Regional differences in capillary density, perfusion rate, and P-glycoprotein activity: A quantitative analysis of regional drug exposure in the brain

Biochemical Pharmacology

Volumn 78, Issue 8, 2009, Pages 1052-1059

  Zhao, Rong ^a   Pollack, Gary M ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Brain capillary density; P glycoprotein; Perfusion flow rate; Regional drug distribution

Indexed keywords

COLCHICINE; DIAZEPAM; GLYCOPROTEIN P; INULIN; LOPERAMIDE; QUINIDINE; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOW VELOCITY; BRAIN CORTEX; BRAIN PERFUSION; CAPILLARY DENSITY; CONTROLLED STUDY; DRUG EXPOSURE; DRUG UPTAKE; MESENCEPHALON; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TISSUE DISTRIBUTION;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CALCIUM CHANNEL BLOCKERS; CAPILLARIES; COLCHICINE; DOSE-RESPONSE RELATIONSHIP, DRUG; INFUSIONS, SUBCUTANEOUS; INULIN; LEAST-SQUARES ANALYSIS; LINEAR MODELS; LOPERAMIDE; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICRODISSECTION; P-GLYCOPROTEIN; PERFUSION; QUINIDINE; REGIONAL BLOOD FLOW; SUBSTRATE SPECIFICITY; VERAPAMIL;

EID: 69349089453     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.06.001     Document Type: Article

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