Computational modeling of cerebral aneurysm formation - Framework for modeling the interaction between fluid dynamics, signal transduction pathways and arterial wall mechanics

IFMBE Proceedings

Volumn 22, Issue , 2008, Pages 1894-1898

  Schmid, Holger ^a   Watton, P ^b   McCormick, M ^b   Lanir, Y ^c   Ho, H ^d   Lloyd, C ^d   Hunter, P ^d   Ehret, A ^a   Itskov, M ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^d UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Cerebral aneurysms; Fluid mechanics; Mixture theory; Signal transduction pathways

Indexed keywords

ARTERIAL WALL; ARTERIAL WALL MECHANICS; CEREBRAL ANEURYSMS; COMPUTATIONAL MODELING; FURTHER DEVELOPMENT; MECHANO-BIOLOGY; MIXTURE THEORY; MOLECULAR SIGNALING; PHENOMENOLOGICAL MODELS; SIGNAL TRANSDUCTION PATHWAYS;

BACTERIOPHAGES; CONTACTS (FLUID MECHANICS); FLUID DYNAMICS; FLUIDS; MECHANICS;

SIGNAL TRANSDUCTION;

EID: 69249156555     PISSN: 16800737     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1007/978-3-540-89208-3_451     Document Type: Conference Paper

References (28)

1. de la Monte, S. et al., 1985. Risk factors for development and rupture of intracranial berry aneurysms. Am J Med 78, 957-694.
2. Bederson, J. et al., 2000. Recommendations for the management of patients with unruptured intracranial aneurysms. Stroke 31, 2742-2750.
3. Sekhar, L., Heros, R., 1981. Origin, growth, and rupture of saccular aneurysms: a review. Neurosurgery 8, 248-260.
4. Davies, P., 1995. Flow-mediated endothelial mechanotransduction. Physiol Rev 75, 519-560.
5. Papadaki, M., Eskin, S., 1997. Effects of fluid shear stress on gene regulation of vascular cells. Biotechnol Progr 13, 209-221. 6. Rodbard, S., 1975. Vascular caliber. Cardiology 60, 4-49.
6. Humphrey, J., Rajagopal, K., 2003. A constrained mixture model for arterial adaptations to a sustained step change in flow. Biomech Model Mechanobiol 2, 109-126.
7. Skalak, R. et al., 1982. Analytical description of growth. J Theor Biol 94, 555-577.
8. Rodriguez, E. et al., 1994. Stress-dependent finite growth in soft elastic tissues. J Biomech 27, 455-467.
9. Humphrey, J., Rajagopal, K., 2002. A constrained mixture model for growth and remodeling of soft tissues. Math Mod Meth Appl S 12 (3), 407-430.
10. Gleason, R., Humphrey, J., 2005. A 2d constrained mixture model for arterial adaptations to large changes in flow, pressure and axial stretch. Math Med Biol 22, 347-369.
11. Shojima M. et al, 2004, Magnitude and Role of Wall Shear Stress on Cerebral Aneurysm, Stroke, 35, 2500-2505.
12. C. Were, The free-ALE method for unsteady incompressible flow in deforming geometries, PhD thesis, 1997
13. Nobile, F., 2001, Numerical Approximation of Fluid-Structure Interaction Problems with Application to Haemodynamics, PhD thesis, EPF Lausanne.
14. Ali M., Schumacker P., 2002. Endothelial responses to mechanical stress: Where is the mechanosensor? Crit Care Med 30, S198.
15. Kondo S. et al., 1998. Apoptosis of Medial Smooth Muscle Cells in the Development of Saccular Cerebral Aneurysms in Rats. Stroke 29, 181-189.
16. Schmid F. et al., 2003 Ascending aortic aneurysm associated with bicuspid and tricuspid aortic valve. European J Cardiothor Surg 23, 537-543.
17. Gilbert D. et al., 2006, Computational methodologies for modelling, analysis and simulation of signalling networks. Brief Bioinf 7, 339-353.
18. www.cellml.org
19. Bhalla U., Iyengar R., 1999. Emergent Properties of Networks of Biological Signalling Pathways, Science, 283, 381.
20. Hatakeyama M. et al., 2003. A computational model on the modulation of mitogen activated protein kinase (MAPK) and Akt pathways in heregulin induced ErbB signalling. Biochem J 373, 451-463.
21. Karagiannis E., Popel A., 2006, Distinct modes of collagen type I proteolysis by matrix metalloproteinase MMP-2 and membrane type I MMP during the migration of a tip endothelial cell. J Theor Biol 238, 124-145.
22. Saucerman J. et al., 2003. Modelling beta adrenergic control of cardiac myocyte contractility in silico. J Biol Chem 278, 47997-03.
23. Chen K., Popel A., 2007, Vascular and perivascular NO release and transport. Free Radical Bio Med 42, 811-822.
24. Humphrey, J., 1999. Remodeling of a collageneous tissue at fixed length. Journal of Biomechanical Engineering 121, 591-597.
25. Watton, P. et al., 2004, A mathematical model for the growth of the abdominal aortic aneurysm, Biomech Model Mechanobiol, 3, 98-113.
26. Tsamis, A., Stergiopulos, N., 2007, Arterial remodeling in response to hypertension using a constituent-based model, Am J Phsiol, 293, H3130-39.
27. www.cmiss.org
28. Schmid, H., O'Callaghan, P., Nash,M., Lin,W., Legrice, I., Smaill, B., Young, A., Hunter, P., 2007. Myocardial material parameter estimation from simple shear tests - a non-homogeneous finite element study. Biomechanics and Modeling in Mechanobiology, ISSN: 1617-7959.