메뉴 건너뛰기




Volumn 30, Issue 2, 2006, Pages 329-347

Future chelation monotherapy and combination therapy strategies in thalassemia and other conditions. Comparison of deferiprone, deferoxamine, ICL670, GT56-252, L1NAll and starch deferoxamine polymers

Author keywords

Combination therapies; Deferiprone (L1); Deferoxamine (DFO); ICL670; Iron chelators; Iron overload; Thalassemia

Indexed keywords

1 ALLYL 2 METHYL 3 HYDROXYPYRID 4 ONE; DEFERASIROX; DEFERIPRONE; DEFERITRIN; DEFEROXAMINE; DEFEROXAMINE STARCH POLYMER; FERRITIN; HEMOSIDERIN; IRON; IRON CHELATING AGENT; TRANSFERRIN; UNCLASSIFIED DRUG;

EID: 33745578223     PISSN: 03630269     EISSN: 1532432X     Source Type: Journal    
DOI: 10.1080/03630260600642674     Document Type: Conference Paper
Times cited : (28)

References (82)
  • 1
    • 0036800592 scopus 로고    scopus 로고
    • A genetic view of haemochromatosis
    • Andrews NC. A genetic view of haemochromatosis. Semin Hematol 2002; 39(4):227-234.
    • (2002) Semin Hematol , vol.39 , Issue.4 , pp. 227-234
    • Andrews, N.C.1
  • 3
    • 0020648765 scopus 로고
    • Community control of hereditary anaemias
    • World Health Organisation. Community control of hereditary anaemias. WHO Bull 1983; 61(1):63-80.
    • (1983) WHO Bull , vol.61 , Issue.1 , pp. 63-80
  • 6
    • 0027453417 scopus 로고
    • Present status and future prospects of oral iron chelation therapy in thalassemia and other diseases
    • Kontoghiorghes GJ. Present status and future prospects of oral iron chelation therapy in thalassemia and other diseases. Indian J Paediatr 1993; 60(4):485-507.
    • (1993) Indian J Paediatr , vol.60 , Issue.4 , pp. 485-507
    • Kontoghiorghes, G.J.1
  • 7
    • 0038649860 scopus 로고    scopus 로고
    • Benefits and risks of deferiprone in iron overload in thalassemia and other conditions
    • Kontoghiorghes GJ, Neocleous K, Kolnagou A. Benefits and risks of deferiprone in iron overload in thalassemia and other conditions. Drug Saf 2003; 26(8):553-584.
    • (2003) Drug Saf , vol.26 , Issue.8 , pp. 553-584
    • Kontoghiorghes, G.J.1    Neocleous, K.2    Kolnagou, A.3
  • 8
  • 11
    • 3242753676 scopus 로고    scopus 로고
    • The design and development of deferiprone (L1) and other iron chelators for clinical use: Targeting methods and application prospects
    • Kontoghiorghes GJ, Pattichis K, Neocleous K, Kolnagou A. The design and development of deferiprone (L1) and other iron chelators for clinical use: targeting methods and application prospects. Curr Med Chem 2004; 11(162161-2183.
    • (2004) Curr Med Chem , vol.11 , Issue.16 , pp. 2161-2183
    • Kontoghiorghes, G.J.1    Pattichis, K.2    Neocleous, K.3    Kolnagou, A.4
  • 12
    • 0028840530 scopus 로고
    • Comparative efficacy and toxicity of desferrioxamine, deferiprone and other iron and aluminium chelating drugs
    • Kontoghiorghes GJ. Comparative efficacy and toxicity of desferrioxamine, deferiprone and other iron and aluminium chelating drugs. Toxicol Lett 1995; 80(1-3):1-18.
    • (1995) Toxicol Lett , vol.80 , Issue.1-3 , pp. 1-18
    • Kontoghiorghes, G.J.1
  • 13
    • 7444249085 scopus 로고
    • The biochemistry of desferrioxamine and its relation to iron metabolism
    • Keberle H. The biochemistry of desferrioxamine and its relation to iron metabolism. Ann NY Acad Sci 1964; 119:758-768.
    • (1964) Ann NY Acad Sci , vol.119 , pp. 758-768
    • Keberle, H.1
  • 14
    • 0026571807 scopus 로고
    • Pulmonary toxic effects of continuous desferrioxamine administration in acute iron poisoning
    • Tenenbein M, Kowalski S, Sienko A, Bowden DH, Adamson IYR. Pulmonary toxic effects of continuous desferrioxamine administration in acute iron poisoning. Lancet 1992; 1(8795):699-701.
    • (1992) Lancet , vol.1 , Issue.8795 , pp. 699-701
    • Tenenbein, M.1    Kowalski, S.2    Sienko, A.3    Bowden, D.H.4    Adamson, I.Y.R.5
  • 15
    • 0025267012 scopus 로고
    • Acute bone marrow aplasia associated with intravenous administration of deferoxamine (desferrioxamine)
    • Sofroniadou K, Drossou M, Foundoulaki M, Konstantopoulos K, Kyriakou D, Zervas J. Acute bone marrow aplasia associated with intravenous administration of deferoxamine (desferrioxamine). Drug Saf 1990; 5(2):152-154.
    • (1990) Drug Saf , vol.5 , Issue.2 , pp. 152-154
    • Sofroniadou, K.1    Drossou, M.2    Foundoulaki, M.3    Konstantopoulos, K.4    Kyriakou, D.5    Zervas, J.6
  • 17
    • 0034631379 scopus 로고    scopus 로고
    • Survival in β-thalassaemia major in the UK: Data from the UK register
    • Modell B, Khan M, Darlison M. Survival in β-thalassaemia major in the UK: data from the UK register. Lancet 2000; 355(9220):2051-2052.
    • (2000) Lancet , vol.355 , Issue.9220 , pp. 2051-2052
    • Modell, B.1    Khan, M.2    Darlison, M.3
  • 19
    • 0021357262 scopus 로고
    • Desferrioxamine to improve cardiac function in iron-overloaded patients with thalassemia major
    • Marcus RE, Davies SG, Bantock HM, Underwood SR, Walton S, Huehns ER. Desferrioxamine to improve cardiac function in iron-overloaded patients with thalassemia major. Lancet 1984; 1(8373):392-393.
    • (1984) Lancet , vol.1 , Issue.8373 , pp. 392-393
    • Marcus, R.E.1    Davies, S.G.2    Bantock, H.M.3    Underwood, S.R.4    Walton, S.5    Huehns, E.R.6
  • 20
    • 7944230624 scopus 로고    scopus 로고
    • Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: A prospective study using T2* cardiovascular magnetic resonance
    • Anderson LJ, Westwood MA, Holden S, Davis B, Prescott E, Wonke B, Porter JB, Walker JM, Pennell DJ. Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: a prospective study using T2* cardiovascular magnetic resonance. Br J Haematol 2004; 127(3):348-355.
    • (2004) Br J Haematol , vol.127 , Issue.3 , pp. 348-355
    • Anderson, L.J.1    Westwood, M.A.2    Holden, S.3    Davis, B.4    Prescott, E.5    Wonke, B.6    Porter, J.B.7    Walker, J.M.8    Pennell, D.J.9
  • 21
    • 0030830275 scopus 로고    scopus 로고
    • Evaluation of a new method of administration of the iron chelating agent deferoxamine
    • Borgna-Pignatti C, Cohen A. Evaluation of a new method of administration of the iron chelating agent deferoxamine. J Pediatr 1997; 130(1):86-88.
    • (1997) J Pediatr , vol.130 , Issue.1 , pp. 86-88
    • Borgna-Pignatti, C.1    Cohen, A.2
  • 22
    • 27744603798 scopus 로고    scopus 로고
    • Phase 1b study of the safety, pharmacokinetics, acute tolerability, and efficacy of ascending single doses of 40SD02 (CHF5140, GS460) in iron loaded patients
    • Abstract 423
    • Harmatz P, Grady RW, Vichinsky E, Giardina PJ, Jeng M, Madden J, Nugent KA, Dragsten P. Phase 1b study of the safety, pharmacokinetics, acute tolerability, and efficacy of ascending single doses of 40SD02 (CHF5140, GS460) in iron loaded patients. Blood 2003; 102(11):Abstract 423.
    • (2003) Blood , vol.102 , Issue.11
    • Harmatz, P.1    Grady, R.W.2    Vichinsky, E.3    Giardina, P.J.4    Jeng, M.5    Madden, J.6    Nugent, K.A.7    Dragsten, P.8
  • 24
    • 0023877695 scopus 로고
    • L1 (1,2-dimethyl-3-hydroxypyrid-4-one)
    • Kontoghiorghes GJ. L1 (1,2-dimethyl-3-hydroxypyrid-4-one). Drugs Future 1988; 13(5):413-415.
    • (1988) Drugs Future , vol.13 , Issue.5 , pp. 413-415
    • Kontoghiorghes, G.J.1
  • 25
    • 0025007785 scopus 로고
    • Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one
    • Kontoghiorghes GJ, Goddard JG, Bartlett AN, Sheppard L. Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one. Clin Pharm Ther 1990; 48(3):255-261.
    • (1990) Clin Pharm Ther , vol.48 , Issue.3 , pp. 255-261
    • Kontoghiorghes, G.J.1    Goddard, J.G.2    Bartlett, A.N.3    Sheppard, L.4
  • 26
    • 0028897880 scopus 로고
    • New concepts of iron and aluminium chelation therapy with oral L1 (Deferiprone) and other chelators
    • Kontoghiorghes GJ. New concepts of iron and aluminium chelation therapy with oral L1 (Deferiprone) and other chelators. Analyst 1995; 120(3):845-851.
    • (1995) Analyst , vol.120 , Issue.3 , pp. 845-851
    • Kontoghiorghes, G.J.1
  • 27
    • 0027056363 scopus 로고
    • Synthesis and metabolism of L1 and other novel α- ketohydroxypyridine iron chelators and their metal complexes
    • Sheppard L, Kontoghiorghes GJ. Synthesis and metabolism of L1 and other novel α-ketohydroxypyridine iron chelators and their metal complexes. Drugs Today 1992; 28(Suppl A):3-10.
    • (1992) Drugs Today , vol.28 , Issue.SUPPL. A , pp. 3-10
    • Sheppard, L.1    Kontoghiorghes, G.J.2
  • 28
    • 0025018222 scopus 로고
    • Long term trial with the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1). (I) Iron chelation and metabolic studies
    • Kontoghiorghes GJ, Bartlett AN, Hoffbrand AV, Goddard JG, Sheppard L, Barr J, Nortey P. Long term trial with the oral chelator 1,2-dimethyl-3- hydroxypyrid-4-one (L1). (I) Iron chelation and metabolic studies. Br J Haematol 1990; 76(2):295-300.
    • (1990) Br J Haematol , vol.76 , Issue.2 , pp. 295-300
    • Kontoghiorghes, G.J.1    Bartlett, A.N.2    Hoffbrand, A.V.3    Goddard, J.G.4    Sheppard, L.5    Barr, J.6    Nortey, P.7
  • 29
    • 0029120697 scopus 로고
    • Oral iron chelation therapy with deferiprone (L1): Monitoring of biochemical, drug and iron excretion changes
    • Kontoghiorghes GJ, Bartlett AN, Sheppard L, Barr J, Nortey P. Oral iron chelation therapy with deferiprone (L1): monitoring of biochemical, drug and iron excretion changes. Arzn Forsch/Drug Res 1995; 45(1):65-69.
    • (1995) Arzn Forsch/Drug Res , vol.45 , Issue.1 , pp. 65-69
    • Kontoghiorghes, G.J.1    Bartlett, A.N.2    Sheppard, L.3    Barr, J.4    Nortey, P.5
  • 30
    • 0021932825 scopus 로고
    • Site specificity of iron removal from transferrin by α- kytohydroxypyridine chelators
    • Kontoghiorghes GJ, Evans RW. Site specificity of iron removal from transferrin by α-kytohydroxypyridine chelators. FEBS Lett 1985;189(1):141-144.
    • (1985) FEBS Lett , vol.189 , Issue.1 , pp. 141-144
    • Kontoghiorghes, G.J.1    Evans, R.W.2
  • 31
    • 0022629886 scopus 로고
    • The study of iron mobilization from transferrin using α-ketohydroxy heteroaromatic chelators
    • Kontoghiorghes GJ. The study of iron mobilization from transferrin using α-ketohydroxy heteroaromatic chelators. Biochim Biophys Acta 1986; 869(2):141-146.
    • (1986) Biochim Biophys Acta , vol.869 , Issue.2 , pp. 141-146
    • Kontoghiorghes, G.J.1
  • 32
    • 0027080322 scopus 로고
    • The effect of α-ketohydroxypyridine chelators on transferrin saturation in vitro and in vivo
    • Evans RW, Sharma M, Ogwang W, Patel KJ, Bartlett AN, Kontoghiorghes GJ. The effect of α-ketohydroxypyridine chelators on transferrin saturation in vitro and in vivo. Drugs Today 1992; 28(Suppl A):19-23.
    • (1992) Drugs Today , vol.28 , Issue.SUPPL. A , pp. 19-23
    • Evans, R.W.1    Sharma, M.2    Ogwang, W.3    Patel, K.J.4    Bartlett, A.N.5    Kontoghiorghes, G.J.6
  • 33
    • 0033788665 scopus 로고    scopus 로고
    • Fast biological iron chelators: Kinetics of iron removal from human diferric transferrin by multidentate hydroxypyridonates
    • Turcot I, Stintzi A, Xu J. Raymond KN. Fast biological iron chelators: kinetics of iron removal from human diferric transferrin by multidentate hydroxypyridonates. J Biol Inorg Chem 2000; 5(5):634-641.
    • (2000) J Biol Inorg Chem , vol.5 , Issue.5 , pp. 634-641
    • Turcot, I.1    Stintzi, A.2    Xu, J.3    Raymond, K.N.4
  • 34
    • 0026680591 scopus 로고
    • Reduction of tissue iron stores and normalization of serum ferritin during treatment with the oral iron chelator L1 in thalassemia intermedia
    • Olivieri NF, Koren G, Matsuii D, Liu PP, Blendis L, Cameron R, McClelland RA, Templeton DM. Reduction of tissue iron stores and normalization of serum ferritin during treatment with the oral iron chelator L1 in thalassemia intermedia. Blood 1992; 79(10):2741-2748.
    • (1992) Blood , vol.79 , Issue.10 , pp. 2741-2748
    • Olivieri, N.F.1    Koren, G.2    Matsuii, D.3    Liu, P.P.4    Blendis, L.5    Cameron, R.6    McClelland, R.A.7    Templeton, D.M.8
  • 35
    • 0031859182 scopus 로고    scopus 로고
    • Liver iron fibrosis during long-term treatment with deferiprone in Swiss thalassaemic patients
    • Tondury P, Zimmerman A, Nielsen P, Hirt A. Liver iron fibrosis during long-term treatment with deferiprone in Swiss thalassaemic patients. Br J. Haematol 1998; 101(3):413-415.
    • (1998) Br J Haematol , vol.101 , Issue.3 , pp. 413-415
    • Tondury, P.1    Zimmerman, A.2    Nielsen, P.3    Hirt, A.4
  • 36
    • 7944221912 scopus 로고    scopus 로고
    • Prophylactic use of deferiprone (L1) and magnetic resonance imaging T2* or T2 for preventing heart disease in thalassaemia
    • Kolnagou A, Fessas Ch, Papatryphonas A, Economides Ch, Kontoghiorghes GJ. Prophylactic use of deferiprone (L1) and magnetic resonance imaging T2* or T2 for preventing heart disease in thalassaemia. Br J Haematol 2004; 127(3):360-361.
    • (2004) Br J Haematol , vol.127 , Issue.3 , pp. 360-361
    • Kolnagou, A.1    Fessas, Ch.2    Papatryphonas, A.3    Economides, Ch.4    Kontoghiorghes, G.J.5
  • 37
    • 0037125595 scopus 로고    scopus 로고
    • Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in β-thalassaemia
    • Anderson LJ, Wonke B, Prescott E, Holden S, Walker JM, Pennel DJ. Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in β-thalassaemia. Lancet 2002; 360(9332):516-520.
    • (2002) Lancet , vol.360 , Issue.9332 , pp. 516-520
    • Anderson, L.J.1    Wonke, B.2    Prescott, E.3    Holden, S.4    Walker, J.M.5    Pennel, D.J.6
  • 38
    • 0042736560 scopus 로고    scopus 로고
    • Do we need more iron chelating drugs?
    • Kontoghiorghes GJ. Do we need more iron chelating drugs? Lancet 2003; 362(9382):495-496.
    • (2003) Lancet , vol.362 , Issue.9382 , pp. 495-496
    • Kontoghiorghes, G.J.1
  • 39
    • 0038472463 scopus 로고    scopus 로고
    • Safety monitoring of cardiac and hepatic systems in β-thalassemia patients with chelating treatment in Taiwan
    • Peng CT, Chow KC, Chen JH, Chiang YP, Lin TY, Tsai CH. Safety monitoring of cardiac and hepatic systems in β-thalassemia patients with chelating treatment in Taiwan. Eur J Haematol 2003; 70(6):392-397.
    • (2003) Eur J Haematol , vol.70 , Issue.6 , pp. 392-397
    • Peng, C.T.1    Chow, K.C.2    Chen, J.H.3    Chiang, Y.P.4    Lin, T.Y.5    Tsai, C.H.6
  • 40
  • 41
    • 0023214937 scopus 로고
    • 1, 2-Dimethyl-3-hydroxypyrid-4-one, an orally active chelator for the treatment of transfusional iron overload
    • Kontoghiorghes GJ, Aldouri MA, Sheppard LN, Hoffbrand AV. 1, 2-Dimethyl-3-hydroxypyrid-4-one, an orally active chelator for the treatment of transfusional iron overload. Lancet 1987; 1(8545):1294-1295.
    • (1987) Lancet , vol.1 , Issue.8545 , pp. 1294-1295
    • Kontoghiorghes, G.J.1    Aldouri, M.A.2    Sheppard, L.N.3    Hoffbrand, A.V.4
  • 42
    • 0027093057 scopus 로고
    • Long term treatment of transfusion hemosiderosis with the oral iron chelator L1
    • Goudsmit R, Kersten MJ. Long term treatment of transfusion hemosiderosis with the oral iron chelator L1. Drugs Today 1992; 28(suppl. A):133-135.
    • (1992) Drugs Today , vol.28 , Issue.SUPPL. A , pp. 133-135
    • Goudsmit, R.1    Kersten, M.J.2
  • 43
    • 0027066787 scopus 로고
    • Iron overload in polytransfused patients with MDS; use of L1 for oral iron chelation
    • Jaeger M, Aul C, Sohngen D, Germing U, Schneider W. Iron overload in polytransfused patients with MDS; use of L1 for oral iron chelation. Drugs Today. 1992; 28(Suppl A):143-147.
    • (1992) Drugs Today , vol.28 , Issue.SUPPL. A , pp. 143-147
    • Jaeger, M.1    Aul, C.2    Sohngen, D.3    Germing, U.4    Schneider, W.5
  • 44
    • 0027053573 scopus 로고
    • Long term assessment of efficacy and toxicity of L1 (1,2-dimethyl-3- hydroxypyrid-4-one) in transfusion dependent thalassemia. Indian trial
    • Agarwal M.B, Gupta SS, Viswanathan C, Vasandani D, Ramanathan J, Desai N, Puniyani RR, Chhablani AT. Long term assessment of efficacy and toxicity of L1 (1,2-dimethyl-3-hydroxypyrid-4-one) in transfusion dependent thalassemia. Indian trial. Drugs Today 1992; 28(Suppl A):107-114.
    • (1992) Drugs Today , vol.28 , Issue.SUPPL. A , pp. 107-114
    • Agarwal, M.B.1    Gupta, S.S.2    Viswanathan, C.3    Vasandani, D.4    Ramanathan, J.5    Desai, N.6    Puniyani, R.R.7    Chhablani, A.T.8
  • 45
  • 47
    • 0024403012 scopus 로고
    • Prospects for effective oral iron chelation therapy in man with 1,2-dimethyl-3-hydroxypyrid-4-one and other α-ketohydroxypyridines
    • Kontoghiorghes GJ, Bartlett AH, Hoffbrand AV. Prospects for effective oral iron chelation therapy in man with 1,2-dimethyl-3-hydroxypyrid-4-one and other α-ketohydroxypyridines. Prog Clin Biol Res 1989; 309:107-114.
    • (1989) Prog Clin Biol Res , vol.309 , pp. 107-114
    • Kontoghiorghes, G.J.1    Bartlett, A.H.2    Hoffbrand, A.V.3
  • 49
    • 0026507913 scopus 로고
    • Advances in oral iron chelation in man
    • Kontoghiorghes GJ. Advances in oral iron chelation in man. Int J Haematol 1992; 55(1):27-38.
    • (1992) Int J Haematol , vol.55 , Issue.1 , pp. 27-38
    • Kontoghiorghes, G.J.1
  • 50
    • 0031784438 scopus 로고    scopus 로고
    • Combined therapy with deferiprone and deferoxamine
    • Wonke B, Wright C, Hoffbrand AV. Combined therapy with deferiprone and deferoxamine. Br J. Haematol 1998; 103(2):361-364.
    • (1998) Br J. Haematol , vol.103 , Issue.2 , pp. 361-364
    • Wonke, B.1    Wright, C.2    Hoffbrand, A.V.3
  • 51
    • 0034783438 scopus 로고    scopus 로고
    • Chelation therapy in β-thalassemia: An optimistic update
    • Giardina PJ, Grady RW. Chelation therapy in β-thalassemia: an optimistic update. Semin Hematol 2001; 38(4):360-366.
    • (2001) Semin Hematol , vol.38 , Issue.4 , pp. 360-366
    • Giardina, P.J.1    Grady, R.W.2
  • 53
    • 0022649329 scopus 로고
    • Ocular toxicity of desferrioxamine: Light microscopic histochemical and ultrastructural findings
    • Rahi AHS, Hungerford JL, Ahmed AI. Ocular toxicity of desferrioxamine: light microscopic histochemical and ultrastructural findings. Br J Ophthal 1986; 70(5):373-381.
    • (1986) Br J Ophthal , vol.70 , Issue.5 , pp. 373-381
    • Rahi, A.H.S.1    Hungerford, J.L.2    Ahmed, A.I.3
  • 55
    • 0021321289 scopus 로고
    • Visual loss in patient on high dose subcutaneous desferrioxamine
    • Borgna-Pignatti C, De Stefano P, Broglia AM. Visual loss in patient on high dose subcutaneous desferrioxamine. Lancet 1984; 1(8378):68.
    • (1984) Lancet , vol.1 , Issue.8378 , pp. 68
    • Borgna-Pignatti, C.1    De Stefano, P.2    Broglia, A.M.3
  • 57
    • 14544276809 scopus 로고    scopus 로고
    • Iron-chelating therapy with the new oral agent ICL670 (Exjade)
    • Cappelini MD. Iron-chelating therapy with the new oral agent ICL670 (Exjade). Best Prac Res Clin Hematol 2005; 18(2):289-298.
    • (2005) Best Prac Res Clin Hematol , vol.18 , Issue.2 , pp. 289-298
    • Cappelini, M.D.1
  • 60
    • 0037906104 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to β-thalassemia
    • Galanello R, Piga A, Alberti D, Rouan MC, Bigler H, Sechaud R. Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to β-thalassemia J Clin Pharmacol 2003; 43(6):565-572.
    • (2003) J Clin Pharmacol , vol.43 , Issue.6 , pp. 565-572
    • Galanello, R.1    Piga, A.2    Alberti, D.3    Rouan, M.C.4    Bigler, H.5    Sechaud, R.6
  • 61
    • 0035865702 scopus 로고    scopus 로고
    • ICL670A: A new synthetic oral chelator: evaluation in hypertransfused rats with selective radio iron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture
    • Hershko C, Konjin MA, Nick HP, Breuer W, Cabantchik Z I, Link G. ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radio iron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood 2001; 97(4):1115-1122.
    • (2001) Blood , vol.97 , Issue.4 , pp. 1115-1122
    • Hershko, C.1    Konjin, M.A.2    Nick, H.P.3    Breuer, W.4    Cabantchik, Z.I.5    Link, G.6
  • 62
    • 15844398915 scopus 로고    scopus 로고
    • Dose response of deferoxamine, deferiprone, and ICL670 chelation therapy in a Gerbil model of iron overload
    • Abstract 3621
    • Wood JC, Otto-Duessel M, Aguilar M, Nick H, Coates TD, Rex M. Dose response of deferoxamine, deferiprone, and ICL670 chelation therapy in a Gerbil model of iron overload. Blood 2004, 104(4):Abstract 3621.
    • (2004) Blood , vol.104 , Issue.4
    • Wood, J.C.1    Otto-Duessel, M.2    Aguilar, M.3    Nick, H.4    Coates, T.D.5    Rex, M.6
  • 64
    • 27644456657 scopus 로고    scopus 로고
    • Phase III evaluation of once-daily oral therapy with ICL670 (Exjade) versus deferoxamine in patients with β-thalassemia and transfusional hemosiderosis
    • Abstract 3619
    • Cappelini M, Bejaoui M, Perrota S, Agaoglou L, Kattamis A, Giardina P, Janka-Schaub G, Opitz H, Ressayre-Djaffer C, Alberti D. Phase III evaluation of once-daily oral therapy with ICL670 (Exjade) versus deferoxamine in patients with β-thalassemia and transfusional hemosiderosis. Blood 2004; 104(11):Abstract 3619.
    • (2004) Blood , vol.104 , Issue.11
    • Cappelini, M.1    Bejaoui, M.2    Perrota, S.3    Agaoglou, L.4    Kattamis, A.5    Giardina, P.6    Janka-Schaub, G.7    Opitz, H.8    Ressayre-Djaffer, C.9    Alberti, D.10
  • 65
    • 27644547811 scopus 로고    scopus 로고
    • A phase II study with ICL670 (Exjade), a once-daily oral iron chelator, in patients with various transfusion-dependent anemias and iron overload
    • Abstract 3193
    • Porter J, Vichinsky E, Rose C, Piga A, Olivieri N, Gattermann I, Maertens J, Rabault B, Gathmann I, Alberti D. A phase II study with ICL670 (Exjade), a once-daily oral iron chelator, in patients with various transfusion-dependent anemias and iron overload. Blood 2004; 104(11):Abstract 3193.
    • (2004) Blood , vol.104 , Issue.11
    • Porter, J.1    Vichinsky, E.2    Rose, C.3    Piga, A.4    Olivieri, N.5    Gattermann, I.6    Maertens, J.7    Rabault, B.8    Gathmann, I.9    Alberti, D.10
  • 66
    • 27744544284 scopus 로고    scopus 로고
    • Advances in iron overload therapies. Prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1Nall and their combinations
    • Kontoghiorghes GJ, Eracleous E, Economides Ch, Kolnagou A. Advances in iron overload therapies. Prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1Nall and their combinations. Curr Med Chem 2005, 12(23):2663-2681.
    • (2005) Curr Med Chem , vol.12 , Issue.23 , pp. 2663-2681
    • Kontoghiorghes, G.J.1    Eracleous, E.2    Economides, C.3    Kolnagou, A.4
  • 67
    • 26944496130 scopus 로고    scopus 로고
    • Effects of ICL670 (deferasirox) on cardiac iron concentration
    • Kontoghiorghes GJ. Effects of ICL670 (deferasirox) on cardiac iron concentration. Lancet 2005; 366(9488):804.
    • (2005) Lancet , vol.366 , Issue.9488 , pp. 804
    • Kontoghiorghes, G.J.1
  • 70
    • 14644422467 scopus 로고    scopus 로고
    • The safety and pharmacokinetics of GT56-252, a novel orally available iron chelator
    • Abstract 139
    • Donovan JM, Palmer PA, Plone MA, Wonke B. The safety and pharmacokinetics of GT56-252, a novel orally available iron chelator. Eur J Clin Invest 2004, 34 (Suppl I):39, Abstract 139.
    • (2004) Eur J Clin Invest , vol.34 , Issue.SUPPL. I , pp. 39
    • Donovan, J.M.1    Palmer, P.A.2    Plone, M.A.3    Wonke, B.4
  • 71
    • 45949113016 scopus 로고
    • Simple synthesis of the potent iron chelators 1-alkyl-3-hydroxy-2- methylpyrid-4-ones
    • Kontoghiorghes GJ, Sheppard L. Simple synthesis of the potent iron chelators 1-alkyl-3-hydroxy-2-methylpyrid-4-ones. Inorg Chim Acta 1987, 136:L11-L12.
    • (1987) Inorg Chim Acta , vol.136
    • Kontoghiorghes, G.J.1    Sheppard, L.2
  • 72
    • 0038593465 scopus 로고
    • L1NAll. 1-Allyl-2-methyl-3-hydroxypyrid-4-one
    • Kontoghiorghes GJ. L1NAll. 1-Allyl-2-methyl-3-hydroxypyrid-4-one. Drugs Future 1990; 15(3):230-232.
    • (1990) Drugs Future , vol.15 , Issue.3 , pp. 230-232
    • Kontoghiorghes, G.J.1
  • 73
    • 0021914999 scopus 로고
    • New orally active iron chelators
    • Kontoghiorghes GJ. New orally active iron chelators. Lancet 1985; 1(8432):817.
    • (1985) Lancet , vol.1 , Issue.8432 , pp. 817
    • Kontoghiorghes, G.J.1
  • 74
    • 0027403243 scopus 로고
    • Selection of a new generation of orally active α- ketohydroxypyridine iron chelators intended for use in the treatment of iron overload
    • Kontoghiorghes GJ, Barr J, Nortey P, Sheppard L. Selection of a new generation of orally active α-ketohydroxypyridine iron chelators intended for use in the treatment of iron overload. Am J Hematol 1993; 42(4):340-349.
    • (1993) Am J Hematol , vol.42 , Issue.4 , pp. 340-349
    • Kontoghiorghes, G.J.1    Barr, J.2    Nortey, P.3    Sheppard, L.4
  • 76
    • 0027053965 scopus 로고
    • Effect on iron excretion and animal toxicology of L1 and other α-ketohydroxypyridine chelators
    • Nortey P, Barr J, Matsakis M, Nasseri-Sina P, Kontoghiorghes GJ. Effect on iron excretion and animal toxicology of L1 and other α- ketohydroxypyridine chelators. Drugs Today 1992; 28(Suppl A):81-88.
    • (1992) Drugs Today , vol.28 , Issue.SUPPL. A , pp. 81-88
    • Nortey, P.1    Barr, J.2    Matsakis, M.3    Nasseri-Sina, P.4    Kontoghiorghes, G.J.5
  • 77
    • 0027098148 scopus 로고
    • Study of L1NAll, a new oral iron chelator in two experimental models of human β-thalassemia
    • Sauvage C, Rouyer-Fessard R, Turlin B, Brissot P, Beuzard Y. Study of L1NAll, a new oral iron chelator in two experimental models of human β-thalassemia. Drugs Today, 1992; 28(Suppl A):65-71.
    • (1992) Drugs Today , vol.28 , Issue.SUPPL. A , pp. 65-71
    • Sauvage, C.1    Rouyer-Fessard, R.2    Turlin, B.3    Brissot, P.4    Beuzard, Y.5
  • 78
    • 27744583390 scopus 로고
    • Results of the mutagenecity tests of 1,2-dimethyl-3-hydroxypyrid-4-one (L1) 1-allyl-2-methyl-3-hydroxypyrid-4-one (L1NAll) and their iron complexes
    • Nasseri-Sina P, Murray BP, Boobis AR, Kontoghiorghes GJ. Results of the mutagenecity tests of 1,2-dimethyl-3-hydroxypyrid-4-one (L1) 1-allyl-2-methyl-3-hydroxypyrid-4-one (L1NAll) and their iron complexes. Plzen Lek Shorn 1990; 62:221-224.
    • (1990) Plzen Lek Shorn , vol.62 , pp. 221-224
    • Nasseri-Sina, P.1    Murray, B.P.2    Boobis, A.R.3    Kontoghiorghes, G.J.4
  • 79
    • 0027102249 scopus 로고
    • Interaction of L1, L1NAll and deferoxamine with gallium in vivo
    • Eybl V, Svihovcova P, Koutensky J, Kontoghiorghes GJ. Interaction of L1, L1NAll and deferoxamine with gallium in vivo. Drugs Today, 1992; 28(Suppl A):173-175.
    • (1992) Drugs Today , vol.28 , Issue.SUPPL. A , pp. 173-175
    • Eybl, V.1    Svihovcova, P.2    Koutensky, J.3    Kontoghiorghes, G.J.4
  • 82
    • 33645119733 scopus 로고    scopus 로고
    • New oral iron-chelating drugs for the treatment of transfusional iron overload and other diseases
    • Kontoghiorghes GJ. New oral iron-chelating drugs for the treatment of transfusional iron overload and other diseases. Drugs Future 2006; 30(12):1241-1251.
    • (2006) Drugs Future , vol.30 , Issue.12 , pp. 1241-1251
    • Kontoghiorghes, G.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.