메뉴 건너뛰기




Volumn 25, Issue 5, 2009, Pages 441-446

Neural and hormonal regulation of pancreatic secretion

Author keywords

Endocrine; Exocrine; Pancreas; Regulation; Secretion

Indexed keywords

AMYLASE; CALCIUM; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ OCTAPEPTIDE; GHRELIN; GLUCAGON LIKE PEPTIDE 1; LEPTIN; MELATONIN; NATRIURETIC PEPTIDE TYPE C; NEUROPEPTIDE Y; OBESTATIN; OREXIN A; OREXIN B;

EID: 69749088076     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e32832e9c41     Document Type: Review
Times cited : (66)

References (38)
  • 1
    • 0002572979 scopus 로고
    • Cholecystokinin
    • Walsh JH, Dockray GJ, editors. New York: Raven Press
    • Liddle RA. Cholecystokinin. In: Walsh JH, Dockray GJ, editors. Gut peptides: biochemistry and physiology. New York: Raven Press; 1994. pp. 175-216.
    • (1994) Gut Peptides: Biochemistry and Physiology , pp. 175-216
    • Liddle, R.A.1
  • 2
    • 0024839869 scopus 로고
    • Integrated actions of cholecystokinin on the gastrointestinal tract: Use of the cholecystokinin bioassay
    • Liddle RA. Integrated actions of cholecystokinin on the gastrointestinal tract: use of the cholecystokinin bioassay. Gastroenterol Clin North Am 1989;18:735-756.
    • (1989) Gastroenterol Clin North Am , vol.18 , pp. 735-756
    • Liddle, R.A.1
  • 3
    • 57649173548 scopus 로고    scopus 로고
    • Secretion from acinar cells of the exocrine pancreas: Role of enteropancreatic reflexes and cholecystokinin
    • Singer MV, Niebergall-Roth E. Secretion from acinar cells of the exocrine pancreas: role of enteropancreatic reflexes and cholecystokinin. Cell Biol Int 2009; 33:1-9.
    • (2009) Cell Biol Int , vol.33 , pp. 1-9
    • Singer, M.V.1    Niebergall-Roth, E.2
  • 6
    • 48549100809 scopus 로고    scopus 로고
    • 2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells
    • This was the first study to show that CCK-8 and CCK-58 can act directly on human pancreatic acinar cells to elicit exocrine secretion.
    • 2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology 2008; 135:632-641. This was the first study to show that CCK-8 and CCK-58 can act directly on human pancreatic acinar cells to elicit exocrine secretion.
    • (2008) Gastroenterology , vol.135 , pp. 632-641
    • Murphy, J.A.1    Criddle, D.N.2    Sherwood, M.3
  • 7
    • 0028897595 scopus 로고
    • Presynaptic inhibition by serotonin of nerve-mediated secretion of pancreatic amylase
    • Kirchgessner AL, Gershon MD. Presynaptic inhibition by serotonin of nerve-mediated secretion of pancreatic amylase. Am J Physiol Gastrointest Liver Physiol 1995; 268:G339-G345.
    • (1995) Am J Physiol Gastrointest Liver Physiol , vol.268
    • Kirchgessner, A.L.1    Gershon, M.D.2
  • 9
    • 56949099158 scopus 로고    scopus 로고
    • Activation of cholecystokinin (CCK1) and serotonin (5-HT3) receptors increases the discharge of pancreatic vagal afferents
    • This article showed that cholecystokinin and serotonin mediate pancreatic secretion by activating CCK1 and 5-HT3 receptors located on dorsal vagal afferents. Whereas CCK did not activate serotonin receptors, phenylbiguanide, a serotonin receptor agonist, increased pancreatic secretion by stimulating CCK1 receptors.
    • Mussa BM, Sartor DM, Verberne AJM. Activation of cholecystokinin (CCK1) and serotonin (5-HT3) receptors increases the discharge of pancreatic vagal afferents. Eur J Pharmacol 2008; 601:198-206. This article showed that cholecystokinin and serotonin mediate pancreatic secretion by activating CCK1 and 5-HT3 receptors located on dorsal vagal afferents. Whereas CCK did not activate serotonin receptors, phenylbiguanide, a serotonin receptor agonist, increased pancreatic secretion by stimulating CCK1 receptors.
    • (2008) Eur J Pharmacol , vol.601 , pp. 198-206
    • Mussa, B.M.1    Sartor, D.M.2    Verberne, A.J.M.3
  • 10
    • 38149063840 scopus 로고    scopus 로고
    • Involvement of vagal nerves in the pancreatostimulatory effects of luminal melatonin, or its precursor L-tryptophan. Study in the rats
    • Nawrot-Pora̧bka K, Jaworek J, Leja-Szpak A, et al. Involvement of vagal nerves in the pancreatostimulatory effects of luminal melatonin, or its precursor L-tryptophan. Study in the rats. J Physiol Pharmacol 2007; 58 (Suppl 6):81-95.
    • (2007) J Physiol Pharmacol , vol.58 , Issue.SUPPL. 6 , pp. 81-95
    • Nawrot-Pora̧bka, K.1    Jaworek, J.2    Leja-Szpak, A.3
  • 11
    • 49649118349 scopus 로고    scopus 로고
    • 2+ signals and mitochondrial membrane potential in exocrine cells are prevented by melatonin
    • Oral administration of melatonin restored calcium oscillations and exocrine secretion in aging acinar cells.
    • 2+ signals and mitochondrial membrane potential in exocrine cells are prevented by melatonin. J Pineal Res 2008; 45:191-198. Oral administration of melatonin restored calcium oscillations and exocrine secretion in aging acinar cells.
    • (2008) J Pineal Res , vol.45 , pp. 191-198
    • Camello-Almaraz, C.1    Gomez-Pinilla, P.J.2    Pozo, M.J.3
  • 13
    • 63049102683 scopus 로고    scopus 로고
    • Natriuretic peptides as regulatory mediators of secretory activity in the digestive system
    • Sabbatini ME. Natriuretic peptides as regulatory mediators of secretory activity in the digestive system. Regul Pept 2009; 154:5-15.
    • (2009) Regul Pept , vol.154 , pp. 5-15
    • Sabbatini, M.E.1
  • 14
    • 35448989408 scopus 로고    scopus 로고
    • C-type natriuretic peptide stimulates pancreatic exocrine secretion in the rat: Role of vagal afferent and efferent pathways
    • DOI 10.1016/j.ejphar.2007.08.043, PII S0014299907009910
    • Sabbatini ME, Rodriguez MR, Dabas P, et al. C-type natriuretic peptide stimulates pancreatic exocrine secretion in the rat: role of vagal afferent and efferent pathways. Eur J Pharmacol 2007; 577:192-202. (Pubitemid 47632536)
    • (2007) European Journal of Pharmacology , vol.577 , Issue.1-3 , pp. 192-202
    • Sabbatini, M.E.1    Rodriguez, M.R.2    Dabas, P.3    Vatta, M.S.4    Bianciotti, L.G.5
  • 15
    • 59349103952 scopus 로고    scopus 로고
    • Involvement of cannabinoid CB1- And CB2-receptors in the modulation of exocrine pancreatic secretion
    • This article showed that CB1 and CB2 were expressed in acinar cells of rat. Activation of the receptors decreased amylase release possibly by inhibiting release of acetylcholine from the presynaptic terminals.
    • Linari G, Agostini S, Amadoro G, et al. Involvement of cannabinoid CB1- and CB2-receptors in the modulation of exocrine pancreatic secretion. Pharmacol Res 2009; 59:207-214. This article showed that CB1 and CB2 were expressed in acinar cells of rat. Activation of the receptors decreased amylase release possibly by inhibiting release of acetylcholine from the presynaptic terminals.
    • (2009) Pharmacol Res , vol.59 , pp. 207-214
    • Linari, G.1    Agostini, S.2    Amadoro, G.3
  • 17
    • 39049091518 scopus 로고    scopus 로고
    • Presence of functional cannabinoid receptors in human endocrine pancreas
    • This study showed that CB1 receptor was expressed in human glucagon and insulin-producing cells, but was absent in the acinar cells. Stimulation of CB1 caused the release of insulin from dissociated islet cells.
    • Bermudez-Silva FJ, Suarez J, Baixeras E, et al. Presence of functional cannabinoid receptors in human endocrine pancreas. Diabetologia 2008;51:476-487. This study showed that CB1 receptor was expressed in human glucagon and insulin-producing cells, but was absent in the acinar cells. Stimulation of CB1 caused the release of insulin from dissociated islet cells.
    • (2008) Diabetologia , vol.51 , pp. 476-487
    • Bermudez-Silva, F.J.1    Suarez, J.2    Baixeras, E.3
  • 18
    • 48249136051 scopus 로고    scopus 로고
    • Emerging role of cannabinoids in gastrointestinal and liver diseases: Basic and clinical aspects
    • Izzo AA, Camilleri M. Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects. Gut 2008; 57:1140-1155.
    • (2008) Gut , vol.57 , pp. 1140-1155
    • Izzo, A.A.1    Camilleri, M.2
  • 20
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402:656-660. (Pubitemid 129516334)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 21
    • 34748827410 scopus 로고    scopus 로고
    • The ghrelin system in acinar cells: Localization, expression, and regulation in the exocrine pancreas
    • Lai KC, Cheng CH, Leung PS. The ghrelin system in acinar cells: localization, expression, and regulation in the exocrine pancreas. Pancreas 2007;35:e1-e8.
    • (2007) Pancreas , vol.35
    • Lai, K.C.1    Cheng, C.H.2    Leung, P.S.3
  • 23
    • 38149098503 scopus 로고    scopus 로고
    • Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin: A study on isolated islets from mouse and rat pancreas
    • This study demonstrated that the three pro-ghrelin-derived peptides (acyl ghrelin, desacyl ghrelin, and obestatin) had either similar or opposing roles in endocrine secretion.
    • Qader SS, Hakanson R, Rehfeld JF, et al. Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin: a study on isolated islets from mouse and rat pancreas. Regul Pept 2008; 146:230-237. This study demonstrated that the three pro-ghrelin-derived peptides (acyl ghrelin, desacyl ghrelin, and obestatin) had either similar or opposing roles in endocrine secretion.
    • (2008) Regul Pept , vol.146 , pp. 230-237
    • Qader, S.S.1    Hakanson, R.2    Rehfeld, J.F.3
  • 24
    • 27744600963 scopus 로고    scopus 로고
    • Medicine: Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake
    • DOI 10.1126/science.1117255
    • Zhang JV, Ren P-G, Avsian-Kretchmer O, et al. Obestatin, a peptide encoded by the ghrelin gene opposes ghrelin's effects on food intake. Science 2005;310:996-999. (Pubitemid 41611907)
    • (2005) Science , vol.310 , Issue.5750 , pp. 996-999
    • Zhang, J.V.1    Ren, P.-G.2    Avsian-Kretchmer, O.3    Luo, C.-W.4    Rauch, R.5    Klein, C.6    Hsueh, A.J.W.7
  • 25
    • 42449124783 scopus 로고    scopus 로고
    • Obestatin promotes survival of pancreatic β-cells and human islets and induces expression of genes involved in the regulation of b-cell mass and function
    • In addition to stimulating insulin release, obestatin had a proliferative and antiapoptotic effect on beta cells. This finding has clinical implications in the treatment of diabetes.
    • Granata R, Settanni F, Gallo D, et al. Obestatin promotes survival of pancreatic β-cells and human islets and induces expression of genes involved in the regulation of b-cell mass and function. Diabetes 2008; 57:967-979. In addition to stimulating insulin release, obestatin had a proliferative and antiapoptotic effect on beta cells. This finding has clinical implications in the treatment of diabetes.
    • (2008) Diabetes , vol.57 , pp. 967-979
    • Granata, R.1    Settanni, F.2    Gallo, D.3
  • 27
    • 41549114640 scopus 로고    scopus 로고
    • Orexin-A inhibits glucagon secretion and gene expression through a Foxo1-dependent pathway
    • This study showed that orexin A modulated proglucagon gene expression via a pathway mediated by intracellular calcium, CREB, and Foxo1 transcription factor.
    • Göncz E, Strowski MZ, Grotzinger C, et al. Orexin-A inhibits glucagon secretion and gene expression through a Foxo1-dependent pathway. Endocrinology 2008; 149:1618-1626. This study showed that orexin A modulated proglucagon gene expression via a pathway mediated by intracellular calcium, CREB, and Foxo1 transcription factor.
    • (2008) Endocrinology , vol.149 , pp. 1618-1626
    • Göncz, E.1    Strowski, M.Z.2    Grotzinger, C.3
  • 28
    • 43849102318 scopus 로고    scopus 로고
    • Vasopressin potentiates corticotropin-releasing hormone-induced insulin release from mouse pancreatic beta-cells
    • This was the first study to show that AVP potentiated CRH-mediated insulin release from islets by a mechanism dependent on AVPR1b, PKC, and intracellular calcium.
    • O'Carroll AM, Howell GM, Roberts EM, et al. Vasopressin potentiates corticotropin-releasing hormone-induced insulin release from mouse pancreatic beta-cells. J Endocrinol 2008; 197:231-239. This was the first study to show that AVP potentiated CRH-mediated insulin release from islets by a mechanism dependent on AVPR1b, PKC, and intracellular calcium.
    • (2008) J Endocrinol , vol.197 , pp. 231-239
    • O'Carroll, A.M.1    Howell, G.M.2    Roberts, E.M.3
  • 29
    • 0028854403 scopus 로고
    • Peptide YY inhibits exocrine pancreatic secretion in isolated perfused rat pancreas by Y1 receptors
    • Grandt D, Siewert J, Sieburg B, et al. Peptide YY inhibits exocrine pancreatic secretion in isolated perfused rat pancreas by Y1 receptors. Pancreas 1995;10:180-186.
    • (1995) Pancreas , vol.10 , pp. 180-186
    • Grandt, D.1    Siewert, J.2    Sieburg, B.3
  • 30
    • 33846571989 scopus 로고    scopus 로고
    • A role for pancreatic polypeptide in feeding and body weight regulation
    • DOI 10.1016/j.peptides.2006.09.024, PII S0196978106005316, NPY and Cohorts in Human Disease
    • Kojima S, Ueno N, Asakawa A, et al. A role for pancreatic polypeptide in feeding and body weight regulation. Peptides 2007; 28:459-463. (Pubitemid 46176251)
    • (2007) Peptides , vol.28 , Issue.2 , pp. 459-463
    • Kojima, S.1    Ueno, N.2    Asakawa, A.3    Sagiyama, K.4    Naruo, T.5    Mizuno, S.6    Inui, A.7
  • 31
    • 36349009725 scopus 로고    scopus 로고
    • Insulin secretion is increased in pancreatic islets of neuropeptide Y-deficient mice
    • DOI 10.1210/en.2007-0404
    • Imai Y, Patel HR, Hawkins EJ, et al. Insulin secretion is increased in pancreatic islets of neuropeptide Y-deficient mice. Endocrinology 2007; 148:5716-5723. (Pubitemid 350146158)
    • (2007) Endocrinology , vol.148 , Issue.12 , pp. 5716-5723
    • Imai, Y.1    Patel, H.R.2    Hawkins, E.J.3    Doliba, N.M.4    Matschinsky, F.M.5    Ahima, R.S.6
  • 32
    • 41549105255 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, glucose homeostasis and diabetes
    • Holst JJ, Deacon CF, Vilsbøll T, et al. Glucagon-like peptide-1, glucose homeostasis and diabetes. Trends Molec Med 2008; 14:161-168.
    • (2008) Trends Molec Med , vol.14 , pp. 161-168
    • Holst, J.J.1    Deacon, C.F.2    Vilsbøll, T.3
  • 34
    • 55649108863 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
    • This study suggested that GLP-1 inhibited glucagon release via a pathway mediated by somatostatin.
    • de Heer J, Rasmussen C, Coy DH, et al. Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas. Diabetologia 2008; 51:2263-2270. This study suggested that GLP-1 inhibited glucagon release via a pathway mediated by somatostatin.
    • (2008) Diabetologia , vol.51 , pp. 2263-2270
    • De Heer, J.1    Rasmussen, C.2    Coy, D.H.3
  • 36
    • 47749085111 scopus 로고    scopus 로고
    • Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1
    • DOI 10.1371/journal.pone.0002165
    • Salehi A, Meidute Abaraviciene S, Jimenez-Feltstrom J, et al. Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1. PLoS ONE 2008;3:e2165. This study showed that GLP-1 restored insulin secretion from islets of type 2 diabetic rats by inhibiting nitric oxide signaling. (Pubitemid 352025143)
    • (2008) PLoS ONE , vol.3 , Issue.5
    • Salehi, A.1    Meidute Abaraviciene, S.2    Jimenez-Feltstrom, J.3    Ostenson, C.-G.4    Efendic, S.5    Lundquist, I.6
  • 37
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas JL,Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269:543-546.
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.