-
1
-
-
0036800592
-
A genetic view of haemochromatosis
-
Andrews NC. A genetic view of haemochromatosis. Semin Hematol 2002; 39(4):227-234.
-
(2002)
Semin Hematol
, vol.39
, Issue.4
, pp. 227-234
-
-
Andrews, N.C.1
-
3
-
-
0020648765
-
Community control of hereditary anaemias
-
World Health Organisation. Community control of hereditary anaemias. WHO Bull 1983; 61(1):63-80.
-
(1983)
WHO Bull
, vol.61
, Issue.1
, pp. 63-80
-
-
-
6
-
-
0027453417
-
Present status and future prospects of oral iron chelation therapy in thalassemia and other diseases
-
Kontoghiorghes GJ. Present status and future prospects of oral iron chelation therapy in thalassemia and other diseases. Indian J Paediatr 1993; 60(4):485-507.
-
(1993)
Indian J Paediatr
, vol.60
, Issue.4
, pp. 485-507
-
-
Kontoghiorghes, G.J.1
-
7
-
-
0038649860
-
Benefits and risks of deferiprone in iron overload in thalassemia and other conditions
-
Kontoghiorghes GJ, Neocleous K, Kolnagou A. Benefits and risks of deferiprone in iron overload in thalassemia and other conditions. Drug Saf 2003; 26(8):553-584.
-
(2003)
Drug Saf
, vol.26
, Issue.8
, pp. 553-584
-
-
Kontoghiorghes, G.J.1
Neocleous, K.2
Kolnagou, A.3
-
8
-
-
33745582295
-
-
Berlin: Springer-Verlag
-
Gross F. Iron Metabolism. Berlin: Springer-Verlag. 1964.
-
(1964)
Iron Metabolism
-
-
Gross, F.1
-
11
-
-
3242753676
-
The design and development of deferiprone (L1) and other iron chelators for clinical use: Targeting methods and application prospects
-
Kontoghiorghes GJ, Pattichis K, Neocleous K, Kolnagou A. The design and development of deferiprone (L1) and other iron chelators for clinical use: targeting methods and application prospects. Curr Med Chem 2004; 11(162161-2183.
-
(2004)
Curr Med Chem
, vol.11
, Issue.16
, pp. 2161-2183
-
-
Kontoghiorghes, G.J.1
Pattichis, K.2
Neocleous, K.3
Kolnagou, A.4
-
12
-
-
0028840530
-
Comparative efficacy and toxicity of desferrioxamine, deferiprone and other iron and aluminium chelating drugs
-
Kontoghiorghes GJ. Comparative efficacy and toxicity of desferrioxamine, deferiprone and other iron and aluminium chelating drugs. Toxicol Lett 1995; 80(1-3):1-18.
-
(1995)
Toxicol Lett
, vol.80
, Issue.1-3
, pp. 1-18
-
-
Kontoghiorghes, G.J.1
-
13
-
-
7444249085
-
The biochemistry of desferrioxamine and its relation to iron metabolism
-
Keberle H. The biochemistry of desferrioxamine and its relation to iron metabolism. Ann NY Acad Sci 1964; 119:758-768.
-
(1964)
Ann NY Acad Sci
, vol.119
, pp. 758-768
-
-
Keberle, H.1
-
14
-
-
0026571807
-
Pulmonary toxic effects of continuous desferrioxamine administration in acute iron poisoning
-
Tenenbein M, Kowalski S, Sienko A, Bowden DH, Adamson IYR. Pulmonary toxic effects of continuous desferrioxamine administration in acute iron poisoning. Lancet 1992; 1(8795):699-701.
-
(1992)
Lancet
, vol.1
, Issue.8795
, pp. 699-701
-
-
Tenenbein, M.1
Kowalski, S.2
Sienko, A.3
Bowden, D.H.4
Adamson, I.Y.R.5
-
15
-
-
0025267012
-
Acute bone marrow aplasia associated with intravenous administration of deferoxamine (desferrioxamine)
-
Sofroniadou K, Drossou M, Foundoulaki M, Konstantopoulos K, Kyriakou D, Zervas J. Acute bone marrow aplasia associated with intravenous administration of deferoxamine (desferrioxamine). Drug Saf 1990; 5(2):152-154.
-
(1990)
Drug Saf
, vol.5
, Issue.2
, pp. 152-154
-
-
Sofroniadou, K.1
Drossou, M.2
Foundoulaki, M.3
Konstantopoulos, K.4
Kyriakou, D.5
Zervas, J.6
-
16
-
-
0021329590
-
Prophylaxis of systemic yersiniasis in thalassemia major
-
Sharnetzky M, Konig R, Lamomek M, Tillmann W, Schroter W. Prophylaxis of systemic yersiniasis in thalassemia major. Lancet 1984; 2(8380):791.
-
(1984)
Lancet
, vol.2
, Issue.8380
, pp. 791
-
-
Sharnetzky, M.1
Konig, R.2
Lamomek, M.3
Tillmann, W.4
Schroter, W.5
-
17
-
-
0034631379
-
Survival in β-thalassaemia major in the UK: Data from the UK register
-
Modell B, Khan M, Darlison M. Survival in β-thalassaemia major in the UK: data from the UK register. Lancet 2000; 355(9220):2051-2052.
-
(2000)
Lancet
, vol.355
, Issue.9220
, pp. 2051-2052
-
-
Modell, B.1
Khan, M.2
Darlison, M.3
-
18
-
-
0027291099
-
Intravenous infusion pharmacokinetics of desferrioxamine and its relation to iron metabolism
-
Lee P, Mohammed N, Marshall RD, Abeysinghe R, Hider RC, Porter J, Singh S. Intravenous infusion pharmacokinetics of desferrioxamine and its relation to iron metabolism. Drug Metabol Dispos 1993; 21(4):640-644.
-
(1993)
Drug Metabol Dispos
, vol.21
, Issue.4
, pp. 640-644
-
-
Lee, P.1
Mohammed, N.2
Marshall, R.D.3
Abeysinghe, R.4
Hider, R.C.5
Porter, J.6
Singh, S.7
-
19
-
-
0021357262
-
Desferrioxamine to improve cardiac function in iron-overloaded patients with thalassemia major
-
Marcus RE, Davies SG, Bantock HM, Underwood SR, Walton S, Huehns ER. Desferrioxamine to improve cardiac function in iron-overloaded patients with thalassemia major. Lancet 1984; 1(8373):392-393.
-
(1984)
Lancet
, vol.1
, Issue.8373
, pp. 392-393
-
-
Marcus, R.E.1
Davies, S.G.2
Bantock, H.M.3
Underwood, S.R.4
Walton, S.5
Huehns, E.R.6
-
20
-
-
7944230624
-
Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: A prospective study using T2* cardiovascular magnetic resonance
-
Anderson LJ, Westwood MA, Holden S, Davis B, Prescott E, Wonke B, Porter JB, Walker JM, Pennell DJ. Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: a prospective study using T2* cardiovascular magnetic resonance. Br J Haematol 2004; 127(3):348-355.
-
(2004)
Br J Haematol
, vol.127
, Issue.3
, pp. 348-355
-
-
Anderson, L.J.1
Westwood, M.A.2
Holden, S.3
Davis, B.4
Prescott, E.5
Wonke, B.6
Porter, J.B.7
Walker, J.M.8
Pennell, D.J.9
-
21
-
-
0030830275
-
Evaluation of a new method of administration of the iron chelating agent deferoxamine
-
Borgna-Pignatti C, Cohen A. Evaluation of a new method of administration of the iron chelating agent deferoxamine. J Pediatr 1997; 130(1):86-88.
-
(1997)
J Pediatr
, vol.130
, Issue.1
, pp. 86-88
-
-
Borgna-Pignatti, C.1
Cohen, A.2
-
22
-
-
27744603798
-
Phase 1b study of the safety, pharmacokinetics, acute tolerability, and efficacy of ascending single doses of 40SD02 (CHF5140, GS460) in iron loaded patients
-
Abstract 423
-
Harmatz P, Grady RW, Vichinsky E, Giardina PJ, Jeng M, Madden J, Nugent KA, Dragsten P. Phase 1b study of the safety, pharmacokinetics, acute tolerability, and efficacy of ascending single doses of 40SD02 (CHF5140, GS460) in iron loaded patients. Blood 2003; 102(11):Abstract 423.
-
(2003)
Blood
, vol.102
, Issue.11
-
-
Harmatz, P.1
Grady, R.W.2
Vichinsky, E.3
Giardina, P.J.4
Jeng, M.5
Madden, J.6
Nugent, K.A.7
Dragsten, P.8
-
24
-
-
0023877695
-
L1 (1,2-dimethyl-3-hydroxypyrid-4-one)
-
Kontoghiorghes GJ. L1 (1,2-dimethyl-3-hydroxypyrid-4-one). Drugs Future 1988; 13(5):413-415.
-
(1988)
Drugs Future
, vol.13
, Issue.5
, pp. 413-415
-
-
Kontoghiorghes, G.J.1
-
25
-
-
0025007785
-
Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one
-
Kontoghiorghes GJ, Goddard JG, Bartlett AN, Sheppard L. Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one. Clin Pharm Ther 1990; 48(3):255-261.
-
(1990)
Clin Pharm Ther
, vol.48
, Issue.3
, pp. 255-261
-
-
Kontoghiorghes, G.J.1
Goddard, J.G.2
Bartlett, A.N.3
Sheppard, L.4
-
26
-
-
0028897880
-
New concepts of iron and aluminium chelation therapy with oral L1 (Deferiprone) and other chelators
-
Kontoghiorghes GJ. New concepts of iron and aluminium chelation therapy with oral L1 (Deferiprone) and other chelators. Analyst 1995; 120(3):845-851.
-
(1995)
Analyst
, vol.120
, Issue.3
, pp. 845-851
-
-
Kontoghiorghes, G.J.1
-
27
-
-
0027056363
-
Synthesis and metabolism of L1 and other novel α- ketohydroxypyridine iron chelators and their metal complexes
-
Sheppard L, Kontoghiorghes GJ. Synthesis and metabolism of L1 and other novel α-ketohydroxypyridine iron chelators and their metal complexes. Drugs Today 1992; 28(Suppl A):3-10.
-
(1992)
Drugs Today
, vol.28
, Issue.SUPPL. A
, pp. 3-10
-
-
Sheppard, L.1
Kontoghiorghes, G.J.2
-
28
-
-
0025018222
-
Long term trial with the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1). (I) Iron chelation and metabolic studies
-
Kontoghiorghes GJ, Bartlett AN, Hoffbrand AV, Goddard JG, Sheppard L, Barr J, Nortey P. Long term trial with the oral chelator 1,2-dimethyl-3- hydroxypyrid-4-one (L1). (I) Iron chelation and metabolic studies. Br J Haematol 1990; 76(2):295-300.
-
(1990)
Br J Haematol
, vol.76
, Issue.2
, pp. 295-300
-
-
Kontoghiorghes, G.J.1
Bartlett, A.N.2
Hoffbrand, A.V.3
Goddard, J.G.4
Sheppard, L.5
Barr, J.6
Nortey, P.7
-
29
-
-
0029120697
-
Oral iron chelation therapy with deferiprone (L1): Monitoring of biochemical, drug and iron excretion changes
-
Kontoghiorghes GJ, Bartlett AN, Sheppard L, Barr J, Nortey P. Oral iron chelation therapy with deferiprone (L1): monitoring of biochemical, drug and iron excretion changes. Arzn Forsch/Drug Res 1995; 45(1):65-69.
-
(1995)
Arzn Forsch/Drug Res
, vol.45
, Issue.1
, pp. 65-69
-
-
Kontoghiorghes, G.J.1
Bartlett, A.N.2
Sheppard, L.3
Barr, J.4
Nortey, P.5
-
30
-
-
0021932825
-
Site specificity of iron removal from transferrin by α- kytohydroxypyridine chelators
-
Kontoghiorghes GJ, Evans RW. Site specificity of iron removal from transferrin by α-kytohydroxypyridine chelators. FEBS Lett 1985;189(1):141-144.
-
(1985)
FEBS Lett
, vol.189
, Issue.1
, pp. 141-144
-
-
Kontoghiorghes, G.J.1
Evans, R.W.2
-
31
-
-
0022629886
-
The study of iron mobilization from transferrin using α-ketohydroxy heteroaromatic chelators
-
Kontoghiorghes GJ. The study of iron mobilization from transferrin using α-ketohydroxy heteroaromatic chelators. Biochim Biophys Acta 1986; 869(2):141-146.
-
(1986)
Biochim Biophys Acta
, vol.869
, Issue.2
, pp. 141-146
-
-
Kontoghiorghes, G.J.1
-
32
-
-
0027080322
-
The effect of α-ketohydroxypyridine chelators on transferrin saturation in vitro and in vivo
-
Evans RW, Sharma M, Ogwang W, Patel KJ, Bartlett AN, Kontoghiorghes GJ. The effect of α-ketohydroxypyridine chelators on transferrin saturation in vitro and in vivo. Drugs Today 1992; 28(Suppl A):19-23.
-
(1992)
Drugs Today
, vol.28
, Issue.SUPPL. A
, pp. 19-23
-
-
Evans, R.W.1
Sharma, M.2
Ogwang, W.3
Patel, K.J.4
Bartlett, A.N.5
Kontoghiorghes, G.J.6
-
33
-
-
0033788665
-
Fast biological iron chelators: Kinetics of iron removal from human diferric transferrin by multidentate hydroxypyridonates
-
Turcot I, Stintzi A, Xu J. Raymond KN. Fast biological iron chelators: kinetics of iron removal from human diferric transferrin by multidentate hydroxypyridonates. J Biol Inorg Chem 2000; 5(5):634-641.
-
(2000)
J Biol Inorg Chem
, vol.5
, Issue.5
, pp. 634-641
-
-
Turcot, I.1
Stintzi, A.2
Xu, J.3
Raymond, K.N.4
-
34
-
-
0026680591
-
Reduction of tissue iron stores and normalization of serum ferritin during treatment with the oral iron chelator L1 in thalassemia intermedia
-
Olivieri NF, Koren G, Matsuii D, Liu PP, Blendis L, Cameron R, McClelland RA, Templeton DM. Reduction of tissue iron stores and normalization of serum ferritin during treatment with the oral iron chelator L1 in thalassemia intermedia. Blood 1992; 79(10):2741-2748.
-
(1992)
Blood
, vol.79
, Issue.10
, pp. 2741-2748
-
-
Olivieri, N.F.1
Koren, G.2
Matsuii, D.3
Liu, P.P.4
Blendis, L.5
Cameron, R.6
McClelland, R.A.7
Templeton, D.M.8
-
35
-
-
0031859182
-
Liver iron fibrosis during long-term treatment with deferiprone in Swiss thalassaemic patients
-
Tondury P, Zimmerman A, Nielsen P, Hirt A. Liver iron fibrosis during long-term treatment with deferiprone in Swiss thalassaemic patients. Br J. Haematol 1998; 101(3):413-415.
-
(1998)
Br J Haematol
, vol.101
, Issue.3
, pp. 413-415
-
-
Tondury, P.1
Zimmerman, A.2
Nielsen, P.3
Hirt, A.4
-
36
-
-
7944221912
-
Prophylactic use of deferiprone (L1) and magnetic resonance imaging T2* or T2 for preventing heart disease in thalassaemia
-
Kolnagou A, Fessas Ch, Papatryphonas A, Economides Ch, Kontoghiorghes GJ. Prophylactic use of deferiprone (L1) and magnetic resonance imaging T2* or T2 for preventing heart disease in thalassaemia. Br J Haematol 2004; 127(3):360-361.
-
(2004)
Br J Haematol
, vol.127
, Issue.3
, pp. 360-361
-
-
Kolnagou, A.1
Fessas, Ch.2
Papatryphonas, A.3
Economides, Ch.4
Kontoghiorghes, G.J.5
-
37
-
-
0037125595
-
Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in β-thalassaemia
-
Anderson LJ, Wonke B, Prescott E, Holden S, Walker JM, Pennel DJ. Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in β-thalassaemia. Lancet 2002; 360(9332):516-520.
-
(2002)
Lancet
, vol.360
, Issue.9332
, pp. 516-520
-
-
Anderson, L.J.1
Wonke, B.2
Prescott, E.3
Holden, S.4
Walker, J.M.5
Pennel, D.J.6
-
38
-
-
0042736560
-
Do we need more iron chelating drugs?
-
Kontoghiorghes GJ. Do we need more iron chelating drugs? Lancet 2003; 362(9382):495-496.
-
(2003)
Lancet
, vol.362
, Issue.9382
, pp. 495-496
-
-
Kontoghiorghes, G.J.1
-
39
-
-
0038472463
-
Safety monitoring of cardiac and hepatic systems in β-thalassemia patients with chelating treatment in Taiwan
-
Peng CT, Chow KC, Chen JH, Chiang YP, Lin TY, Tsai CH. Safety monitoring of cardiac and hepatic systems in β-thalassemia patients with chelating treatment in Taiwan. Eur J Haematol 2003; 70(6):392-397.
-
(2003)
Eur J Haematol
, vol.70
, Issue.6
, pp. 392-397
-
-
Peng, C.T.1
Chow, K.C.2
Chen, J.H.3
Chiang, Y.P.4
Lin, T.Y.5
Tsai, C.H.6
-
40
-
-
0023489829
-
Effective chelation of iron in β-thalassaemia with the oral chelator 1, 2-dimethyl-3-hydroxypyrid-4-one
-
Kontoghiorghes GJ, Aldouri, MA, Hoffbrand AV, Barr J, Wonke B, Kourouclaris T, Sheppard L. Effective chelation of iron in β-thalassaemia with the oral chelator 1, 2-dimethyl-3-hydroxypyrid-4-one. Br Med J 1987; 295(6612):1509-1512.
-
(1987)
Br Med J
, vol.295
, Issue.6612
, pp. 1509-1512
-
-
Kontoghiorghes, G.J.1
Aldouri, M.A.2
Hoffbrand, A.V.3
Barr, J.4
Wonke, B.5
Kourouclaris, T.6
Sheppard, L.7
-
41
-
-
0023214937
-
1, 2-Dimethyl-3-hydroxypyrid-4-one, an orally active chelator for the treatment of transfusional iron overload
-
Kontoghiorghes GJ, Aldouri MA, Sheppard LN, Hoffbrand AV. 1, 2-Dimethyl-3-hydroxypyrid-4-one, an orally active chelator for the treatment of transfusional iron overload. Lancet 1987; 1(8545):1294-1295.
-
(1987)
Lancet
, vol.1
, Issue.8545
, pp. 1294-1295
-
-
Kontoghiorghes, G.J.1
Aldouri, M.A.2
Sheppard, L.N.3
Hoffbrand, A.V.4
-
42
-
-
0027093057
-
Long term treatment of transfusion hemosiderosis with the oral iron chelator L1
-
Goudsmit R, Kersten MJ. Long term treatment of transfusion hemosiderosis with the oral iron chelator L1. Drugs Today 1992; 28(suppl. A):133-135.
-
(1992)
Drugs Today
, vol.28
, Issue.SUPPL. A
, pp. 133-135
-
-
Goudsmit, R.1
Kersten, M.J.2
-
43
-
-
0027066787
-
Iron overload in polytransfused patients with MDS; use of L1 for oral iron chelation
-
Jaeger M, Aul C, Sohngen D, Germing U, Schneider W. Iron overload in polytransfused patients with MDS; use of L1 for oral iron chelation. Drugs Today. 1992; 28(Suppl A):143-147.
-
(1992)
Drugs Today
, vol.28
, Issue.SUPPL. A
, pp. 143-147
-
-
Jaeger, M.1
Aul, C.2
Sohngen, D.3
Germing, U.4
Schneider, W.5
-
44
-
-
0027053573
-
Long term assessment of efficacy and toxicity of L1 (1,2-dimethyl-3- hydroxypyrid-4-one) in transfusion dependent thalassemia. Indian trial
-
Agarwal M.B, Gupta SS, Viswanathan C, Vasandani D, Ramanathan J, Desai N, Puniyani RR, Chhablani AT. Long term assessment of efficacy and toxicity of L1 (1,2-dimethyl-3-hydroxypyrid-4-one) in transfusion dependent thalassemia. Indian trial. Drugs Today 1992; 28(Suppl A):107-114.
-
(1992)
Drugs Today
, vol.28
, Issue.SUPPL. A
, pp. 107-114
-
-
Agarwal, M.B.1
Gupta, S.S.2
Viswanathan, C.3
Vasandani, D.4
Ramanathan, J.5
Desai, N.6
Puniyani, R.R.7
Chhablani, A.T.8
-
45
-
-
0034094839
-
Safety profile of the oral iron chelator deferiprone: A multicentre study
-
Cohen AR, Galanello R, Piga A, Di Palma A, Voullo C, Tricta F. Safety profile of the oral iron chelator deferiprone: a multicentre study. Br J Haematol 2000; 108(2):305-312.
-
(2000)
Br J Haematol
, vol.108
, Issue.2
, pp. 305-312
-
-
Cohen, A.R.1
Galanello, R.2
Piga, A.3
Di Palma, A.4
Voullo, C.5
Tricta, F.6
-
46
-
-
0026668939
-
Long term assessment of efficacy and safety of L1, an oral iron chelator in transfusion dependent thalassaemia: Indian trial
-
Agarwal MB, Gupta SS, Viswanathan C, Vasantani D, Ramanathan J, Desai N, Puniyani RR, Chablani AT. Long term assessment of efficacy and safety of L1, an oral iron chelator in transfusion dependent thalassaemia: Indian trial. Br J Haematol 1992; 82(2):460-466.
-
(1992)
Br J Haematol
, vol.82
, Issue.2
, pp. 460-466
-
-
Agarwal, M.B.1
Gupta, S.S.2
Viswanathan, C.3
Vasantani, D.4
Ramanathan, J.5
Desai, N.6
Puniyani, R.R.7
Chablani, A.T.8
-
47
-
-
0024403012
-
Prospects for effective oral iron chelation therapy in man with 1,2-dimethyl-3-hydroxypyrid-4-one and other α-ketohydroxypyridines
-
Kontoghiorghes GJ, Bartlett AH, Hoffbrand AV. Prospects for effective oral iron chelation therapy in man with 1,2-dimethyl-3-hydroxypyrid-4-one and other α-ketohydroxypyridines. Prog Clin Biol Res 1989; 309:107-114.
-
(1989)
Prog Clin Biol Res
, vol.309
, pp. 107-114
-
-
Kontoghiorghes, G.J.1
Bartlett, A.H.2
Hoffbrand, A.V.3
-
48
-
-
7944226807
-
Radiographic and MRI features of deferiprone-related arthropathy of the knees in patients with β-thalassemia
-
Kellenberger CJ, Schmugge M, Saurenmann T, Gennaro LD, Eber SW, Willi UV, Babyn PS. Radiographic and MRI features of deferiprone-related arthropathy of the knees in patients with β-thalassemia. Am J Roentgenol 2004; 183(4):989-994.
-
(2004)
Am J Roentgenol
, vol.183
, Issue.4
, pp. 989-994
-
-
Kellenberger, C.J.1
Schmugge, M.2
Saurenmann, T.3
Gennaro, L.D.4
Eber, S.W.5
Willi, U.V.6
Babyn, P.S.7
-
49
-
-
0026507913
-
Advances in oral iron chelation in man
-
Kontoghiorghes GJ. Advances in oral iron chelation in man. Int J Haematol 1992; 55(1):27-38.
-
(1992)
Int J Haematol
, vol.55
, Issue.1
, pp. 27-38
-
-
Kontoghiorghes, G.J.1
-
50
-
-
0031784438
-
Combined therapy with deferiprone and deferoxamine
-
Wonke B, Wright C, Hoffbrand AV. Combined therapy with deferiprone and deferoxamine. Br J. Haematol 1998; 103(2):361-364.
-
(1998)
Br J. Haematol
, vol.103
, Issue.2
, pp. 361-364
-
-
Wonke, B.1
Wright, C.2
Hoffbrand, A.V.3
-
51
-
-
0034783438
-
Chelation therapy in β-thalassemia: An optimistic update
-
Giardina PJ, Grady RW. Chelation therapy in β-thalassemia: an optimistic update. Semin Hematol 2001; 38(4):360-366.
-
(2001)
Semin Hematol
, vol.38
, Issue.4
, pp. 360-366
-
-
Giardina, P.J.1
Grady, R.W.2
-
52
-
-
0020577339
-
Ocular toxicity of high dose intravenous desferrioxamine
-
Davies SC, Marcus RE, Hungerford JL, Miller MH, Arden GB, Huehns ER. Ocular toxicity of high dose intravenous desferrioxamine. Lancet 1983; 2(8343):181-184.
-
(1983)
Lancet
, vol.2
, Issue.8343
, pp. 181-184
-
-
Davies, S.C.1
Marcus, R.E.2
Hungerford, J.L.3
Miller, M.H.4
Arden, G.B.5
Huehns, E.R.6
-
53
-
-
0022649329
-
Ocular toxicity of desferrioxamine: Light microscopic histochemical and ultrastructural findings
-
Rahi AHS, Hungerford JL, Ahmed AI. Ocular toxicity of desferrioxamine: light microscopic histochemical and ultrastructural findings. Br J Ophthal 1986; 70(5):373-381.
-
(1986)
Br J Ophthal
, vol.70
, Issue.5
, pp. 373-381
-
-
Rahi, A.H.S.1
Hungerford, J.L.2
Ahmed, A.I.3
-
54
-
-
0022002352
-
Ocular toxicity of desferrioxamine
-
Rubinstein M, Dupont P, Doppel JP, Ducobu J, Hainant J. Ocular toxicity of desferrioxamine. Lancet 1985; 1(8432):817-818.
-
(1985)
Lancet
, vol.1
, Issue.8432
, pp. 817-818
-
-
Rubinstein, M.1
Dupont, P.2
Doppel, J.P.3
Ducobu, J.4
Hainant, J.5
-
55
-
-
0021321289
-
Visual loss in patient on high dose subcutaneous desferrioxamine
-
Borgna-Pignatti C, De Stefano P, Broglia AM. Visual loss in patient on high dose subcutaneous desferrioxamine. Lancet 1984; 1(8378):68.
-
(1984)
Lancet
, vol.1
, Issue.8378
, pp. 68
-
-
Borgna-Pignatti, C.1
De Stefano, P.2
Broglia, A.M.3
-
56
-
-
0021874024
-
Acute deafness and desferrioxamine
-
Guerin A, London G, Marchais S, Mativier F, Pelisse JM. Acute deafness and desferrioxamine. Lancet 1985; 2(8445):39-40.
-
(1985)
Lancet
, vol.2
, Issue.8445
, pp. 39-40
-
-
Guerin, A.1
London, G.2
Marchais, S.3
Mativier, F.4
Pelisse, J.M.5
-
57
-
-
14544276809
-
Iron-chelating therapy with the new oral agent ICL670 (Exjade)
-
Cappelini MD. Iron-chelating therapy with the new oral agent ICL670 (Exjade). Best Prac Res Clin Hematol 2005; 18(2):289-298.
-
(2005)
Best Prac Res Clin Hematol
, vol.18
, Issue.2
, pp. 289-298
-
-
Cappelini, M.D.1
-
58
-
-
0038324389
-
Development of tridentate iron chelators: From desferrithiocin to ICL670
-
Nick H, Acklin P, Lattmann R, Buechlmayer P, Hauffe S, Hauffe S, Schupp J, Alberti D. Development of tridentate iron chelators: from desferrithiocin to ICL670. Curr Med Chem 2003; 10(12):1065-1076.
-
(2003)
Curr Med Chem
, vol.10
, Issue.12
, pp. 1065-1076
-
-
Nick, H.1
Acklin, P.2
Lattmann, R.3
Buechlmayer, P.4
Hauffe, S.5
Hauffe, S.6
Schupp, J.7
Alberti, D.8
-
59
-
-
10744230223
-
Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: A randomised, double-blind, placebo-controlled, dose-escalation trial
-
Nisbet-Brown E, Olivieri NF, Giardina PJ, Grady RW, Neufeld EJ, Sechaud R, Krebs-Brown AJ, Anderson JR, Alberti D, Sizer KC, Nathan DG. Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet 2003; 361(9369):1597-1602.
-
(2003)
Lancet
, vol.361
, Issue.9369
, pp. 1597-1602
-
-
Nisbet-Brown, E.1
Olivieri, N.F.2
Giardina, P.J.3
Grady, R.W.4
Neufeld, E.J.5
Sechaud, R.6
Krebs-Brown, A.J.7
Anderson, J.R.8
Alberti, D.9
Sizer, K.C.10
Nathan, D.G.11
-
60
-
-
0037906104
-
Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to β-thalassemia
-
Galanello R, Piga A, Alberti D, Rouan MC, Bigler H, Sechaud R. Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to β-thalassemia J Clin Pharmacol 2003; 43(6):565-572.
-
(2003)
J Clin Pharmacol
, vol.43
, Issue.6
, pp. 565-572
-
-
Galanello, R.1
Piga, A.2
Alberti, D.3
Rouan, M.C.4
Bigler, H.5
Sechaud, R.6
-
61
-
-
0035865702
-
ICL670A: A new synthetic oral chelator: evaluation in hypertransfused rats with selective radio iron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture
-
Hershko C, Konjin MA, Nick HP, Breuer W, Cabantchik Z I, Link G. ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radio iron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood 2001; 97(4):1115-1122.
-
(2001)
Blood
, vol.97
, Issue.4
, pp. 1115-1122
-
-
Hershko, C.1
Konjin, M.A.2
Nick, H.P.3
Breuer, W.4
Cabantchik, Z.I.5
Link, G.6
-
62
-
-
15844398915
-
Dose response of deferoxamine, deferiprone, and ICL670 chelation therapy in a Gerbil model of iron overload
-
Abstract 3621
-
Wood JC, Otto-Duessel M, Aguilar M, Nick H, Coates TD, Rex M. Dose response of deferoxamine, deferiprone, and ICL670 chelation therapy in a Gerbil model of iron overload. Blood 2004, 104(4):Abstract 3621.
-
(2004)
Blood
, vol.104
, Issue.4
-
-
Wood, J.C.1
Otto-Duessel, M.2
Aguilar, M.3
Nick, H.4
Coates, T.D.5
Rex, M.6
-
63
-
-
27744518242
-
Once-daily treatment with the oral iron chelator ICL670 (Exjade): Results of a phase II study in pediatric patients with β-thalassemia major
-
Abstract 3614
-
Piga A, Galanello R, Foschini ML, Zappu A, Bordone E, Longo F, Forni GL, Lavagetto A, Bertrand Y, Maseruka H, Latham N, Alberti D. Once-daily treatment with the oral iron chelator ICL670 (Exjade): results of a phase II study in pediatric patients with β-thalassemia major. Blood 2004; 104(11):Abstract 3614.
-
(2004)
Blood
, vol.104
, Issue.11
-
-
Piga, A.1
Galanello, R.2
Foschini, M.L.3
Zappu, A.4
Bordone, E.5
Longo, F.6
Forni, G.L.7
Lavagetto, A.8
Bertrand, Y.9
Maseruka, H.10
Latham, N.11
Alberti, D.12
-
64
-
-
27644456657
-
Phase III evaluation of once-daily oral therapy with ICL670 (Exjade) versus deferoxamine in patients with β-thalassemia and transfusional hemosiderosis
-
Abstract 3619
-
Cappelini M, Bejaoui M, Perrota S, Agaoglou L, Kattamis A, Giardina P, Janka-Schaub G, Opitz H, Ressayre-Djaffer C, Alberti D. Phase III evaluation of once-daily oral therapy with ICL670 (Exjade) versus deferoxamine in patients with β-thalassemia and transfusional hemosiderosis. Blood 2004; 104(11):Abstract 3619.
-
(2004)
Blood
, vol.104
, Issue.11
-
-
Cappelini, M.1
Bejaoui, M.2
Perrota, S.3
Agaoglou, L.4
Kattamis, A.5
Giardina, P.6
Janka-Schaub, G.7
Opitz, H.8
Ressayre-Djaffer, C.9
Alberti, D.10
-
65
-
-
27644547811
-
A phase II study with ICL670 (Exjade), a once-daily oral iron chelator, in patients with various transfusion-dependent anemias and iron overload
-
Abstract 3193
-
Porter J, Vichinsky E, Rose C, Piga A, Olivieri N, Gattermann I, Maertens J, Rabault B, Gathmann I, Alberti D. A phase II study with ICL670 (Exjade), a once-daily oral iron chelator, in patients with various transfusion-dependent anemias and iron overload. Blood 2004; 104(11):Abstract 3193.
-
(2004)
Blood
, vol.104
, Issue.11
-
-
Porter, J.1
Vichinsky, E.2
Rose, C.3
Piga, A.4
Olivieri, N.5
Gattermann, I.6
Maertens, J.7
Rabault, B.8
Gathmann, I.9
Alberti, D.10
-
66
-
-
27744544284
-
Advances in iron overload therapies. Prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1Nall and their combinations
-
Kontoghiorghes GJ, Eracleous E, Economides Ch, Kolnagou A. Advances in iron overload therapies. Prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1Nall and their combinations. Curr Med Chem 2005, 12(23):2663-2681.
-
(2005)
Curr Med Chem
, vol.12
, Issue.23
, pp. 2663-2681
-
-
Kontoghiorghes, G.J.1
Eracleous, E.2
Economides, C.3
Kolnagou, A.4
-
67
-
-
26944496130
-
Effects of ICL670 (deferasirox) on cardiac iron concentration
-
Kontoghiorghes GJ. Effects of ICL670 (deferasirox) on cardiac iron concentration. Lancet 2005; 366(9488):804.
-
(2005)
Lancet
, vol.366
, Issue.9488
, pp. 804
-
-
Kontoghiorghes, G.J.1
-
68
-
-
0033552882
-
Desazadesmethyldesferrithiocin analogues as orally effective iron chelators
-
Bergeron RJ, Wiegand J, Weimar WR, Vinson JR, Bussenious J, Yao GW, MacManis JS. Desazadesmethyldesferrithiocin analogues as orally effective iron chelators. J Med Chem 1999; 42(1):95-108.
-
(1999)
J Med Chem
, vol.42
, Issue.1
, pp. 95-108
-
-
Bergeron, R.J.1
Wiegand, J.2
Weimar, W.R.3
Vinson, J.R.4
Bussenious, J.5
Yao, G.W.6
MacManis, J.S.7
-
69
-
-
27744552854
-
Pharmacokinetic of GT56-252, a novel orally available iron chelator in rat, dog and monkey
-
Marquis J, Dagher R, Bree M, Appelqvist T, Guillaumat PO, Forster R. Pharmacokinetic of GT56-252, a novel orally available iron chelator in rat, dog and monkey. Biomarkers Environment 2003; 6(1):7-9.
-
(2003)
Biomarkers Environment
, vol.6
, Issue.1
, pp. 7-9
-
-
Marquis, J.1
Dagher, R.2
Bree, M.3
Appelqvist, T.4
Guillaumat, P.O.5
Forster, R.6
-
70
-
-
14644422467
-
The safety and pharmacokinetics of GT56-252, a novel orally available iron chelator
-
Abstract 139
-
Donovan JM, Palmer PA, Plone MA, Wonke B. The safety and pharmacokinetics of GT56-252, a novel orally available iron chelator. Eur J Clin Invest 2004, 34 (Suppl I):39, Abstract 139.
-
(2004)
Eur J Clin Invest
, vol.34
, Issue.SUPPL. I
, pp. 39
-
-
Donovan, J.M.1
Palmer, P.A.2
Plone, M.A.3
Wonke, B.4
-
71
-
-
45949113016
-
Simple synthesis of the potent iron chelators 1-alkyl-3-hydroxy-2- methylpyrid-4-ones
-
Kontoghiorghes GJ, Sheppard L. Simple synthesis of the potent iron chelators 1-alkyl-3-hydroxy-2-methylpyrid-4-ones. Inorg Chim Acta 1987, 136:L11-L12.
-
(1987)
Inorg Chim Acta
, vol.136
-
-
Kontoghiorghes, G.J.1
Sheppard, L.2
-
72
-
-
0038593465
-
L1NAll. 1-Allyl-2-methyl-3-hydroxypyrid-4-one
-
Kontoghiorghes GJ. L1NAll. 1-Allyl-2-methyl-3-hydroxypyrid-4-one. Drugs Future 1990; 15(3):230-232.
-
(1990)
Drugs Future
, vol.15
, Issue.3
, pp. 230-232
-
-
Kontoghiorghes, G.J.1
-
73
-
-
0021914999
-
New orally active iron chelators
-
Kontoghiorghes GJ. New orally active iron chelators. Lancet 1985; 1(8432):817.
-
(1985)
Lancet
, vol.1
, Issue.8432
, pp. 817
-
-
Kontoghiorghes, G.J.1
-
74
-
-
0027403243
-
Selection of a new generation of orally active α- ketohydroxypyridine iron chelators intended for use in the treatment of iron overload
-
Kontoghiorghes GJ, Barr J, Nortey P, Sheppard L. Selection of a new generation of orally active α-ketohydroxypyridine iron chelators intended for use in the treatment of iron overload. Am J Hematol 1993; 42(4):340-349.
-
(1993)
Am J Hematol
, vol.42
, Issue.4
, pp. 340-349
-
-
Kontoghiorghes, G.J.1
Barr, J.2
Nortey, P.3
Sheppard, L.4
-
76
-
-
0027053965
-
Effect on iron excretion and animal toxicology of L1 and other α-ketohydroxypyridine chelators
-
Nortey P, Barr J, Matsakis M, Nasseri-Sina P, Kontoghiorghes GJ. Effect on iron excretion and animal toxicology of L1 and other α- ketohydroxypyridine chelators. Drugs Today 1992; 28(Suppl A):81-88.
-
(1992)
Drugs Today
, vol.28
, Issue.SUPPL. A
, pp. 81-88
-
-
Nortey, P.1
Barr, J.2
Matsakis, M.3
Nasseri-Sina, P.4
Kontoghiorghes, G.J.5
-
77
-
-
0027098148
-
Study of L1NAll, a new oral iron chelator in two experimental models of human β-thalassemia
-
Sauvage C, Rouyer-Fessard R, Turlin B, Brissot P, Beuzard Y. Study of L1NAll, a new oral iron chelator in two experimental models of human β-thalassemia. Drugs Today, 1992; 28(Suppl A):65-71.
-
(1992)
Drugs Today
, vol.28
, Issue.SUPPL. A
, pp. 65-71
-
-
Sauvage, C.1
Rouyer-Fessard, R.2
Turlin, B.3
Brissot, P.4
Beuzard, Y.5
-
78
-
-
27744583390
-
Results of the mutagenecity tests of 1,2-dimethyl-3-hydroxypyrid-4-one (L1) 1-allyl-2-methyl-3-hydroxypyrid-4-one (L1NAll) and their iron complexes
-
Nasseri-Sina P, Murray BP, Boobis AR, Kontoghiorghes GJ. Results of the mutagenecity tests of 1,2-dimethyl-3-hydroxypyrid-4-one (L1) 1-allyl-2-methyl-3-hydroxypyrid-4-one (L1NAll) and their iron complexes. Plzen Lek Shorn 1990; 62:221-224.
-
(1990)
Plzen Lek Shorn
, vol.62
, pp. 221-224
-
-
Nasseri-Sina, P.1
Murray, B.P.2
Boobis, A.R.3
Kontoghiorghes, G.J.4
-
79
-
-
0027102249
-
Interaction of L1, L1NAll and deferoxamine with gallium in vivo
-
Eybl V, Svihovcova P, Koutensky J, Kontoghiorghes GJ. Interaction of L1, L1NAll and deferoxamine with gallium in vivo. Drugs Today, 1992; 28(Suppl A):173-175.
-
(1992)
Drugs Today
, vol.28
, Issue.SUPPL. A
, pp. 173-175
-
-
Eybl, V.1
Svihovcova, P.2
Koutensky, J.3
Kontoghiorghes, G.J.4
-
80
-
-
0033989136
-
First human studies with a high-molecular-weight iron chelator
-
Dragsten PR, Hallaway PE, Hanson GJ, Berger AE, Bernard B, Hedlund BE. First human studies with a high-molecular-weight iron chelator. J Lab Clin Med 2000; 135(1):57-65.
-
(2000)
J Lab Clin Med
, vol.135
, Issue.1
, pp. 57-65
-
-
Dragsten, P.R.1
Hallaway, P.E.2
Hanson, G.J.3
Berger, A.E.4
Bernard, B.5
Hedlund, B.E.6
-
82
-
-
33645119733
-
New oral iron-chelating drugs for the treatment of transfusional iron overload and other diseases
-
Kontoghiorghes GJ. New oral iron-chelating drugs for the treatment of transfusional iron overload and other diseases. Drugs Future 2006; 30(12):1241-1251.
-
(2006)
Drugs Future
, vol.30
, Issue.12
, pp. 1241-1251
-
-
Kontoghiorghes, G.J.1
|