In vivo genotoxicity of EMS: Statistical assessment of the dose response curves

Toxicology Letters

Volumn 190, Issue 3, 2009, Pages 298-302

  Gocke, Elmar ^a   Wall, Michael ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b Strassburgerallee 127   (Switzerland)

Author keywords

DNA damage; lacZ mutations; Linear dose response; Micronucleus; Risk assessment; Threshold

Indexed keywords

MESYLIC ACID ETHYL ESTER;

ARTICLE; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; GENOTOXICITY; IN VIVO STUDY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; STATISTICAL ANALYSIS; STATISTICAL MODEL; TOXICITY TESTING;

ALKYLATING AGENTS; ANIMALS; CONFIDENCE INTERVALS; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CONTAMINATION; ETHYL METHANESULFONATE; HIV PROTEASE INHIBITORS; HUMANS; LAC OPERON; LINEAR MODELS; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MUTAGENICITY TESTS; MUTAGENS; MUTATION; NELFINAVIR; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RISK ASSESSMENT;

MUS;

EID: 69449086697     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.03.008     Document Type: Article

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