Investigation of factors influencing production of the monocyclic carotenoid torulene in metabolically engineered Escherichia coli

Applied Microbiology and Biotechnology

Volumn 65, Issue 5, 2004, Pages 538-546

  Lee, Pyung Cheon ^a   Mijts, Benjamin N ^a   Schmidt Dannert, Claudia ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOREACTORS; CELL CULTURE; DISSOLUTION; ENZYMES; GENES; METABOLISM; OXYGEN; TEMPERATURE CONTROL;

AEROBIC CULTURES; CAROTENOGENIC; DISSOLVED OXYGEN; ENZYME EXPRESSIONS; GENE DOSAGE;

ESCHERICHIA COLI;

BETA CAROTENE; CAROTENOID; GENOMIC DNA; GLUCOSE; GLYCEROL; ISOPRENOID; LYCOPENE; TORULENE; UNCLASSIFIED DRUG;

BIOTECHNOLOGY;

ARTICLE; BACTERIUM CULTURE; BIOREACTOR; BIOSYNTHESIS; ESCHERICHIA COLI; GENE DOSAGE; GENE OVEREXPRESSION; GENETIC ENGINEERING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION;

AEROBIOSIS; ALDOSE-KETOSE ISOMERASES; ALKYL AND ARYL TRANSFERASES; BETA CAROTENE; BIOTECHNOLOGY; CARBON-CARBON DOUBLE BOND ISOMERASES; CAROTENOIDS; CULTURE MEDIA; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; GENE DOSAGE; GENE EXPRESSION REGULATION, BACTERIAL; GERANYLTRANSTRANSFERASE; GLUCOSE; GLYCEROL; INTRAMOLECULAR LYASES; MULTIENZYME COMPLEXES; OXIDOREDUCTASES; TEMPERATURE; TRANSFERASES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 6944235684     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-004-1619-1     Document Type: Article

References (29)

1. Albrecht M, Takaichi S, Misawa N, Schnurr G, Boger P, Sandmann G (1997) Synthesis of atypical cyclic and acyclic hydroxy carotenoids in Escherichia coli transformants. J Biotechnol 8:177-185
2. Albrecht M, Misawa N, Sandmann G (1999) Metabolic engineering of the terpenoid biosynthetic pathway of Escherichia coli for production of the carotenoids beta-carotene and zeaxanthin. Biotechnol Lett 21:791-795
3. Alexeeva S, Hellingwerf KJ, Teixeira de Mattos MJ (2003) Requirement of ArcA for redox regulation in Escherichia coli under microaerobic but not anaerobic or aerobic conditions. J Bacteriol 185:204-209
4. Armstrong G (1997) Genetics of eubacterial carotenoid biosynthesis: A colorful tale. Annu Rev Microbiol 51:629-659
5. Bridges BA, Timms A (1998) Effect of endogenous carotenoids and defective RpoS sigma factor on spontaneous mutation under starvation conditions in Escherichia coli: evidence for the possible involvement of singlet oxygen. Mutat Res 403:21-28
6. Carter OA, Peters RJ, Croteau R (2003) Monoterpene biosynthesis pathway construction in Escherichia coli. Phytochemistry 64:425-433
7. Fang A, Demain AL (1997) Influence of aeration and carbon source on production of microcin B17 by Escherichia coli ZK650. Appl Microbiol Biotechnol 47:547-553
8. Farmer WR, Liao JC (2001) Precursor balancing for metabolic engineering of lycopene production in Escherichia coli. Biotechnol Prog 17:57-61
9. Johnson E, Schroeder W (1995) Microbial carotenoids. Adv Biochem Eng Biotechnol 53:119-178
10. Jones KL, Kim SW, Keasling JD (2000) Low-copy plasmids can perform as well as or better than high-copy plasmids for metabolic engineering of bacteria. Metab Eng 2:328-338
11. Kajiwara S, Fraser P, Kondo K, Misawa N (1997) Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli. Biochem J 324:421-426
12. Kidwell J, Valentin HE, Dennis D (1995) Regulated expression of the Alcaligenes eutrophus pha biosynthesis genes in Escherichia coli. Appl Environ Microbiol 61:1391-1398
13. Kovach ME et al (1995) Four new derivatives of the broad-host-range cloning vector pBBR1MCS, carrying different antibiotic-resistance cassettes. Gene 166:175-176
14. Lee PC, Schmidt-Dannert C (2002) Metabolic engineering towards biotechnological production of carotenoids in microorganisms. Appl Microbiol Biotechnol 60:1-11
15. Lee PC, Lee WG, Lee SY, Chang HN (2001) Succinic acid production with reduced by-product formation in the fermentation of Anaerobiospirillum succiniciproducens using glycerol as a carbon source. Biotechnol Bioeng 72:41-48
16. Lee PC, Momen AZ, Mijts BN, Schmidt-Dannert C (2003) Biosynthesis of structurally novel carotenoids in Escherichia coli. Chem Biol 10:453-462
17. 15 N isotope labeling of bacterially expressed protein. Biotechniques 32:1248-1250
18. Martin VJ, Yoshikuni Y, Keasling JD (2001) The in vivo synthesis of plant sesquiterpenes by Escherichia coli. Biotechnol Bioeng 75:497-503
19. Matthews PD, Wurtzel ET (2000) Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase. Appl Microbiol Biotechnol 53:396-400
20. Peng L, Shimizu K (2003) Global metabolic regulation analysis for Escherichia coli K12 based on protein expression by 2-dimensional electrophoresis and enzyme activity measurement. Appl Microbiol Biotechnol 61:163-178
21. Perry KL, Simonitch TA, Harrison-Lavoie KJ, Liu ST (1986) Cloning and regulation of Erwinia herbicola pigment genes. J Bacteriol 168:607-612
22. Ruther A, Misawa N, Boger P, Sandmann G (1997) Production of zeaxanthin in Escherichia coli transformed with different carotenogenic plasmids. Appl Microbiol Biotechnol 48:162-167
23. Sambrook J, Russel DW (2001) Molecular cloning: a laboratory manual, 3rd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
24. Schiedt K, Liaaen-Jensen S (1995) Isolation and analysis. In: Britton G (ed) Carotenoids: isolation and analysis. Birkhäuser, Basel
25. Schmidt-Dannert C, Umeno D, Arnold FH (2000) Molecular breeding of carotenoid biosynthetic pathways. Nat Biotechnol 18:750-753
26. Vershinin A (1999) Biological functions of carotenoids - diversity and evolution. Biofactors 10:99-104
27. Wang F, Lee SY (1997) Production of poly(3-hydroxybutyrate) by fed-batch culture of filamentation-suppressed recombinant Escherichia coli. Appl Environ Microbiol 63:4765-4769
28. Wang C, Oh M, Liao J (1999) Engineered isoprenoid pathway enhances astaxanthin production in Escherichia coli. Biotechnol Bioeng 62:235-241
29. Wang C, Oh M, Liao J (2000) Directed evolution of metabolically engineered Escherichia coli for carotenoid production. Biotechnol Prog 16:922-926