The link between structural damage and pain in a genetic model of osteoarthritis and intervertebral disc degeneration: A joint misadventure

Arthritis and Rheumatism

Volumn 60, Issue 9, 2009, Pages 2550-2552

  Goldring, Mary B ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; BIGLYCAN; CALCITONIN GENE RELATED PEPTIDE; CELL SURFACE RECEPTOR; COLLAGEN FIBRIL; COLLAGEN TYPE 11; COLLAGEN TYPE 2; COLLAGEN TYPE 9; COLLAGENASE; COLLAGENASE 3; DISCOIDIN; FIBROMODULIN; MATRILIN 3; MESSENGER RNA; NEUROPEPTIDE Y; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

ACTION POTENTIAL; ARTHRALGIA; BONE DYSPLASIA; CARTILAGE CELL; CARTILAGE DEGENERATION; CHONDRODYSPLASIA; EDITORIAL; EXPERIMENTAL MOUSE; EXTRACELLULAR MATRIX; GENE MUTATION; GENETIC LINKAGE; GENETIC MODEL; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; INTERVERTEBRAL DISK DEGENERATION; JOINT INJURY; JOINT INSTABILITY; KNEE OSTEOARTHRITIS; MECHANICAL STIMULATION; NOCICEPTION; NOCICEPTIVE RECEPTOR; NONHUMAN; OSTEOARTHRITIS; POSTMENOPAUSE; PRIORITY JOURNAL; SENSORY NERVE CONDUCTION; SPORT INJURY; STICKLER SYNDROME; SYMPTOMATOLOGY;

ANIMALS; ARTHRALGIA; COLLAGEN TYPE IX; DISEASE MODELS, ANIMAL; INTERVERTEBRAL DISK; MICE; MICE, KNOCKOUT; MODELS, GENETIC; OSTEOARTHRITIS;

EID: 69449087193     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24771     Document Type: Editorial

References (16)

1. Glasson SS, Blanchet TJ, Morris EA. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage 2007;15:1061-1069
2. Kamekura S, Kawasaki Y, Hoshi K, Shimoaka T, Chikuda H, Maruyama Z, et al. Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum 2006;54:2462-2470 (Pubitemid 44205006)
3. Valdes AM, Loughlin J, Oene MV, Chapman K, Surdulescu GL, Doherty M, et al. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis Rheum 2007;56:137-146 (Pubitemid 46106186)
4. Allen KD, Griffin TM, Rodriguiz RM, Wetsel WC, Kraus VB, Huebner JL, et al. Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen. Arthritis Rheum 2009;60:2684-2693
5. Ameye LG, Young MF. Animal models of osteoarthritis: lessons learned while seeking the "Holy Grail". Curr Opin Rheumatol 2006;18:537-547
6. Li Y, Xu L, Olsen BR. Lessons from genetic forms of osteoarthritis for the pathogenesis of the disease. Osteoarthritis Cartilage 2007;15:1101-1105 (Pubitemid 47387056)
7. Kannu P, Bateman JF, Belluoccio D, Fosang AJ, Savarirayan R. Employing molecular genetics of chondrodysplasias to inform the study of osteoarthritis. Arthritis Rheum 2009;60:325-334
8. Millward-Sadler SJ, Salter DM. Integrin-dependent signal cascades in chondrocyte mechanotransduction. Ann Biomed Eng 2004;32:435-446
9. Hu K, Xu L, Cao L, Flahiff CM, Brussiau J, Ho K, et al. Pathogenesis of osteoarthritis-like changes in the joints of mice deficient in type IX collagen. Arthritis Rheum 2006;54:2891-2900 (Pubitemid 44497768)
10. Xu L, Peng H, Wu D, Hu K, Goldring MB, Olsen BR, et al. Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice. J Biol Chem 2005;280:548-555 (Pubitemid 40165020)
11. Xu L, Peng H, Glasson S, Lee PL, Hu K, Ijiri K, et al. Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis. Arthritis Rheum 2007;56:2663-2673 (Pubitemid 47237284)
12. McDougall JJ. Arthritis and pain: neurogenic origin of joint pain. Arthritis Res Ther 2006;8:220.
13. Schaible HG, Ebersberger A, Von Banchet GS. Mechanisms of pain in arthritis. Ann N Y Acad Sci 2002;966:343-354
14. Schuelert N, McDougall JJ. Electrophysiological evidence that the vasoactive intestinal peptide receptor antagonist VIP6-28 reduces nociception in an animal model of osteoarthritis. Osteoarthritis Cartilage 2006;14:1155-1162 (Pubitemid 44490312)
15. Ma HL, Blanchet TJ, Peluso D, Hopkins B, Morris EA, Glasson SS. Osteoarthritis severity is sex dependent in a surgical mouse model. Osteoarthritis Cartilage 2007;15:695-700. (Pubitemid 46760614)
16. Wang CJ, Iida K, Egusa H, Hokugo A, Jewett A, Nishimura I. Trabecular bone deterioration in col9a1+/- mice associated with enlarged osteoclasts adhered to collagen IX-deficient bone. J Bone Miner Res 2008;23:837-849 (Pubitemid 351768802)