Down-regulation of αv integrin by retroviral delivery of small interfering RNA reduces multicellular resistance of HT29

Cancer Letters

Volumn 284, Issue 2, 2009, Pages 182-188

  He, Jian ming ^a   Wang, Feng chao ^a   Qi, Hua bing ^a   Li, Yan ^a   Liang, Hou jie ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Chemotherapy; Colon cancer; Integrin; Multicellular resistance; Oxaliplatin

Indexed keywords

ALPHA5 INTEGRIN; OXALIPLATIN; RETROVIRUS VECTOR; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; ALKYLATING AGENT; CD51 ANTIGEN; MAP2K7 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; PLATINUM COMPLEX; RELA PROTEIN, HUMAN; TUMOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL JUNCTION; CELL STRAIN HT29; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG SENSITIVITY; FEMALE; HUMAN; HUMAN CELL; MOUSE; MULTICELLULAR SPHEROID; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SINGLE DRUG DOSE; VIRAL GENE DELIVERY SYSTEM; ADENOCARCINOMA; ANIMAL; BIOSYNTHESIS; COLON TUMOR; DRUG EFFECT; DRUG RESISTANCE; DRUG SCREENING; GENE THERAPY; GENE VECTOR; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; RETROVIRUS; RNA INTERFERENCE; TRANSPLANTATION; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL ADHESION; CELL LINE, TUMOR; COLONIC NEOPLASMS; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; GENE THERAPY; GENETIC VECTORS; INTEGRIN ALPHAV; MAP KINASE KINASE 7; MICE; NEOPLASM PROTEINS; ORGANOPLATINUM COMPOUNDS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RETROVIRIDAE; RNA INTERFERENCE; RNA, SMALL INTERFERING; SPHEROIDS, CELLULAR; TRANSCRIPTION FACTOR RELA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 69549138084     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.04.023     Document Type: Article

References (35)

1. Teicher B.A., Herman T.S., Holden S.A., Wang Y.Y., Pfeffer M.R., Crawford J.W., and Frei III E. Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo. Science 247 (1990) 1457-1461
2. Desoize B., and Jardillier J. Multicellular resistance: a paradigm for clinical resistance?. Crit Rev Oncol Hematol 36 (2000) 193-207
3. Kang H.G., Jenabi J.M., Zhang J., Keshelava N., Shimada H., May W.A., Ng T., Reynolds C.P., Triche T.J., and Sorensen P.H. E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase. Cancer Res 67 (2007) 3094-3105
4. Oktem G., Bilir A., Selvi N., Yurtseven M.E., Vatansever S., Ates U., Uysal A., and Omay S.B. Chemotherapy influences inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) activity on 3D breast cancer cell line. Oncol Res 16 (2006) 195-203
5. Bates R.C., Buret A., Van Helden D.F., Horton M.A., and Burns G.F. Apoptosis induced by inhibition of intercellular contact. J Cell Biol 125 (1994) 403-415
6. Mueller-Klieser W. Three-dimensional cell cultures: from molecular mechanisms to clinical applications. Am J Physiol 273 (1997) C1109-1123
7. Bates R.C., Edwards N.S., and Yates J.D. Spheroids and cell survival. Crit Rev Oncol Hematol 36 (2000) 61-74
8. Sakamoto Y., Ogita H., Hirota T., Kawakatsu T., Fukuyama T., Yasumi M., Kanzaki N., Ozaki M., and Takai Y. Interaction of integrin αvβ3 with nectin. Implication in cross-talk between cell-matrix and cell-cell junctions. J Biol Chem 281 (2006) 19631-19644
9. Sakamoto Y., Ogita H., Komura H., and Takai Y. Involvement of nectin in inactivation of integrin αvβ3 after the establishment of cell-cell adhesion. J Biol Chem 283 (2008) 496-505
10. Choudhuri T., Verma S.C., Lan K., and Robertson E.S. Expression of αv integrin is modulated by Epstein-Barr virus nuclear antigen 3C and the metastasis suppressor Nm23-H1 through interaction with the GATA-1 and Sp1 transcription factors. Virology 351 (2006) 58-72
11. Canonici A., Steelant W., Rigot V., Khomitch-Baud A., Boutaghou-Cherid H., Bruyneel E., Van Roy F., Garrouste F., Pommier G., and Andre F. Insulin-like growth factor-I receptor, E-cadherin and αv integrin form a dynamic complex under the control of alpha-catenin. Int J Cancer 122 (2008) 572-582
12. Vellon L., Menendez J.A., and Lupu R. A bidirectional αvβ3 integrin-ERK1/ERK2 MAPK connection regulates the proliferation of breast cancer cells. Mol Carcinog 45 (2006) 795-804
13. Vallon M., and Essler M. Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin αvβ3 to glycosaminoglycans. J Biol Chem 281 (2006) 34179-34188
14. Voland C., Bord A., Peleraux A., Penarier G., Carriere D., Galiegue S., Cvitkovic E., Jbilo O., and Casellas P. Repression of cell cycle-related proteins by oxaliplatin but not cisplatin in human colon cancer cells. Mol Cancer Ther 5 (2006) 2149-2157
15. Howells L.M., Mitra A., and Manson M.M. Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines. Int J Cancer 121 (2007) 175-183
16. Brummelkamp T.R., Bernards R., and Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296 (2002) 550-553
17. Guo J., Verma U.N., Gaynor R.B., Frenkel E.P., and Becerra C.R. Enhanced chemosensitivity to irinotecan by RNA interference-mediated down-regulation of the NF-κB p65 subunit. Clin Cancer Res 10 (2004) 3333-3341
18. Zhang X., Wei L., Yang Y., and Yu Q. Sodium 4-phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway. J Cell Biochem 93 (2004) 819-829
19. Nakagawa T., Takahashi M., Ozaki T., Watanabe Ki K., Todo S., Mizuguchi H., Hayakawa T., and Nakagawara A. Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter. Mol Cell Biol 22 (2002) 2575-2585
20. Jemal A., Siegel R., Ward E., Murray T., Xu J., Smigal C., and Thun M.J. Cancer statistics, 2006. CA Cancer J Clin 56 (2006) 106-130
21. Luo B.H., Carman C.V., and Springer T.A. Structural basis of integrin regulation and signaling. Annu Rev Immunol 25 (2007) 619-647
22. Yang G.Y., Xu K.S., Pan Z.Q., Zhang Z.Y., Mi Y.T., Wang J.S., Chen R., and Niu J. Integrin αvβ6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver. Cancer Sci 99 (2008) 879-887
23. Gloe T., Sohn H.Y., Meininger G.A., and Pohl U. Shear stress-induced release of basic fibroblast growth factor from endothelial cells is mediated by matrix interaction via integrin αvβ3. J Biol Chem 277 (2002) 23453-23458
24. Delon I., and Brown N.H. Integrins and the actin cytoskeleton. Curr Opin Cell Biol 19 (2007) 43-50
25. Craig D., Gao M., Schulten K., and Vogel V. Structural insights into how the MIDAS ion stabilizes integrin binding to an RGD peptide under force. Structure 12 (2004) 2049-2058
26. Xie C., Shimaoka M., Xiao T., Schwab P., Klickstein L.B., and Springer T.A. The integrin α-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation. Proc Natl Acad Sci USA 101 (2004) 15422-15427
27. Alon R., and Dustin M.L. Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells. Immunity 26 (2007) 17-27
28. Biswas D.K., Shi Q., Baily S., Strickland I., Ghosh S., Pardee A.B., and Iglehart J.D. NF-κB activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc Natl Acad Sci USA 101 (2004) 10137-10142
29. Sabapathy K., and Wagner E.F. JNK2: a negative regulator of cellular proliferation. Cell Cycle 3 (2004) 1520-1523
30. Bieler G., Hasmim M., Monnier Y., Imaizumi N., Ameyar M., Bamat J., Ponsonnet L., Chouaib S., Grell M., Goodman S.L., Lejeune F., and Ruegg C. Distinctive role of integrin-mediated adhesion in TNF-induced PKB/Akt and NF-κB activation and endothelial cell survival. Oncogene 26 (2007) 5722-5732
31. Urbinati C., Bugatti A., Giacca M., Schlaepfer D., Presta M., and Rusnati M. Αvβ3-integrin-dependent activation of focal adhesion kinase mediates NF-κB activation and motogenic activity by HIV-1 Tat in endothelial cells. J Cell Sci 118 (2005) 3949-3958
32. Lee D.Y., Yeh C.R., Chang S.F., Lee P.L., Chien S., Cheng C.K., and Chiu J.J. Integrin-mediated expression of bone formation-related genes in osteoblast-like cells in response to fluid shear stress: roles of extracellular matrix, Shc, and mitogen-activated protein kinase. J Bone Miner Res 23 (2008) 1140-1149
33. Kriehuber E., Bauer W., Charbonnier A.S., Winter D., Amatschek S., Tamandl D., Schweifer N., Stingl G., and Maurer D. Balance between NF-κB and JNK/AP-1 activity controls dendritic cell life and death. Blood 106 (2005) 175-183
34. Marsh D., Dickinson S., Neill G.W., Marshall J.F., Hart I.R., and Thomas G.J. Αvβ6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation. Cancer Res 68 (2008) 3295-3303
35. Van Aarsen L.A., Leone D.R., Ho S., Dolinski B.M., Mccoon P.E., Lepage D.J., Kelly R., Heaney G., Rayhorn P., Reid C., Simon K.J., Horan G.S., Tao N., Gardner H.A., Skelly M.M., Gown A.M., Thomas G.J., Weinreb P.H., Fawell S.E., and Violette S.M. Antibody-mediated blockade of integrin αvβ6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism. Cancer Res 68 (2008) 561-570