-
1
-
-
5144222255
-
Complement: A unique innate immune sensor for danger signals
-
Gasque, P. (2004) Complement: a unique innate immune sensor for danger signals. Mol. Immunol. 41, 1089-1098.
-
(2004)
Mol. Immunol.
, vol.41
, pp. 1089-1098
-
-
Gasque, P.1
-
3
-
-
33646404373
-
Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2
-
Selander, B., Martensson, U., Weintraub, A., Holmstrom, E., Matsushita, M., Thiel, S., Jensenius, J. C., Truedsson, L., and Sjoholm, A. G. (2006) Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2. J. Clin. Invest. 116, 1425-1434.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1425-1434
-
-
Selander, B.1
Martensson, U.2
Weintraub, A.3
Holmstrom, E.4
Matsushita, M.5
Thiel, S.6
Jensenius, J.C.7
Truedsson, L.8
Sjoholm, A.G.9
-
4
-
-
34548849117
-
The role of complement in inflammatory diseases from behind the scenes into the spotlight
-
Markiewski, M. M., and Lambris, J. D. (2007) The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am. J. Pathol. 171, 715-727.
-
(2007)
Am. J. Pathol.
, vol.171
, pp. 715-727
-
-
Markiewski, M.M.1
Lambris, J.D.2
-
5
-
-
0020047810
-
The activation of the alternative pathway C3 convertase by human plasma kallikrein
-
DiScipio, R. G. (1982) The activation of the alternative pathway C3 convertase by human plasma kallikrein. Immunology 45, 587-595. (Pubitemid 12165625)
-
(1982)
Immunology
, vol.45
, Issue.3
, pp. 587-595
-
-
Discipio, R.G.1
-
6
-
-
0023887276
-
Binding and activation of C4 and C3 on the red cell surface by non-complement enzymes
-
Kirschfink, M., and Borsos, T. (1988) Binding and activation of C4 and C3 on the red cell surface by non-complement enzymes. Mol. Immunol. 25, 505-512.
-
(1988)
Mol. Immunol.
, vol.25
, pp. 505-512
-
-
Kirschfink, M.1
Borsos, T.2
-
7
-
-
0034628448
-
Protease inhibitors: Current status and future prospects
-
Leung, D., Abbenante, G., and Fairlie, D. P. (2000) Protease inhibitors: current status and future prospects. J. Med. Chem. 43, 305-341.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 305-341
-
-
Leung, D.1
Abbenante, G.2
Fairlie, D.P.3
-
8
-
-
33845339435
-
Protease inhibitors in the clinic
-
Abbenante, G., and Fairlie, D. P. (2005) Protease inhibitors in the clinic. Med. Chem. 1, 71-104.
-
(2005)
Med. Chem.
, vol.1
, pp. 71-104
-
-
Abbenante, G.1
Fairlie, D.P.2
-
9
-
-
0034691542
-
C3 activation is inhibited by analogs of compstatin but not by serine protease inhibitors or peptidyl alpha-ketoheterocycles
-
DOI 10.1016/S0162-3109(00)00205-8, PII S0162310900002058
-
Furlong, S. T., Dutta, A. S., Coath, M. M., Gormley, J. J., Hubbs, S. J., Lloyd, D., Mauger, R. C., Strimpler, A. M., Sylvester, M. A., Scott, C. W., and Edwards, P. D. (2000) C3 activation is inhibited by analogs of compstatin but not by serine protease inhibitors or peptidyl alpha-ketoheterocycles. Immunopharmacology 48, 199-212. (Pubitemid 30608676)
-
(2000)
Immunopharmacology
, vol.48
, Issue.2
, pp. 199-212
-
-
Furlong, S.T.1
Dutta, A.S.2
Coath, M.M.3
Gormley, J.J.4
Hubbs, S.J.5
Lloyd, D.6
Mauger, R.C.7
Strimpler, A.M.8
Sylvester, M.A.9
Scott, C.W.10
Edwards, P.D.11
-
10
-
-
0018603223
-
Limited proteolysis of complement components C2 and factor B. Structural analogy and limited sequence homology
-
Kerr, M. A. (1979) Limited proteolysis of complement components C2 and factor B. Structural analogy and limited sequence homology. Biochem. J. 183, 615-622.
-
(1979)
Biochem. J.
, vol.183
, pp. 615-622
-
-
Kerr, M.A.1
-
11
-
-
0021319287
-
Isolation of cDNA clones for human complement component C2
-
Bentley, D. R., and Porter, R. R. (1984) Isolation of cDNA clones for human complement component C2. Proc. Natl. Acad. Sci. U.S.A. 81, 1212-1215.
-
(1984)
Proc. Natl. Acad. Sci. U.S.A.
, vol.81
, pp. 1212-1215
-
-
Bentley, D.R.1
Porter, R.R.2
-
12
-
-
0022467696
-
Primary structure of human complement component C2. Homology to two unrelated protein families
-
Bentley, D. R. (1986) Primary structure of human complement component C2. Homology to two unrelated protein families. Biochem. J. 239, 339-345.
-
(1986)
Biochem. J.
, vol.239
, pp. 339-345
-
-
Bentley, D.R.1
-
13
-
-
0032476058
-
A conserved element in the serine protease domain of complement factor B
-
Hourcade, D. E., Mitchell, L. M., and Oglesby, T. J. (1998) A conserved element in the serine protease domain of complement factor B. J. Biol. Chem. 273, 25996-26000.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 25996-26000
-
-
Hourcade, D.E.1
Mitchell, L.M.2
Oglesby, T.J.3
-
14
-
-
0141643292
-
Formation of high affinity C5 convertase of the classical pathway of complement
-
Rawal, N., and Pangburn, M. K. (2003) Formation of high affinity C5 convertase of the classical pathway of complement. J. Biol. Chem. 278, 38476-38483.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 38476-38483
-
-
Rawal, N.1
Pangburn, M.K.2
-
15
-
-
0019144945
-
The human complement system: Assembly of the classical pathway C3 convertase
-
Kerr, M. A. (1980) The human complement system: assembly of the classical pathway C3 convertase. Biochem. J. 189, 173-181.
-
(1980)
Biochem. J.
, vol.189
, pp. 173-181
-
-
Kerr, M.A.1
-
16
-
-
0023245340
-
Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates
-
Kam, C. M., McRae, B. J., Harper, J. W., Niemann, M. A., Volanakis, J. E., and Powers, J. C. (1987) Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates. J. Biol. Chem. 262, 3444-3451.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 3444-3451
-
-
Kam, C.M.1
McRae, B.J.2
Harper, J.W.3
Niemann, M.A.4
Volanakis, J.E.5
Powers, J.C.6
-
17
-
-
0016817486
-
Enzymatic activity of the second component of complement
-
Cooper, N. R. (1975) Enzymatic activity of the second component of complement. Biochemistry 14, 4245-4251.
-
(1975)
Biochemistry
, vol.14
, pp. 4245-4251
-
-
Cooper, N.R.1
-
18
-
-
0019522629
-
A fluorescent assay for complement activation
-
Caporale, L. H., Gaber, S. S., Kell, W., and Gotze, O. (1981) A fluorescent assay for complement activation. J. Immunol. 126, 1963-1965.
-
(1981)
J. Immunol.
, vol.126
, pp. 1963-1965
-
-
Caporale, L.H.1
Gaber, S.S.2
Kell, W.3
Gotze, O.4
-
19
-
-
33645419787
-
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
-
Gold, B., Merriam, J. E., Zernant, J., Hancox, L. S., Taiber, A. J., Gehrs, K., Cramer, K., Neel, J., Bergeron, J., Barile, G. R., Smith, R. T., Hageman, G. S., Dean, M., and Allikmets, R. (2006) Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat. Genet. 38, 458-462.
-
(2006)
Nat. Genet.
, vol.38
, pp. 458-462
-
-
Gold, B.1
Merriam, J.E.2
Zernant, J.3
Hancox, L.S.4
Taiber, A.J.5
Gehrs, K.6
Cramer, K.7
Neel, J.8
Bergeron, J.9
Barile, G.R.10
Smith, R.T.11
Hageman, G.S.12
Dean, M.13
Allikmets, R.14
-
20
-
-
12344319511
-
Hereditary C2 deficiency in Sweden: Frequent occurrence of invasive infection, atherosclerosis, and rheumatic disease
-
DOI 10.1097/01.md.0000152371.22747.1e
-
Jonsson, G., Truedsson, L., Sturfelt, G., Oxelius, V. A., Braconier, J. H., and Sjoholm, A. G. (2005) Hereditary C2 deficiency in Sweden: frequent occurrence of invasive infection, atherosclerosis, and rheumatic disease. Medicine 84, 23-34. (Pubitemid 40130182)
-
(2005)
Medicine
, vol.84
, Issue.1
, pp. 23-34
-
-
Jonsson, G.1
Truedsson, L.2
Sturfelt, G.3
Oxelius, V.-A.4
Braconier, J.H.5
Sjoholm, A.G.6
-
21
-
-
34447318872
-
Rheumatological manifestations, organ damage and autoimmunity in hereditary C2 deficiency
-
DOI 10.1093/rheumatology/kem023
-
Jonsson, G., Sjoholm, A. G., Truedsson, L., Bengtsson, A. A., Braconier, J. H., and Sturfelt, G. (2007) Rheumatological manifestations, organ damage and autoimmunity in hereditary C2 deficiency. Rheumatology 46, 1133-1139. (Pubitemid 47050617)
-
(2007)
Rheumatology
, vol.46
, Issue.7
, pp. 1133-1139
-
-
Jonsson, G.B.1
Sjoholm, A.G.2
Truedsson, L.3
Bengtsson, A.A.4
Braconier, J.H.5
Sturfelt, G.6
-
22
-
-
34547681653
-
C2 deficiency primary meningococcal arthritis of the elbow by Neisseria meningitidis serogroup Y in a 12-year old girl [1]
-
DOI 10.1007/s15010-007-3039-5
-
Hussain, A., Prasad, K. S., Bhattacharyya, D., and El-Bouri, K. (2007) C2 deficiency primary meningococcal arthritis of the elbow by Neisseria meningitidis serogroup Y in a 12-year old girl. Infection 35, 287-288. (Pubitemid 47222268)
-
(2007)
Infection
, vol.35
, Issue.4
, pp. 287-288
-
-
Hussain, A.1
Prasad, K.S.R.K.2
Bhattacharyya, D.3
El-Bouri, K.4
-
23
-
-
10744229857
-
Immunoglobulin deficiencies and susceptibility to infection among homozygotes and heterozygotes for C2 deficiency
-
Alper, C. A., Xu, J., Cosmopoulos, K., Dolinski, B., Stein, R., Uko, G., Larsen, C. E., Dubey, D. P., Densen, P., Truedsson, L., Sturfelt, G., and Sjoholm, A. G. (2003) Immunoglobulin deficiencies and susceptibility to infection among homozygotes and heterozygotes for C2 deficiency. J. Clin. Immunol. 23, 297-305.
-
(2003)
J. Clin. Immunol.
, vol.23
, pp. 297-305
-
-
Alper, C.A.1
Xu, J.2
Cosmopoulos, K.3
Dolinski, B.4
Stein, R.5
Uko, G.6
Larsen, C.E.7
Dubey, D.P.8
Densen, P.9
Truedsson, L.10
Sturfelt, G.11
Sjoholm, A.G.12
-
24
-
-
49449089864
-
Increased susceptibility of complement factor B/C2 double knockout mice and mannan-binding lectin knockout mice to systemic infection with Candida albicans
-
Held, K., Thiel, S., Loos, M., and Petry, F. (2008) Increased susceptibility of complement factor B/C2 double knockout mice and mannan-binding lectin knockout mice to systemic infection with Candida albicans. Mol. Immunol. 45, 3934-3941.
-
(2008)
Mol. Immunol.
, vol.45
, pp. 3934-3941
-
-
Held, K.1
Thiel, S.2
Loos, M.3
Petry, F.4
-
25
-
-
36048937343
-
Complement-targeted therapeutics
-
Ricklin, D., and Lambris, J. D. (2007) Complement-targeted therapeutics. Nat. Biotechnol. 25, 1265-1275.
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 1265-1275
-
-
Ricklin, D.1
Lambris, J.D.2
-
26
-
-
35348821843
-
Function, structure and therapeutic potential of complement C5a receptors
-
Monk, P. N., Scola, A. M., Madala, P., and Fairlie, D. P. (2007) Function, structure and therapeutic potential of complement C5a receptors. Br. J. Pharmacol. 152, 429-448.
-
(2007)
Br. J. Pharmacol.
, vol.152
, pp. 429-448
-
-
Monk, P.N.1
Scola, A.M.2
Madala, P.3
Fairlie, D.P.4
-
27
-
-
12144290258
-
Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity
-
March, D. R., Proctor, L. M., Stoermer, M. J., Sbaglia, R., Abbenante, G., Reid, R. C., Woodruff, T. M., Wadi, K., Paczkowski, N., Tyndall, J. D., Taylor, S. M., and Fairlie, D. P. (2004) Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity. Mol. Pharmacol. 65, 868-879.
-
(2004)
Mol. Pharmacol.
, vol.65
, pp. 868-879
-
-
March, D.R.1
Proctor, L.M.2
Stoermer, M.J.3
Sbaglia, R.4
Abbenante, G.5
Reid, R.C.6
Woodruff, T.M.7
Wadi, K.8
Paczkowski, N.9
Tyndall, J.D.10
Taylor, S.M.11
Fairlie, D.P.12
-
28
-
-
0035500616
-
Novel small molecule inhibitor of C1s exerts cardioprotective effects in ischemia-reperfusion injury in rabbits
-
Buerke, M., Schwertz, H., Seitz, W., Meyer, J., and Darius, H. (2001) Novel small molecule inhibitor of C1s exerts cardioprotective effects in ischemia-reperfusion injury in rabbits. J. Immunol. 167, 5375-5380. (Pubitemid 33009777)
-
(2001)
Journal of Immunology
, vol.167
, Issue.9
, pp. 5375-5380
-
-
Buerke, M.1
Schwertz, H.2
Seitz, W.3
Meyer, J.4
Darius, H.5
-
29
-
-
33645093430
-
Compstatin inhibits complement activation by binding to the beta-chain of complement factor 3
-
Soulika, A. M., Holland, M. C., Sfyroera, G., Sahu, A., and Lambris, J. D. (2006) Compstatin inhibits complement activation by binding to the beta-chain of complement factor 3. Mol. Immunol. 43, 2023-2029.
-
(2006)
Mol. Immunol.
, vol.43
, pp. 2023-2029
-
-
Soulika, A.M.1
Holland, M.C.2
Sfyroera, G.3
Sahu, A.4
Lambris, J.D.5
-
30
-
-
0026088150
-
FUT-175 as a potent inhibitor of C5/C3 convertase activity for production of C5a and C3a
-
Inagi, R., Miyata, T., Maeda, K., Sugiyama, S., Miyama, A., and Nakashima, I. (1991) FUT-175 as a potent inhibitor of C5/C3 convertase activity for production of C5a and C3a. Immunol. Lett. 27, 49-52.
-
(1991)
Immunol. Lett.
, vol.27
, pp. 49-52
-
-
Inagi, R.1
Miyata, T.2
Maeda, K.3
Sugiyama, S.4
Miyama, A.5
Nakashima, I.6
-
31
-
-
0034580407
-
An efficient Fmoc strategy for the rapid synthesis of peptide paranitroanalides
-
Abbenante, G., Leung, D., Bond, T., and Fairlie, D. P. (2001) An efficient Fmoc strategy for the rapid synthesis of peptide paranitroanalides. Lett. Pept. Sci. 7, 347-351.
-
(2001)
Lett. Pept. Sci.
, vol.7
, pp. 347-351
-
-
Abbenante, G.1
Leung, D.2
Bond, T.3
Fairlie, D.P.4
-
32
-
-
0033657140
-
Novel hydrazino-carbonylamino-methylated polystyrene (HCAM) resin methodology for the synthesis of P1-aldehyde protease inhibitor candidates
-
Siev, D. V., and Semple, J. E. (2000) Novel hydrazino-carbonylamino- methylated polystyrene (HCAM) resin methodology for the synthesis of P1-aldehyde protease inhibitor candidates. Org. Lett. 2, 19-22.
-
(2000)
Org. Lett.
, vol.2
, pp. 19-22
-
-
Siev, D.V.1
Semple, J.E.2
-
33
-
-
36849046139
-
Profiling the enzymatic properties and inhibition of human complement factor B
-
Le, G. T., Abbenante, G., and Fairlie, D. P. (2007) Profiling the enzymatic properties and inhibition of human complement factor B. J. Biol. Chem. 282, 34809-34816.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 34809-34816
-
-
Le, G.T.1
Abbenante, G.2
Fairlie, D.P.3
-
34
-
-
19944430192
-
Functional analysis of the classical, alternative, and MBL pathways of the complement system: Standardization and validation of a simple ELISA
-
DOI 10.1016/j.jim.2004.11.016, PII S002217590400420X
-
Seelen, M. A., Roos, A., Wieslander, J., Mollnes, T. E., Sjoholm, A. G., Wurzner, R., Loos, M., Tedesco, F., Sim, R. B., Garred, P., Alexopoulos, E., Turner, M. W., and Daha, M. R. (2005) Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA. J. Immunol. Methods 296, 187-198. (Pubitemid 40174752)
-
(2005)
Journal of Immunological Methods
, vol.296
, Issue.1-2
, pp. 187-198
-
-
Seelen, M.A.1
Roos, A.2
Wieslander, J.3
Mollnes, T.E.4
Sjoholm, A.G.5
Wurzner, R.6
Loos, M.7
Tedesco, F.8
Sim, R.B.9
Garred, P.10
Alexopoulos, E.11
Turner, M.W.12
Daha, M.R.13
-
35
-
-
18744371008
-
Functional characterization of the lectin pathway of complement in human serum
-
Roos, A., Bouwman, L. H., Munoz, J., Zuiverloon, T., Faber-Krol, M. C., Fallaux-van den Houten, F. C., Klar-Mohamad, N., Hack, C. E., Tilanus, M. G., and Daha, M. R. (2003) Functional characterization of the lectin pathway of complement in human serum. Mol. Immunol. 39, 655-668.
-
(2003)
Mol. Immunol.
, vol.39
, pp. 655-668
-
-
Roos, A.1
Bouwman, L.H.2
Munoz, J.3
Zuiverloon, T.4
Faber-Krol, M.C.5
Fallaux-van Den Houten, F.C.6
Klar-Mohamad, N.7
Hack, C.E.8
Tilanus, M.G.9
Daha, M.R.10
-
36
-
-
0021753327
-
Comparative study of the fluid-phase proteolytic cleavage of human complement subcomponents C4 and C2 by C1s and C1r2-C1s2
-
Thielens, N. M., Villiers, C. L., Villiers, M. B., and Colomb, M. G. (1984) Comparative study of the fluid-phase proteolytic cleavage of human complement subcomponents C4 and C2 by C1s and C1r2-C1s2. FEBS Lett. 165, 111-116.
-
(1984)
FEBS Lett.
, vol.165
, pp. 111-116
-
-
Thielens, N.M.1
Villiers, C.L.2
Villiers, M.B.3
Colomb, M.G.4
-
37
-
-
0020511564
-
Surface modulation of classical pathway activation: C2 and C3 convertase formation and regulation on sheep, guinea pig, and human erythrocytes
-
Brown, E. J., Ramsey, J., Hammer, C. H., and Frank, M. M. (1983) Surface modulation of classical pathway activation: C2 and C3 convertase formation and regulation on sheep, guinea pig, and human erythrocytes. J. Immunol. 131, 403-408.
-
(1983)
J. Immunol.
, vol.131
, pp. 403-408
-
-
Brown, E.J.1
Ramsey, J.2
Hammer, C.H.3
Frank, M.M.4
-
38
-
-
37349079469
-
Role of complement and complement regulators in the removal of apoptotic cells
-
Trouw, L. A., Blom, A. M., and Gasque, P. (2008) Role of complement and complement regulators in the removal of apoptotic cells. Mol. Immunol. 45, 1199-1207.
-
(2008)
Mol. Immunol.
, vol.45
, pp. 1199-1207
-
-
Trouw, L.A.1
Blom, A.M.2
Gasque, P.3
-
39
-
-
33847044475
-
The crystal structure of C2a, the catalytic fragment of classical pathway C3 and C5 convertase of human complement
-
Krishnan, V., Xu, Y., Macon, K., Volanakis, J. E., and Narayana, S. V. (2007) The crystal structure of C2a, the catalytic fragment of classical pathway C3 and C5 convertase of human complement. J. Mol. Biol. 367, 224-233.
-
(2007)
J. Mol. Biol.
, vol.367
, pp. 224-233
-
-
Krishnan, V.1
Xu, Y.2
Macon, K.3
Volanakis, J.E.4
Narayana, S.V.5
-
40
-
-
33847651701
-
Factor B structure provides insights into activation of the central protease of the complement system
-
Milder, F. J., Gomes, L., Schouten, A., Janssen, B. J., Huizinga, E. G., Romijn, R. A., Hemrika, W., Roos, A., Daha, M. R., and Gros, P. (2007) Factor B structure provides insights into activation of the central protease of the complement system. Nat. Struct. Mol. Biol. 14, 224-228.
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 224-228
-
-
Milder, F.J.1
Gomes, L.2
Schouten, A.3
Janssen, B.J.4
Huizinga, E.G.5
Romijn, R.A.6
Hemrika, W.7
Roos, A.8
Daha, M.R.9
Gros, P.10
-
41
-
-
0034677208
-
New structural motifs on the chymotrypsin fold and their potential roles in complement factor B
-
Jing, H., Xu, Y., Carson, M., Moore, D., Macon, K. J., Volanakis, J. E., and Narayana, S. V. (2000) New structural motifs on the chymotrypsin fold and their potential roles in complement factor B. EMBO J. 19, 164-173. (Pubitemid 30042699)
-
(2000)
EMBO Journal
, vol.19
, Issue.2
, pp. 164-173
-
-
Jing, H.1
Xu, Y.2
Carson, M.3
Moore, D.4
Macon, K.J.5
Volanakis, J.E.6
Narayana, S.V.L.7
-
42
-
-
58649113845
-
Structure of West Nile Virus NS3 Protease: Ligand stabilization of the catalytic conformation
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Robin, G., Chappell, K., Stoermer, M. J., Hu, S.-H., Young, P. R., Fairlie, D. P., and Martin, J. L. (2009) Structure of West Nile Virus NS3 Protease: Ligand stabilization of the catalytic conformation. J. Mol. Biol. 385, 1568-1577.
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(2009)
J. Mol. Biol.
, vol.385
, pp. 1568-1577
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Robin, G.1
Chappell, K.2
Stoermer, M.J.3
Hu, S.-H.4
Young, P.R.5
Fairlie, D.P.6
Martin, J.L.7
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