Epigenetics and cancer

Biotherapy

Volumn 23, Issue 4, 2009, Pages 281-286

  Toyota, Minoru ^a   Suzuki, Hiromu ^a   Takamaru, Hiroyuki ^a   Shinomura, Yasuhisa ^a  

^a SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

DNA methylation; Epigenetics; Histone; Tumor suppressor gene

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MICRORNA; PROTEIN P53; WNT PROTEIN;

CANCER CHEMOTHERAPY; CARCINOGENESIS; DNA DAMAGE; DNA METHYLATION; DNA REPAIR; EPIGENETICS; GENE EXPRESSION; GENE IDENTIFICATION; NEOPLASM; REVIEW; TREATMENT RESPONSE;

EID: 69549110276     PISSN: 09142223     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (15)

1. Sjöblom, T., Jones, S., Wood, L.D., et al.: The consensus coding sequences of human breast and colorectal cancers. Science 314: 268-274, 2006. (Pubitemid 44571966)
2. Toyota, M. and Issa, J.P.: Epigenetic changes in solid and hematopoietic tumors. Semin. Oncol. 32: 521-530, 2005.
3. Suzuki, H., Watkins, D.N., Jair, K.W., et al.: Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat. Genet. 36: 417-422, 2004.
4. Toyota, M., Ahuja, N., Ohe-Toyota, M., et al.: CpG island methylator phenotype in colorectal cancer. Proc. Natl. Acad. Sci. USA 96: 8681-8686, 1999. (Pubitemid 29354851)
5. Shen, L., Toyota, M., Kondo, Y., et al.: Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc. Natl. Acad. Sci. USA 104: 18654-18659, 2007.
6. Saito, Y., Liang, G., Egger, G., et al.: Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9: 435-443, 2006. (Pubitemid 43832188)
7. Toyota, M., Suzuki, H., Sasaki, Y., et al.: Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res. 68: 4123-4132, 2008.
8. Kozaki, K., Imoto, I., Mogi, S., et al.: Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res. 68: 2094-2105, 2008.
9. Toyota, M., Ho, C., Ahuja, N., et al.: Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Cancer Res. 59: 2307-2312, 1999.
10. Toyota, M., Suzuki, H., Yamashita, T., et al.: Cancer epigenomics: implications of DNA methylation in personalized cancer therapy. Cancer Sci. 100: 787-791, 2009.
11. Ogi, K., Toyota, M., Mita, H., et al.: Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors. Cancer Biol. Ther. 4: 773-780, 2005.
12. Satoh, A., Toyota, M., Itoh, F., et al.: Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer. Cancer Res. 63: 8606-8613, 2003.
13. Toyota, M., Sasaki, Y., Satoh, A., et al.: Epigenetic inactivation of CHFR in human tumors. Proc. Natl. Acad. Sci. USA 100: 7818-7823, 2003.
14. Esteller, M., Garcia-Foncillas, J., Andion, E., et al.: Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N. Engl. J. Med. 343: 1350-1354, 2000.
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