Effect of expressional alteration of KAI1 on breast cancer cell growth, adhesion, migration and invasion

Cancer Genomics and Proteomics

Volumn 6, Issue 4, 2009, Pages 205-213

  Malik, Faraz Arshad ^a,b   Sanders, Andrew J ^a   Kayani, Mahmood A ^b   Jiang, Wen G ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^b Department of Electrical Computer Engineering   (Pakistan)

Author keywords

Breast cancer; CD82; Cell migration; Invasion; Kai 1

Indexed keywords

CD82 ANTIGEN;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL MOTILITY; COMPARATIVE STUDY; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; TRANSGENE;

EID: 69549086639     PISSN: 11096535     EISSN: 17906245     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Freije JMP, MacDonald N and Steeg PS: Nm23 and tumour metastasis: Basic and translational advances. Biochemal Society Symposium 63: 261-271, 1988.
2. Ichikawa T, Ichikawa Y and Isaacs JT: Genetic factors and suppression of metastatic ability of prostatic cancer. Cancer Res. 51: 3788-3792, 1991.
3. Dong J-T, Lamb PW, Rinker-Schaeffer CW, Vukanovic J, Ichikawa T, Isaacs JT and Barrett JC: KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 268: 884-886, 1995.
4. Todeschini AR, Dos Santos JN, Handa K and Hakomori SI: Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway. Jr. Proc Natl Acad Sci 105: 1925-1930, 2008.
5. Miyazaki T, Kato H, Shitara Y, Yoshikawa M, Tajima K, Masuda N, Shouji H, Tsukada K, Nakajima T and Kuwano H: Mutation and expression of the metastasis suppressor gene KAI1 in esophageal squamous cell carcinoma. Cancer 189: 955-962. 2000. (Pubitemid 30664075)
6. Malik FA, Kayani MA, Iqbal, Jiang WG and Sadiq I: Screening of coding region of metastasis suppressor genes KISS1 and KAI1 for germ line mutations in breast cancer patients. Gene Ther Mol Biol Vol12: 239-246, 2008.
7. Mashimo T, Watabe M, Hirota S, Hosobe S, Miura K, Tegtmeyer PJ, Rinker-Shaeffer CW and Watabe K: The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53. Proc Nat Acad Sci 95: 11307-11311, 1998. (Pubitemid 28450124)
8. Briese J, Schulte HM, Sajin M, Bamberger C, Redlin K, Milde-Langosch K, Löning T and Bamberger A-M: Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas. Virchows Archiv 453: 89-96, 2008.
9. Marreiros A, Czolij R, Yardley G, Crossley M and Jackson P: Identification of regulatory regions within the KAI1 promoter: a role for binding of API, AP2 and p53. Gene 302: 155-164, 2003. (Pubitemid 36078407)
10. Kim JH, Kim B, Cai L, Choi HJ, Ohgi KA, Tran C, Chen C, Chung CH, Huber O, Rose DW, Sawyers C L, Rosenfeld M G and Baek S H: Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature 434: 921-926, 2005. (Pubitemid 40559007)
11. Son BH, Choi JS and Lee JH: Prognostic values of KAI1 and survivin expression in an infiltrating ductal carcinoma of the breast. Pathology 37: 131-136, 2005. (Pubitemid 40593404)
12. Stark AM, Tongers K, Maass N, Mehdorn HM and Held-Feindt J: Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. J Cancer Res Clin Oncology 131: 191-198, 2005. (Pubitemid 40175014)
13. Malik FA, Sanders AJ, Jones AD, Mansel RE and Jiang WG: Transcriptional and translational modulation of KAI1 expression in ductal carcinoma of the breast and the prognostic significance. Int J Mol Med 23: 273-278, 2009.
14. Jiang WG, Grimshaw D, Leterra J, Abounader R, Lane J and Mansel RE: Supression of invasiveness and cellular motility of breast cancer cells by a hammerhead ribozyme encoding cMET antisense. Clin Cancer Res 7: 2555-2562, 2001.
15. Jiang WG, Martin TA, Lewis-Russell JM, Douglas-Jones A, Ye L and Mansel RE: Eplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome. Mol Cancer 7: 71, 2008.
16. Parr C, Sanders AJ, Davies G, Martin TA, Lane J, Mason MD, Mansel RE and Jiang WG: Matriptase-2 inhibits breast tumour growth in vivo, suppresses breast cancer cell invasion and migration in vitro, and is associated with good prognosis in breast cancer patients. Clin Cancer Res 15: 3568-3576, 2007.
17. Sanders AJ, Parr C, Mason MD and Jiang WG: Suppression of hepatocyte growth factor activator inhibitor-1 leads to a more aggressive phenotype of prostate cancer cells in vitro. Int J Mol Med 20: 613-619, 2007.
18. Ye L, Kynaston H and Jiang WG: Bone morphogenetic protein-9 induces apoptosis in prostate cancer cells, the role of prostate apoptosis response-4. Mol Cancer Res 6: 1594-1606, 2008.
19. Jiang WG, Redfern A, Bryce RP, Horrobin DF and Mansel RE: Peroxisome proliferator activated receptor-gamma (PPAR-gamma) mediates the action of gamma linolenic acid in breast cancer cells. Prostaglandin Leuk Ess Fatty Acid 62: 119-129, 2000. (Pubitemid 30216391)
20. Jiang WG, Hiscox S, Horrobin DF, Bryce RP and Mansel RE: Gamma linolenic acid regulates expression of maspin and the motility of cancer cells Biochem Biophys Res Commun 237: 639-644, 1997.
21. Jiang WG, Hiscox SE, Parr C, Martin TA, Matsumoto K, Nakamura T and Mansel RE: Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells. Clin Cancer Res 5: 3695-3703, 1999.
22. Hemler ME: Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol 6: 801-811, 2005.
23. He B, Liu L, Cook GA, Grgurevich S, Jennings LK and Zhang XA: Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin α6-mediated cell adhesion. J Biol Chem 280: 3346-3354, 2005. (Pubitemid 40223797)
24. Zijlstra A and Quigley JP: The DARC side of metastasis: Shining a light on KAI1-mediated metastasis suppression in the vascular tunnel. Cancer Cell 10: 177-178, 2006. (Pubitemid 44311069)
25. Odintsova E, Voortman J, Gilbert E and Berditchevski F: Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR. J Cell Sci 116: 4557-4566, 2003. (Pubitemid 37461610)
26. Cannon KS and Cresswell P: Quality control of transmembrane domain assembly in the tetraspanin CD82. EMBO J 20: 2443-2453, 2001.
27. Jee BK, Lee JY, Lim Y, Lee KH and Jo YH: Effect of KAI1/CD82 on the β1 integrin matuaration in highly migratory carcinoma cells. Biochem Biophys Res Commun 359: 703-708, 2007. (Pubitemid 46899009)
28. Jiang WG, Puntis MCA and Hallett MB. The molecular and cellular basis of cancer invasion and metastasis and its implications for treatment. Br J Surg 81: 1576-1590, 1994. (Pubitemid 24349926)
29. Parr C, Davies G, Nakamura T, Matsumoto K, Mason MD and Jiang WG: The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variant. Biochem Biophys Res Commun 276: 25005-25013, 2001. (Pubitemid 32912929)
30. Zhang XA, Bontrager AL and Hemler ME: Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific βl integrins. J Biol Chem 276: 25005-25013, 2001. (Pubitemid 37412976)
31. Abe M, Sugiura T, Takahashi M, Ishii K, Shimoda M and Shirasuna K: A novel function of CD82/KAI-1 on E-cadherin-mediated homophilic cellular adhesion of cancer cells. Cancer Lett 8: 163-170, 2008.
32. Liu L, Wu DH, Li ZG, Yang GZ and Ding YQ: Effects of KAI1/CD82 on biological behavior of human colorectal carcinoma cell line. World J Gastroenterol 9: 1231-1236, 2003. (Pubitemid 36805658)
33. Giancotti FG and Mainiero F: Integrin-mediated adhesion and signalling in tumorigenesis. Biochim Biophys Acta 27: 47-64, 1994.
34. Shibagaki N, Hanada K, Yamashita H, Shimada S and Hamada H: Overexpression of CD82 on human T cells enhances LFA-1/ICAM-1-mediated cell-cell adhesion: functional association between CD82 and LFA-1 in T-cell activation. Eur J Immunol 29: 4081-4091, 1999.
35. Clark KL, Oelke A, Johnson ME, Eilert KD, Simpson PC and Todd SC: CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent Manner. J Biol Chem 279: 19401-19406, 2004. (Pubitemid 38623373)
36. Bandyopadhyay S, Pai SK, Gross SC, Hirota S, Hosobe S, Miura K, Saito K, Commes T, Hayashi S, Watabe M and Watabe K: The Drg-1 gene suppresses tumor metastasis in prostate cancer. Cancer Res 63: 1731-1736, 2003. (Pubitemid 36460828)
37. Bandyopadhyay S, Pai SK, Hirota S, Hosobe S, Takano Y, Saito K, Piquemal D, Commes T, Watabe M, Gross SC, Wang Y, Ran S and Watabe K: Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression. Oncogene 25: 5675-5681, 2004. (Pubitemid 39093045)
38. Jiang WG, Lloyds D, Puntis MC, Nakamura T and Hallett MB: Regulation of spreading and growth of colon cancer cells by hepatocyte growth factor. Clin Exp Metastasis 11: 235-242, 1993. (Pubitemid 23138522)
39. Liu ML, Mars WM and Michalopoulos GK: Hepatocyte growth factor inhibits cell proliferation in vivo of rat hepatocellular carcinomas induced by diethylnitrosamine. Carcinogenesis 16: 841-843, 1995.
40. Jiang WG, Martin TA, Parr C, Davies G, Matsumoto K and Nakamura T: Hepatocyte growth factor, its receptor, and their potential value in cancer therapies. Crit Rev Oncol Hematol 53: 35-69, 2005. (Pubitemid 39656109)