Five-year follow-up after transepicardial implantation of autologous bone marrow mononuclear cells to ungraftable coronary territories for patients with ischaemic cardiomyopathy

European Journal of Cardio-thoracic Surgery

Volumn 36, Issue 4, 2009, Pages 633-643

  Akar, Ahmet Ruchan ^a   Durdu, Serkan ^a   Arat, Mutlu ^a   Kilickap, Mustafa ^a   Kucuk, Nuriye Ozlem ^a   Arslan, Onder ^a   Kuzu, Isinsu ^a   Ozyurda, Umit ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Angiogenesis; Heart failure; Ischaemia; Left ventricular function; Stem cells; Survival

Indexed keywords

ADULT; AGED; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; CARDIOMYOPATHY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY BYPASS GRAFT; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; ISCHEMIC CARDIOMYOPATHY; MALE; MONONUCLEAR CELL; OVERALL SURVIVAL; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; SCORING SYSTEM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TREATMENT OUTCOME;

ADULT; AGED; BONE MARROW TRANSPLANTATION; CORONARY ARTERY BYPASS; CORONARY CIRCULATION; ELECTROCARDIOGRAPHY, AMBULATORY; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; STROKE VOLUME; TREATMENT OUTCOME;

EID: 69849097502     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2009.04.045     Document Type: Article

References (25)

1. Akar A.R., Durdu S., Corapcioglu T., and Ozyurda U. Regenerative medicine for cardiovascular disorders-new milestones: adult stem cells. Artif Organs 30 (2006) 213-232
2. Orlic D., Kajstura J., Chimenti S., Jakoniuk I., Anderson S.M., Li B.S., Pickel J., Mckay R., Nadal-Ginard B., Bodine D.M., Leri A., and Anversa P. Bone marrow cells regenerate infarcted myocardium. Nature 410 (2001) 701-705
3. Kocher A.A., Schuster M.D., Szabolcs M.J., Takuma S., Burkhoff D., Wang J., Homma S., Edwards N.M., and Itescu S. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 7 (2001) 430-436
4. Beltrami A.P., Barlucchi L., Torella D., Baker M., Limana F., Chimenti S., Kasahara H., Rota M., Musso E., Urbanek K., Leri A., Kajstura J., Nadal-Ginard B., and Anversa P. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114 (2003) 763-776
5. Murry C.E., Soonpaa M.H., Reinecke H., Nakajima H., Nakajima H.O., Rubart M., Pasumarthi K.B., Virag J.I., Bartelmez S.H., Poppa V., Bradford G., Dowell J.D., Williams D.A., and Field L.J. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 428 (2004) 664-668
6. Siminiak T., Fiszer D., Jerzykowska O., Grygielska B., Rozwadowska N., Kalmucki P., and Kurpisz M. Percutaneous trans-coronary-venous transplantation of autologous skeletal myoblasts in the treatment of post-infarction myocardial contractility impairment: the POZNAN trial. Eur Heart J 26 (2005) 1188-1195
7. Menasche P., Alfieri O., Janssens S., McKenna W., Reichenspurner H., Trinquart L., Vilquin J.T., Marolleau J.P., Seymour B., Larghero J., Lake S., Chatellier G., Solomon S., Desnos M., and Hagege A.A. The myoblast autologous grafting in ischemic cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circulation 117 (2008) 1189-1200
8. Strauer B.E., Brehm M., Zeus T., Kostering M., Hernandez A., Sorg R.V., Kogler G., and Wernet P. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106 (2002) 1913-1918
9. Assmus B., Schachinger V., Teupe C., Britten M., Lehmann R., Dobert N., Grunwald F., Aicher A., Urbich C., Martin H., Hoelzer D., Dimmeler S., and Zeiher A.M. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation 106 (2002) 3009-3017
10. Tse H.F., Kwong Y.L., Chan J.K., Lo G., Ho C.L., and Lau C.P. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet 361 (2003) 47-49
11. Perin E.C., Dohmann H.F., Borojevic R., Silva S.A., Sousa A.L., Silva G.V., Mesquita C.T., Belem L., Vaughn W.K., Rangel F.O., Assad J.A., Carvalho A.C., Branco R.V., Rossi M.I., Dohmann H.J., and Willerson J.T. Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy. Circulation 110 (2004) II213-II218
12. Wollert K.C., Meyer G.P., Lotz J., Ringes-Lichtenberg S., Lippolt P., Breidenbach C., Fichtner S., Korte T., Hornig B., Messinger D., Arseniev L., Hertenstein B., Ganser A., and Drexler H. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 364 (2004) 141-148
13. Lunde K., Solheim S., Aakhus S., Arnesen H., Abdelnoor M., Egeland T., Endresen K., Ilebekk A., Mangschau A., Fjeld J.G., Smith H.J., Taraldsrud E., Grogaard H.K., Bjornerheim R., Brekke M., Muller C., Hopp E., Ragnarsson A., Brinchmann J.E., and Forfang K. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 355 (2006) 1199-1209
14. Schachinger V., Erbs S., Elsasser A., Haberbosch W., Hambrecht R., Holschermann H., Yu J., Corti R., Mathey D.G., Hamm C.W., Suselbeck T., Werner N., Haase J., Neuzner J., Germing A., Mark B., Assmus B., Tonn T., Dimmeler S., and Zeiher A.M. Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial. Eur Heart J 27 (2006) 2775-2783
15. Janssens S., Dubois C., Bogaert J., Theunissen K., Deroose C., Desmet W., Kalantzi M., Herbots L., Sinnaeve P., Dens J., Maertens J., Rademakers F., Dymarkowski S., Gheysens O., Van Cleemput J., Bormans G., Nuyts J., Belmans A., Mortelmans L., Boogaerts M., and Van de W.F. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet 367 (2006) 113-121
16. Kang H.J., Kim H.S., Zhang S.Y., Park K.W., Cho H.J., Koo B.K., Kim Y.J., Soo L.D., Sohn D.W., Han K.S., Oh B.H., Lee M.M., and Park Y.B. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet 363 (2004) 751-756
17. Ozbaran M., Omay S.B., Nalbantgil S., Kultursay H., Kumanlioglu K., Nart D., and Pektok E. Autologous peripheral stem cell transplantation in patients with congestive heart failure due to ischemic heart disease. Eur J Cardiothorac Surg 25 (2004) 342-350
18. Meyer G.P., Wollert K.C., Lotz J., Steffens J., Lippolt P., Fichtner S., Hecker H., Schaefer A., Arseniev L., Hertenstein B., Ganser A., and Drexler H. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation 113 (2006) 1287-1294
19. Ince H., and Nienaber C.A. Future investigations in stem cell activation with granulocyte-colony-stimulating factor after myocardial infarction. Nat Clin Pract Cardiovasc Med 4 Suppl. 1 (2007) S119-S122
20. Cerqueira M.D., Weissman N.J., Dilsizian V., Jacobs A.K., Kaul S., Laskey W.K., Pennell D.J., Rumberger J.A., Ryan T., and Verani M.S. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 105 (2002) 539-542
21. Durdu S., Akar A.R., Arat M., Sancak T., Eren N.T., and Ozyurda U. Autologous bone-marrow mononuclear cell implantation for patients with Rutherford grade II-III thromboangiitis obliterans. J Vasc Surg 44 (2006) 732-739
22. Soydan E., Ayyildiz E., Dalva K., Topcuoglu P., Tol M., Arslan O., Ilhan O., and Arat M. Impact of harvest product volume in erythrocyte depletion of allogeneic or autologous bone marrow using COBE spectra. Transfus Apher Sci 36 (2007) 269-273
23. Kissel C.K., Lehmann R., Assmus B., Aicher A., Honold J., Fischer-Rasokat U., Heeschen C., Spyridopoulos I., Dimmeler S., and Zeiher A.M. Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. J Am Coll Cardiol 49 (2007) 2341-2349
24. Heeschen C., Lehmann R., Honold J., Assmus B., Aicher A., Walter D.H., Martin H., Zeiher A.M., and Dimmeler S. Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation 109 (2004) 1615-1622
25. Hou D., Youssef E.A., Brinton T.J., Zhang P., Rogers P., Price E.T., Yeung A.C., Johnstone B.H., Yock P.G., and March K.L. Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials. Circulation 112 (2005) I150-I156