Propranolol adrenergic blockade inhibits human brain endothelial cells tubulogenesis and matrix metalloproteinase-9 secretion

Pharmacological Research

Volumn 60, Issue 5, 2009, Pages 438-445

  Annabi, Borhane ^a   Lachambre, Marie Paule ^b   Plouffe, Karine ^b   Moumdjian, Robert ^c   Béliveau, Richard ^b  

^a Centre de Recherche BioMED   (Canada)

^b UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^c Surgery Department   (Canada)

Author keywords

Adrenergic receptors; Angiogenesis; Brain endothelial cells; HuR; MMP 9

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; GELATINASE A; GELATINASE B; MATRIGEL; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PROPRANOLOL;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL CELL; ARTICLE; BRAIN BLOOD VESSEL; BRAIN CELL; CELL MIGRATION; CELL NUCLEUS; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; DRUG TARGETING; ENDOTHELIUM CELL; ENZYME RELEASE; FEMALE; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; TUMOR BIOPSY; TUMOR VASCULARIZATION; VASCULAR ENDOTHELIUM; ZYMOGRAPHY;

ADRENERGIC BETA-ANTAGONISTS; ANGIOGENESIS INHIBITORS; ANIMALS; BRAIN; BRAIN NEOPLASMS; CELL LINE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; MATRIX METALLOPROTEINASE 9; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; PROPRANOLOL; RECEPTORS, ADRENERGIC, BETA;

EID: 69549088156     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.05.005     Document Type: Article

References (50)

1. Lakka S.S., Gondi C.S., and Rao J.S. Proteases and glioma angiogenesis. Brain Pathol 15 (2005) 327-341
2. Annabi B., Rojas-Sutterlin S., Laroche M., Lachambre M.P., Moumdjian R., and Béliveau R. The diet-derived sulforaphane inhibits matrix metalloproteinase-9-activated human brain microvascular endothelial cell migration and tubulogenesis. Mol Nutr Food Res 52 (2008) 692-700
3. Roomi M.W., Monterrey J.C., Kalinovsky T., Rath M., and Niedzwiecki A. Distinct patterns of matrix metalloproteinase-2 and -9 expression in normal human cell lines. Oncol Rep 21 (2009) 821-826
4. Jadhav U., Chigurupati S., Lakka S.S., and Mohanam S. Inhibition of matrix metalloproteinase-9 reduces in vitro invasion and angiogenesis in human microvascular endothelial cells. Int J Oncol 25 (2004) 1407-1414
5. Kleinman M.E., Greives M.R., Churgin S.S., Blechman K.M., Chang E.I., Ceradini D.J., et al. Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma. Arterioscler Thromb Vasc Biol 27 (2007) 2664-2670
6. Léauté-Labrèze C., Dumas de la Roque E., Hubiche T., Boralevi F., Thambo J.B., and Taïeb A. Propranolol for severe hemangiomas of infancy. N Engl J Med 358 (2008) 2649-2651
7. Siegfried E.C., Keenan W.J., and Al-Jureidini S. More on propranolol for hemangiomas of infancy. N Engl J Med 359 (2008) 359-2846 [author reply, 2846-2847]
8. Bauland C.G., van Steensel M.A., Steijlen P.M., Rieu P.N., and Spauwen P.H. The pathogenesis of hemangiomas: a review. Plast Reconstr Surg 117 (2006) 29e-35e
9. Ohara Y., McCarron R.M., Hoffman T.T., Sugano H., Bembry J., Lenz F.A., et al. Adrenergic mediation of TNF alpha-stimulated ICAM-1 expression on human brain microvascular endothelial cells. Acta Neurochir Suppl 76 (2000) 117-120
10. Hetzel M., Walcher D., Grüb M., Bach H., Hombach V., and Marx N. Inhibition of MMP-9 expression by PPARgamma activators in human bronchial epithelial cells. Thorax 58 (2003) 778-783
11. Annabi B., Rojas-Sutterlin S., Laflamme C., Lachambre M.P., Rolland Y., Sartelet H., et al. Tumor environment dictates medulloblastoma cancer stem cell expression and invasive phenotype. Mol Cancer Res 6 (2008) 907-916
12. Annabi B, Lachambre MP, Plouffe K, Sartelet H, Béliveau R. Modulation of invasive properties of CD133(+) glioblastoma stem cells: a role for MT1-MMP in bioactive lysophospholipid signaling. Mol Carcinog; in press.
13. Stins M.F., Gilles F., and Kim K.S. Selective expression of adhesion molecules on human brain microvascular endothelial cells. J Neuroimmunol 76 (1997) 81-90
14. Greiffenberg L., Goebel W., Kim K.S., Weiglein I., Bubert A., Engelbrecht F., et al. Interaction of Listeria monocytogenes with human brain microvascular endothelial cells: InlB-dependent invasion, long-term intracellular growth, and spread from macrophages to endothelial cells. Infect Immun 66 (1998) 5260-5267
15. Annabi B., Currie J.C., Moghrabi A., and Béliveau R. Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg. Leuk Res 31 (2007) 1277-1284
16. McLaughlin N., Annabi B., Sik Kim K., Bahary J.P., Moumdjian R., and Béliveau R. The response to brain tumor-derived growth factors is altered in radioresistant human brain endothelial cells. Cancer Biol Ther 5 (2006) 1539-1545
17. Lamy S., Gingras D., and Béliveau R. Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. Cancer Res 62 (2002) 381-385
18. Sina A., Lord-Dufour S., and Annabi B. Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation. Cancer Lett 279 (2009) 171-176
19. Fortier S., Touaibia M., Lord-Dufour S., Galipeau J., Roy R., and Annabi B. Tetra- and hexavalent mannosides inhibit the pro-apoptotic, antiproliferative and cell surface clustering effects of concanavalin-A: impact on MT1-MMP functions in marrow-derived mesenchymal stromal cells. Glycobiology 18 (2008) 195-204
20. Annabi B., Pilorget A., Bousquet-Gagnon N., Gingras D., and Béliveau R. Calmodulin inhibitors trigger the proteolytic processing of membrane type-1 matrix metalloproteinase, but not its shedding in glioblastoma cells. Biochem J 359 (2001) 325-333
21. Shigemori Y., Katayama Y., Mori T., Maeda T., and Kawamata T. Matrix metalloproteinase-9 is associated with blood-brain barrier opening and brain edema formation after cortical contusion in rats. Acta Neurochir Suppl 96 (2006) 130-133
22. Abécassis I., Olofsson B., Schmid M., Zalcman G., and Karniguian A. RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion. Exp Cell Res 291 (2003) 363-376
23. Handsley M.M., and Edwards D.R. Metalloproteinases and their inhibitors in tumor angiogenesis. Int J Cancer 115 (2005) 849-860
24. Noël A., Jost M., and Maquoi E. Matrix metalloproteinases at cancer tumor-host interface. Semin Cell Dev Biol 19 (2008) 52-60
25. Akool el-S, Kleinert H., Hamada F.M., Abdelwahab M.H., Förstermann U., Pfeilschifter J., et al. Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR. Mol Cell Biol 23 (2003) 4901-4916
26. Audic Y., and Hartley R.S. Post-transcriptional regulation in cancer. Biol Cell 96 (2004) 479-498
27. Emilien G., and Maloteaux J.M. Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol 53 (1998) 389-404
28. Benish M., Bartal I., Goldfarb Y., Levi B., Avraham R., Raz A., et al. Perioperative use of beta-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis. Ann Surg Oncol 15 (2008) 2042-2052
29. Park P.G., Merryman J., Orloff M., and Schuller H.M. Beta-adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: implications for individuals with preexisting chronic lung disease. Cancer Res 55 (1995) 3504-3508
30. Yang E.V., Sood A.K., Chen M., Li Y., Eubank T.D., Marsh C.B., et al. Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res 66 (2006) 10357-10364
31. Al-Wadei HA, Al-Wadei MH, Schuller HM. Prevention of pancreatic cancer by the beta-blocker propranolol. Anticancer Drugs; in press.
32. Palm D., Lang K., Niggemann B., Drell IV T.L., Masur K., Zaenker K.S., et al. The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers. Int J Cancer 118 (2006) 2744-2749
33. Ahn G.O., and Brown J.M. Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells. Cancer Cell 13 (2008) 193-205
34. Leenders W.P., Küsters B., and de Waal R.M. Vessel co-option: how tumors obtain blood supply in the absence of sprouting angiogenesis. Endothelium 9 (2002) 83-87
35. Reardon D.A., and Wen P.Y. Therapeutic advances in the treatment of glioblastoma: rationale and potential role of targeted agents. Oncologist 11 (2006) 152-164
36. Simpson L., and Galanis E. Recurrent glioblastoma multiforme: advances in treatment and promising drug candidates. Expert Rev Anticancer Ther 6 (2006) 1593-1607
37. Schuuring J., Bussink J., Bernsen H.J., Peeters W., and van Der Kogel A.J. Irradiation combined with SU5416: microvascular changes and growth delay in a human xenograft glioblastoma tumor line. Int J Radiat Oncol Biol Phys 61 (2005) 529-534
38. Stupp R., and Weber D.C. The role of radio- and chemotherapy in glioblastoma. Onkologie 28 (2005) 315-317
39. Demeule M., Régina A., Annabi B., Bertrand Y., Bojanowski M.W., and Béliveau R. Brain endothelial cells as pharmacological targets in brain tumors. Mol Neurobiol 30 (2004) 157-183
40. McLaughlin N., Annabi B., Lachambre M.P., Kim K.S., Bahary J.P., Moumdjian R., et al. Combined low dose ionizing radiation and green tea-derived epigallocatechin-3-gallate treatment induces human brain endothelial cells death. J Neurooncol 80 (2006) 111-121
41. Bian C., Zhao K., Tong G.X., Zhu Y.L., and Chen P. Immortalization of human umbilical vein endothelial cells with telomerase reverse transcriptase and simian virus 40 large T antigen. J Zhejiang Univ Sci B 6 (2005) 631-636
42. Yuan H., Gaber M.W., Boyd K., Wilson C.M., Kiani M.F., and Merchant T.E. Effects of fractionated radiation on the brain vasculature in a murine model: blood-brain barrier permeability, astrocyte proliferation, and ultrastructural changes. Int J Radiat Oncol Biol Phys 66 (2006) 860-866
43. López de Silanes I., Fan J., Galbán C.J., Spencer R.G., Becker K.G., and Gorospe M. Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity. Gene Expr 12 (2004) 49-59
44. Levy A.P. Hypoxic regulation of VEGF mRNA stability by RNA-binding proteins. Trends Cardiovasc Med 8 (1998) 246-250
45. Sheflin L.G., Zou A.P., and Spaulding S.W. Androgens regulate the binding of endogenous HuR to the AU-rich 3′UTRs of HIF-1alpha and EGF mRNA. Biochem Biophys Res Commun 322 (2004) 644-651
46. Masur K., Niggemann B., Zanker K.S., and Entschladen F. Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers. Cancer Res 61 (2001) 2866-2869
47. Sood A.K., Bhatty R., Kamat A.A., Landen C.N., Han L., Thaker P.H., et al. Stress hormone-mediated invasion of ovarian cancer cells. Clin Cancer Res 12 (2006) 369-375
48. Sokołowska P., and Nowak J.Z. Constitutive activity of beta-adrenergic receptors in C6 glioma cells. Pharmacol Rep 57 (2005) 659-663
49. Bai Y., Lu H., and Machida C.A. CRM 1-mediated degradation and agonist-induced down-regulation of beta-adrenergic receptor mRNAs. Biochim Biophys Acta 1763 (2006) 1076-1089
50. Blaxall B.C., Pellett A.C., Wu S.C., Pende A., and Port J.D. Purification and characterization of beta-adrenergic receptor mRNA-binding proteins. J Biol Chem 275 (2000) 4290-4297