Inhibition of vascular calcium-gated chloride currents by blockers of K Ca1.1, but not by modulators of K Ca2.1 or K Ca2.3 channels

British Journal of Pharmacology

Volumn 158, Issue 2, 2009, Pages 521-531

  Sones, W R ^a   Leblanc, N ^b   Greenwood, I A ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

1 EBIO; Calcium activated chloride currents; Calcium activated potassium currents; Iberiotoxin; K Ca1.1; K Ca2.1; K Ca2.3; Mslo; Vascular smooth muscle

Indexed keywords

1 EBIO; CALCIUM ACTIVATED CHLORIDE CHANNEL; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ACTIVATED POTASSIUM CHANNEL BLOCKING AGENT; CALCIUM ACTIVATED POTASSIUM CHANNEL KCA1.1; CALCIUM ACTIVATED POTASSIUM CHANNEL KCA2.1; CALCIUM ACTIVATED POTASSIUM CHANNEL KCA2.3; CALCIUM CHANNEL; CHLORIDE CHANNEL; ESTRADIOL; IBERIOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; NIFLUMIC ACID; NS 309; PAXILLIN; PENITREM A; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; TAMOXIFEN; TRAM 34; UCL 1684; UNCLASSIFIED DRUG;

AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM BINDING; CALCIUM TRANSPORT; CHLORIDE TRANSPORT; CONTROLLED STUDY; MOUSE; NONHUMAN; PATCH CLAMP; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN DOMAIN; VASCULAR SMOOTH MUSCLE;

ANIMALS; CHLORIDE CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; INDOLES; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MICE; MICE, INBRED BALB C; MYCOTOXINS; MYOCYTES, SMOOTH MUSCLE; PATCH-CLAMP TECHNIQUES; PEPTIDES; PORTAL VEIN; POTASSIUM CHANNEL BLOCKERS; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS;

EID: 69549129521     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00332.x     Document Type: Article

References (39)

1. Alexander SPH, Mathie A, Peters JA (2008). Guide to receptors and channels (GRAC), 3rd edition (2008 revision). Br J Pharmacol 153 (Suppl. 2 S1 S209.
2. - currents by phosphorylation in pulmonary arterial smooth muscle cells. J Gen Physiol 128 : 73 87.
3. Benham CD, Bolton TB (1986). Spontaneous transient outward currents in single visceral and vascular smooth muscle cells of the rabbit. J Physiol 381 : 385 406.
4. Cl(Ca) in murine portal vein smooth muscle cells. J Physiol 539 : 107 117.
5. + channel. Biophys J 63 : 583 590.
6. Caputo A, Caci E, Ferrera L, Pedemonte NM, Barsanti C, Sondo E et al. (2008). TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science 322 : 590 594.
7. Dick GM, Rossow CF, Smirnov S, Horowitz B, Sanders KM (2001). Tamoxifen activates smooth muscle BK channels through the regulatory beta 1 subunit. J Biol Chem 276 : 34594 34599.
8. + channels in rat adrenal chromaffin cells in culture. Eur J Pharmacol 368 : 119 123.
9. Faber ES, Sah P (2003). Calcium-activated potassium channels: multiple contributions to neuronal function. Neuroscientist 9 : 181 194.
10. Gao YD, Garcia ML (2003). Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels. Proteins 52 : 146 154.
11. Giangiacomo KM, Garcia ML, McManus OB (1992). Mechanism of iberiotoxin block of the large-conductance calcium-activated potassium channel from bovine aortic smooth muscle. Biochemistry 31 : 6719 6727.
12. Greenwood IA, Large WA (1995). Comparison of the effects of fenamates on Ca-activated chloride and potassium currents in rabbit portal vein smooth muscle cells. Br J Pharmacol 116 : 2939 2948.
13. - current activated by cell swelling in rabbit portal vein vascular smooth muscle cells. Am J Physiol 275 : H1524 H1532.
14. + channels. Trends Pharmacol Sci 28 : 1 5.
15. 2+-calmodulin-dependent kinase. J Physiol 534 : 395 408.
16. Cl(Ca) in rabbit pulmonary artery smooth muscle cells. J Biol Chem 279 : 38830 38837.
17. Hartzell C, Putzier I, Arreola J (2005). Calcium-activated chloride channels. Annu Rev Physiol 67 : 719 758.
18. Ca channel activator, NS1619, on rat cerebral artery smooth muscle. Br J Pharmacol 117 : 119 129.
19. + currents in rat vas deferens. Eur J Pharmacol 325 : 21 27.
20. + channel α-subunit. Mol Pharmacol 62 : 836 846.
21. + channel of intermediate conductance: a molecular target for novel treatments? Curr Drug Targets 2 : 401 422.
22. Knaus HG, McManus OB, Lee SH, Schmalhofer WA, Garcia-Calvo M, Helms LM et al. (1994). Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 33 : 5819 5828.
23. Leblanc N, Ledoux J, Saleh S, Sanguinetti A, Angermann J, O'Driscoll K et al. (2005). Regulation of calcium-activated chloride channels in smooth muscle cells: a complex picture is emerging. Can J Physiol Pharmacol 83 : 541 556.
24. - channel modulation by niflumic acid in rabbit coronary arterial myocytes. Mol Pharmacol 67 : 163 173.
25. + channels in rat mesenteric arterial cells. Eur J Pharmacol 372 : 103 107.
26. + channels by novel benzimidazolone. Eur J Pharmacol 251 : 53 59.
27. Ca channels by niflumic, flufenamic, and mefenamic acids. Biophys J 67 : 2272 2279.
28. Piper AS, Greenwood IA (2003). Anomalous effect of anthracene-9- carboxylic acid on calcium-activated chloride currents in rabbit pulmonary artery smooth muscle cells. Br J Pharmacol 138 : 31 38.
29. - currents in rabbit pulmonary artery smooth muscle cells. J Physiol 539 : 119 131.
30. Saleh S, Greenwood IA (2005). Activation of chloride currents in murine portal vein smooth muscle cells by membrane depolarization involves intracellular calcium release. Am J Physiol 288 : C122 C131.
31. + channel modulators NS1619 [1,3-dihydro-1-[2- hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one] and isopimaric acid. J Pharmacol Exp Ther 321 : 1075 1084.
32. Sanchez M, McManus OB (1996). Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology 35 : 963 968.
33. Schroeder BC, Cheng T, Jan YN, Jan LY (2008). Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 134 : 1019 1029.
34. Stocker M (2004). Ca(2+)-activated K+ channels: molecular determinants and function of the SK family. Nat Rev Neurosci 5 : 758 770.
35. + channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim Biophys Acta 1665 : 1 5.
36. Toma C, Greenwood IA, Helliwell RM, Large WA (1996). Activation of potassium currents by inhibitors of calcium-activated chloride conductance in rabbit portal vein smooth muscle cells. Br J Pharmacol 118 : 513 520.
37. Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev 57 : 463 472. (Pubitemid 43036436)
38. + channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci USA 97 : 8151 8156.
39. Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS et al. (2008) TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 455 : 1210 1215.