Medial vascular calcification in diabetes mellitus and chronic kidney disease: The role of inflammation

Cardiovascular and Hematological Disorders - Drug Targets

Volumn 7, Issue 1, 2007, Pages 1-6

  Al Aly, Ziyad ^a,b  

^a SAINT LOUIS UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Chronic kidney disease; Diabetes mellitus; Inflammation; TNF alpha; Vascular calcification

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CALCIUM; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

BLOOD VESSEL CALCIFICATION; BONE METABOLISM; CHRONIC KIDNEY DISEASE; DIABETES MELLITUS; DYSLIPIDEMIA; HOMEOSTASIS; HUMAN; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; MINERAL METABOLISM; MORBIDITY; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOGENESIS; PHENOTYPE; REVIEW; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 33947167667     PISSN: 1871529X     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152907780059047     Document Type: Review

References (57)

1. Edmonds, M.E.; Morrison, N.; Laws, J.W.; Watkins, P.J. Medial arterial calcification and diabetic neuropathy. Br. Med. J. (Clin. Res. Ed.) 1982, 284, 928-930.
2. London, G.M.; Guerin, A.P.; Marchais, S.J.; Metivier, F.; Pannier, B.; Adda, H. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol. Dial Transplant. 2003, 18, 1731-1740.
3. Al Aly, Z.; Edwards, J.C. Vascular biology in uremia: insights into novel mechanisms of vascular injury. Adv. Chronic. Kidney Dis. 2004, 11, 310-318.
4. Lehto, S.; Niskanen, L.; Suhonen, M.; Ronnemaa, T.; Laakso, M. Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus. Arterioscler. Thromb. Vasc. Biol. 1996, 16, 978-983.
5. Salgueira, M.; Del Toro, N.; Moreno-Alba, R.; Jimenez, E.; Areste, N.; Palma, A. Vascular calcification in the uremic patient: A cardiovascular risk? Kidney Int. Suppl. 2003, 119-121.
6. Reslerova, M.; Moe, S.M. Vascular calcification in dialysis patients: pathogenesis and consequences. Am. J. Kidney Dis. 2003, 41, S96-99.
7. Blacher, J.; Guerin, A.P.; Pannier, B.; Marchais, S.J.; London, G.M. Arterial calcifications, arterial stiffness, cardiovascular risk in end-stage renal disease. Hypertension 2001, 38, 938-942.
8. Ganesh, S.K.; Stack, A,G.; Levin, N.W.; Hulbert-Shearon, T.; Port, F.K. Association of elevated serum PO(4), Ca × PO(4) product, parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients. J. Am. Soc. Nephrol. 2001, 12, 2131-2138.
9. Olson, J.C.; Edmundowicz, D.; Becker, D.J.; Kuller, L.H.; Orchard, T.J. Coronary calcium in adults with type 1 diabetes: a stronger correlate of clinical coronary artery disease in men than in women. Diabetes 2000, 49, 1571-1578.
10. Cheng, S.L.; Shao, J.S.; Charlton-Kachigian, N.; Loewy, A.P.; Towler, D.A. MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors. J. Biol. Chem. 2003, 278, 45969-45977.
11. Towler, D.A.; Bidder, M.; Latifi, T.; Coleman, T.; Semenkovich, C.F. Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. J. Biol. Chem. 1998, 273, 30427-30434.
12. Shao, J.S.; Cheng, S.L.; Charlton-Kachigian, N.; Loewy, A.P.; Towler, D.A. Teriparatide (human parathyroid hormone (1-34)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptor-deficient mice. J. Biol. Chem. 2003, 278, 50195-50202.
13. Karsenty, G. Minireview: transcriptional control of osteoblast differentiation. Endocrinology 2001, 142, 2731-2733.
14. Demer, L.L. Tintut, Y. Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lecture. Arterioscler. Thromb. Vasc. Biol. 2003, 23, 1739-1743.
15. Giachelli, C.M. Vascular calcification mechanisms. J. Am. Soc. Nephrol. 2004, 15, 2959-2964.
16. Jono, S.; McKee, M.D.; Murry, C.E.; Shioi, A.; Nishizawa, Y.; Mori, K.; Morii, H.; Giachelli, C.M. Phosphate regulation of vascular smooth muscle cell calcification. Circ. Res. 2000, 87, E10-17.
17. Giachelli, C.M.; Jono, S.; Shioi, A.; Nishizawa, Y.; Mori, K.; Morii, H. Vascular calcification and inorganic phosphate. Am. J. Kidney Dis. 2001, 38, S34-37.
18. Yang, H.; Curinga, G.; Giachelli, C.M. Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro. Kidney Int. 2004, 66, 2293-2299.
19. Murshed, M.; Harmey, D.; Millan, J.L.; McKee, M.D.; Karsenty, G. Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev. 2005, 19, 1093-1104.
20. Beck, G.R.; Jr.; Zerler, B.; Moran, E. Phosphate is a specific signal for induction of osteopontin gene expression. Proc. Natl. Acad. Sci. USA 2000, 97, 8352-8357.
21. Chen, N.X.; O'Neill, K.D.; Duan, D.; Moe, S.M. Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells. Kidney Int. 2002, 62, 1724-1731.
22. Lomashvili, K.A.; Cobbs, S.; Hennigar, R.A.; Hardcastle, K.I.; O'Neill, W.C. Phosphate-induced vascular calcification: role of pyrophosphate and osteopontin. J. Am. Soc. Nephrol. 2004, 15, 1392-1401.
23. Rutsch, F.; Ruf, N.; Vaingankar, S.; Toliat, M.R.; Suk, A.; Hohne, W.; Schauer, G.; Lehmann, M.; Roscioli, T.; Schnabel, D.; Epplen, J.T.; Knisely, A.; Superti-Furga, A.; McGill, J.; Filippone, M.; Sinaiko, A.R.; Vallance, H.; Hinrichs, B.; Smith, W.; Ferre, M.; Terkeltaub, R.; Nurnberg, P. Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification. Nat. Genet. 2003, 34, 379-381.
24. Budoff, M.J.; Yu, D.; Nasir, K.; Mehrotra, R.; Chen, L.; Takasu, J.; Agrawal, N.; Liu, S.T.; Blumenthal, R.S. Diabetes and progression of coronary calcium under the influence of statin therapy. Am. Heart J. 2005, 149, 695-700.
25. Snell-Bergeon, J.K.; Hokanson, J.E.; Jensen, L.; MacKenzie, T.; Kinney, G.; Dabelea, D.; Eckel, R.H.; Ehrlich, J.; Garg, S.; Rewers, M. Progression of coronary artery calcification in type 1 diabetes: the importance of glycemic control. Diabetes Care 2003, 26, 2923-2928.
26. Dabelea., D.; Kinney, G.; Snell-Bergeon, J.K.; Hokanson, J.E.; Eckel, R.H.; Ehrlich, J.; Garg, S.; Hamman, R.F.; Rewers, M. Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. Diabetes 2003, 52, 2833-2839.
27. Budoff, M.J.; Lane, K.L.; Bakhsheshi, H.;. Mao, S.; Grassmann, B.O.; Friedman, B.C.; Brundage, B.H. Rates of progression of coronary calcium by electron beam tomography. Am. J. Cardiol. 2000, 86, 8-11.
28. Mehrotra, R.; Budoff, M.; Hokanson, J.E.; Ipp, E.; Takasu, J.; Adler, S. Progression of coronary artery calcification in diabetics with and without chronic kidney disease. Kidney Int. 2005, 68, 1258-1266.
29. Goodman, W.G.; Goldin, J.; Kuizon, B.D.; Yoon, C.; Gales, B.; Sider, D.; Wang, Y.; Chung, J.; Emerick, A.; Greaser, L.; Elashoff, R.M.; Salusky, I.B. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl. J. Med. 2000, 342, 1478-1483.
30. Goodman, W.G.; London, G.; Amann, K.; Block, G.A.; Giachelli, C.; Hruska, K.A.; Ketteler, M.; Levin, A.; Massy, Z.; McCarron, D.A.; Raggi, P.; Shanahan, C.M.; Yorioka, N. Vascular calcification in chronic kidney disease. Am. J. Kidney Dis. 2004, 43, 572-579.
31. Goodman, W.G. Vascular calcification in chronic renal failure. Lancet 2001, 358, 1115-1116.
32. Taniwaki, H.; Ishimura, E.; Tabata, T.; Tsujimoto, Y.; Shioi, A.; Shoji, T.; Inaba, M.; Inoue, T.; Nishizawa, Y. Aortic calcification in haemodialysis patients with diabetes mellitus. Nephrol. Dial Transplant. 2005, 20(11), 2472-278.
33. Wellen, K.E. and Hotamisligil, G.S. Inflammation, stress, diabetes. J. Clin. Invest. 2005, 115, 1111-1119.
34. Helmersson, J.; Vessby, B.; Larsson, A.; Basu, S. Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population. Circulation 2004, 109, 1729-1734.
35. Duncan, B.B.; Schmidt, M.I.; Pankow, J.S.; Ballantyne, C.M.; Couper, D.; Vigo, A.; Hoogeveen, R.; Folsom, A.R.; Heiss, G. Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes 2003, 52, 1799-1805.
36. Schmidt, M.I.; Duncan, B.B.; Sharrett, A.R.; Lindberg, G.; Savage, P.J.; Offenbacher, S.; Azambuja, M.I.; Tracy, R.P.; Heiss, G. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 1999, 353, 1649-1652.
37. Barzilay, J.I.; Abraham, L.; Heckbert, S.R.; Cushman, M.; Kuller, L.H.; Resnick, H.E.; Tracy, R.P. The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study. Diabetes 2001, 50, 2384-2389.
38. Hotamisligil, G.S.; Shargill, N.S.; Spiegelman, B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259, 87-91.
39. Knobler, H.; Zhornicky, T.; Sandler, A.; Haran, N.; Ashur, Y.; Schattner, A. Tumor necrosis factor-alpha-induced insulin resistance may mediate the hepatitis C virus-diabetes association. Am. J. Gastroenterol. 2003, 98, 2751-2756.
40. Bahtiyar, G.; Shin, J.J.; Aytaman, A.; Sowers, J.R.; McFarlane, S.I. Association of diabetes and hepatitis C infection: epidemiologic evidence and pathophysiologic insights. Curr. Diab. Rep. 2004, 4, 194-198.
41. Rana, J.S.; Mittleman, M.A.; Sheikh, J.; Hu, F.B.; Manson, J.E.; Colditz, G.A.; Speizer, F.E.; Barr, R.G.; Camargo, C.A.; Jr. Chronic obstructive pulmonary disease, asthma, risk of type 2 diabetes in women. Diabetes Care 2004, 27, 2478-2484.
42. Sattar, N.; McCarey, D.W.; Capell, H.; McInnes, I.B. Explaining how "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation 2003, 108, 2957-2963.
43. Pradhan, A.D.; Manson, J.E.; Rifai, N.; Buring, J.E.; Ridker, P.M. C-reactive protein, interleukin 6, risk of developing type 2 diabetes mellitus. JAMA 2001, 286, 327-334.
44. Stehouwer, C.D.; Gall, M.A.; Twisk, J.W.; Knudsen, E.; Emeis, J.J.; Parving, H.H. Increased urinary albumin excretion, endothelial dysfunction, chronic low-grade inflammation in type 2 diabetes: progressive, interrelated, independently associated with risk of death. Diabetes 2002, 51, 1157-1165.
45. Kimmel, P.L.; Phillips, T.M.; Simmens, S.J.; Peterson, R.A.; Weihs, K.L.; Alleyne, S.; Cruz, I.; Yanovski, J.A.; Veis, J.H. Immunologic function and survival in hemodialysis patients. Kidney Int. 1998, 54, 236-244.
46. Wetmore, J.B.; Hung, A.M.; Lovett, D.H.; Sen, S.; Quersby, O.; Johansen, K.L. Interleukin-1 gene cluster polymorphisms predict risk of ESRD. Kidney Int. 2005, 68, 278-284.
47. Tonelli, M.; Sacks, F.; Pfeffer, M.; Jhangri, G.S.; Curhan, G. Biomarkers of inflammation and progression of chronic kidney disease. Kidney Int. 2005, 68, 237-245.
48. Tripepi, G.; Mallamaci, F.; Zoccali, C. Inflammation markers, adhesion molecules, all-cause and cardiovascular mortality in patients with ESRD: searching for the best risk marker by multivariate modeling. J. Am. Soc. Nephrol. 2005, 16(Suppl. 1), S83-88.
49. Moe, S.M. and Chen, N.X. Inflammation and vascular calcification. Blood Purif. 2005, 23, 64-71.
50. Tintut, Y.; Patel, J.; Parhami, F.; Demer, L.L. Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation 2000, 102, 2636-2642.
51. Li, X.; Massa, P.E.; Hanidu, A.; Peet, G.W.; Aro, P.; Savitt, A.; Mische, S.; Li, J.; Marcu, K.B. IKKalpha, IKKbeta, NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program. J. Biol. Chem. 2002, 277, 45129-45140.
52. Zhang, L.; Zalewski, A.; Liu, Y.; Mazurek, T.; Cowan, S.; Martin, J.L.; Hofmann, S.M.; Vlassara, H.; Shi, Y. Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries. Circulation 2003, 108, 472-478.
53. Tintut, Y.; Patel, J.; Territo, M.; Saini, T.; Parhami, F.; Demer, L.L. Monocyte/macrophage regulation of vascular calcification in vitro. Circulation 2002, 105, 650-655.
54. Nadra, I.; Mason, J.C.; Philippidis, P.; Florey, O.; Smythe, C.D.; McCarthy, G.M.; Landis, R.C.; Haskard, D.O. Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification? Circ. Res. 2005, 96, 1248-1256.
55. Speer, M.Y.; Chien, Y.C.; Quan, M.; Yang, H.Y.; Vali, H.; McKee, M.D.; Giachelli, C.M. Smooth muscle cells deficient in osteopontin have enhanced susceptibility to calcification in vitro. Cardiovasc. Res. 2005, 66, 324-333.
56. Yildirir, A. and Muderrisoglu., H. Non-lipid effects of statins: emerging new indications. Curr. Vasc. Pharmacol. 2004, 2, 309-318.
57. Kizu, A.; Shioi, A.; Jono, S.; Koyama, H.; Okuno, Y.; Nishizawa, Y. Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators. J. Cell Biochem. 2004, 93, 1011-1019.