody to Mycobacterium tuberculosis antigen 5 in cerebrospinal fluid and the radioactive bromide partition test for the early diagnosis of tuberculosis meningitis. Arch Dis Child 61 5 (1986) 428-435
61. Lopez-Cortes L.F., Cruz-Ruiz M., Gomez-Mateos J., Jimenez-Hernandez D., Jimenez-Mejias E., Pachon J., et al. Adenosine deaminase activity in the CSF of patients with aseptic meningitis: utility in the diagnosis of tuberculous meningitis or neurobrucellosis. Clin Infect Dis 20 3 (1995) 525-530
62. Mishra O.P., Loiwal V., Ali Z., Nath G., Chandra L., and Das B.K. Cerebrospinal fluid adenosine deaminase activity and C-reactive protein in tuberculous and partially treated bacterial meningitis. Indian Pediatr 32 8 (1995) 886-889
63. Baro M., Acevedo L., and Lagos M.E. Usefulness of adenosine deaminase determination in cerebrospinal fluid for the diagnosis of meningeal tuberculosis: 4 years experience at a public hospital. Rev Med Chil 124 3 (1996) 319-326
64. Mishra O.P., Loiwal V., Ali Z., Nath G., and Chandra L. Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in children. J Trop Pediatr 42 3 (1996) 129-132
65. Gambhir I.S., Mehta M., Singh D.S., and Khanna H.D. Evaluation of CSF-adenosine deaminase activity in tubercular meningitis. J Assoc Physicians India 47 2 (1999) 192-194
66. John M.A., and Coovadia Y.M. Shortfalls in the use of adenosine deaminase in tuberculous meningitis. Trop Doct 31 3 (2001) 138-139
67. Schutte C.M., Ungerer J.P., du Plessis H., and van der Meyden C.H. Significance of cerebrospinal fluid adenosine deaminase isoenzymes in tuberculous (TB) meningitis. J Clin Lab Anal 15 5 (2001) 236-238
68. Corral I., Quereda C., Navas E., Martin-Davila P., Perez-Elias M.J., Casado J.L., et al. Adenosine deaminase activity in cerebrospinal fluid of HIV-infected patients: limited value for diagnosis of tuberculous meningitis. Eur J Clin Microbiol Infect Dis 23 6 (2004) 471-476
69. Kashyap R.S., Kainthla R.P., Mudaliar A.V., Purohit H.J., Taori G.M., and Daginawala H.F. Cerebrospinal fluid adenosine deaminase activity: a complimentary tool in the early diagnosis of tuberculous meningitis. Cerebrospinal Fluid Res 3 (2006) 5
70. Kashyap R.S., Ramteke S.P., Deshpande P.S., Purohit H.J., Taori G.M., and Daginawala H.F. Comparison of an adenosine deaminase assay with ELISA for the diagnosis of tuberculous meningitis infection. Med Sci Monit 13 9 (2007) BR200-BR204
71. Gautam N., Aryal M., Bhatta N., Bhattacharya S.K., Baral N., and Lamsal M. Comparative study of cerebrospinal fluid adenosine deaminase activity in patients with meningitis. Nepal Med Coll J 9 2 (2007) 104-106
72. Ferrara G., Losi M., D'Amico R., Roversi P., Piro R., Meacci M., et al. Use in routine clinical practice of two commercial blood tests for diagnosis of infection with Mycobacterium tuberculosis: a prospective study. Lancet 367 9519 (2006) 1328-1334
73. Dosanjh D.P., Hinks T.S., Innes J.A., Deeks J.J., Pasvol G., Hackforth S., et al. Improved diagnostic evaluation of suspected tuberculosis. Ann Intern Med 148 5 (2008) 325-336
74. Jafari C., Ernst M., Kalsdorf B., Greinert U., Diel R., Kirsten D., et al. Rapid diagnosis of smear-negative tuberculosis by bronchoalveolar lavage enzyme-linked immunospot. Am J Respir Crit Care Med 174 9 (2006) 1048-1054
75. Kosters K., Nau R., Bossink A., Greiffendorf I., Jentsch M., Ernst M., et al. Rapid Diagnosis of CNS tuberculosis by a t-cell interferon-gamma release assay on cerebrospinal fluid mononuclear cells. Infection (2008)
76. Murakami S., Takeno M., Oka H., Ueda A., Kurokawa T., Kuroiwa Y., et al. Diagnosis of tuberculous meningitis due to ESAT-6-specific IFN-gamma production detected by enzyme-linked immunospot assay in cerebrospinal fluid. Clin Vaccine Immunol (2008)
77. Simmons C.P., Thwaites G.E., Quyen N.T., Chau T.T., Mai P.P., Dung N.T., et al. The clinical benefit of adjunctive dexamethasone in tuberculous meningitis is not associated with measurable attenuation of peripheral or local immune responses. J Immunol 175 1 (2005) 579-590
78. Simmons C.P., Thwaites G.E., Quyen N.T., Torok E., Hoang D.M., Chau T.T., et al. Pretreatment intracerebral and peripheral blood immune responses in Vietnamese adults with tuberculous meningitis: diagnostic value and relationship to disease severity and outcome. J Immunol 176 3 (2006) 2007-2014
79. Yaramis A., Bukte Y., Katar S., and Ozbek M.N. Chest computerized tomography scan findings in 74 children with tuberculous meningitis in southeastern Turkey. Turk J Pediatr 49 4 (2007) 365-369
80. Ozates M., Kemaloglu S., Gurkan F., Ozkan U., Hosoglu S., and Simsek M.M. CT of the brain in tuberculous meningitis. A review of 289 patients. Acta Radiol 41 1 (2000) 13-17
81. Srikanth S.G., Taly A.B., Nagarajan K., Jayakumar P.N., and Patil S. Clinicoradiological features of tuberculous meningitis in patients over 50 years of age. J Neurol Neurosurg Psychiatry 78 5 (2007) 536-538
82. Koh S.B., Kim B.J., Park M.H., Yu S.W., Park K.W., and Lee D.H. Clinical and laboratory characteristics of cerebral infarction in tuberculous meningitis: a comparative study. J Clin Neurosci 14 11 (2007) 1073-1077
83. Chan K.H., Cheung R.T., Lee R., Mak W., and Ho S.L. Cerebral infarcts complicating tuberculous meningitis. Cerebrovasc Dis 19 6 (2005) 391-395
84. Hsieh F.Y., Chia L.G., and Shen W.C. Locations of cerebral infarctions in tuberculous meningitis. Neuroradiology 34 3 (1992) 197-199
85. Andronikou S., Smith B., Hatherhill M., Douis H., and Wilmshurst J. Definitive neuroradiological diagnostic features of tuberculous meningitis in children. Pediatr Radiol 34 11 (2004) 876-885
86. Abdelmalek R., Kanoun F., Kilani B., Tiouiri H., Zouiten F., Ghoubantini A., et al. Tuberculous meningitis in adults: MRI contribution to the diagnosis in 29 patients. Int J Infect Dis 10 5 (2006) 372-377
87. Oztoprak I., Gumus C., Oztoprak B., and Engin A. Contrast medium-enhanced MRI findings and changes over time in stage I tuberculous meningitis. Clin Radiol 62 12 (2007) 1206-1215
88. Foerster B.R., Thurnher M.M., Malani P.N., Petrou M., Carets-Zumelzu F., and Sundgren P.C. Intracranial infections: clinical and imaging characteristics. Acta Radiol 48 8 (2007) 875-893
89. Sonmez G., Ozturk E., Sildiroglu H.O., Mutlu H., Cuce F., Senol M.G., et al. MRI findings of intracranial tuberculomas. Clin Imaging 32 2 (2008) 88-92
90. Wasay M., Kheleani B.A., Moolani M.K., Zaheer J., Pui M., Hasan S., et al. Brain CT and MRI findings in 100 consecutive patients with intracranial tuberculoma. J Neuroimaging 13 3 (2003) 240-247
91. du Plessis J., Andronikou S., Wieselthaler N., Theron S., George R., and Mapukata A. CT features of tuberculous intracranial abscesses in children. Pediatr Radiol 37 2 (2007) 167-172
92. Garg R.K., Desai P., Kar M., and Kar A.M. Multiple ring enhancing brain lesions on computed tomography: an Indian perspective. J Neurol Sci 266 1-2 (2008) 92-96
93. Kingsley P.B., Shah T.C., and Woldenberg R. Identification of diffuse and focal brain lesions by clinical magnetic resonance spectroscopy. NMR Biomed 19 4 (2006) 435-462
94. Pretell E.J., Martinot Jr. C., Garcia H.H., Alvarado M., Bustos J.A., and Martinot C. Differential diagnosis between cerebral tuberculosis and neurocysticercosis by magnetic resonance spectroscopy. J Comput Assist Tomogr 29 1 (2005) 112-114
95. Moorthy S., and Prabhu N.K. Spectrum of MR imaging findings in spinal tuberculosis. AJR Am J Roentgenol 179 4 (2002) 979-983
96. Narlawar R.S., Shah J.R., Pimple M.K., Patkar D.P., Patankar T., and Castillo M. Isolated tuberculosis of posterior elements of spine: magnetic resonance imaging findings in 33 patients. Spine 27 3 (2002) 275-281
97. Danchaivijitr N., Temram S., Thepmongkhol K., and Chiewvit P. Diagnostic accuracy of MR imaging in tuberculous spondylitis. J Med Assoc Thai 90 8 (2007) 1581-1589
98. Jung N.Y., Jee W.H., Ha K.Y., Park C.K., and Byun J.Y. Discrimination of tuberculous spondylitis from pyogenic spondylitis on MRI. AJR Am J Roentgenol 182 6 (2004) 1405-1410
99. Chang M.C., Wu H.T., Lee C.H., Liu C.L., and Chen T.H. Tuberculous spondylitis and pyogenic spondylitis: comparative magnetic resonance imaging features. Spine 31 7 (2006) 782-788
100. Cordero M., and Sanchez I. Brucellar and tuberculous spondylitis. A comparative study of their clinical features. J Bone Joint Surg Br 73 1 (1991) 100-103
101. Parmar H., Shah J., Patkar D., and Varma R. Intramedullary tuberculomas. MR findings in seven patients. Acta Radiol 41 6 (2000) 572-577
102. Sharma A., Goyal M., Mishra N.K., Gupta V., and Gaikwad S.B. MR imaging of tubercular spinal arachnoiditis. AJR Am J Roentgenol 168 3 (1997) 807-812
103. Wasay M., Arif H., Khealani B., and Ahsan H. Neuroimaging of tuberculous myelitis: analysis of ten cases and review of literature. J Neuroimaging 16 3 (2006) 197-205
104. Ellard G.A., Humphries M.J., and Allen B.W. Cerebrospinal fluid drug concentrations and the treatment of tuberculous meningitis. Am Rev Respir Dis 148 3 (1993) 650-655
105. Kaojarern S., Supmonchai K., Phuapradit P., Mokkhavesa C., and Krittiyanunt S. Effect of steroids on cerebrospinal fluid penetration of antituberculous drugs in tuberculous meningitis. Clin Pharmacol Ther 49 1 (1991) 6-12
106. Mitchison D.A. Role of individual drugs in the chemotherapy of tuberculosis. Int J Tuberc Lung Dis 4 9 (2000) 796-806
107. Thwaites G.E., Lan N.T., Dung N.H., Quy H.T., Oanh D.T., Thoa N.T., et al. Effect of antituberculosis drug resistance on response to treatment and outcome in adults with tuberculous meningitis. J Infect Dis 192 1 (2005) 79-88
108. Ellard G.A., Humphries M.J., Gabriel M., and Teoh R. Penetration of pyrazinamide into the cerebrospinal fluid in tuberculous meningitis. Br Med J (Clin Res Ed) 294 6567 (1987) 284-285
109. Donald P.R., and Seifart H. Cerebrospinal fluid pyrazinamide concentrations in children with tuberculous meningitis. Pediatr Infect Dis J 7 7 (1988) 469-471
110. Humphries M. The management of tuberculous meningitis. Thorax 47 8 (1992) 577-581
111. Thwaites G.E., Nguyen D.B., Nguyen H.D., Hoang T.Q., Do T.T., Nguyen T.C., et al. Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med 351 17 (2004) 1741-1751
112. Bobrowitz I.D. Ethambutol in tuberculous meningitis. Chest 61 7 (1972) 629-632
113. Gundert-Remy U., Klett M., and Weber E. Concentration of ethambutol in cerebrospinal fluid in man as a function of the non-protein-bound drug fraction in serum. Eur J Clin Pharmacol 6 2 (1973) 133-136
114. WHO. Anti-tuberculosis drug resistance in the World. Fourth Global Report (2008), World Health Organization, Geneva
115. Donald P.R., Maher D., Maritz J.S., and Qazi S. Ethambutol dosage for the treatment of children: literature review and recommendations. Int J Tuberc Lung Dis 10 12 (2006) 1318-1330
116. Donald P.R., and Seifart H.I. Cerebrospinal fluid concentrations of ethionamide in children with tuberculous meningitis. J Pediatr 115 3 (1989) 483-486
117. Barsic B., Himbele J., Beus I., Schonwald S., Marton E., and Lisic M. Entry of ciprofloxacin into cerebrospinal fluid during bacterial, viral and tuberculous meningitis. Neurol Croat 40 2 (1991) 111-116
118. Berning S.E., Cherry T.A., and Iseman M.D. Novel treatment of meningitis caused by multidrug-resistant Mycobacterium tuberculosis with intrathecal levofloxacin and amikacin: case report. Clin Infect Dis 32 4 (2001) 643-646
119. Alffenaar J.W., de Vries P.M., Luijckx G.J., van Soolingen D., van der Werf T.S., and van Altena R. Plasma and CSF pharmacokinetics of moxifloxacin in a patient with tuberculous meningitis. Antimicrobial Agents Chemother (2008)
120. Mehlhorn A.J., and Brown D.A. Safety concerns with fluoroquinolones. Ann Pharmacother 41 11 (2007) 1859-1866
121. Diacon A.H., Patientia R.F., Venter A., van Helden P.D., Smith P.J., McIlleron H., et al. Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears. Antimicrobial Agents Chemother 51 8 (2007) 2994-2996
122. van Loenhout-Rooyackers J.H., Keyser A., Laheij R.J., Verbeek A.L., and van der Meer J.W. Tuberculous meningitis: is a 6-month treatment regimen sufficient?. Int J Tuberc Lung Dis 5 11 (2001) 1028-1035
123. Treatment of tuberculosis. MMWR Recomm Rep 52 RR-11 (2003) 1-77
124. The National Collaborating Centre for Chronic Conditions. Tuberculosis: clinical diagnosis and management of tuberculosis, and measures for its prevention and control (2006), Royal College of Physicians, London
125. Prasad K., and Singh M.B. Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev 1 (2008) CD002244
126. Afghani B., and Leiberman J.M. Paradoxical enlargement or development of intracranial tuberculomas during therapy: case report and review. Clin Infect Dis 19 (1994) 1092-1099
127. Roca B. Intradural extramedullary tuberculoma of the spinal cord: a review of reported cases. J Infect 50 5 (2005) 425-431
128. Roberts M.T., Mendelson M., Meyer P., Carmichael A., and Lever A.M. The use of thalidomide in the treatment of intracranial tuberculomas in adults: two case reports. J Infect 47 3 (2003) 251-255
129. Schoeman J.F., Ravenscroft A., and Hartzenberg H.B. Possible role of adjunctive thalidomide therapy in the resolution of a massive intracranial tuberculous abscess. Childs Nerv Syst 17 6 (2001) 370-372
130. Schoeman J.F., Fieggen G., Seller N., Mendelson M., and Hartzenberg B. Intractable intracranial tuberculous infection responsive to thalidomide: report of four cases. J Child Neurol 21 4 (2006) 301-308
131. Schoeman J.F., Springer P., van Rensburg A.J., Swanevelder S., Hanekom W.A., Haslett P.A., et al. Adjunctive thalidomide therapy for childhood tuberculous meningitis: results of a randomized study. J Child Neurol 19 4 (2004) 250-257
132. Schoeman J., Donald P., van Zyl L., Keet M., and Wait J. Tuberculous hydrocephalus: comparison of different treatments with regard to ICP, ventricular size and clinical outcome. Dev Med Child Neurol 33 5 (1991) 396-405
133. Mathew J.M., Rajshekhar V., and Chandy M.J. Shunt surgery in poor grade patients with tuberculous meningitis and hydrocephalus: effects of response to external ventricular drainage and other variables on long term outcome. J Neurol Neurosurg Psychiatry 65 1 (1998) 115-118
134. Kemaloglu S., Ozkan U., Bukte Y., Ceviz A., and Ozates M. Timing of shunt surgery in childhood tuberculous meningitis with hydrocephalus. Pediatr Neurosurg 37 4 (2002) 194-198
135. Yadav Y.R., Pande S., Raina V.K., and Singh M. Lumboperitoneal shunts: review of 409 cases. Neurol India 52 2 (2004) 188-190
136. Lamprecht D., Schoeman J., Donald P., and Hartzenberg H. Ventriculoperitoneal shunting in childhood tuberculous meningitis. Br J Neurosurg 15 2 (2001) 119-125
137. Agrawal D., Gupta A., and Mehta V.S. Role of shunt surgery in pediatric tubercular meningitis with hydrocephalus. Indian Pediatr 42 3 (2005) 245-250
138. Figaji A.A., Fieggen A.G., and Peter J.C. Endoscopy for tuberculous hydrocephalus. Childs Nerv Syst 23 1 (2007) 79-84
139. Jha D., Khatri P., Choudhary A., Sethi R., and Kumar S. Endoscopic third ventriculostomy in prepontine-suprasellar tuberculoma with tuberculous meningitis hydrocephalus: a case report. Pediatr Neurosurg 43 1 (2007) 42-46
140. Jha D.K., Mishra V., Choudhary A., Khatri P., Tiwari R., Sural A., et al. Factors affecting the outcome of neuroendoscopy in patients with tuberculous meningitis hydrocephalus: a preliminary study. Surg Neurol 68 1 (2007) 35-41 discussion 41-2
141. Tyson G., Newman P., and Strachan W.E. Tuberculous brain abscess. Surg Neurol 10 5 (1978) 323-325
142. Vidal J.E., Penalva de Oliveira A.C., Bonasser Filho F., Schiavon Nogueira R., Dauar R.F., Leite A.G., et al. Tuberculous brain abscess in AIDS patients: report of three cases and literature review. Int J Infect Dis 9 4 (2005) 201-207
143. Mohanty A., Venkatarama S.K., Vasudev M.K., Khanna N., and Anandh B. Role of stereotactic aspiration in the management of tuberculous brain abscess. Surg Neurol 51 4 (1999) 443-446 discussion 446-7
144. Kumar R., Pandey C.K., Bose N., and Sahay S. Tuberculous brain abscess: clinical presentation, pathophysiology and treatment (in children). Childs Nerv Syst 18 3-4 (2002) 118-123
145. Jutte P.C., and Van Loenhout-Rooyackers J.H. Routine surgery in addition to chemotherapy for treating spinal tuberculosis. Cochrane Database Syst Rev 1 (2006) CD004532
146. Jain A.K., and Dhammi I.K. Tuberculosis of the spine: a review. Clin Orthop Relat Res 460 (2007) 39-49
147. Turgut M. Spinal tuberculosis (Pott's disease): its clinical presentation, surgical management, and outcome. A survey study on 694 patients. Neurosurg Rev 24 1 (2001) 8-13
148. Muthukumar N., Venkatesh G., Senthilbabu S., and Rajbaskar R. Surgery for intramedullary tuberculoma of the spinal cord: report of 2 cases. Surg Neurol 66 1 (2006) 69-74 discussion 74
149. Sharma M.C., Arora R., Deol P.S., Mahapatra A.K., Sinha A.K., and Sarkar C. Intramedullary tuberculoma of the spinal cord: a series of 10 cases. Clin Neurol Neurosurg 104 4 (2002) 279-284
150. Moreira J., Alarcon F., Bisoffi Z., Rivera J., Salinas R., Menten J., et al. Tuberculous meningitis: does lowering the treatment threshold result in many more treated patients?. Trop Med Int Health 13 1 (2008) 68-75
151. Poonnoose S.I., and Rajshekhar V. Rate of resolution of histologically verified intracranial tuberculomas. Neurosurgery 53 4 (2003) 873-878 discussion 878-9
152. Katrak S.M., Shembalkar P.K., Bijwe S.R., and Bhandarkar L.D. The clinical, radiological and pathological profile of tuberculous meningitis in patients with and without human immunodeficiency virus infection. J Neurol Sci 181 1-2 (2000) 118-126
153. Thwaites G.E., Duc Bang N., Huy Dung N., Thi Quy H., Thi Tuong Oanh D., Thi Cam Thoa N., et al. The influence of HIV infection on clinical presentation, response to treatment, and outcome in adults with Tuberculous meningitis. J Infect Dis 192 12 (2005) 2134-2141
154. Schutte C.M. Clinical, cerebrospinal fluid and pathological findings and outcomes in HIV-positive and HIV-negative patients with tuberculous meningitis. Infection 29 4 (2001) 213-217
155. Skiest D.J. Focal neurological disease in patients with acquired immunodeficiency syndrome. Clin Infect Dis 34 1 (2002) 103-115
156. Offiah C.E., and Turnbull I.W. The imaging appearances of intracranial CNS infections in adult HIV and AIDS patients. Clin Radiol 61 5 (2006) 393-401
157. Smego Jr. R.A., Orlovic D., and Wadula J. An algorithmic approach to intracranial mass lesions in HIV/AIDS. Int J STD AIDS 17 4 (2006) 271-276
158. Antinori A., Ammassari A., De Luca A., Cingolani A., Murri R., Scoppettuolo G., et al. Diagnosis of AIDS-related focal brain lesions: a decision-making analysis based on clinical and neuroradiologic characteristics combined with polymerase chain reaction assays in CSF. Neurology 48 3 (1997) 687-694
159. Menendez J.A., Lilien D.L., Nanda A., and Polin R.S. Use of fluorodeoxyglucose-positron emission tomography for the differentiation of cerebral lesions in patients with acquired immune deficiency syndrome. Neurosurg Focus 8 2 (2000) e2
160. Dean G.L., Edwards S.G., Ives N.J., Matthews G., Fox E.F., Navaratne L., et al. Treatment of tuberculosis in HIV-infected persons in the era of highly active antiretroviral therapy. AIDS 16 1 (2002) 75-83
161. Lawn S.D., Myer L., Bekker L.G., and Wood R. Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa. AIDS 21 3 (2007) 335-341
162. Schiffer J.T., and Sterling T.R. Timing of antiretroviral therapy initiation in tuberculosis patients with AIDS: a decision analysis. J Acquir Immune Defic Syndr 44 2 (2007) 229-234
163. Lawn S.D., Bekker L.G., and Miller R.F. Immune reconstitution disease
164. Shelburne S.A., Visnegarwala F., Darcourt J., Graviss E.A., Giordano T.P., White Jr. A.C., et al. Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy. AIDS 19 4 (2005) 399-406
165. Crump J.A., Tyrer M.J., Lloyd-Owen S.J., Han L.Y., Lipman M.C., and Johnson M.A. Military tuberculosis with paradoxical expansion of intracranial tuberculomas complicating human immunodeficiency virus infection in a patient receiving highly active antiretroviral therapy. Clin Infect Dis 26 4 (1998) 1008-1009
166. Dautremer J., Pacanowski J., Girard P.M., Lalande V., Sivignon F., and Meynard J.L. A new presentation of immune reconstitution inflammatory syndrome followed by a severe paradoxical reaction in an HIV-1-infected patient with tuberculous meningitis. AIDS 21 3 (2007) 381-382
167. Kwara A., Carter E.J., Rich J.D., and Flanigan T.P. Development of opportunistic infections after diagnosis of active tuberculosis in HIV-infected patients. AIDS Patient Care STDS 18 6 (2004) 341-347
168. McIlleron H., Meintjes G., Burman W.J., and Maartens G. Complications of antiretroviral therapy in patients with tuberculosis: drug interactions, toxicity, and immune reconstitution inflammatory syndrome. J Infect Dis 196 Suppl. 1 (2007) S63-S75
169. Meintjes G., Lawn S.D., Scano F., Maartens G., French M.A., Worodria W., et al. Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infect Dis 8 8 (2008) 516-523
170. Dhasmana D.J., Dheda K., Ravn P., Wilkinson R.J., and Meintjes G. Immune reconstitution inflammatory syndrome in HIV-infected patients receiving antiretroviral therapy: pathogenesis, clinical manifestations and management. Drugs 68 2 (2008) 191-208
171. Byrd T.F., and Davis L.E. Multidrug-resistant tuberculous meningitis. Curr Neurol Neurosci Rep 7 6 (2007) 470-475
172. Cynamon M.H., Zhang Y., Harpster T., Cheng S., and DeStefano M.S. High-dose isoniazid therapy for isoniazid-resistant murine Mycobacterium tuberculosis infection. Antimicrobial Agents Chemother 43 12 (1999) 2922-2924
173. Abate G., Hoffner S.E., Thomsen V.O., and Miorner H. Characterization of isoniazid-resistant strains of Mycobacterium tuberculosis on the basis of phenotypic properties and mutations in katG. Eur J Clin Microbiol Infect Dis 20 5 (2001) 329-333
174. Patel V.B., Padayatchi N., Bhigjee A.I., Allen J., Bhagwan B., Moodley A.A., et al. Multidrug-resistant tuberculous meningitis in KwaZulu-Natal, South Africa. Clin Infect Dis 38 6 (2004) 851-856
175. Daikos G.L., Cleary T., Rodriguez A., and Fischl M.A. Multidrug-resistant tuberculous meningitis in patients with AIDS. Int J Tuberc Lung Dis 7 4 (2003) 394-398
176. Organisation WH. Guidelines for the pragmatic management of drug-resistant tuberculosis, 2006.
177. Holdiness M.R. Cerebrospinal fluid pharmacokinetics of the antituberculosis drugs. Clin Pharmacokinet 10 6 (1985) 532-534
178. Berning S.E. The role of fluoroquinolones in tuberculosis today. Drugs 61 1 (2001) 9-18
179. Cotton M.F., Donald P.R., Schoeman J.F., Van Zyl L.E., Aalbers C., and Lombard C.J. Raised intracranial pressure, the syndrome of inappropriate antidiuretic hormone secretion, and arginine vasopressin in tuberculous meningitis. Childs Nerv Syst 9 1 (1993) 10-15 discussion 15-6
180. Narotam P.K., Kemp M., Buck R., Gouws E., van Dellen J.R., and Bhoola K.D. Hyponatremic natriuretic syndrome in tuberculous meningitis: the probable role of atrial natriuretic peptide. Neurosurgery 34 6 (1994) 982-988 discussion 988
181. Dass R., Nagaraj R., Murlidharan J., and Singhi S. Hyponatraemia and hypovolemic shock with tuberculous meningitis. Indian J Pediatr 70 12 (2003) 995-997
182. Celik U.S., Alabaz D., Yildizdas D., Alhan E., Kocabas E., and Ulutan S. Cerebral salt wasting in tuberculous meningitis: treatment with fludrocortisone. Ann Trop Paediatr 25 4 (2005) 297-302
183. Smith J., and Godwin-Austen R. Hypersecretion of anti-diuretic hormone due to tuberculous meningitis. Postgrad Med J 56 651 (1980) 41-44
184. Chambers S.T., Hendrickse W.A., Record C., Rudge P., and Smith H. Paradoxical expansion of intracranial tuberculomas during chemotherapy. Lancet 2 8396 (1984) 181-184
185. Coulter J.B., Baretto R.L., Mallucci C.L., Romano M.I., Abernethy L.J., Isherwood D.M., et al. Tuberculous meningitis: protracted course and clinical response to interferon-gamma. Lancet Infect Dis 7 3 (2007) 225-232
186. Blackmore T.K., Manning L., Taylor W.J., and Wallis R.S. Therapeutic use of infliximab in tuberculosis to control severe paradoxical reaction of the brain and lymph nodes. Clin Infect Dis 47 10 (2008) e83-e85
187. Yew W.W., and Leung C.C. Antituberculosis drugs and hepatotoxicity. Respirology 11 6 (2006) 699-707
188. Tostmann A., Boeree M.J., Aarnoutse R.E., de Lange W.C., van der Ven A.J., and Dekhuijzen R. Antituberculosis drug-induced hepatotoxicity: concise up-to-date review. J Gastroenterol Hepatol 23 2 (2008) 192-202
189. Frontera Izquierdo P., Unceta Aguirre L., Tomas Vila M., Calvo Rigual F., and Perez Tamarit D. Hepatotoxicity of rifampicin and isoniazid in the treatment of tuberculous meningitis (author's transl). An Esp Pediatr 15 6 (1981) 549-552
190. British Thoracic Society. Chemotherapy and management of tuberculosis in the United Kingdom: recommendations 1998. Joint Tuberculosis Committee of the British Thoracic Society. Thorax 53 7 (1998) 536-548
191. Thompson N.P., Caplin M.E., Hamilton M.I., Gillespie S.H., Clarke S.W., Burroughs A.K., et al. Anti-tuberculosis medication and the liver: dangers and recommendations in management. Eur Respir J 8 8 (1995) 1384-1388
192. Tahaoglu K., Atac G., Sevim T., Tarun T., Yazicioglu O., Horzum G., et al. The management of anti-tuberculosis drug-induced hepatotoxicity. Int J Tuberc Lung Dis 5 1 (2001) 65-69
193. Girgis N.I., Farid Z., Kilpatrick M.E., Sultan Y., and Mikhail I.A. Dexamethasone adjunctive treatment for tuberculous meningitis. Pediatr Infect Dis J 10 3 (1991) 179-183
194. Schoeman J.F., Van Zyl L.E., Laubscher J.A., and Donald P.R. Effect of corticosteroids on intracranial pressure, computed tomographic findings, and clinical outcome in young children with tuberculous meningitis. Pediatrics 99 2 (1997) 226-231