Enhanced permeability of charged dendrimers across tense lipid bilayer membranes

ACS Nano

Volumn 3, Issue 8, 2009, Pages 2171-2176

  Yan, Li Tang ^a   Yu, Xiaobo ^b  

^a UNIVERSITY OF BAYREUTH   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Complex; Cytotoxicity; Dendrimer; Enhanced permeability; Tense bilayer membrane

Indexed keywords

CHARGED DENDRIMERS; COMPLEX; DIRECT MEASUREMENT; DRUG MOLECULES; ENHANCED PERMEABILITY; INTRACELLULAR DELIVERY; LIPID BILAYER MEMBRANES; MESOSCOPIC SIMULATION; NANO-DEVICES; NANOSCALE COMPLEXES; PORE NUCLEATION; SINGLE CELLS; STRUCTURAL CHANGE; TENSE BILAYER MEMBRANE; WATER SOLUBILITIES;

BIOCHEMISTRY; BIOCOMPATIBILITY; CAPILLARITY; CYTOTOXICITY; DENDRIMERS; DRUG DELIVERY; FUNCTIONAL POLYMERS; LIPID BILAYERS; MEMBRANES; NANOSTRUCTURED MATERIALS; SURFACE TENSION;

CELL MEMBRANES;

DENDRIMER;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; LIPID BILAYER;

DENDRIMERS; LIPID BILAYERS; MODELS, MOLECULAR;

EID: 69549096190     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn9004236     Document Type: Article

References (23)

1. Langer, R. Drug Delivery and Targeting. Nature 1998, 392, 5-10.
2. Tomalia, D. A. Birth of a New Macromolecular Architecture: Dendrimers as Quantized Building Blocks for Nanoscale Synthetic Polymer Chemistry. Prog. Polym. Sci. 2005, 30, 294-324.
3. Leroueil, P. R.; Hong, S.; Mecke, A.; Baker, J. R.; Orr, B. G.; Banaszak Holl, M. M. Nanoparticles Interaction with Biological Membranes: Does Nanotechnology Present a Janus Face. Acc. Chem. Res. 2007, 40, 335-342.
4. Hong, S.; Leroueil, P. R.; Janus, E. K.; Peters, J. L.; Kober, M. M.; Islam, M. T.; Orr, B. G.; Baker, J. R.; Banaszak Holl, M. M. the Interaction of Polyamidoamine (PAMAM) Dendrimers with Supported Lipid Bilayers and Cells: Nanoscale Hole Formation and Enhanced Membrane Permeability. Bioconjugate Chem. 2006, 17, 728-734.
5. Landmark, K. J.; DiMaggio, S.; Ward, J.; Kelly, C.; Vogt, S.; Hong, S.; Kotlyar, A.; Myc, A.; Thomas, T. P.; Penner-Hahn, J. E.; Baker, J. R.; Banaszak Holl, M. M.; Orr, B. G. Synthesis, Characterization, and In Vitro Testing of Superparamagnetic Iron Oxide Nanoparticles Targeted Using Folic Acid-Conjugated Dendrimers. ACS Nano 2008, 2, 773-783.
6. Kuokowska-Latallo, J. F.; Bielinska, A. U.; Johnson, J.; Spindler, R.; Tomalia, D. A.; Baker, J. R. Efficient Transfer of Genetic Material into Mammalian Cells Using Starburst Polyamidoamine Dendrimers. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 4897-4902.
7. Marrink, S. J.; Mark, A. E. the Mechanism of Vesicle Fusion As Revealed by Molecular Dynamic Simulations. J. Am. Chem. Soc. 2003, 125, 11144-11145.
8. Reynwar, B. J.; Iiiya, G.; Harmandaris, V. A.; Müller, M. M.; Kremer, K.; Deserno, M. Aggregaion and Vesiculation of Membrane Proteins by Curvature-Mediated Interactions. Nature 2007, 447, 461-464.
9. 60 and Its Derivatives across a Lipid Bilayer. Nano Lett. 2007, 7, 615-619.
10. Wang, Z. J.; Frenkel, D. Pore Nucleation in Mechanically Stretched Bilayer Membranes. J. Chem. Phys. 2005, 123, 154701.
11. Lee, H.; Larson, R. G. Molecular Dynamics Simulations of PAMAM Dendrimer-Induced Pore Formation in DPPC Bilayers with a Coarse-Grained Model. J. Phys. Chem. B 2006, 110, 18204-18211.
12. Kelly, C. V.; Leroueil, P. R.; Nett, E. K.; Wereszczynski, J. M.; Baker, J. R.; Orr, B. G.; Banaszak Holl, M. M.; Andricioaei, I. Poly(amidoamine) Dendrimers on Lipid Bilayers I: Free Energy and Conformation of Binding. J. Phys. Chem. B 2008, 112, 9337-9345.
13. Groot, R. D.; Warren, P. B. Dissipative Particle Dynamics: Bridging the Gap between Atomistic and Mesoscopic Simulation. J. Chem. Phys. 1997, 107, 4423-4435.
14. Smith, K. A.; Jasnow, D.; Balazs, A. C. Designing Synthetic Vesicles That Engulf Nanoparticles. J. Chem. Phys. 2007, 127, 084703.
15. Shillcock, J. C.; Lipowsky, R. Equilibrium Structure and Lateral Stress Distribution of Amphiphilic Bilayers from Dissipative Particle Dynamics. J. Chem. Phys. 2002, 117, 5048-5061.
16. Shillcock, J. C.; Lipowsky, R. Tension-Induced Fusion of Bilayer Membranes and Vesicles. Nat. Mater. 2005, 4, 225-228.
17. Alexeev, A.; Uspal, W. E.; Balazs, A. C. Harnessing Janus Nanoparticles to Create Controllable Pores in Membranes. ACS Nano 2008, 2, 1117-1122.
18. Laradji, M.; Sunil Kumar, P. B. Dynamics of Domain Growth in Self-Assembled Fluid Vesicles. Phys. Rev. Lett. 2004, 93, 198105.
19. Tieleman, D. P.; Leontiadou, H.; Mark, A. E.; Marrink, S. J. Simulation of Pore Formation in Lipid Bilayers by Mechanical Stress and Electrical Fields. J. Am. Chem. Soc. 2003, 125, 6382-6383.
20. ka Profile Calculation for a Lipid Membrane-Exposed Arginine Side Chain. J. Phys. Chem. B 2008, 112, 9574-9587.
21. Groot, R. D. Electrostatic Interactions in Dissipative Particle Dynamics Simulation of Polyelectrolytes and Anionic Surfactants. J. Chem. Phys. 2003, 115, 11265-11277.
22. Vattulainen, I.; Karttunen, M.; Besold, G.; Polson, J. M. Integration Schemes for Dissipative Particle Dynamics Simulations: From Softly Interacting Systems towards Hybrid Models. J. Chem. Phys. 2002, 116, 3967-3979.
23. Huang, H. W.; Chen, F.-Y.; Lee, M.-T. Molecular Mechanism of Peptide-Induced Pores in Membranes. Phys. Rev. Lett. 2004, 92, 198304.