Differential distribution of inflammatory cells in large and small airways in smokers

Journal of Clinical Pathology

Volumn 60, Issue 8, 2007, Pages 907-911

  Battaglia, Salvatore ^a,b   Mauad, Thais ^a,c   Van Schadewijk, Annemarie M ^a   Vignola, Antonio M ^b   Rabe, Klaus F ^a   Bellia, Vincenzo ^b   Sterk, Peter J ^a   Hiemstra, Pieter S ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF PALERMO   (Italy)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

AIRWAY OBSTRUCTION; ARTICLE; CELL DENSITY; CELL INFILTRATION; CELLULAR DISTRIBUTION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; LAMINA PROPRIA; LUNG CANCER; LYMPHOCYTE; MACROPHAGE; MALE; MAST CELL; NEUTROPHIL; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SMOKING;

CELL COUNT; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG; LUNG NEOPLASMS; LYMPHOCYTES; MACROPHAGES; MALE; MAST CELLS; MIDDLE AGED; NEUTROPHILS; PHAGOCYTES; RESPIRATORY MUCOSA; SMOKING;

EID: 34547786671     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2006.037002     Document Type: Article

References (30)

1. NHLBI/WHO. Global initiative for chronic obstructive lung disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Workshop report. Update of the Management Sections. Bethesda (MD) National Institutes of Health, National Heart, Lung, and Blood Institute, 2001 (date updated: 1 July 2003), http://www.goldcopd.com (accessed 20 Apr 2007).
2. Saetta M, Turato G, Maestrelli P, et al. Cellular and structural bases of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001;163:1304-9.
3. Lams BE, Sousa AR, Rees PJ, et al. Subepithelial immunopathology of the large airways in smokers with and without chronic obstructive pulmonary disease. Eur Respir J 2000;15:512-16.
4. Bosken CH, Hards J, Gatter K, et al. Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers using immunocytochemistry. Am Rev Respir Dis 1992;145:911-17.
5. Lams BE, Sousa AR, Rees PJ, et al. Immunopathology of the small-airway submucosa in smokers with and without chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;158:1518-23.
6. Saetta M, Di Stefano A, Turato G, et al. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;157:822-6.
7. Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 2004;364:709-21.
8. Lapperre TS, Postma DS, Gosman MM, et al. Relation between duration of smoking cessation and bronchial inflammation in COPD. Thorax 2005;61:115-21.
9. Gamble E, Grootendorst DC, Brightling CE, et al. Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003;168:976-82.
10. Hogg JC, Chu F, Utokaparch S, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004;350:2645-53.
11. Hamid Q, Song Y, Kotsimbos TC, et al. Inflammation of small airways in asthma. J Allergy Clin Immunol 1997;100:44-51.
12. Miller LA, Hurst SD, Coffman RL, et al. Airway generation-specific differences in the spatial distribution of immune cells and cytokines in allergen-challenged rhesus monkeys. Clin Exp Allergy 2005;35:894-906.
13. Bai A, Eidelman DH, Hogg JC, et al. Proposed nomenclature for quantifying subdivisions of the bronchial wall. J Appl Physiol 1994;77:1011-4.
14. Saetta M, Turato G, Baraldo S, et al. Goblet cell hyperplasia and epithelial inflammation in peripheral airways of smokers with both symptoms of chronic bronchitis and chronic airflow limitation. Am J Respir Crit Care Med 2000;161:1016-21.
15. Sont JK, de Boer WI, van Schadewijk AM, et al. Fully automated assessment of inflammatory cell counts and cytokine expression in bronchial tissue. Am J Respir Crit Care Med 2003;167:1496-503.
16. Haley KJ, Sunday ME, Wiggs BR, et al. Inflammatory cell distribution within and along asthmatic airways. Am J Respir Crit Care Med 1998;158:565-72.
17. O'Donnell RA, Peebles C, Ward JA, et al. Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD. Thorax 2004;59:837-42.
18. Baraldo S, Turato G, Badin C, et al. Neutrophilic infiltration within the airway smooth muscle in patients with COPD. Thorax 2004;59:308-12.
19. Grashoff WF, Sont JK, Sterk PJ, et al. Chronic obstructive pulmonary disease: role of bronchiolar mast cells and macrophages. Am J Pathol 1997;151:1785-90.
20. Amin K, Ekberg-Jansson A, Lofdahl CG, et al. Relationship between inflammatory cells and structural changes in the lungs of asymptomatic and never smokers: a biopsy study. Thorax 2003;58:135-42.
21. Luettig B, Kaiser M, Bode U, et al. Naive and memory T cells migrate in comparable numbers through the normal rat lung: only effector T cells accumulate and proliferate in the lamina propria of the bronchi. Am J Respir Cell Mol Biol 2001;25:69-77.
22. Ainslie MP, McNulty CA, Huynh T, et al. Characterisation of adhesion receptors mediating lymphocyte adhesion to bronchial endothelium provides evidence for a distinct lung homing pathway. Thorax 2002;57:1054-9.
23. Pabst R, Tschernig T. Perivascular capillaries in the lung: an important but neglected vascular bed in immune reactions? J Allerqy Clin Immunol 2002;110:209-14.
24. Schmiedl A, Tschernig T, Luhrmann A, et al. Leukocyte infiltration of the periarterial space of the lung after allergen provocation in a rat asthma model. Pathobiology 2005;72:308-15.
25. de Boer WI, Sont JK, van Schadewijk A, et al. Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD. J Pathol 2000;190:619-26.
26. Jeffery P, Holgate S, Wenzel S. Methods for the assessment of endobronchial biopsies in clinical research: application to studies of pathogenesis and the effects of treatment. Am J Respir Crit Care Med 2003;168:S1-17.
27. Mandarim-de-Lacerda CA. Stereological tools in biomedical research. An Acad Bras Cienc 2003;75:469-86.
28. de Boer WI, Hiemstra PS, Sont JK, et al. Image analysis and quantification in lung tissue. Clin Exp Allergy 2001;31:504-8.
29. Fehrenbach H. Design-based counting. Am J Respir Crit Care Med 2004;169:1170.
30. Carroll NG, Mutavdzic S, James AL. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 2002;19:879-85.