Airway mechanics and methods used to visualize smooth muscle dynamics in vitro

Pulmonary Pharmacology and Therapeutics

Volumn 22, Issue 5, 2009, Pages 398-406

  Cooper, P R ^a   McParland, B E ^b   Mitchell, H W ^c   Noble, P B ^c   Politi, A Z ^d   Ressmeyer, A R ^e   West, A R ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d UNIVERSITY OF AUCKLAND   (New Zealand)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Airway narrowing; Airway smooth muscle; Bronchial segment; Calcium; Imaging; Precision cut lung slice

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; CALMODULIN; ELASTASE; METHACHOLINE; MYOSIN LIGHT CHAIN KINASE; MYOSIN LIGHT CHAIN PHOSPHATASE; SEROTONIN;

AIRWAY; AIRWAY SMOOTH MUSCLE; ARTICLE; BIOMECHANICS; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CALCIUM CELL LEVEL; CALCIUM SIGNALING; COMPUTER MODEL; DISEASE MODEL; ENZYME ACTIVITY; HISTOLOGY; HUMAN; IMAGING; IN VITRO STUDY; LUNG FUNCTION; LUNG SLICE; MICROSCOPY; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RADIOGRAPHY; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTION;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; LUNG; MICROSCOPY, VIDEO; MODELS, BIOLOGICAL; MODELS, STATISTICAL; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RESPIRATORY MECHANICS; TISSUE CULTURE TECHNIQUES;

EID: 69249222712     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2008.09.008     Document Type: Article

References (147)

1. Huxley H.E. The mechanism of muscular contraction. Science 164 (1969) 1356-1365
2. Gunst S.J., and Tang D.D. The contractile apparatus and mechanical properties of airway smooth muscle. Eur Respir J 15 (2000) 600-616
3. Stephens N.L. Airway smooth muscle. Lung 179 (2001) 333-373
4. Stephens N.L., and Van Niekerk W. Isometric and isotonic contractions in airway smooth muscle. Can J Physiol Pharmacol 55 (1977) 833-838
5. Kamm K.E., and Stull J.T. Activation of smooth muscle contraction: relation between myosin phosphorylation and stiffness. Science 232 (1986) 80-82
6. Kamm K.E., and Stull J.T. The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Annu Rev Pharmacol Toxicol 25 (1985) 593-620
7. Kimura K., Ito M., Amano M., Chihara K., Fukata Y., Nakafuku M., et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273 (1996) 245-248
8. Uehata M., Ishizaki T., Satoh H., Ono T., Kawahara T., Morishita T., et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389 (1997) 990-994
9. Kitazawa T., Eto M., Woodsome T.P., and Brautigan D.L. Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. J Biol Chem 275 (2000) 9897-9900
10. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83 (2003) 1325-1358
11. Macklem P.T. Mechanical factors determining maximum bronchoconstriction. Eur Respir J Suppl 6 (1989) 516s-519s
12. Macklem P.T. A theoretical analysis of the effect of airway smooth muscle load on airway narrowing. Am J Respir Crit Care Med 153 (1996) 83-89
13. Kapsali T., Permutt S., Laube B., Scichilone N., and Togias A. Potent bronchoprotective effect of deep inspiration and its absence in asthma. J Appl Physiol 89 (2000) 711-720
14. Skloot G., Permutt S., and Togias A. Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration. J Clin Invest 96 (1995) 2393-2403
15. Noble P.B., McFawn P.K., and Mitchell H.W. Responsiveness of the isolated airway during simulated deep inspirations: effect of airway smooth muscle stiffness and strain. J Appl Physiol 103 (2007) 787-795
16. Woolcock A.J., Anderson S.D., Peat J.K., Du Toit J.I., Zhang Y.G., et al. Salome CM. Characteristics of bronchial hyperresponsiveness in chronic obstructive pulmonary disease and in asthma. Am Rev Respir Dis 143 (1991) 1438-1443
17. Yager D., Kamm R.D., and Drazen J.M. Airway wall liquid. Sources and role as an amplifier of bronchoconstriction. Chest 107 (1995) 105S-110S
18. Bramley A.M., Thomson R.J., Roberts C.R., and Schellenberg R.R. Hypothesis: excessive bronchoconstriction in asthma is due to decreased airway elastance. Eur Respir J 7 (1994) 337-341
19. Ebina M., Yaegashi H., Chiba R., Takahashi T., Motomiya M., and Tanemura M. Hyperreactive site in the airway tree of asthmatic patients revealed by thickening of bronchial muscles. A morphometric study. Am Rev Respir Dis 141 (1990) 1327-1332
20. Hirst S.J. Airway smooth muscle as a target in asthma. Clin Exp Allergy 30 Suppl 1 (2000) 54-59
21. Scichilone N., Permutt S., and Togias A. The lack of the bronchoprotective and not the bronchodilatory ability of deep inspiration is associated with airway hyperresponsiveness. Am J Respir Crit Care Med 163 (2001) 413-419
22. Fish J.E., Ankin M.G., Kelly J.F., and Peterman V.I. Regulation of bronchomotor tone by lung inflation in asthmatic and nonasthmatic subjects. J Appl Physiol 50 (1981) 1079-1086
23. Gillis H.L., and Lutchen K.R. Airway remodeling in asthma amplifies heterogeneities in smooth muscle shortening causing hyperresponsiveness. J Appl Physiol 86 (1999) 2001-2012
24. Lambert R.K., Wiggs B.R., Kuwano K., Hogg J.C., and Pare P.D. Functional significance of increased airway smooth muscle in asthma and COPD. J Appl Physiol 74 (1993) 2771-2781
25. Moreno R.H., Hogg J.C., and Pare P.D. Mechanics of airway narrowing. Am Rev Respir Dis 133 (1986) 1171-1180
26. Ammit A.J., Armour C.L., and Black J.L. Smooth-muscle myosin light-chain kinase content is increased in human sensitized airways. Am J Respir Crit Care Med 161 (2000) 257-263
27. Kong S.-K., Halayko A.J., and Stephens N.L. Increased myosin phosphorylation in sensitized canine tracheal smooth muscle. Am J Physiol 259 (1990) L53-L56
28. Mitchell R.W., Ndukwu I.M., Arbetter K., Solway J., and Leff A.R. Effect of airway inflammation on smooth muscle shortening and contractility in guinea pig trachealis. Am J Physiol 265 (1993) L549-L554
29. Benamou A.E., Marlin D.J., Callingham B.C., Hiley R.C., and Lekeux R. Spasmogenic action of endothelin-1 on isolated equine pulmonary artery and bronchus. Equine Vet J 35 (2003) 190-196
30. Aizawa H., Inoue H., Matsumoto K., Koto H., Nakano H., and Hara N. Thromboxane A2 antagonist inhibits leukotriene D4-induced smooth muscle contraction in guinea-pig lung parenchyma, but not in trachea. Prostaglandins Leukotrienes Essent Fatty Acids 55 (1996) 437-440
31. Schachter E.N., Zuskin E., Buck M.G., Maayani S., Marom Z., Goswami S., et al. Pharmacologic characterization of wool dust extract in isolated guinea pig trachea. Environ Res 69 (1995) 90-95
32. Slapke J. Serine esterase inhibitor reduces contractions with isolated trachea and lung strips from guinea pigs induced by phospholipase A2. Allergol Immunopathol (Madr) 12 (1984) 289-292
33. Lulich K.M., Mitchell H.W., and Sparrow M.P. The cat lung strip as an in vitro preparation of peripheral airways: a comparison of ß-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea. Br J Pharmacol 58 (1976) 71-79
34. Drazen J.M., and Schneider M.W. Comparative responses of tracheal spirals and parenchymal strips to histamine and carbachol in vitro. J Clin Invest 61 (1978) 1441-1447
35. Martin C., Wohlsen A., and Uhlig S. Changes in airway resistance by simultaneous exposure to TNF-alpha and IL-1beta in perfused rat lungs. Am J Physiol Lung Cell Mol Physiol 280 (2001) L595-L601
36. Sundstrom E., Lastbom L., Ryrfeldt A., and Dahlen S.E. Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. J Pharmacol Exp Ther 307 (2003) 408-418
37. Held H.D., Martin C., and Uhlig S. Characterization of airway and vascular responses in murine lungs. Br J Pharmacol 126 (1999) 1191-1199
38. Azri S., Mata H.P., Reid L.L., Gandolfi A.J., and Brendel K. Further examination of the selective toxicity of CCl4 in rat liver slices. Toxicol Appl Pharmacol 112 (1992) 81-86
39. Fisher R., Brendel K., and Hanzlik R.P. Correlation of metabolism, covalent binding and toxicity for a series of bromobenzene derivatives using rat liver slices in vitro. Chem Biol Interact 88 (1993) 191-198
40. Dandurand R.J., Wang C.G., Phillips N.C., and Eidelman D.H. Responsiveness of individual airways to methacholine in adult rat lung explants. J Appl Physiol 75 (1993) 364-372
41. Martin C., Uhlig S., and Ullrich V. Videomicroscopy of methacholine-induced contraction of individual airways in precision-cut lung slices. Eur Respir J 9 (1996) 2479-2487
42. 2+ signaling of small airways in mouse lung slices. Am J Respir Cell Mol Biol. (2007)
43. Opazo Saez A.M., Seow C.Y., and Pare P.D. Peripheral airway smooth muscle mechanics in obstructive airways disease. Am. J. Respir. Crit. Care Med. 161 (2000) 910-917
44. Ressmeyer A.R., Larsson A.K., Vollmer E., Dahlen S.E., Uhlig S., and Martin C. Characterisation of guinea pig precision-cut lung slices: comparison with human tissues. Eur Respir J 28 (2006) 603-611
45. Bergner A., and Sanderson M.J. Acetylcholine-induced calcium signaling and contraction of airway smooth muscle cells in lung slices. J Gen Physiol 119 (2002) 187-198
46. 2+ oscillations and contraction in airway smooth muscle cells of mouse lung slices. Am J Physiol Lung Cell Mol Physiol 283 (2002) L1271-L1279
47. Perez J.F., and Sanderson M.J. The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles. J Gen Physiol 125 (2005) 535-553
48. 2+ oscillations induced by 5-HT, KCl. J Gen Physiol 125 (2005) 555-567
49. 2+ sensitization. Am J Physiol Lung Cell Mol Physiol 293 (2007) L1000-L1011
50. 2+ oscillations of porcine tracheal smooth muscle. Am J Physiol 272 (1997) L659-L664
51. 2+ sensitivity of airway smooth muscle cells in murine lung slices. Am J Physiol Lung Cell Mol Physiol 291 (2006) L208-L221
52. Saetta M., Turato G., Baraldo S., Zanin A., Braccioni F., Mapp C.E., et al. Goblet cell hyperplasia and epithelial inflammation in peripheral airways of smokers with both symptoms of chronic bronchitis and chronic airflow limitation. Am J Respir Crit Care Med 161 (2000) 1016-1021
53. Bosken C.H., Wiggs B.R., Pare P.D., and Hogg J.C. Small airway dimensions in smokers with obstruction to airflow. Am Rev Respir Dis 142 (1990) 563-570
54. Hirota J.A., Ellis R., and Inman M.D. Regional differences in the pattern of airway remodeling following chronic allergen exposure in mice. Respir Res 7 (2006) 120
55. Battaglia S., Mauad T., van Schadewijk A.M., Vignola A.M., Rabe K.F., Bellia V., et al. Differential distribution of inflammatory cells in large and small airways in smokers. J Clin Pathol 60 (2007) 907-911
56. Takizawa H., Tanaka M., Takami K., Ohtoshi T., Ito K., Satoh M., et al. Increased expression of inflammatory mediators in small-airway epithelium from tobacco smokers. Am J Physiol Lung Cell Mol Physiol 278 (2000) L906-L913
57. Pare P.D., Wiggs B.R., James A., Hogg J.C., and Bosken C. The comparative mechanics and morphology of airways in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 143 (1991) 1189-1193
58. Verbeken E.K., Cauberghs M., Mertens I., and Lauweryns J.M. Van de Woestijne KP. Tissue and airway impedance of excised normal, senile, and emphysematous lungs. J Appl Physiol 72 (1992) 2343-2353
59. Khan M.A., Kianpour S., Stampfli M.R., and Janssen L.J. Kinetics of in vitro bronchoconstriction in an elastolytic mouse model of emphysema. Eur Respir J 30 (2007) 691-700
60. Wohlsen A., Uhlig S., and Martin C. Immediate allergic response in small airways. Am J Respir Crit Care Med 163 (2001) 1462-1469
61. 2+ signaling of smooth muscle cells in different generations of mouse airways. Am J Respir Cell Mol Biol 36 (2007) 122-130
62. Wohlsen A., Martin C., Vollmer E., Branscheid D., Magnussen H., Becker W.M., et al. The early allergic response in small airways of human precision-cut lung slices. Eur Respir J 21 (2003) 1024-1032
63. Sturton R.G., Trifilieff A., Nicholson A.G., and Barnes P.J. Pharmacological characterization of indacaterol, a novel once daily inhaled 2 adrenoceptor agonist, on small airways in human and rat precision-cut lung slices. J Pharmacol Exp Ther 324 (2008) 270-275
64. 2+ oscillations induced by a cAMP-mediated inhibition of the IP3 receptor. Respir Res 7 (2006) 34
65. Martin H.B., and Proctor D.F. Pressure-volume measurements on dog bronchi. J Appl Physiol 13 (1958) 337-343
66. Marshall R. Effect of lung inflation on bronchial dimensions in the dog. J Appl Physiol 17 (1962) 596-600
67. Hughes J.M., Jones H.A., Wilson A.G., Grant B.J., and Pride N.B. Stability of intrapulmonary bronchial dimensions during expiratory flow in excised lungs. J Appl Physiol 37 (1974) 684-694
68. Sasaki H., and Hoppin F.G. Jr. Takishima T. Peribronchial pressure in excised dog lungs. J Appl Physiol 45 (1978) 858-869
69. Widdicombe J.G. Reflexes from the lungs in the control of breathing. Recent Adv Physiol 9 (1974) 239-278
70. Gunst S.J., Stropp J.Q., and Service J. Mechanical modulation of pressure-volume characteristics of contracted canine airways in vitro. J Appl Physiol 68 (1990) 2223-2229
71. Mitchell H.W., and Sparrow M.P. Video-imaging of lumen narrowing; muscle shortening and flow responsiveness in isolated bronchial segments of the pig. Eur Respir J 7 (1994) 1317-1325
72. Turner D.J., Noble P.B., Lucas M.P., and Mitchell H.W. Decreased airway narrowing and smooth muscle contraction in hyperresponsive pigs. J Appl Physiol 93 (2002) 1296-1300
73. Mansell A.L., McAteer A.L., and Oldmixon E.H. Mechanical dissociation of bronchi from parenchyma in the immature piglet lung. J Appl Physiol 89 (2000) 228-234
74. Mitchell H.W., Turner D.J., Gray P.R., and McFawn P.K. Compliance and stability of the bronchial wall in a model of allergen-induced lung inflammation. J Appl Physiol 86 (1999) 932-937
75. Murtagh P.S., Proctor D.F., Permutt S., Kelly B.L., and Evering S. Bronchial mechanics in excised dog lobes. J Appl Physiol 31 (1971) 403-408
76. Hyatt R.E., and Flath R.E. Influence of lung parenchyma on pressure-diameter behavior of dog bronchi. J Appl Physiol 21 (1966) 1448-1452
77. McParland B.E., Johnson P.R., Armour C.L., and Black J.L. Novel adaptation of a method to assess responsiveness of bronchial segments in vitro. Eur Respir J 11 (1998) 1248-1256
78. Mitchell H.W., and Sparrow M.P. Increased responsiveness to cholinergic stimulation of small compared to large diameter cartilaginous bronchi. Eur Respir J 7 (1994) 298-305
79. Gunst S.J., and Mitzner W. Mechanical properties of contracted canine bronchial segments in vitro. J Appl Physiol 50 (1981) 1236-1247
80. Noble P.B., Turner D.J., and Mitchell H.W. Relationship of airway narrowing, compliance, and cartilage in isolated bronchial segments. J Appl Physiol 92 (2002) 1119-1124
81. Mitchell H.W., Cvetkovski R., Sparrow M.P., Gray P.R., and McFawn P.K. Concurrent measurement of smooth muscle shortening, lumen narrowing and flow to acetylcholine in large and small porcine bronchi. Eur Respir J 12 (1998) 1053-1061
82. Miller T.L., Altman A.R., Tsuda T., and Shaffer T.H. An ultrasound imaging method for in vivo tracheal bulk and Young's moduli of elasticity. J Biomech 40 (2007) 1615-1621
83. Armstrong J.J., Leigh M.S., Sampson D.D., Walsh J.H., Hillman D.R., and Eastwood P.R. Quantitative upper airway imaging with anatomic optical coherence tomography. Am J Respir Crit Care Med 173 (2006) 226-233
84. Drexler W., Morgner U., Ghanta R.K., Kartner F.X., Schuman J.S., and Fujimoto J.G. Ultrahigh-resolution ophthalmic optical coherence tomography. Nat Med 7 (2001) 502-507
85. Bechara F.G., Gambichler T., Stucker M., Orlikov A., Rotterdam S., Altmeyer P., et al. Histomorphologic correlation with routine histology and optical coherence tomography. Skin Res Technol 10 (2004) 169-173
86. Sheller J.R., and Brigham K.L. Bronchomotor responses of isolated sheep airways to electrical field stimulation. J Appl Physiol 53 (1982) 1088-1093
87. Woisin F.E., Herd C.M., Douglas G.J., Raynor K., Spina D., Mitchell H.W., et al. Relationship of airway responsiveness with airway morphometry in normal and immunised rabbits. Pulmon Pharmacol Ther 14 (2001) 75-83
88. Tiddens H.A., Hofhuis W., Bogaard J.M., Hop W.C., de Bruin H., Willems L.N., et al. Compliance, hysteresis, and collapsibility of human small airways. Am J Respir Crit Care Med 160 (1999) 1110-1118
89. Omari T.I., Sparrow M.P., and Mitchell H.W. Responsiveness of human isolated bronchial segments and its relationship to epithelial loss. Br J Clin Pharm 35 (1993) 357-365
90. Bergner A., and Sanderson M.J. Airway contractility and smooth muscle Ca(2+) signaling in lung slices from different mouse strains. J Appl Physiol 95 (2003) 1325-1332 discussion 1314
91. Delmotte P., and Sanderson M.J. Ciliary beat frequency is maintained at a maximal rate in the small airways of mouse lung slices. Am J Respir Cell Mol Biol 35 (2006) 110-117
92. Khangure S.R., Noble P.B., Sharma A., Chia P.Y., McFawn P.K., and Mitchell H.W. Cyclical elongation regulates contractile responses of isolated airways. J Appl Physiol 97 (2004) 913-919
93. Lambert R.K., and Pare P.D. Lung parenchymal shear modulus, airway wall remodeling, and bronchial hyperresponsiveness. J Appl Physiol 83 (1997) 140-147
94. Noble P.B., Sharma A., McFawn P.K., and Mitchell H.W. Airway narrowing in porcine bronchi with and without lung parenchyma. Eur Respir J 26 (2005) 804-811
95. Sparrow M.P., and Mitchell H.W. Modulation by the epithelium of the extent of bronchial narrowing produced by substances perfused through the lumen. Br J Pharmacol 103 (1991) 1160-1164
96. Munakata M., Mitzner W., and Menkes H. Osmotic stimuli induce epithelial-dependent relaxation in the guinea pig trachea. J Appl Physiol 64 (1988) 466-471
97. Munakata M., Huang I., Mitzner W., and Menkes H. Protective role of epithelium in the guinea pig airway. J Appl Physiol 66 (1989) 1547-1552
98. Mitchell H.W., Fisher J.T., and Sparrow M.P. The integrity of the epithelium is a major determinant of the responsiveness of the dog bronchial segment to mucosal provocation. Pulmon Pharmacol 6 (1993) 263-268
99. King G.G., Moore B.J., Seow C.Y., and Pare P.D. Time course of increased airway narrowing caused by inhibition of deep inspiration during methacholine challenge. Am J Respir Crit Care Med 160 (1999) 454-457
100. Crimi E., Pellegrino R., Milanese M., and Brusasco V. Deep breaths, methacholine, and airway narrowing in healthy and mild asthmatic subjects. J Appl Physiol 93 (2002) 1384-1390
101. Weist A., Williams T., Kisling J., Clem C., and Tepper R.S. Volume history and effect on airway reactivity in infants and adults. J Appl Physiol 93 (2002) 1069-1074
102. Gunst S.J. Contractile force of canine airway smooth muscle during cyclical length changes. J Appl Physiol 55 (1983) 759-769
103. Gunst S.J. Effect of length history on contractile behavior of canine tracheal smooth muscle. Am J Physiol 250 (1986) C146-C154
104. Wang L., Pare P.D., and Seow C.Y. Effects of length oscillation on the subsequent force development in swine tracheal smooth muscle. J Appl Physiol 88 (2000) 2246-2250
105. Gump A., Haughney L., and Fredberg J. Relaxation of activated airway smooth muscle: relative potency of isoproterenol vs. tidal stretch. J Appl Physiol 90 (2001) 2306-2310
106. Fredberg J.J., Jones K.A., Nathan M., Raboudi S., Prakash Y.S., Shore S.A., et al. Friction in airway smooth muscle: mechanism, latch, and implications in asthma. J Appl Physiol 81 (1996) 2703-2712
107. Fredberg J.J. Airway smooth muscle in asthma. Perturbed equilibria of myosin binding. Am J Respir Crit Care Med 161 (2000) S158-S160
108. Fredberg J.J., Inouye D.S., Mijailovich S.M., and Butler J.P. Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm. Am J Respir Crit Care Med 159 (1999) 959-967
109. Kuo K.H., Wang L., Pare P.D., Ford L.E., and Seow C.Y. Myosin thick filament lability induced by mechanical strain in airway smooth muscle. J Appl Physiol 90 (2001) 1811-1816
110. Gunst S.J., Tang D.D., and Opazo Saez A. Cytoskeletal remodeling of the airway smooth muscle cell: a mechanism for adaptation to mechanical forces in the lung. Respir Physiol Neurobiol 137 (2003) 151-168
111. Dowell M.L., Lakser O.J., Gerthoffer W.T., Fredberg J.J., Stelmack G.L., Halayko A.J., et al. Latrunculin B increases force fluctuation-induced relengthening of ACh-contracted, isotonically shortened canine tracheal smooth muscle. J Appl Physiol 98 (2005) 489-497
112. Oliver M.N., Fabry B., Marinkovic A., Mijailovich S.M., Butler J.P., and Fredberg J.J. Airway hyperresponsiveness, remodeling, and smooth muscle mass: right answer, wrong reason?. Am J Respir Cell Mol Biol 37 (2007) 264-272
113. Brown R.H., and Mitzner W. Airway response to deep inspiration: role of inflation pressure. J Appl Physiol 91 (2001) 2574-2578
114. Salerno F.G., Pellegrino R., Trocchio G., Spanevello A., Brusasco V., and Crimi E. Attenuation of induced bronchoconstriction in healthy subjects: effects of breathing depth. J Appl Physiol 98 (2005) 817-821
115. Noble P.B., Sharma A., McFawn P.K., and Mitchell H.W. Elastic properties of the bronchial mucosa: epithelial unfolding and stretch in response to airway inflation. J Appl Physiol 99 (2005) 2061-2066
116. Lambert R.K., Pare P.D., and Okazawa M. Stiffness of peripheral airway folding membrane in rabbits. J. Appl. Physiol 90 (2001) 2041-2047
117. Maksym G.N., Deng L., Fairbank N.J., Lall C.A., and Connolly S.C. Beneficial and harmful effects of oscillatory mechanical strain on airway smooth muscle. Can J Physiol Pharmacol 83 (2005) 913-922
118. Smith P.G., Garcia R., and Kogerman L. Strain reorganizes focal adhesions and cytoskeleton in cultured airway smooth muscle cells. Exp Cell Res 232 (1997) 127-136
119. Smith P.G., Moreno R., and Ikebe M. Strain increases airway smooth muscle contractile and cytoskeletal proteins in vitro. Am J Physiol 272 (1997) L20-L27
120. Smith P.G., Roy C., Dreger J., and Brozovich F. Mechanical strain increases velocity and extent of shortening in cultured airway smooth muscle cells. Am J Physiol 277 (1999) L343-L348
121. Smith P.G., Roy C., Fisher S., Huang Q.Q., and Brozovich F. Selected contribution: mechanical strain increases force production and calcium sensitivity in cultured airway smooth muscle cells. J Appl Physiol 89 (2000) 2092-2098
122. Wang L., Liu H.W., McNeill K.D., Stelmack G., Scott J.E., and Halayko A.J. Mechanical strain inhibits airway smooth muscle gene transcription via protein kinase C signaling. Am J Respir Cell Mol Biol 31 (2004) 54-61
123. Smith P.G., Roy C., Zhang Y.N., and Chauduri S. Mechanical stress increases RhoA activation in airway smooth muscle cells. Am J Respir Cell Mol Biol 28 (2003) 436-442
124. Liu H.W., Halayko A.J., Fernandes D.J., Harmon G.S., McCauley J.A., Kocieniewski P., et al. The RhoA/Rho kinase pathway regulates nuclear localization of serum response factor. Am J Respir Cell Mol Biol 29 (2003) 39-47
125. Hinson J.S., Medlin M.D., Lockman K., Taylor J.M., and Mack C.P. Smooth muscle cell-specific transcription is regulated by nuclear localization of the myocardin-related transcription factors. Am J Physiol Heart Circ Physiol 292 (2007) H1170-H1180
126. Yoshida T., Sinha S., Dandre F., Wamhoff B.R., Hoofnagle M.H., Kremer B.E., et al. Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes. Circ Res 92 (2003) 856-864
127. Mitchell H.W., and Gray P.R. Uncoupling in the wall of the cartilaginous bronchus of the pig produced by smooth muscle contraction. Pulmon Pharmacol 9 (1996) 29-34
128. Mitchell H.W., and Gray P.R. Assessment of the dynamic relationship between external diameter and lumen flow in isolated bronchi. Respir Physiol 116 (1999) 67-76
129. Thiberville L., Moreno-Swirc S., Vercauteren T., Peltier E., Cave C., and Bourg Heckly G. In vivo imaging of the bronchial wall microstructure using fibered confocal fluorescence microscopy. Am J Respir Crit Care Med 175 (2007) 22-31
130. James A.L., Pare P.D., and Hogg J.C. The mechanics of airway narrowing in asthma. Am Rev Respir Dis 139 (1989) 242-246
131. Lambert R.K., Ramchandani R., Shen X., Gunst S.J., and Tepper R.S. Computational model of airway narrowing: mature vs. immature rabbit. J Appl Physiol 93 (2002) 611-619
132. Bates J.H., and Lauzon A.M. Parenchymal tethering, airway wall stiffness, and the dynamics of bronchoconstriction. J Appl Physiol 102 (2007) 1912-1920
133. Wiggs B.R., Bosken C., Pare P.D., James A.L., and Hogg J.C. A model of airway narrowing in asthmatic and in chronic obstructive pulmonary disease. Am Rev Respir Dis 145 (1992) 1251-1258
134. Hai C.M., and Murphy R.A. Cross-bridge phosphorylation and regulation of latch state in smooth muscle. Am J Physiol 254 (1988) C99-C106
135. Lambert R.K., Pare P.D., and Seow C.Y. Mathematical description of geometric and kinematic aspects of smooth muscle plasticity and some related morphometrics. J Appl Physiol 96 (2004) 469-476
136. Silveira P.S., Butler J.P., and Fredberg J.J. Length adaptation of airway smooth muscle: a stochastic model of cytoskeletal dynamics. J Appl Physiol 99 (2005) 2087-2098
137. Herrera A.M., McParland B.E., Bienkowska A., Tait R., Pare P.D., and Seow C.Y. 'Sarcomeres' of smooth muscle: functional characteristics and ultrastructural evidence. J Cell Sci 118 (2005) 2381-2392
138. Suki B., Barabasi A.L., and Lutchen K.R. Lung tissue viscoelasticity: a mathematical framework and its molecular basis. J Appl Physiol 76 (1994) 2749-2759
139. Fredberg J.J., and Kamm R.D. Stress transmission in the lung: pathways from organ to molecule. Annu Rev Physiol 68 (2006) 507-541
140. Trepat X., Deng L., An S.S., Navajas D., Tschumperlin D.J., Gerthoffer W.T., et al. Universal physical responses to stretch in the living cell. Nature 447 (2007) 592-595
141. Wang I., Politi A.Z., Tania N., Bai Y., Sanderson M.J., and Sneyd J. A mathematical model of airway and pulmonary arteriole smooth muscle. Biophys J 94 (2008) 2053-2064
142. Tepper R.S., Ramchandani R., Argay E., Zhang L., Xue Z., Liu Y., et al. Chronic strain alters the passive and contractile properties of rabbit airways. J Appl Physiol 98 (2005) 1949-1954
143. Ramchandani R., Shen X., Gunst S.J., and Tepper R.S. Comparison of elastic properties and contractile responses of isolated airway segments from mature and immature rabbits. J Appl Physiol 95 (2003) 265-271
144. James A.L., Pare P.D., and Hogg J.C. Effects of lung volume, bronchoconstriction, and cigarette smoke on morphometric airway dimensions. J Appl Physiol 64 (1988) 913-919
145. Wiggs B.R., Hrousis C.A., Drazen J.M., and Kamm R.D. On the mechanism of mucosal folding in normal and asthmatic airways. J Appl Physiol 83 (1997) 1814-1821
146. Seow C.Y., Wang L., and Pare P.D. Airway narrowing and internal structural constraints. J Appl Physiol 88 (2000) 527-533
147. Meiss R.A. Influence of intercellular tissue connections on airway muscle mechanics. J Appl Physiol 86 (1999) 5-15