The intracellular domain of the low affinity p75 nerve growth factor receptor is a death effector domain

Molecular Medicine Reports

Volumn 2, Issue 4, 2009, Pages 539-541

  Hyun, Ho Park ^a  

^a Yeungnam University   (South Korea)

Author keywords

Apoptosis; Caspase recruitment domain; Death effector domain; Deathdomain; Inflammation; p75 NGFR; Pyrin domain

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 4; DEATH RECEPTOR; NEUROTROPHIN RECEPTOR P75;

AMINO ACID SEQUENCE; ARTICLE; HYDROGEN BOND; INTRACELLULAR MEMBRANE; MOLECULAR BIOLOGY; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

EID: 69549108464     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr-00000133     Document Type: Article

References (26)

1. Ibáñez C: Jekyll-Hyde neurotrophins: the story of proNGF. Trends Neurosci 25: 284-286, 2002.
2. Buxser S, Puma P and Johnson G: Properties of the nerve growth factor receptor. Relationship between receptor structure and affinity. J Biol Chem 260: 1917-1926, 1985.
3. Bothwell M: Functional interactions of neurotrophins and neurotrophin receptors. Annu Rev Neurosci 18: 223-253, 1995.
4. Bibel M and Barde YA: Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev 14: 2919-2937, 2000.
5. Huang EJ and Reichardt LF: Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem 72: 609-642, 2003. (Pubitemid 36930455)
6. Rabizadeh S and Bredesen DE: Ten years on: medication of cell death by the common neurotrophin receptor p75(NTR). Cytokine Growth Factor Rev 14: 225-239, 2003. (Pubitemid 36693143)
7. Reed JC, Doctor KS and Godzik A: The domains of apoptosis: a genomics perspective. Sci STKE 239: re9, 2004.
8. Yan N and Shi Y: Mechanisms of apoptosis through structural biology. Annu Rev Cell Dev Biol 21: 35-56, 2005. (Pubitemid 41740626)
9. McEntyre JR and Gibson TJ: Patterns and clusters within the PSM column in TiBS. Trends Biochem. Sci 29: 627-633, 2004
10. Park HH, Lo YC, Lin SC, Wang L, Yang JK and Wu H: The death domain superfamily in intracellular signaling of apoptosis and inflammation. Annu Rev Immunol 25: 561-586, 2007. (Pubitemid 46697917)
11. Park HH, Logette M, Raunser S, Cuenin S, Walz T, Tschopp J, and Wu H: Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell 128: 533-546, 2007. (Pubitemid 46198901)
12. Chinnaiyan AM, O'Rourke K, Tewari M and Dixit VM: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: 505-512, 1995.
13. Stanger BZ, Leder P, Lee TH, Kim E and Seed B: RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81: 513-523, 1995.
14. Hsu H, Xiong J and Goeddel DV: The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81: 495-504, 1995.
15. Boldin MP, Varfolomeev EE, Pancer Z, Mett IL, Camonis JH and Wallach DA: A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem 270: 7795-7798, 1995.
16. Cleveland JL and Ihle JN: Contenders in FasL/TNF death signaling. Cell 81: 479-482, 1995.
17. Feinstein E, Kimchi A, Wallach D, Boldin M and Varfolomeev E The death domain: a module shared by proteins with diverse cellular functions. Trends Biochem Sci 20: 342-344, 1995.
18. Liepinsh E, Hag LL, Otting G and Ibáñez CF: NMR structure of the death domain of the p75 neurotrophin receptor. EMBO J 16: 4999-5005, 1997. (Pubitemid 27348408)
19. Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhäuser N, BöhmMatthaei R, Baeuerle PA and Barde YA: Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75. Science 272: 542-545, 1996. (Pubitemid 26138196)
20. Yang JK, Wang L, Zheng L, Wan F, Ahmed M, Lenardo MJ and Wu H: Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition. Mol Cell 20: 939-949, 2005. (Pubitemid 41814882)
21. Holm L, Kaariainen S, Rosenstrom P and Schenkel A: Searching protein structure databases with DaliLite v3. Bioinformatics 24: 2780-2781, 2008 (Pubitemid 352722625)
22. Larkin MA, Blackshields G, Brown NP et al: Clustal W and Clustal X version 2. Bioinformatics 23: 2947-2948, 2007.
23. Huang B, Eberstadt M, Olejniczak ET, Meadows RP and Fesik SW: NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain. Nature 384: 638-641, 1996. (Pubitemid 27021516)
24. Eberstadt M, Huang B, Chen Z, Meadows RP Ng S-C, Zheng L, and Fesik SW: NMR structure and mutagenesis of the FADD (Mort1) death-effector domain. Nature 392: 941-945, 1998. (Pubitemid 28232068)
25. Chou JJ, Matsuo H, Duan H and Wagner G: Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell 94: 171-180, 1998. (Pubitemid 28348005)
26. Hiller S, Kohl A, Fiorito F, Herrmann T, Wider G, Tschopp J, Grutter MG and Wuthrich K: NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. Structure 11: 1199-1205, 2003. (Pubitemid 37214882)