TPH2 polymorphisms may modify clinical picture in treatment-resistant depression

Neuroscience Letters

Volumn 464, Issue 1, 2009, Pages 43-46

  Anttila, Sami ^a,b   Viikki, Merja ^a,c   Huuhka, Kaija ^a,b   Huuhka, Martti ^a,b   Huhtala, Heini ^a   Rontu, Riikka ^a,b   Lehtimäki, Terho ^a,b   Leinonen, Esa ^a,b  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c Tampere Health Centre   (Finland)

Author keywords

ECT; Polymorphism; TPH2; Treatment resistant depression

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; HYPNOTIC AGENT; NEUROLEPTIC AGENT; TRYPTOPHAN HYDROXYLASE 2;

ADULT; ARTICLE; CONTROLLED STUDY; DEPRESSIVE PSYCHOSIS; DISEASE SEVERITY; ELECTROCONVULSIVE THERAPY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MONTGOMERY ASBERG DEPRESSION RATING SCALE; PHENOTYPE; PRIORITY JOURNAL; REMISSION; SEROTONINERGIC SYSTEM; TREATMENT RESPONSE;

DEPRESSIVE DISORDER, MAJOR; ELECTROCONVULSIVE THERAPY; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; TRYPTOPHAN HYDROXYLASE;

EID: 69249209627     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.08.018     Document Type: Article

References (34)

1. Abumaria N., Rygula R., Hiemke C., Fuchs E., Havemann-Reinecke U., Ruther E., and Flugge G. Effect of chronic citalopram on serotonin-related and stress-regulated genes in the dorsal raphe nucleus of the rat. Eur. Neuropsychopharmacol. 17 (2007) 417-429
2. Ansorge M.S., Hen R., and Gingrich J.A. Neurodevelopmental origins of depressive disorders. Curr. Opin. Pharmacol. 7 (2007) 8-17
3. Anttila S., Huuhka K., Huuhka M., Illi A., Rontu R., Leinonen E., and Lehtimäki T. Catechol-O-methyltransferase (COMT) polymorphisms predict treatment response in electroconvulsive therapy. Pharmacogenomics J. 8 (2008) 113-116
4. Anttila S., Huuhka K., Huuhka M., Rontu R., Mattila K.M., Leinonen E., and Lehtimäki T. Interaction between TPH1 and GNB3 genotypes and electroconvulsive therapy in major depression. J. Neural. Transm. 114 (2007) 461-468
5. Bach-Mizrachi H., Underwood M.D., Kassir S.A., Bakalian M.J., Sibille E., Tamir H., Mann J.J., and Arango V. Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. Neuropsychopharmacology 31 (2006) 814-824
6. Bijak M., Zahorodna A., and Tokarski K. Opposite effects of antidepressants and corticosterone on the sensitivity of hippocampal CA1 neurons to 5-HT1A and 5-HT4 receptor activation. Naunyn Schmiedebergs Arch. Pharmacol. 363 (2001) 491-498
7. Burnet P.W., Sharp T., LeCorre S.M., and Harrison P.J. Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock. Neurosci. Lett. 277 (1999) 79-82
8. Cervo L., Canetta A., Calcagno E., Burbassi S., Sacchetti G., Caccia S., Fracasso C., Albani D., Forloni G., and Invernizzi R.W. Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression. J. Neurosci. 25 (2005) 8165-8172
9. Dygalo N.N., Shishkina G.T., Kalinina T.S., Yudina A.M., and Ovchinnikova E.S. Effect of repeated treatment with fluoxetine on tryptophan hydroxylase-2 gene expression in the rat brainstem. Pharmacol. Biochem. Behav. 85 (2006) 220-227
10. Fitzgerald L.R., Vaidya V.A., Terwillinger R.Z., and Duman R.S. Electroconvulsive seizure increases the expression of CREM (cyclic AMP response element modulator) and ICER (inducible cyclic AMP early repressor) in rat brain. J. Neurochem. 1 (1996) 429-432
11. Gaspar P., Cases O., and Maroteaux L. The developmental role of serotonin: news from mouse molecular genetics. Nat. Rev. Neurosci. 4 (2003) 1002-1012
12. Green A.R., Heal D.J., and Vincent N.D. The effects of single and repeated electroconvulsive shock administration on the release of 5-hydroxytryptamine and noradrenaline from cortical slices of rat brain. Br. J. Pharmacol. 92 (1987) 25-30
13. Gutknecht L., Waider J., Kraft S., Kriegebaum C., Holtmann B., Reif A., Schmitt A., and Lesch K.P. Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. J. Neural. Transm. 115 (2008) 1127-1132
14. Huuhka K., Anttila S., Huuhka M., Hietala J., Huhtala H., Mononen N., Lehtimäki T., and Leinonen E. Dopamine 2 receptor C957T and catechol-o-methyltransferase Val158Met polymorphisms are associated with treatment response in electroconvulsive therapy. Neurosci. Lett. 448 (2008) 79-83
15. Invernizzi R.W. Role of TPH-2 in brain function: news from behavioral and pharmacologic studies. J. Neurosci. Res. 85 (2007) 3030-3035
16. Ishihara K., and Sasa M. Mechanism underlying the therapeutic effects of electroconvulsive therapy (ECT) on depression. Jpn. J. Pharmacol. 80 (1999) 185-189
17. Koubi D., Bezin L., Cottet-Emard J.M., Gharib A., Bobillier P., and Sarda N. Regulation of expression and enzymatic activities of tyrosine and tryptophan hydroxylases in rat brain after acute electroconvulsive shock. Brain Res. 905 (2001) 161-170
18. Lammers C.H., Diaz J., Schwartz J.C., and Sokoloff P. Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments. Mol. Psychiatry 4 (2000) 378-388
19. Livak K.J. Allelic discrimination using fluorogenic probes and the 5′ nuclease assay. Genet. Anal. 14 (1999) 143-149
20. Montgomery S.A., and Åsberg M. A new depression scale designed to be sensitive to change. Br. J. Psychiatry 134 (1979) 382-389
21. Nakamura K., Sugawara Y., Sawabe K., Ohashi A., Tsurui H., Xiu Y., Ohtsuji M., Lin Q.S., Nishimura H., Hasegawa H., and Hirose S. Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. J. Neurosci. 26 (2006) 530-534
22. Patel P.D., Pontrello C., and Burke S. Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biol. Psychiatry 55 (2004) 428-433
23. Peters E.J., Slager S.L., Jenkins G.D., Reinalda M.S., Garriock H.A., Shyn S.I., Kraft J.B., McGrath P.J., and Hamilton S.P. Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response. Pharmacogenet. Genomics 19 (2009) 1-10
24. Peters E.J., Slager S.L., McGrath P.J., Knowles J.A., and Hamilton S.P. Investigation of serotonin-related genes in antidepressant response. Mol. Psychiatry 9 (2004) 879-889
25. Schatzberg A.F., Posener J.A., DeBattista C., Kalehzan B.M., Rothschild A.J., and Shear P.K. Neuropsychological deficits in psychotic versus nonpsychotic major depression and no mental illness. Am. J. Psychiatry 157 (2000) 1095-1100
26. Shen H., Numachi Y., Yoshida S., Toda S., Awata S., Matsuoka H., and Sato M. Electroconvulsive shock regulates serotonin transporter mRNA expression in rat raphe nucleus. Psychiatry Clin. Neurosci. 55 (2001) 75-77
27. Tzvetkov M.V., Brockmöller J., Roots I., and Kirchheiner J. Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment. Pharmacogenet. Genomics 18 (2008) 495-506
28. UK ECT Review Group. Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet 361 (2003) 799-808
29. Walther D.J., and Bader M. A unique central tryptophan hydroxylase isoform. Biochem. Pharmacol. 66 (2003) 1673-1680
30. Yoshida K., Higuchi H., Kamata M., Yoshimoto M., Shimizu T., and Hishikawa Y. Single and repeated electroconvulsive shocks activate dopaminergic and 5-hydroxytryptaminergic neurotransmission in the frontal cortex of rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 22 (1998) 435-444
31. Zhang X., Beaulieu J.M., Sotnikova T.D., Gainetdinov R.R., and Caron M.G. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305 (2004) 217
32. Zill P., Baghai T.C., Zwanzger P., Schule C., Eser D., Rupprecht R., Moller H.J., Bondy B., and Ackenheil M. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol. Psychiatry 9 (2004) 1030-1036
33. Zill P., Buttner A., Eisenmenger W., Moller H.J., Ackenheil M., and Bondy B. Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study. J. Psychiatr. Res. 41 (2007) 168-173
34. Zill P., Buttner A., Eisenmenger W., Moller H.J., Bondy B., and Ackenheil M. Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol. Psychiatry 56 (2004) 581-658