Adenoviral infection or deferoxamine? Two approaches to overexpress VEGF in β-cell lines

Journal of Drug Targeting

Volumn 17, Issue 6, 2009, Pages 415-422

  Langlois, Allan ^a   Bietiger, William ^a   Sencier, Marie Christine ^a   Maillard, Elisa ^a   Pinget, Michel ^a   Kessler, Laurence ^a   Sigrist, Severine ^a  

^a University of Strasbourg   (France)

Author keywords

cells; Adenovirus; Angiogenesis; Apoptosis; Deferoxamine; Gene therapy; HIF 1 ; Hypoxia; Insulin; VEGF

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; DEFEROXAMINE; PROTEIN BAX; PROTEIN BCL 2; VASCULOTROPIN; VASCULOTROPIN 165; VASCULOTROPIN A;

ADENOVIRUS INFECTION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE THERAPY; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ADENOVIRUS; ANGIOGENESIS; ANIMAL; CELL SURVIVAL; COMPARATIVE STUDY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; HUMAN; INSULINOMA; METABOLISM; METHODOLOGY; PANCREAS ISLET TRANSPLANTATION; PANCREAS TUMOR; TUMOR CELL LINE;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DEFEROXAMINE; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC VECTORS; HUMANS; INSULINOMA; ISLETS OF LANGERHANS TRANSPLANTATION; NEOVASCULARIZATION, PHYSIOLOGIC; PANCREATIC NEOPLASMS; RATS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 69449086705     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860902929832     Document Type: Article

References (40)

1. Agani F, Semenza GL. (1998). Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia- inducible factor 1 activity. Mol Pharmacol, 54, 749-754.
2. Andersson A, Korsgren O, Jansson L. (1989). Intraportally transplanted pancreatic islets revascularized from hepatic arterial system. Diabetes, 1, 192-195.
3. Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 72, 248-254.
4. Brissova M, Shostak A, Shiota M, Wiebe PO, Poffenberger G, Kantz J, Chen Z, Carr C, Jerome WG, Chen J, Baldwin HS, Nicholson W, Bader DM, Jetton T, Gannon M, Powers AC. (2006). Pancreatic islet production of vascular endothelial growth factor-A is essential for islet vascularization, revascularization, and function. Diabetes, 55, 2974-2985.
5. Carlsson PO, Liss P, Andersson A, Jansson L. (1998). Measurements of oxygen tension in native and transplanted rat pancreatic islets. Diabetes, 47, 1027-1032.
6. Cheng K, Fraga D, Zhang C, Kotb M, Gaber AO, Guntaka RV, Mahato RI. (2004). Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets. Gene Ther, 11, 1105-1116. (Pubitemid 39117306)
7. Cheng Y, Liu YF, Zhang JL, Li TM, Zhao N. (2007). Elevation of vascular endothelial growth factor production and its effect on revascularization and function of graft islets in diabetic rats. World J Gastroenterol, 13, 2862-2866.
8. Chenoufi N, Baffet G, Drénou B, Cariou S, Desille M, Clément B, Brissot P, Lescoat G, Loréal O. (1998). Deferoxamine arrests in vitro the proliferation of porcine hepatocyte in G1 phase of the cell cycle. Liver, 18, 60-66.
9. Csete ME, Benhamou PY, Drazan KE, Wu L, McIntee DF, Afra R, Mullen Y, Busuttil RW, Shaked A. (1995). Efficient gene transfer to pancreatic islets mediated by adenoviral vectors. Transplantation, 59, 263-268.
10. Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GC. (1996). Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes, 45, 1161-1167.
11. Fernández-Real JM, López-Bermejo A, Ricart W. (2002). Cross-talk between iron metabolism and diabetes. Diabetes, 51, 2348-2354. [Review]
12. Ferrara N. (2000). Vascular endothelial growth factor and the regulation of angiogenesis. Recent Prog Horm Res, 55, 15-35; discussion 35-36.
13. Gorden DL, Mandriota SJ, Montesano R, Orci L, Pepper MS. (1997). Vascular endothelial growth factor is increased in devascularized rat islets of Langerhans in vitro. Transplantation, 63, 436-443.
14. Guillygomarc'h A, Mendler MH, Moirand R, Lainé; F, Quentin V, David V, Brissot P, Deugnier Y. (2001). Venesection therapy of insulin resistance-associated hepatic iron overload. J Hepatol, 35, 344-349.
15. Kessler L, Bucher P, Milliat-Guittard L, Benhamou PY, Berney T, Penfornis A, Badet L, Thivolet C, Bayle F, Oberholzer J, Renoult E, Brun MJ, Rifle G, Atlan C, Colin C, Morel P; GRAGIL Group. (2004). Influence of islet transportation on pancreatic islet allotransplantation in type 1 diabetic patients within the Swiss-French GRAGIL network. Transplantation, 77, 1301-1304.
16. Kuroda M, Oka T, Oka Y, Yamochi T, Ohtsubo K, Mori S, Watanabe T, Machinami R, Ohnishi S. (1995). Colocalization of vascular endothelial growth factor (vascular permeability factor) and insulin in pancreatic islet cells. J Clin Endocrinol Metab, 80, 3196-3200.
17. Lai Y, Schneider D, Kidszun A, Hauck-Schmalenberger I, Breier G, Brandhorst D, Brandhorst H, Iken M, Brendel MD, Bretzel RG, Linn T. (2005). Vascular endothelial growth factor increases functional beta-cell mass by improvement of angiogenesis of isolated human and murine pancreatic islets. Transplantation, 79, 1530-1536.
18. Le CT, Hollaar L, Van der Valk EJ, Van der Laarse A. (1994). Desferrioxamine protects myocytes against peroxide-induced myocyte damage without affecting glutathione redox cycle turnover. J Mol Cell Cardiol, 26, 877-887.
19. Markel TA, Crisostomo PR, Wang M, Herring CM, Meldrum KK, Lillemoe KD, Meldrum DR. (2007). The struggle for iron: gastrointestinal microbes modulate the host immune response during infection. J Leukoc Biol, 81, 393-400.
20. Mattsson G. (2005). The endothelial cells in islets of langerhans. Ups J Med Sci, 110, 1-15.
21. Mendola J, Wright JR Jr, Lacy PE. (1989). Oxygen free-radical scavengers and immune destruction of murine islets in allograft rejection and multiple low-dose streptozocin-induced insulitis. Diabetes, 38, 379-385.
22. Messaris E, Antonakis PT, Memos N, Chatzigianni E, Leandros E, Konstadoulakis MM. (2004). Deferoxamine administration in septic animals: improved survival and altered apoptotic gene expression. Int Immunopharmacol, 4, 455-459.
23. Narang AS, Mahato RI. (2006). Biological and biomaterial approaches for improved islet transplantation. Pharmacol Rev, 58, 194-243.
24. Narang AS, Sabek O, Gaber AO, Mahato RI. (2006). Co-expression of vascular endothelial growth factor and interleukin-1 receptor antagonist improves human islet survival and function. Pharm Res, 23, 1970-1982.
25. Olejnicka BT, Ollinger K, Brunk UT. (1997). A short exposure to a high-glucose milieu stabilizes the acidic vacuolar apparatus of insulinoma cells in culture to ensuing oxidative stress. APMIS, 105, 689-698.
26. Olejnicka BT, Andersson A, Tyrberg B, Dalen H, Brunk UT. (1999). Beta-cells, oxidative stress, lysosomal stability, and apoptotic/ necrotic cell death. Antioxid Redox Signal, 1, 305-315.
27. Rogers SA, Chen F, Talcott M, Hammerman MR. (2004). Islet cell engraftment and control of diabetes in rats after transplantation of pig pancreatic anlagen. Am J Physiol Endocrinol Metab, 286, E502-E509.
28. Ryan EA, Paty BW, Senior PA, Bigam D, Alfadhli E, Kneteman NM, Lakey JR, Shapiro AM. (2005). Five-year follow-up after clinical islet transplantation. Diabetes, 54, 2060-2069. (Pubitemid 40911269)
29. Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems JA, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DE, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JR. (2006). International trial of the Edmonton protocol for islet transplantation. N Engl J Med, 355, 1318-1330.
30. Sigalla J, David A, Anegon I, Fiche M, Huvelin JM, Boeffard F, Cassard A, Soulillou JP, Le Mauff B. (1997). Adenovirus-mediated gene transfer into isolated mouse adult pancreatic islets: normal beta-cell function despite induction of an anti-adenovirus immune response. Hum Gene Ther, 8, 1625-1634.
31. Sigrist S, Mechine-Neuville A, Mandes K, Calenda V, Braun S, Legeay G, Bellocq JP, Pinget M, Kessler L. (2003a). Influence of VEGF on the viability of encapsulated pancreatic rat islets after transplantation in diabetic mice. Cell Transplant, 12, 627-635.
32. Sigrist S, Mechine-Neuville A, Mandes K, Calenda V, Legeay G, Bellocq JP, Pinget M, Kessler L. (2003b). Induction of angiogenesis in omentum with vascular endothelial growth factor: influence on the viability of encapsulated rat pancreatic islets during transplantation. J Vasc Res, 40, 359-367.
33. Sigrist S, Langlois A, Mandes K, Kessler L, Pinget M. Optimisation of VEGF overexpression into pancreatic Rat islets due to an in vivo transduction method. Unpublished data.
34. Stagner JI, Samols E. (1990). The induction of capillary bed development by endothelial cell growth factor before islet transplantation may prevent islet ischemia. Transplant Proc, 22, 824-828.
35. Vasir B, Aiello LP, Yoon KH, Quickel RR, Bonner-Weir S, Weir GC. (1998). Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells. Diabetes, 47, 1894-1903.
36. Vasir B, Reitz P, Xu G, Sharma A, Bonner-Weir S, Weir GC. (2000). Effects of diabetes and hypoxia on gene markers of angiogenesis (HGF, cMET, uPA and uPAR, TGF-alpha, TGF-beta, bFGF and Vimentin) in cultured and transplanted rat islets. Diabetologia, 43, 763-772.
37. Vasir B, Jonas JC, Steil GM, Hollister-Lock J, Hasenkamp W, Sharma A, Bonner-Weir S, Weir GC. (2001). Gene expression of VEGF and its receptors Flk-1/KDR and Flt-1 in cultured and transplanted rat islets. Transplantation, 71, 924-935.
38. Xiao YF, Wu DD, Liu SX, Chen X, Ren LF. (2007). Effect of arsenic trioxide on vascular endothelial cell proliferation and expression of vascular endothelial growth factor receptors Flt-1 and KDR in gastric cancer in nude mice. World J Gastroenterol, 13, 6498-6505.
39. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. (2000). Vascular-specific growth factors and blood vessel formation. Nature, 407, 242-248.
40. Zhang N, Richter A, Suriawinata J, Harbaran S, Altomonte J, Cong L, Zhang H, Song K, Meseck M, Bromberg J, Dong H. (2004). Elevated vascular endothelial growth factor production in islets improves islet graft vascularization. Diabetes, 53, 963-970.