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Volumn 16, Issue 10, 2004, Pages 1017-1025

Failure of the gut barrier system enhances liver injury in rats: Protection of hepatocytes by gut-derived hepatocyte growth factor

Author keywords

Apoptosis; Fas ligand; Gut defence; Lipopolysaccharide; Toll like receptor

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CD14 ANTIGEN; CD68 ANTIGEN; ENDOTOXIN; FAS LIGAND; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; SCATTER FACTOR; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 6944246195     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-200410000-00011     Document Type: Article
Times cited : (17)

References (51)
  • 1
    • 0026062620 scopus 로고
    • Gram-negative endotoxin: An extraordinary lipid with profound effects on eukaryotic signal transduction
    • Raetz CR, Ulevitch RJ, Wright SD, Sibley CH, Ding A, Nathan CF. Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J 1991; 5:2652-2660.
    • (1991) FASEB J , vol.5 , pp. 2652-2660
    • Raetz, C.R.1    Ulevitch, R.J.2    Wright, S.D.3    Sibley, C.H.4    Ding, A.5    Nathan, C.F.6
  • 2
    • 0029888481 scopus 로고    scopus 로고
    • Role of Kupffer cells and the spleen in modulation of endotoxin-induced liver injury after partial hepatectomy
    • Suzuki S, Nakamura S, Serizawa A, Sakaguchi T, Konno H, Muro H, et al. Role of Kupffer cells and the spleen in modulation of endotoxin-induced liver injury after partial hepatectomy. Hepatology 1996; 24:219-225.
    • (1996) Hepatology , vol.24 , pp. 219-225
    • Suzuki, S.1    Nakamura, S.2    Serizawa, A.3    Sakaguchi, T.4    Konno, H.5    Muro, H.6
  • 3
    • 0031928131 scopus 로고    scopus 로고
    • Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin
    • Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H, Brenner DA, et al. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology 1998; 115:443-451.
    • (1998) Gastroenterology , vol.115 , pp. 443-451
    • Enomoto, N.1    Ikejima, K.2    Bradford, B.3    Rivera, C.4    Kono, H.5    Brenner, D.A.6
  • 4
    • 0031965991 scopus 로고    scopus 로고
    • Infection, sepsis and systemic inflammatory response syndrome in obstructive jaundice
    • Whalan C, Drew P, Maddern G. Infection, sepsis and systemic inflammatory response syndrome in obstructive jaundice. J Gastroenterol Hepatol 1998; 13:354-355.
    • (1998) J Gastroenterol Hepatol , vol.13 , pp. 354-355
    • Whalan, C.1    Drew, P.2    Maddern, G.3
  • 5
    • 0028796860 scopus 로고
    • Antibiotics prevent liver injury in rats following long-term exposure to ethanol
    • Adachi Y, Moore LE, Bradford BU, Gao W, Thurman RG. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 1995; 108:218-224.
    • (1995) Gastroenterology , vol.108 , pp. 218-224
    • Adachi, Y.1    Moore, L.E.2    Bradford, B.U.3    Gao, W.4    Thurman, R.G.5
  • 8
    • 0024075132 scopus 로고
    • Proposed mechanism for the translocation of intestinal bacteria
    • Wells CL, Maddaus MA, Simmons RL. Proposed mechanism for the translocation of intestinal bacteria. Rev Infect Dis 1988; 10:958-979.
    • (1988) Rev Infect Dis , vol.10 , pp. 958-979
    • Wells, C.L.1    Maddaus, M.A.2    Simmons, R.L.3
  • 10
    • 0033510549 scopus 로고    scopus 로고
    • Intestinal cytokine response after gut ischemia: Role of gut barrier failure
    • Grotz MR, Deitch EA, Ding J, Xu D, Huang Q, Regel G. Intestinal cytokine response after gut ischemia: role of gut barrier failure. Ann Surg 1999; 229:478-486.
    • (1999) Ann Surg , vol.229 , pp. 478-486
    • Grotz, M.R.1    Deitch, E.A.2    Ding, J.3    Xu, D.4    Huang, Q.5    Regel, G.6
  • 11
    • 0029366301 scopus 로고
    • The gut: A cytokine-generating organ in systemic inflammation
    • Mainous MR, Ertel W, Chaudry IH, Deitch EA. The gut: a cytokine-generating organ in systemic inflammation. Shock 1995; 4:193-199.
    • (1995) Shock , vol.4 , pp. 193-199
    • Mainous, M.R.1    Ertel, W.2    Chaudry, I.H.3    Deitch, E.A.4
  • 12
    • 0034075754 scopus 로고    scopus 로고
    • The IL-1 receptor/toll-like receptor superfamily: Crucial receptors for inflammation and host defense
    • O'Neill LA, Dinarello CA. The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunol Today 2000; 21:206-209.
    • (2000) Immunol Today , vol.21 , pp. 206-209
    • O'Neill, L.A.1    Dinarello, C.A.2
  • 13
    • 0034680145 scopus 로고    scopus 로고
    • Toll-like receptors in the induction of the innate immune response
    • Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 2000; 406:782-787.
    • (2000) Nature , vol.406 , pp. 782-787
    • Aderem, A.1    Ulevitch, R.J.2
  • 15
    • 0033574415 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
    • Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 1999; 274:10689-10692.
    • (1999) J Biol Chem , vol.274 , pp. 10689-10692
    • Chow, J.C.1    Young, D.W.2    Golenbock, D.T.3    Christ, W.J.4    Gusovsky, F.5
  • 16
    • 0033037943 scopus 로고    scopus 로고
    • The gut's role in metabolism, mucosal barrier function and gut immunology
    • DeWitt RC, Kudsk KA. The gut's role in metabolism, mucosal barrier function and gut immunology. Infect Dis Clin North Am 1999; 13: 465-481.
    • (1999) Infect Dis Clin North Am , vol.13 , pp. 465-481
    • DeWitt, R.C.1    Kudsk, K.A.2
  • 17
    • 0034650930 scopus 로고    scopus 로고
    • Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing toll-like receptors
    • Cario E, Rosenberg IM, Brandwein SL, Beck PL, Reinecker HC, Podolsky DK. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing toll-like receptors. J Immunol 2000; 164:966-972.
    • (2000) J Immunol , vol.164 , pp. 966-972
    • Cario, E.1    Rosenberg, I.M.2    Brandwein, S.L.3    Beck, P.L.4    Reinecker, H.C.5    Podolsky, D.K.6
  • 18
    • 0036121583 scopus 로고    scopus 로고
    • Bacterial translocation or lymphatic drainage of toxic products from the gut: What is important in human beings?
    • Deitch EA. Bacterial translocation or lymphatic drainage of toxic products from the gut: what is important in human beings? Surgery 2002; 131:241-244.
    • (2002) Surgery , vol.131 , pp. 241-244
    • Deitch, E.A.1
  • 19
    • 0025855880 scopus 로고
    • Native and recombinant human hepatocyte growth factors are highly potent promoters of DNA synthesis in both human and rat hepatocytes
    • Strain AJ, Ismail T, Tsubouchi H, Arakaki N, Hishida T, Kitamura N, et al. Native and recombinant human hepatocyte growth factors are highly potent promoters of DNA synthesis in both human and rat hepatocytes. J Clin Invest 1991; 87:1853-1857.
    • (1991) J Clin Invest , vol.87 , pp. 1853-1857
    • Strain, A.J.1    Ismail, T.2    Tsubouchi, H.3    Arakaki, N.4    Hishida, T.5    Kitamura, N.6
  • 20
    • 0028040336 scopus 로고
    • In vivo response of hepatocytes to growth factors requires an initial priming stimulus
    • Webber EM, Godowski PJ, Fausto N. In vivo response of hepatocytes to growth factors requires an initial priming stimulus. Hepatology 1994; 19:489-497.
    • (1994) Hepatology , vol.19 , pp. 489-497
    • Webber, E.M.1    Godowski, P.J.2    Fausto, N.3
  • 21
    • 0032004585 scopus 로고    scopus 로고
    • Perioperative continuous hepatocyte growth factor supply prevents postoperative liver failure in rats with liver cirrhosis
    • Kaido T, Seto S, Yamaoka S, Yoshikawa A, Imamura M. Perioperative continuous hepatocyte growth factor supply prevents postoperative liver failure in rats with liver cirrhosis. J Surg Res 1998; 74:173-178.
    • (1998) J Surg Res , vol.74 , pp. 173-178
    • Kaido, T.1    Seto, S.2    Yamaoka, S.3    Yoshikawa, A.4    Imamura, M.5
  • 22
    • 0025279239 scopus 로고
    • Effect of hemorrhagic shock on bacterial translocation, intestinal morphology, and intestinal permeability in conventional and antibiotic- decontaminated rats
    • Deitch EA, Morrison J, Berg R, Specian RD. Effect of hemorrhagic shock on bacterial translocation, intestinal morphology, and intestinal permeability in conventional and antibiotic-decontaminated rats. Crit Care Med 1990; 18:529-536.
    • (1990) Crit Care Med , vol.18 , pp. 529-536
    • Deitch, E.A.1    Morrison, J.2    Berg, R.3    Specian, R.D.4
  • 23
    • 0032111776 scopus 로고    scopus 로고
    • Pure endotoxin does not pass across the intestinal epithelium in vitro
    • Benoit R, Rowe S, Watkins SC, Boyle P, Garrett M, Alber S, et al. Pure endotoxin does not pass across the intestinal epithelium in vitro. Shock 1998; 10:43-48.
    • (1998) Shock , vol.10 , pp. 43-48
    • Benoit, R.1    Rowe, S.2    Watkins, S.C.3    Boyle, P.4    Garrett, M.5    Alber, S.6
  • 24
    • 0034950477 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice
    • Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 2001; 34:101-108.
    • (2001) Hepatology , vol.34 , pp. 101-108
    • Uesugi, T.1    Froh, M.2    Arteel, G.E.3    Bradford, B.U.4    Thurman, R.G.5
  • 25
    • 0021352090 scopus 로고
    • The leaky gut of alcoholism: Possible route of entry for toxic compounds
    • Bjarnason I, Peters TJ, Wise RJ. The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet 1984; i:179-182.
    • (1984) Lancet
    • Bjarnason, I.1    Peters, T.J.2    Wise, R.J.3
  • 27
    • 0031572443 scopus 로고    scopus 로고
    • IL-18 accounts for both TNF-alpha and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice
    • Tsutsui H, Matsui K, Kawada N, Hyodo Y, Hayashi N, Okamura H, et al. IL-18 accounts for both TNF-alpha and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice. J Immunol 1997; 159:3961-3967.
    • (1997) J Immunol , vol.159 , pp. 3961-3967
    • Tsutsui, H.1    Matsui, K.2    Kawada, N.3    Hyodo, Y.4    Hayashi, N.5    Okamura, H.6
  • 28
    • 0029123132 scopus 로고
    • Preparation of specific antibodies against murine IL-1 ra and the establishment of IL-1 ra as an endogenous regulator of bacteria-induced fulminant hepatitis in mice
    • Fujioka N, Mukaida N, Harada A, Akiyama M, Kasahara T, Kuno K, et al. Preparation of specific antibodies against murine IL-1 ra and the establishment of IL-1 ra as an endogenous regulator of bacteria-induced fulminant hepatitis in mice. J Leukoc Biol 1995; 58:90-98.
    • (1995) J Leukoc Biol , vol.58 , pp. 90-98
    • Fujioka, N.1    Mukaida, N.2    Harada, A.3    Akiyama, M.4    Kasahara, T.5    Kuno, K.6
  • 30
    • 0033802726 scopus 로고    scopus 로고
    • Murine concanavalin A-induced hepatitis is prevented by interleukin 12 (IL-12) antibody and exacerbated by exogenous IL-12 through an interferon-gamma-dependent mechanism
    • Nicoletti F, Di Marco R, Zaccone P, Salvaggio A, Magro G, Bendtzen K, et al. Murine concanavalin A-induced hepatitis is prevented by interleukin 12 (IL-12) antibody and exacerbated by exogenous IL-12 through an interferon-gamma-dependent mechanism. Hepatology 2000; 32: 728-733.
    • (2000) Hepatology , vol.32 , pp. 728-733
    • Nicoletti, F.1    Di Marco, R.2    Zaccone, P.3    Salvaggio, A.4    Magro, G.5    Bendtzen, K.6
  • 32
    • 0021285134 scopus 로고
    • Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats
    • Nakamura T, Nawa K, Ichihara A. Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun 1984; 122:1450-1459.
    • (1984) Biochem Biophys Res Commun , vol.122 , pp. 1450-1459
    • Nakamura, T.1    Nawa, K.2    Ichihara, A.3
  • 33
    • 0025665128 scopus 로고
    • Expression of hepatocyte growth factor gene in endothelial and Kupffer cells of damaged rat livers, as revealed by in situ hybridization
    • Noji S, Tashiro K, Koyama E, Nohno T, Ohyama K, Taniguchi S, et al. Expression of hepatocyte growth factor gene in endothelial and Kupffer cells of damaged rat livers, as revealed by in situ hybridization. Biochem Biophys Res Commun 1990; 173:42-47.
    • (1990) Biochem Biophys Res Commun , vol.173 , pp. 42-47
    • Noji, S.1    Tashiro, K.2    Koyama, E.3    Nohno, T.4    Ohyama, K.5    Taniguchi, S.6
  • 35
    • 0025734655 scopus 로고
    • Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET
    • Naldini L, Vigna E, Narsimhan RP, Gaudino G, Zarnegar R, Michalopoulos GK, et al. Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene 1991; 6:501-504.
    • (1991) Oncogene , vol.6 , pp. 501-504
    • Naldini, L.1    Vigna, E.2    Narsimhan, R.P.3    Gaudino, G.4    Zarnegar, R.5    Michalopoulos, G.K.6
  • 36
    • 0033975089 scopus 로고    scopus 로고
    • Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis
    • Xian CJ, Couper R, Howarth GS, Read LC, Kallincos NC. Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis. Br J Cancer 2000; 82:945-952.
    • (2000) Br J Cancer , vol.82 , pp. 945-952
    • Xian, C.J.1    Couper, R.2    Howarth, G.S.3    Read, L.C.4    Kallincos, N.C.5
  • 37
    • 0033067527 scopus 로고    scopus 로고
    • Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice
    • Kosai K, Matsumoto K, Funakoshi H, Nakamura T. Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice. Hepatology 1999; 30:151-159.
    • (1999) Hepatology , vol.30 , pp. 151-159
    • Kosai, K.1    Matsumoto, K.2    Funakoshi, H.3    Nakamura, T.4
  • 38
    • 0025226107 scopus 로고
    • Biological and clinical aspects of interleukin 6
    • Hirano T, Akira S, Taga T, Kishimoto T. Biological and clinical aspects of interleukin 6. Immunol Today 1990; 11:443-449.
    • (1990) Immunol Today , vol.11 , pp. 443-449
    • Hirano, T.1    Akira, S.2    Taga, T.3    Kishimoto, T.4
  • 39
    • 0025805971 scopus 로고
    • Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation
    • Ulich T, Yin S, Guo K, Yi E, Remick D, del Castillo J. Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation. Am J Pathol 1991; 138:1097-1101.
    • (1991) Am J Pathol , vol.138 , pp. 1097-1101
    • Ulich, T.1    Yin, S.2    Guo, K.3    Yi, E.4    Remick, D.5    Del Castillo, J.6
  • 40
    • 0028300351 scopus 로고
    • T cell activation-associated hepatic injury: Mediation by tumor necrosis factors and protection by interleukin 6
    • Mizuhara H, O'Neill E, Seki N, Ogawa T, Kusunoki C, Otsuka K, et al. T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6. J Exp Med 1994; 179: 1529-1537.
    • (1994) J Exp Med , vol.179 , pp. 1529-1537
    • Mizuhara, H.1    O'Neill, E.2    Seki, N.3    Ogawa, T.4    Kusunoki, C.5    Otsuka, K.6
  • 41
    • 20644465187 scopus 로고    scopus 로고
    • Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent
    • Camargo CA Jr, Madden JF, Gao W, Selvan RS, Clavien PA. Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. Hepatology 1997; 26:1513-1520.
    • (1997) Hepatology , vol.26 , pp. 1513-1520
    • Camargo Jr., C.A.1    Madden, J.F.2    Gao, W.3    Selvan, R.S.4    Clavien, P.A.5
  • 42
    • 0029952558 scopus 로고    scopus 로고
    • Acute reactant cytokines and neutrophil adhesion after following warm ischemia in cirrhotic and noncirrhotic human livers
    • Clavien PA, Camargo CA Jr, Gorczynski R, Washington MK, Levy GA, Langer B, et al. Acute reactant cytokines and neutrophil adhesion after following warm ischemia in cirrhotic and noncirrhotic human livers. Hepatology 1996; 23:1456-1463.
    • (1996) Hepatology , vol.23 , pp. 1456-1463
    • Clavien, P.A.1    Camargo Jr., C.A.2    Gorczynski, R.3    Washington, M.K.4    Levy, G.A.5    Langer, B.6
  • 43
    • 0032421572 scopus 로고    scopus 로고
    • Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide
    • Solomon KR, Kurt-Jones EA, Saladino RA, Stack AM, Dunn IF, Ferretti M, et al. Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide. J Clin Invest 1998; 102:2019-2027.
    • (1998) J Clin Invest , vol.102 , pp. 2019-2027
    • Solomon, K.R.1    Kurt-Jones, E.A.2    Saladino, R.A.3    Stack, A.M.4    Dunn, I.F.5    Ferretti, M.6
  • 44
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388:394-397.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 46
    • 0033458799 scopus 로고    scopus 로고
    • Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
    • Underhill DM, Ozinsky A, Smith KD, Aderem A. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc Natl Acad Sci USA 1999; 96:14459-14463.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14459-14463
    • Underhill, D.M.1    Ozinsky, A.2    Smith, K.D.3    Aderem, A.4
  • 47
    • 0034670047 scopus 로고    scopus 로고
    • Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages
    • Matsuguchi T, Musikacharoen T, Ogawa T, Yoshikai Y. Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages. J Immunol 2000; 165:5767-5772.
    • (2000) J Immunol , vol.165 , pp. 5767-5772
    • Matsuguchi, T.1    Musikacharoen, T.2    Ogawa, T.3    Yoshikai, Y.4
  • 48
    • 0031002790 scopus 로고    scopus 로고
    • Essential roles of the Fas ligand in the development of hepatitis
    • Kondo T, Suda T, Fukuyama H, Adachi M, Nagata S. Essential roles of the Fas ligand in the development of hepatitis. Nat Med 1997; 3: 409-413.
    • (1997) Nat Med , vol.3 , pp. 409-413
    • Kondo, T.1    Suda, T.2    Fukuyama, H.3    Adachi, M.4    Nagata, S.5
  • 50
    • 0035077724 scopus 로고    scopus 로고
    • Role of Fas/FasL in Kupffer cell-dependent deletion of alloantigen activated T cells following liver transplantation
    • Sun Z, Wada T, Uchikura K, Ceppa E, Klein AS. Role of Fas/FasL in Kupffer cell-dependent deletion of alloantigen activated T cells following liver transplantation. Transplant Proc 2001; 33:279-282.
    • (2001) Transplant Proc , vol.33 , pp. 279-282
    • Sun, Z.1    Wada, T.2    Uchikura, K.3    Ceppa, E.4    Klein, A.S.5
  • 51
    • 0027722140 scopus 로고
    • Kupffer cells can present alloantigen in vitro: An effect abrogated by gadolinium
    • Squiers EC, Brunson ME, Salomon DR. Kupffer cells can present alloantigen in vitro: an effect abrogated by gadolinium. J Surg Res 1993: 55:571-574.
    • (1993) J Surg Res , vol.55 , pp. 571-574
    • Squiers, E.C.1    Brunson, M.E.2    Salomon, D.R.3


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